LOCUS       NM_011436              10726 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus sortilin-related receptor, LDLR class A
            repeats-containing (Sorl1), transcript variant 1, mRNA.
ACCESSION   NM_011436
VERSION     NM_011436.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10726)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 10726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 10726)
  AUTHORS   Shih,A.Z.L., Chen,Y.C., Speckmann,T., Sondergaard,E., Schurmann,A.,
            Verchere,C.B. and Willnow,T.E.
  TITLE     SORLA mediates endocytic uptake of proIAPP and protects against
            islet amyloid deposition
  JOURNAL   Mol Metab 65, 101585 (2022)
   PUBMED   36055578
  REMARK    GeneRIF: SORLA mediates endocytic uptake of proIAPP and protects
            against islet amyloid deposition.
REFERENCE   4  (bases 1 to 10726)
  AUTHORS   Schmidt,V., Horvath,C., Dong,H., Bluher,M., Qvist,P., Wolfrum,C.
            and Willnow,T.E.
  TITLE     SORLA is required for insulin-induced expansion of the adipocyte
            precursor pool in visceral fat
  JOURNAL   J Cell Biol 220 (12) (2021)
   PUBMED   34779857
  REMARK    GeneRIF: SORLA is required for insulin-induced expansion of the
            adipocyte precursor pool in visceral fat.
REFERENCE   5  (bases 1 to 10726)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10726)
  AUTHORS   Hampe,W., Riedel,I.B., Lintzel,J., Bader,C.O., Franke,I. and
            Schaller,H.C.
  TITLE     Ectodomain shedding, translocation and synthesis of SorLA are
            stimulated by its ligand head activator
  JOURNAL   J Cell Sci 113 Pt 24, 4475-4485 (2000)
   PUBMED   11082041
REFERENCE   7  (bases 1 to 10726)
  AUTHORS   Stoykova,A., Treichel,D., Hallonet,M. and Gruss,P.
  TITLE     Pax6 modulates the dorsoventral patterning of the mammalian
            telencephalon
  JOURNAL   J Neurosci 20 (21), 8042-8050 (2000)
   PUBMED   11050125
REFERENCE   8  (bases 1 to 10726)
  AUTHORS   Hirayama,S., Bujo,H., Yamazaki,H., Kanaki,T., Takahashi,K.,
            Kobayashi,J., Schneider,W.J. and Saito,Y.
  TITLE     Differential expression of LR11 during proliferation and
            differentiation of cultured neuroblastoma cells
  JOURNAL   Biochem Biophys Res Commun 275 (2), 365-373 (2000)
   PUBMED   10964672
REFERENCE   9  (bases 1 to 10726)
  AUTHORS   Kanaki,T., Bujo,H., Hirayama,S., Tanaka,K., Yamazaki,H.,
            Seimiya,K., Morisaki,N., Schneider,W.J. and Saito,Y.
  TITLE     Developmental regulation of LR11 expression in murine brain
  JOURNAL   DNA Cell Biol 17 (8), 647-657 (1998)
   PUBMED   9726247
REFERENCE   10 (bases 1 to 10726)
  AUTHORS   Hermans-Borgmeyer,I., Hampe,W., Schinke,B., Methner,A., Nykjaer,A.,
            Susens,U., Fenger,U., Herbarth,B. and Schaller,H.C.
  TITLE     Unique expression pattern of a novel mosaic receptor in the
            developing cerebral cortex
  JOURNAL   Mech Dev 70 (1-2), 65-76 (1998)
   PUBMED   9510025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160051.2, AK147303.1 and AC103610.9.
