LOCUS       NM_030889               5722 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus sortilin-related VPS10 domain containing receptor 2
            (Sorcs2), mRNA.
ACCESSION   NM_030889
VERSION     NM_030889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5722)
  AUTHORS   Chen,W.J., Zhu,B.L., Qian,J.J., Zhao,J., Zhang,F., Jiang,B. and
            Zhao,H.Y.
  TITLE     Hippocampal SorCS2 overexpression represses chronic stress-induced
            depressive-like behaviors by promoting the BDNF-TrkB system
  JOURNAL   Pharmacol Biochem Behav 242, 173820 (2024)
   PUBMED   38996926
  REMARK    GeneRIF: Hippocampal SorCS2 overexpression represses chronic
            stress-induced depressive-like behaviors by promoting the BDNF-TrkB
            system.
REFERENCE   2  (bases 1 to 5722)
  AUTHORS   Kalnytska,O., Qvist,P., Kunz,S., Conrad,T., Willnow,T.E. and
            Schmidt,V.
  TITLE     SORCS2 activity in pancreatic alpha-cells safeguards insulin
            granule formation and release from glucose-stressed beta-cells
  JOURNAL   iScience 27 (1), 108725 (2023)
   PUBMED   38226160
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5722)
  AUTHORS   Thomasen,P.B., Salasova,A., Kjaer-Sorensen,K., Woloszczukova,L.,
            Lavicky,J., Login,H., Tranberg-Jensen,J., Almeida,S., Beel,S.,
            Kavkova,M., Qvist,P., Kjolby,M., Ovesen,P.L., Nolte,S.,
            Vestergaard,B., Udrea,A.C., Nejsum,L.N., Chao,M.V., Van Damme,P.,
            Krivanek,J., Dasen,J., Oxvig,C. and Nykjaer,A.
  TITLE     SorCS2 binds progranulin to regulate motor neuron development
  JOURNAL   Cell Rep 42 (11), 113333 (2023)
   PUBMED   37897724
  REMARK    GeneRIF: SorCS2 binds progranulin to regulate motor neuron
            development.
REFERENCE   4  (bases 1 to 5722)
  AUTHORS   Vignoli,B., Sansevero,G., Sasi,M., Rimondini,R., Blum,R.,
            Bonaldo,V., Biasini,E., Santi,S., Berardi,N., Lu,B. and Canossa,M.
  TITLE     Astrocytic microdomains from mouse cortex gain molecular control
            over long-term information storage and memory retention
  JOURNAL   Commun Biol 4 (1), 1152 (2021)
   PUBMED   34611268
  REMARK    GeneRIF: Astrocytic microdomains from mouse cortex gain molecular
            control over long-term information storage and memory retention.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5722)
  AUTHORS   Yang,J., Ma,Q., Dincheva,I., Giza,J., Jing,D., Marinic,T.,
            Milner,T.A., Rajadhyaksha,A., Lee,F.S. and Hempstead,B.L.
  TITLE     SorCS2 is required for social memory and trafficking of the NMDA
            receptor
  JOURNAL   Mol Psychiatry 26 (3), 927-940 (2021)
   PUBMED   31988435
  REMARK    GeneRIF: SorCS2 is required for social memory and trafficking of
            the NMDA receptor.
REFERENCE   6  (bases 1 to 5722)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 5722)
  AUTHORS   Hermey,G., Plath,N., Hubner,C.A., Kuhl,D., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     The three sorCS genes are differentially expressed and regulated by
            synaptic activity
  JOURNAL   J Neurochem 88 (6), 1470-1476 (2004)
   PUBMED   15009648
  REMARK    GeneRIF: SorCS3 and the homologous sorCS1 and sorCS2 genes were
            expressed in a combinatorial mostly non-overlapping pattern in the
            developing and mature central nervous system; activity-dependent
            induction of sorCS3 did not require protein synthesis
REFERENCE   8  (bases 1 to 5722)
  AUTHORS   Simon,R. and Lufkin,T.
