LOCUS       NM_146126               2259 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus sorbitol dehydrogenase (Sord), mRNA.
ACCESSION   NM_146126
VERSION     NM_146126.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Sano,H., Nakamura,A., Yamane,M., Niwa,H., Nishimura,T., Araki,K.,
            Takemoto,K., Ishiguro,K.I., Aoki,H., Kato,Y. and Kojima,M.
  TITLE     The polyol pathway is an evolutionarily conserved system for
            sensing glucose uptake
  JOURNAL   PLoS Biol 20 (6), e3001678 (2022)
   PUBMED   35687590
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Mohammad,F. E, Hasan,W.A. and Mohamed,E.G.
  TITLE     Natural antioxidant flavonoids in formalin-induced mice paw
            inflammation; inhibition of mitochondrial sorbitol dehydrogenase
            activity
  JOURNAL   J Biochem Mol Toxicol 31 (7) (2017)
   PUBMED   28422384
  REMARK    GeneRIF: flavonoids induced marked improvement in paw licking time,
            paw edema %, malondialdehyde content, superoxide dismutase, and
            sorbitol dehydrogenase activities, with slight progress in paw
            interlukin-1beta. Additionally, silymarin augmented brain content
            of dopamine and norepinephrine.
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Dai,J., Xu,W., Zhao,X., Zhang,M., Zhang,D., Nie,D., Bao,M.,
            Wang,Z., Wang,L. and Qiao,Z.
  TITLE     Protein profile screening: reduced expression of Sord in the mouse
            epididymis induced by nicotine inhibits tyrosine phosphorylation
            level in capacitated spermatozoa
  JOURNAL   Reproduction 151 (3), 227-237 (2016)
   PUBMED   26647419
  REMARK    GeneRIF: Nicotine-induced reduced expression of Sord could be
            involved in impaired secretory functions of the epididymis.
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Kim,T.H. and Shivdasani,R.A.
  TITLE     Notch signaling in stomach epithelial stem cell homeostasis
  JOURNAL   J Exp Med 208 (4), 677-688 (2011)
   PUBMED   21402740
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Maret,W. and Auld,D.S.
  TITLE     Purification and characterization of human liver sorbitol
            dehydrogenase
  JOURNAL   Biochemistry 27 (5), 1622-1628 (1988)
   PUBMED   3365415
REFERENCE   8  (bases 1 to 2259)
  AUTHORS   Satoh,H. and Yoshida,M.C.
  TITLE     Gene mapping in the Chinese hamster and conservation of syntenic
            groups and Q-band homologies between Chinese hamster and mouse
            chromosomes
  JOURNAL   Cytogenet Cell Genet 39 (4), 285-291 (1985)
   PUBMED   3863747
REFERENCE   9  (bases 1 to 2259)
  AUTHORS   Tulsiani,D.R. and Touster,O.
  TITLE     Studies on dehydrogenases of the glucuronate-xylulose cycle in the
            livers of diabetic mice and rats
  JOURNAL   Diabetes 28 (9), 793-798 (1979)
   PUBMED   38160
REFERENCE   10 (bases 1 to 2259)
  AUTHORS   Holmes,R.S., Jones,J.T. and Peters,J.
  TITLE     Genetic variation, cellular distribution and ontogeny of sorbitol
            dehydrogenase and alcohol dehydrogenase isozymes in male
            reproductive tissues of the mouse
  JOURNAL   J Exp Zool 206 (2), 279-288 (1978)
   PUBMED   722274
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL844573.4 and
            AL844566.8.