            
            On Oct 24, 2017 this sequence version replaced NM_011436.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147303.1, AB015790.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC160051.2         165669-165676
            9-6946              AK147303.1         2-6939
            6947-10726          AC103610.9         56395-60174         c
FEATURES             Location/Qualifiers
     source          1..10726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 23.55 cM"
     gene            1..10726
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="sortilin-related receptor, LDLR class A
                     repeats-containing"
                     /db_xref="GeneID:20660"
                     /db_xref="MGI:MGI:1202296"
     exon            1..469
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..6832
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sorLA-1; LDLR relative with 11 ligand-binding
                     repeats; sorting protein-related receptor containing LDLR
                     class A repeats; low-density lipoprotein receptor relative
                     with 11 ligand-binding repeats"
                     /codon_start=1
                     /product="sortilin-related receptor isoform 1 precursor"
                     /protein_id="NP_035566.2"
                     /db_xref="CCDS:CCDS40594.1"
                     /db_xref="GeneID:20660"
                     /db_xref="MGI:MGI:1202296"
                     /translation="MATRSSRRESRLPFLFALVALLPRGALGGGWTQRLHGGPAPLPQ
                     DRGFFVVQGDPRDLRLGTHGDAPGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSH
                     NQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFSKISEKLNFGVGNNS
                     EAVISQFYHSPADNKRYIFVDAYAQYLWITFDFCSTIHGFSIPFRAADLLLHSKASNL
                     LLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNAIYIERHEPFGFST
                     VLRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLPGSQQQSSVQLWVSFGRKP
                     MRAAQFVTKHPINEYYIADAAEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYY
                     SPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTW
                     EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATG
                     SVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTN
                     EGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVP
                     CTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDY
                     ECDFGFKMSEDLSLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGD
                     VEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYE
                     RNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKI
                     EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSYMDGSAAYR
                     LVSEDVKWPNGISVDSQWIYWTDAYLDCIERITFSGQQRSVILDSLPHPYAIAVFKNE
                     IYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNAGSNACVPQPCSLLC
                     LPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNNTCVKEENTCLRNQYRCSNG
                     NCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFRCQESGTCIPLSYKCDLEDDCGD
                     NSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF
                     QCHNGHCIPQRWACDGDADCQDGSDEDPVSCEKKCNGFHCPNGTCIPSSKHCDGLRDC
                     PDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIVQCRDGSDEDAAFAGCSQDPE
                     FHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCEN
                     GHCIPNRWKCDRENDCGDWSDEKDCGDSHVLPSPTPGPSTCLPNYFHCSSGACVMGTW
                     VCDGYRDCADGSDEEACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGH
                     QDCQDGQDEANCPTHSTLTCTSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDE
                     LTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKT
                     STVLKVLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGV
                     ILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAV
                     TSRGIGNWSDSKSITTIKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFW
                     SFDAHKQEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGS
                     SPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSVTTSLHNKTVIV
                     SKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVHIGKTSALIKWESPYD
                     SPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDS
                     SIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMSDSAVNLTAY
                     LGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGADAAVIQAA
                     RSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFSAFANSHYSSRLGSAIFSSG
                     DDLGEDDEDAPMITGFSDDVPMVIA"
     exon            470..586
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            587..712
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            713..874
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            875..942
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1123
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1225
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1395
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1588
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1706
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1780
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1869
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2048
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2235
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2364
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2450
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2623
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2755
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2847
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3094
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3233
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3407
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3521
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3644
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3764
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3890
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..3998
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4130
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4262
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4397
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4553
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4703
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4835
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..4962
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..5132
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5245
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5246..5350
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5351..5423
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5424..5506
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5507..5606
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5791
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5911
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            5912..6076
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6077..6251
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6252..6358
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..6551
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6552..6764
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     exon            6765..10726
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7169..7174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="hexamer: AATAAA"
     polyA_site      7192
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="major polyA site"
     regulatory      10383..10388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="hexamer: AATAAA"
     polyA_site      10416
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="major polyA site"
     regulatory      10695..10700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="hexamer: AATAAA"
     polyA_site      10717
                     /gene="Sorl1"
                     /gene_synonym="2900010L19Rik; gp250; LR11; mSorLA; SorLA"
                     /note="major polyA site"
ORIGIN      
        1 gagcgagcgg gacccggcgg cggcggtggc cgtggctgcg gtggcgggcg cagcggagcg
       61 gcccgggcgg cttggagccc cgggagcggc gcgcgcggcc ccggccctgg ccccgcgctg
      121 tcccggcgcg cgctgcacat tctctcctgg cggcggcgcc acctgcggga gcgttcgccc
      181 gaacatggcg acacggagca gcaggaggga gtcgagactc cctttcctat tcgccctggt
      241 cgcgctgcta ccccgcgggg ctctcggcgg gggctggacg cagagattgc acggtggccc
      301 ggcgcccttg ccccaggacc ggggcttctt cgtggtgcag ggcgacccgc gcgatctccg
      361 gctaggaacg cacggggatg ccccgggggc gagcccggcg gccaggaagc cactcaggac
      421 ccggcggagc gctgctctgc agccccagcc tatccaggtg tatggacagg tcagtctgaa
      481 tgactcccac aatcagatgg tggtgcactg ggccggagag aaaagcaacg tgatcgtggc
      541 attagcccga gacagcctgg cgttggcaag gcccaagagc agtgatgtgt atgtgtctta
      601 cgactatgga aaatcattca gtaagatttc agagaagctg aactttggcg tgggcaacaa
      661 cagcgaagct gtgatctccc agttctacca cagccctgct gacaacaaga ggtacatctt
      721 tgtggatgct tacgcccaat acctctggat cacatttgac ttctgcagca ctatccatgg
      781 cttctccatc ccattccggg cggctgatct cctcctccat agcaaggcct ccaacctcct
      841 cttgggcttt gacaggtctc accccaacaa gcagctatgg aagtcagatg attttggcca
      901 gacctggatc atgattcagg aacacgtgaa gtccttctct tggggaatcg acccctatga
      961 tcagccaaac gctatctaca ttgagcgaca tgaacccttt gggttctcca cagtgctccg
     1021 cagtacagac ttcttccagt cccgggaaaa ccaggaagtg atcctggagg aagtgagaga
     1081 ctttcagctt cgcgacaagt atatgtttgc tacaaaggtg gtgcatcttc cgggcagcca
     1141 gcagcagtca tctgtccagc tctgggtctc ctttggccgg aagcctatga gagcagccca
     1201 gtttgtcaca aagcatccta ttaatgaata ttacatcgct gatgccgccg aggaccaggt
     1261 gttcgtgtgt gttagccaca gtaacaacag cactaactta tacatctcag aggcagaggg
     1321 gctgaagttc tccctctcct tggagaatgt gctgtattac agcccaggag gggccggcag
     1381 tgacactctg gtgaggtatt ttgcaaatga gccgtttgcc gactttcacc gcgtggaagg
     1441 cttacaagga gtctatattg ccaccctgat taatggttct atgaatgagg agaacatgag
     1501 gtcggtcatc acctttgaca aagggggaac ctgggaattt cttcaggccc cagccttcac
     1561 aggatatgga gagaaaatca attgtgagct ttctcagggt tgttccctcc acctggccca
     1621 gcgcctcagt caactgctca acctccaact tcggaggatg cctatcctat ccaaggagtc
     1681 agcccccggt ctcatcattg ctaccggctc tgtgggaaag aacttggcca gcaagaccaa
     1741 tgtgtacatc tctagcagtg ctggagccag gtggagagag gctcttcccg gacctcatta
     1801 ctatacttgg ggtgaccatg gaggcatcat catggcgatt gcccagggca tggagaccaa
     1861 cgagctgaag tacagcacca atgaagggga gacctggaag acgttcgtct tctcggagaa
     1921 gcctgtgttt gtgtatgggc ttctcacaga acctggtgag aagagcaccg tcttcaccat
     1981 cttcggctcg aacaaggaga gtgtccacag ctggctcatc ctgcaggtca atgccactga