  TITLE     Postnatal lethality in mice lacking the Sax2 homeobox gene
            homologous to Drosophila S59/slouch: evidence for positive and
            negative autoregulation
  JOURNAL   Mol Cell Biol 23 (24), 9046-9060 (2003)
   PUBMED   14645517
REFERENCE   9  (bases 1 to 5722)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   10 (bases 1 to 5722)
  AUTHORS   Rezgaoui,M., Hermey,G., Riedel,I.B., Hampe,W., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     Identification of SorCS2, a novel member of the VPS10 domain
            containing receptor family, prominently expressed in the developing
            mouse brain
  JOURNAL   Mech Dev 100 (2), 335-338 (2001)
   PUBMED   11165493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047881.1, AK053853.1, AY004316.1, CO428928.1, CV784176.1 and
            AC127275.4.
            
            On Jan 31, 2007 this sequence version replaced NM_030889.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093294.1, AY004316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-742               AK047881.1         2-743
            743-1165            AK053853.1         713-1135
            1166-1435           AY004316.1         1135-1404
            1436-1962           CO428928.1         14-540
            1963-2527           CV784176.1         85-649
            2528-3405           AY004316.1         2497-3374
            3406-3509           AC127275.4         61291-61394
            3510-5722           AC127275.4         63231-65443
FEATURES             Location/Qualifiers
     source          1..5722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.14 cM"
     gene            1..5722
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /note="sortilin-related VPS10 domain containing receptor
                     2"
                     /db_xref="GeneID:81840"
                     /db_xref="MGI:MGI:1932289"
     exon            1..574
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            575..642
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            643..742
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            743..907
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            908..981
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1046
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1165
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1255
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1435
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1582
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1685
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1762
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1854
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1962
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2083
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2217
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2346
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2518
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2705
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2839
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2963
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3076
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3202
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3302
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3405
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3509
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..5722
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5687..5692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /note="hexamer: AATAAA"
     polyA_site      5722