            
            On Oct 19, 2007 this sequence version replaced NM_146126.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015059.1, AK152169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL844573.4         61556-61675
            121-154             AL844573.4         73199-73232
            155-319             AL844573.4         75516-75680
            320-479             AL844573.4         79904-80063
            480-598             AL844566.8         227044-227162       c
            599-664             AL844566.8         224874-224939       c
            665-840             AL844566.8         223649-223824       c
            841-962             AL844566.8         220695-220816       c
            963-2259            AL844566.8         218667-219963       c
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.59 cM"
     gene            1..2259
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /note="sorbitol dehydrogenase"
                     /db_xref="GeneID:20322"
                     /db_xref="MGI:MGI:98266"
     exon            1..120
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1128
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /EC_number="1.1.1.14"
                     /EC_number="1.1.1.9"
                     /note="L-iditol 2-dehydrogenase; sorbitol dehydrogenase 1;
                     polyol dehydrogenase; xylitol dehydrogenase"
                     /codon_start=1
                     /product="sorbitol dehydrogenase"
                     /protein_id="NP_666238.1"
                     /db_xref="CCDS:CCDS16657.1"
                     /db_xref="GeneID:20322"
                     /db_xref="MGI:MGI:98266"
                     /translation="MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGI
                     CGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGELVKHLKPGDRVAIEPGVPREV
                     DEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNADFCYKLPDSVTFEEGALIEPLSV
                     GIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVVTDLSASRLTKAKEVGA
                     DFTIQVGKETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHSGGTLVIVGMG
                     AEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKAVEA
                     FETAKKGVGLKVMIKCDPNDQNP"
     exon            121..154
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            155..319
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            320..479
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            480..598
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            599..664
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            665..840
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            841..962
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
     exon            963..2259
                     /gene="Sord"
                     /gene_synonym="SDH; Sdh-1; Sdh1; Sodh-1; XDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaccacca gctccccgcc gggtccagcg gacacctcga agcaagagag caacatggca
       61 gctccagcta agggcgagaa cctgtccctg gtggtgcacg gacctggaga catccgcctg
      121 gagaactacc caatacctga gctcggccca aatgatgtgt tactaaagat gcactcggtg
      181 gggatttgcg gctcagatgt tcactactgg gagcatggac gaattgggga ctttgttgtg
      241 aaaaagccaa tggtgcttgg gcatgaggct gctggaacag tcacaaaagt aggagagttg
      301 gtgaaacatc tgaaaccagg agatcgggtt gccatcgagc ctggcgttcc ccgagaagta
      361 gatgagtact gcaagattgg ccggtacaac ctgacgccga ctatcttctt ctgtgccacg
      421 cccccggatg atggaaacct ctgccgattc tacaagcaca atgctgactt ctgctacaag
      481 cttcctgaca gtgtcacttt tgaagaaggg gccctgattg aacctctctc tgtggggatc
      541 tatgcctgcc gtcgaggttc agtttccctg gggaacaagg tccttgtgtg tggcgctggg
      601 ccagttggga tggtcacttt gcttgtggcc aaagcaatgg gagctgctca agttgtggtg
      661 actgacctat ccgcttctcg gttgaccaaa gccaaggaag ttggagcaga ctttaccatc
      721 caggttggca aagagacccc tcaggaaatt gccagtaagg tggaaagcct gctgggaagc
      781 aagccggagg ttaccattga gtgcacagga gccgagtcct ccgtccagac gggcatctat
      841 gccactcact ctggtgggac cttggtgatt gtgggaatgg gcgccgagat ggtcaattta
      901 cccctggtgc acgcagccat tcgggaagtg gatatcaaag gcgtgtttcg atactgcaac
      961 acgtggccga tggcaatttc catgcttgca tcgaagacgt tgaatgtaaa gcccttagtt
     1021 acccacagat tccccctgga gaaggcagtt gaagcctttg aaacagccaa aaagggagtg
     1081 gggctgaaag ttatgatcaa gtgtgacccc aatgaccaaa acccctagat gtgaattgat
     1141 ctatgccctc agcccactct ctcagcatcc gagagctaaa tggctagaag gggaggccgt
     1201 aaatgcagaa ctttcttttg aatggtaaaa ataataaact cataagcgga gagcctaaga
     1261 ggagtgggca tgccttaagg acagaagtag ggacaccttg agggaccttg tagccagaat
     1321 gagatgctta tactaaggaa agtctagcac agagagtctg gcagataggt cctgggaacg
     1381 ccttttctct agtaccttcc ttgggtgagg agacacgcat gcctttgtgt gttctactgt
     1441 gattgccaga gagtggggct gacttatgaa gaaatggatt cattaacatg gaagtggccc
     1501 cagggctgaa cttttggtca gctgttcaga gcacaatgtt tctctagtta agtgtcattt
     1561 atttgaggag aataaaagga acttgtctgg acccagacaa ggaactgatc tggaagaata
     1621 agataaatcc cagatgaggt accctagctt acattcccca gatgtggaaa gtataagggc
     1681 actcggctct gcccaaagac tacctctgtc tcagctacta agaattctgt ccttacattt
     1741 gcaaagtgga ggcccacctt cccaacactg ctcattcatg agcaggagca gtattggttg
     1801 ctaggcaacc agattttttt tttcccaacc aaagatctta aatcctgcct agagggccac
     1861 aggagggctt gccccactca gaggattaga ctcctctccc agagtcactc acaggcaatt
     1921 atttcccatt ccactcagtt ctggctacca gaagatgctc ccctctcagc tgggtgaggc
     1981 tgctgatatc tgtcggatgg gtatcacagc gtaatttcat catagggctt ttctttataa
     2041 gatttgggtc caaatcacac cctttgtgat cttaagataa tcaagaaatg cacagtaact
     2101 gatgtaactt gggctgcagt ctgtaatcca cctcttcagc tataagtagg ggacatgtta
     2161 aaaaaaaaaa aaaaaaaaaa aagactctgc tggagaagat catggcccag acctgagctt
     2221 tctcaaactg cttcgcataa taaactgttg atggtgtcc
//