     2041 tgccttgggg gttccttgca cagaaaacga ctacaagctg tggtccccat ctgatgagcg
     2101 aggaaatgag tgtttgctag gacacaagac agttttcaaa aggaggaccc ctcatgccac
     2161 gtgctttaat ggggaagact ttgaccggcc agtggttgtg tccaactgct cctgcacccg
     2221 ggaggactac gaatgtgact ttggcttcaa gatgagcgaa gatctctcct tagaggtttg
     2281 tgttccagac cctgagtttt ctgggaagcc ctacagccct cctgtgcctt gtcctgtggg
     2341 ttcttcatac aggagaacga gaggctatcg gaagatttct ggggatacgt gcagtggagg
     2401 agacgttgaa gcgcggctgg aaggggagct ggtcccctgt ccccttgcag aagagaatga
     2461 gttcatccta tacgccatgc gcaagtccat ctaccgctac gacttggcct cgggagccac
     2521 agagcagctt cctctctcgg ggctgcgggc ggctgtggcc ctggactttg actatgaacg
     2581 caactgcttg tattggtctg acctggcgct ggacaccatc cagcgtctct gcttgaacgg
     2641 gagcacaggg caggaggtga tcatcaattc cggcctggag accgtggagg ctttggcctt
     2701 cgaacccctc agccaattac tttactgggt ggatgccggc tttaaaaaga tcgaggtagc
     2761 taatccagat ggtgacttcc gactgacaat cgtcaattcc tctgtgcttg atcgacccag
     2821 ggctttagtc cttgtacccc aagaaggggt gatgttctgg actgactggg gggacctgaa
     2881 gcctgggatt taccggagct acatggacgg ctctgctgcc taccgccttg tgtcagagga
     2941 cgtgaagtgg cccaatggca tctctgtgga cagccagtgg atctactgga cggatgctta
     3001 cctggactgt atcgagcgca tcactttcag tggccagcag cgttcagtca tccttgacag
     3061 cctcccacac ccctatgcca tcgctgtctt taagaatgag atctactggg atgactggtc
     3121 acagctcagc atcttcagag cttcgaagca cagcagatcc caggtggaga ttctagcaag
     3181 ccagctcacg ggcctcatgg acatgaaggt tttctacaag ggaaagaatg ctggaagcaa
     3241 cgcttgtgtc cctcagccct gcagtctact gtgcctccct aaggccaaca acagcaaaag
     3301 ctgcaggtgt ccagaaggtg tggccagcag tgtcctcccc tctggggacc tgatgtgtga
     3361 ctgccctcag ggctatcaaa ggaagaacaa cacctgtgtc aaagaagaga acacctgtct
     3421 ccgaaaccag tatcgctgca gcaacggcaa ctgtatcaac agcatttggt ggtgtgattt
     3481 cgacaatgac tgtggagaca tgagtgacga gagaaattgc cccacgacgg tctgtgatgc
     3541 agacactcag ttccggtgcc aggagtcggg gacttgcatt ccactctcct ataagtgtga
     3601 ccttgaagat gactgtggag ataacagtga tgagagtcac tgtgagatgc accagtgtcg
     3661 tagcgacgag ttcaactgca gctctgggat gtgcatccgg tcctcctggg tgtgcgatgg
     3721 agacaacgac tgtagggact ggtctgatga agccaactgt actgccatct atcatacctg
     3781 tgaggcctcc aacttccagt gccacaatgg ccactgcatc ccccagcgat gggcatgtga
     3841 cggtgatgcg gattgccagg atggctctga cgaagatccc gtcagctgtg agaaaaagtg
     3901 caatggattc cactgcccaa acggcacgtg catcccgtcc agcaagcatt gtgatgggct
     3961 gagggactgc cccgacggct ccgatgagca gcactgtgag cccttctgca cgcgcttcat
     4021 ggacttcgtg tgtaagaacc gtcagcagtg tctgttccac tccatggtgt gtgacgggat
     4081 cgtccagtgc cgagatggct ctgatgagga tgcggccttc gctggatgct cgcaagaccc
     4141 cgagttccac aaggagtgcg atgagttcgg cttccagtgt cagaacggag tgtgcatcag
     4201 cttgatttgg aaatgcgatg ggatggatga ctgcggggac tactctgacg aggccaactg
     4261 tgaaaacccc acggaagccc caaactgttc ccgttacttt cagttccact gtgagaatgg
     4321 ccactgcatc cccaacaggt ggaaatgtga cagagagaac gactgtgggg actggtctga
     4381 tgagaaggat tgtggagatt cacatgttct accctccccg acccccgggc cctccacgtg
     4441 tctgcccaat tacttccact gcagcagcgg ggcctgtgtg atgggcacct gggtgtgcga
     4501 cggctacagg gactgtgcag atggctctga tgaggaggcc tgcccctctc tagcaaactc
     4561 cactgccgcc tccactccca cccagttcgg gcagtgcgac cgatttgagt tcgagtgtca
     4621 ccaaccaaag aaatgtatcc ccaactggaa gcgctgtgac ggccaccaag attgccaaga
     4681 cggccaggat gaagccaact gccccactca cagcaccttg acctgtacga gcagggagtt
     4741 caagtgtgag gacggcgagg catgcatcgt gctctcggag cgctgtgatg gcttcctgga
     4801 ttgctctgat gagagcgatg agaaggcctg cagcgatgag ttaactgtat acaaagtgca
     4861 gaatctccag tggacagctg atttctccgg agatgtgact ttgacctgga tgcggccaaa