                     /gene="Sorcs2"
                     /gene_synonym="mKIAA1329"
                     /note="major polyA site"
ORIGIN      
        1 cctttctctg cgctcttgct caagctccca gcgccctccc gctctcccgg ccgcggtgtc
       61 gtccgcaccg ccccgccgtt acctaccagc gaccatggcg caccggggac ccccgagcgc
      121 cccgaagcgt cctggcccta ctgcgccgga ccggagcttt caggctctgc tgccgccgtg
      181 ctggccacgt tcgtggccgc tgctgctgct gctgctggtg ctggtggctg cctgcggagc
      241 gatggggcgc tccccccagc ccgggcgcca gggtcccggt gtgcagatca ctaggctgct
      301 gcccgcggga cgcacggagt ccggcgatcg caaagatcca caggcacgag aatcagaacc
      361 cagcgtcccg ggtctcggtc cgggttctgc ttcgggtccc agcaccgatg gcgccccagc
      421 tccgggcaag gggcgcaggg ctcgggcggt gccggtggcc ggtgcggctt cggcttcgcg
      481 cgcacaggtc tcgctcatca gcacgtcgtt cgtgctcaag ggagacgcga cgcacaacca
      541 ggcgatggta cactggacag gagagaacag cagcgtcatc ttgatcctga caaagtacta
      601 ccatgcagac atgggcaagg ttctggaaag ttctctgtgg aggtcctcag attttgggac
      661 aacctacacc aagcttactc tccagcctgg tgtcaccact gtcattgaca acttctatat
      721 ctgcccagct aacaaaagga agatcatcct ggtgagctca tccctcggtg accgggaaca
      781 gagcctcttc ctcagcactg atgagggcgc cacgttccag aagtatcctg tccccttcct
      841 tgtggagatg ctcctcttcc acccgaagga ggaggacaag gtgctggcct acaccaagga
      901 cagcaagctg tatgtgtcat cggacctggg aaagaagtgg acacttctgc aggaacgggt
      961 gaccaaggac cacgtgttct gggctgtgtc tggggtggat gacgacccaa acttggtcca
     1021 cgtggaagct caggacctca gtggaggcta tcggtactac acgtgtctga tctacaactg
     1081 ctcagcccag ccacacatag cacccttctc cggccccatt gaccgcgggt ccctgaccgt
     1141 gcaggatgag tacatctttt tgaaggcaac atcaacaaac cgaaccaagt actatgtctc
     1201 ctatcgccga agtgactttg tcctgatgaa gctgcccaag tatgccctgc ccaaggacct
     1261 acagatcatc agcacggatg agcagcaggt gtttgtggcc gtacaggagt ggaaccaggt
     1321 agacacctac aacctgtacc agtcagacct gcgtggggtt cgctattccc tggtgctgga
     1381 gaatgtgcgc agctcgaggc aagccgagga gaacgtggtc atcgacatcc ttgaggtcag
     1441 aggggtgaag ggagtcttct tggcaaacca gaaagtggat ggcaaggtga ccacagtcat
     1501 aacctacaac aagggccgtg actgggatta cctgaggcca cccagcaccg acatgaatgg
     1561 gaagcccacc aactgccagc cgccggactg ttacctgcac ctgcacttgc ggtgggcaga
     1621 caacccctat gtgtcaggca cggtacacac caaggacact gcccctggtc tcatcatggg
     1681 tgcaggtaac ctgggctcac agctggtgga gtataaagag gagatgtaca tcacatctga
     1741 ctgcgggcac acctggaggc aggtctttga ggaagagcac catgtgttgt acctggacca
     1801 cggtggtgtc attgccgcca tcaaggacac ctccatcccc ctgaagatcc tcaagttcag
     1861 cgtggatgag ggccacacgt ggagcacaca caacttcacc agcacctcag tgttcgtgga
     1921 tgggttgctg agcgagccag gggatgagac gctggtcatg acggtctttg gtcacatcag
     1981 cttccgctct gactgggagc tggtcaaggt tgacttccgg ccctccttcc cccggcagtg
     2041 tggcgaggat gactacagct cctgggacct cactgacctc cagggtgatc actgcatcat
     2101 gggccaacag agaagttacc ggaagagaaa gtccacatcc tggtgtgtca agggacggag
     2161 cttcacatca gcactcacgt cacgtgtgtg caagtgccgg gactccgact tcctctgtga
     2221 ctacgggttt gagcgctcat cttcctcgga gtccactgcc aacaagtgct ctgccaactt
     2281 ctggttcaac cctttgtctc ctcctgaaga ctgtgtcttg ggtcagactt acactagtag
     2341 ccttgggtac cggaaggtgg tgtccaatgt gtgtgaaggt ggtgtggacc tgcagcagag
     2401 cccagtgcag ctgcagtgcc ccctccaggc accccggggc ctgcaggtga gcatccgagg
     2461 agaggcagtg gccgtgcggc ctagagaaga tgtgctgttt gtggtgcgac aggaacaggg
     2521 tgatgtcctg accactaaat atcaggtgga tcttggggat ggcttcaagg ccatgtacgt
     2581 gaacctcact ctgacaggcg agcccattcg acatcactat gagagtcctg gcatctaccg
     2641 agtgtccgtc agggctgaga acatggcagg ccatgatgag gctgtgctct ttgtccaggt
     2701 caactctccc ctgcaggccc tctacctcga ggtagttcct gtcattggcg tcaaccagga
     2761 ggtgaacctc acagccgtgc tgttacccct gaatcccaac ctcactgtct tctactggtg