     4921 gaaaatgcca tctgcttctt gtgtatacaa tgtctactac agggtggttg gagagagcat
     4981 atggaagacc ctggaaaccc acagcaataa aacaagcact gtgctcaagg tcctgaagcc
     5041 agacaccacg taccaggtta aggtccaggt gcactgcctc aacaaggtgc acaacaccaa
     5101 tgactttgtg accctcagga ctccagaagg gttgccagat gcccctcgga atctccagct
     5161 ctccctgaac agtgaagagg aaggtgtgat tctcgggcac tgggctcctc ccgtccacac
     5221 ccatggcctc atccgtgagt acattgtgga atacagcagg agtgggtcca agatgtgggc
     5281 ctcccagaga gctgctagca actctacaga aataaagaac ttactgctca atgccctcta
     5341 cactgtcaga gtggctgcgg tgactagtcg tgggatagga aactggagcg attctaagtc
     5401 catcaccacc ataaaaggaa aagtgatcca agcaccaaat atccacattg acagctacga
     5461 tgaaaattct ctgagcttta ccctgaccat ggatggtgac atcaaggtca atggctacgt
     5521 ggtgaacctt ttctggtcat ttgatgccca caaacaagaa aagaaaaccc tgagcttccg
     5581 cggagggagt gcactgtcac acagagttag caacctgaca gctcatacat cctatgagat
     5641 ttctgcctgg gccaagacag acttgggaga tagcccactg gcctttgagc acatcttgac
     5701 cagaggcagc agtccaccag ctcctagtct caaagccaag gccatcaatc agactgcagt
     5761 ggagtgcatc tggactggcc ccaagaatgt ggtgtatggt attttctatg ccacatcctt
     5821 ccttgacctc taccgaaacc ctaagagcgt aactacttcg ctccacaata agacagtcat
     5881 cgtcagcaag gatgagcagt atctgtttct ggtccgggtg ttgatccctt accaagggcc
     5941 gtcttctgac tacgttgtag tgaagatgat cccagacagc aggctcccgc ctcggcatct
     6001 gcacgcggtc cacataggca aaacctcagc actcatcaaa tgggaatcgc cctatgactc
     6061 tcctgaccag gacttgttct acgccattgc agtgaaagat ctgatcagga agacggacag
     6121 aagctacaaa gtcagatccc gcaacagtac tgtggagtac agcctaagca agctggaacc
     6181 tggagggaaa taccacatca ttgtccagct gggaaacatg agcaaggatt ccagcataaa
     6241 aatcaccaca gtttcgttat cagcacctga tgccttaaaa atcataacgg aaaacgacca
     6301 cgttctcctc ttttggaaaa gcctagcact gaaggaaaag cagttcaatg aaaccagggg
     6361 ctatgagatc cacatgtctg acagcgctgt gaatctcacc gcttacctcg ggaatactac
     6421 ggacaatttc tttaaagtgt ccaacctgaa gatgggtcat aactacactt tcacggtcca
     6481 agcgcggtgt ctctttggta gccagatctg tggggagccc gccgtgctgc tgtacgatga
     6541 actgagctca ggtgcagatg cggcagtgat ccaggctgcc cggtctactg atgttgcagc
     6601 tgtggtggtt cccatcctgt tcctgatcct gctgagcctg ggtgtcggct tcgccatcct
     6661 ctacacgaag caccgtcgct tacaaagcag cttcagcgct ttcgccaaca gccactacag
     6721 ctccaggctg ggctcggcca tcttctcctc aggggatgac ctaggagagg acgatgaaga
     6781 tgctcccatg attactggat tctcagacga tgtccccatg gtgatagcgt gaagagcttt
     6841 tctcattaga aaccaaatgg tgtaaatatt ttatttgata aagatagttg atggtttatt
     6901 ttaaaagatg cactttgagt tgcaatatgt tatttttata tgggccaaaa ctacaaaaaa
     6961 aaaaaagagg aaaagaagga atgaataaac tttgtagtat caactgtgaa ctgaaaccag
     7021 gttgatttta gtaaccacat tctttgattt gacattgatg tcatcttaca gggctgcgct
     7081 tgctgggcat gcttttaagt ctgtgagatc attttgcttc attaagttga ccattctttt
     7141 tgtttttcta agacacagaa atgtatttaa taaaaccttc aagagagagt aatggacgga
     7201 gtgcattctc cttgaaaact gttcagagtt tacgtctcgt ttgggttcag tttacataag
     7261 tgtgtgggtg tcttgtgggg gaaggttctg tgctcttgtt tttgttaatt tattggaact
     7321 ctgtataagg ccatatttta gtggctgtct gaaaccccat gtgtgaaggg ccccttgccc
     7381 aacagggttg aggtggggag caagagcaat ctgtttttat ttgctcgtat gtcagggaca
     7441 ggtgtttggc agaagagact tctaggttac tgctagattc caattcaact gccttgtagc
     7501 ctgggaagcc cagcaagtca taacctcctg tcttctagga acccgtgggc ttttactgtg
     7561 catgtctctg tacaaagtgt acctctggaa gctgccaagt gataacactg ctttcttata
     7621 cactgggatc attgtcactt gaaaaaaaaa acattattgt ggttgtggga gaaagctcta
     7681 gatctgtgcc ataatagata tgcattgcaa ttgtatgcca tgtctccatt ttaaatttga
     7741 gtttcccttt cgtttttact caccaccaaa gaatctcaaa tgtaaaattt tatattgggt
     7801 ttgaaccact gacgtgtcca ttctgatata tgcagtcatt ttgaatttgg tctgtgcctt
     7861 ctctggatcc ctccctagcc tgtgccccga gccgtccata gagagtttgt aggtatttcc
     7921 agggatggag aagatctaag catttgactt ccccatcagt acatttgttc atttgctttc
     7981 tctgtgaaac gccatgattg tctaaacaag tctcccctct gccctgatcc ctttgtacca
     8041 agtcaatggc cacttgaaag ttctgtggac tcccttgtgg cctcaacccg ttcgtccttc
     8101 agcctgtcat ccttcaggca ccgacgccca acctgccgtg acctgtgctg tatgaacaac
     8161 ctcactgagg atttcctccc ggcagaaaag cagcaagctc tgcaaatatc ccaaagttat
     8221 gcctctgaac acatgtcttc tatatgcaag ttttgtgaaa cctgcctcct tcccgtgcaa
     8281 tgtgtccctc ctcacaagtg cttagtttct gttaactaga agtatcattc ttgggtggaa
     8341 ataggtctcc gtttacctga gctgagggtt gtttggaaaa taagagccaa tttttcttag
     8401 aatatatatg tatattaaat gagcatttga cctgtagata catagtgtgc cgtttggcca
     8461 gagctcctgg tgtcaaatgc tgggaacagg agtcttctta caaattattt ttctcctctt
     8521 tcctctcgcc ctctctttca ctattttccc cccagactgg aatttcctca gctttatctt
     8581 gtcttgcttt gaagttttgc tcaatgttcc tcccttccga ccacttccac ttaaataaag
     8641 tctttaagta gctgaaggat taacagtctg gtgggaggca agccattgaa ctgaaccacg
     8701 aggaaagtat attttcttct tttcttttcc tgccaagttt tcggtggcat ttgtagaagc
     8761 tggtgtgaaa ggctaggagg cattgttttc tattattcct cggtgaagcc ttttcccaga
     8821 gcatatgtct ccggcaggca gtgtgggttc ttgccaagca tcagaaccag tctccagggc
     8881 ctcccgacgc cgatccatag tactgtacag acccaccgcc acccttctcc tcggaagatg
     8941 cactgtgctg tttgaaaaca tgtagccgtt taaggctaga gtattttata taaatagaag
     9001 agcttaggtc ctgaagacca aggcagatag atgcagctat gtgtacattg tatatttttg
     9061 tgaacttctc aagcacgcac tcccgtttcc ctctgctttg cagaggtttt gatgtatccc
     9121 tgccgtctgc aagagtccag aggctggact gacagtagga agtagaaata agctatgtgt
     9181 agtcttggaa agttcccacc tcacagggaa tgaaacctag ggaacaccag gtactcggcg
     9241 ccctgtggac tgtgtggaaa ctgatttttc ttttttctat actgaatacc ctttgagatt
     9301 tgtgtgggac atgggtccat gtgggtttag tgacagagaa gagttcctcc aaggactctt
     9361 ggagaggggc cacatctgag gagacaggtg agaagtctcc atcactgctt ggtgcctggc
     9421 aagctggaga ggtcagcctg ctgccaggca actggctgtc tttgggaggg gtggctctta
     9481 agactctacc tctgattgca tcactaggac taactacaag ctggctgggg atactccctt
     9541 gtgtgttctg tcctatccag atggcctgct agattgaatt atactcacca acacatagaa
     9601 caggcccttt agaaggcact aggtgtttgg aggtgagcta ggaagaccag tggtatgttg
     9661 agccccttac agataagcac cggtgtctct ttggtgcacc ttgccttcag atgctcctgg
     9721 tggtcagctc aactagcaag accctagtcc cctgttccaa agccatctca tatgttagtt
     9781 ctctgtccca tgaagagggc cgtggtgagt tcccgagaat tgtctctctt tcagcagaga
     9841 ggtgagggac tcagacatat atctaagttg aatagcatcc ccatcgcagc tgtaagaatt
     9901 gagctgcaga aggtaccctc tgtcgggatt gtatctcgac atccctgtcg cgtttttctt
     9961 agctggagtg tgtgctgcct ttcaggtaca acttttatgt aataaaagcc agagcattaa
    10021 gcttacacag actactttct atgcaagaca gagatatgga ctaggttaca ggaaacgtgc
    10081 accgttggct ccacagacaa gaagtgcatt gccagaagag catcactgaa cggagcggag
    10141 ggaggaccag ttgcatgtgt ttctgcccac tcattttgag cagccatatt ataaaatgga
    10201 tcatcagagc tgagtgacaa cacgagagtg gtactggttt catgtgcgag gacttccatg
    10261 gactgaacat ggatgccgga gcagagcatc aattccttca tagattccaa gtcactcctc
    10321 gatgaagact cttgttgaga cttactaaac actttaggcg cagtcgggag gatctgcagc
    10381 aaaataaagg cctgttctgc tcttatttaa catgaagcac tgtgtacttg tttcttctct
    10441 ccaaagtaaa attagattat ttataacttc gatcgcctcg gctaggtttc caagtcactg
    10501 atttctgctg aagattttac tacgttgttg cacaatttta agataatttt tttttttggt
    10561 cttggtgtca acctttttca ctgaataaaa atttaactgg gttaaaaaag aaaaacaatg
    10621 aaaaaaaata aagacaccgc catcacctat ttaaatatcc actgtgtgtg tcacaaagtt
    10681 gttcttttga gtgcaataaa gatagcttaa cacagtctcc agagca
//