     2821 gatcggccac agcttgcagc ctctgctttc cttggacaac tcggtgacaa caaagtttac
     2881 ggacgctggg gatgtgcgtg tgacagtgca agctgcctgc gggaactcag tgcttcagga
     2941 ctccaggctc gtccgtgtgc tcgatcagtt ccaggtggtg cctctgcggt tctccaggga
     3001 gctggacacc tttaacccca acactcctga atggagggaa gatgtgggac tggtggtcac
     3061 ccgactgctc tccaaggaga ccagcatccc agaggagctg cttgtgactg tggtaaagcc
     3121 agggctgccc accatagccg acttgtatgt gcttctgcct ctgccaaggc ccacaaggaa
     3181 gaggagcctc acaagtgaca agagactggc agccgtgcag caggcgctga actctcatag
     3241 aatcagcttc atccttcgag gagggcttcg tatcctggtg gagctgaggg acacagacac
     3301 aggtcctcag aggccaggtg gcagtggtgg ctactgggcc gtggtggtcc tctttgtcat
     3361 tgggctcttt gcagtaggag cattcatcct ctacaagttc aaaaggaaac gtccaggcag
     3421 gacagtgtac gcccagatgc acaatgagaa ggaacaggag atgacaagtc ccgtgagtca
     3481 cagtgaggat gcccagagca ccatgcaggg caaccactca ggggtggtcc tgagcatcaa
     3541 ctctcgtgag atgcatagct acctggtggg ctgatggcac cagctggcca ggacactctc
     3601 ctcctgcttc ctccggagag ggcacaggac cacaactgca gctggaatga cacaccctct
     3661 gagacccgtg gaaaggccaa ctcctctagc tgtccccact cagaggacag acacttctcc
     3721 ctgtcagccc cagctggccc atgggatcct gggacagccg actcatgacc cacctggaca
     3781 cgggcctgtg gtgccacaca gagtccccac ccttgactct gaggcatcac agtccttaga
     3841 cctgaacatg ctgccctggt tactccatct tgccactgca gcccaggcct ggcttctcct
     3901 gcctggggct ggaccagcct atttctgggg tgagcctgca gccaccacca cccccactcc
     3961 agacttgtag cctgctcagc cctggcccca cagtccctgt ccctgcagag gaccccagag
     4021 tcaggaagtc tctgggccag accaacccaa caccaccttc caggaagcca ctctctccac
     4081 tgcagtgtaa atacctgccc gggtagagct atttgagttt gggggctctt tcttttagct
     4141 ttctgttttc aaggcaggca atagaagcca tcttcgatcc atcagaatcc cactctcaga
     4201 acccctcttt cagaatgccc agagctgggc ctagaggggc aactatctct ctgattttcc
     4261 ctcagggcta cagggttaga ggcaagaaaa gaagggaccc ttacatgcaa ttcctgctcc
     4321 atccagcagg atgtgccctt ctacagcttc taggctgatg gctggcttcc ggtcaggtct
     4381 gggctttaga agagactaca ggccccagaa aggcacatta gtagaacaca tcaggctctg
     4441 atgccctatg gtttgaggaa cccttgtaag aaccaaccag aagaggggtg ggagggcagc
     4501 atctcctggg aaaacgaact agaggatcca gagccttgtg gccctttcac ggtcagagaa
     4561 agaaagcagc agaggtagcc ctagagtcgc ctgctgcctg ctcctacggc caagtcaggg
     4621 acccagcaca ggttgacact gtgagctggc atcattcacc ttttgccttg aaactgaagt
     4681 cagtattccc ttcccttccc ctcctcttcc atcctctcac ctccagactc ttgctgccct
     4741 accagagagc ccaggctggc ctggagcgag gcccgggtgt ctcaacaccc actgctgctg
     4801 ctgctgctgc tgtttggcac actcaccagc acccatcagt tctccctaag gaagaaatgt
     4861 gacccatata gaagaagagg tctcagacag accctcacag gacagctcca gcacttagtc
     4921 tctctgttaa ggactgggct gggtgtctgt ctatacgctc gtcatagaca ggacagcaca
     4981 gagcagggta gctatggggg gcacaaagct ggtctgtggg agtgtctcaa ctgtacccca
     5041 atatctctca ctttctgcca ctctctgggg ctcaggggtc tctgcagagg taactgcggg
     5101 ctgtcctcct tgggaggggc tacaaatggg accctagtgc cagtgaaggt catgacactc
     5161 taagactttt gccccacata ccttcttgct atctcaaatg aaacctaagc agagaccttt
     5221 tccccatctg tatccccaca gcatggaagt accacccagt accacacaga ggagatgctc
     5281 acacacgaca gtctccataa ggcccaaggt cagcacagaa cccctggaca tagcccgcca
     5341 ctttagctca ccagtgcctg gggtgccttc ctcgagcacg ctctcactct caaggacacg
     5401 ggcaggctta ccctagctat ttgggttttt tgttactatt tctatttgaa catttggagc
     5461 gtatagaccc aagatcctcc ctgttctcat ctccatcact gcagatggcc atgcaggcac
     5521 agggtttccc tgcctatcag ctgaggtgcc gtgcattata cagccagggg caaaagccca
     5581 gctcaggggc tcatatcact ctccaccagg ccctgagctt acctgacatg tgggcatagc
     5641 agaggtgatg agttctttgt ttttccttta tataaaaaaa agaaacaata aatcatttgt
     5701 gatgctttta acaaaggtta aa
//
