LOCUS       NM_001252501            4479 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus sortilin-related VPS10 domain containing receptor 1
            (Sorcs1), transcript variant 2, mRNA.
ACCESSION   NM_001252501
VERSION     NM_001252501.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4479)
  AUTHORS   Ribeiro,L.F., Verpoort,B., Nys,J., Vennekens,K.M., Wierda,K.D. and
            de Wit,J.
  TITLE     SorCS1-mediated sorting in dendrites maintains neurexin axonal
            surface polarization required for synaptic function
  JOURNAL   PLoS Biol 17 (10), e3000466 (2019)
   PUBMED   31658245
  REMARK    GeneRIF: SorCS1-mediated sorting in dendritic endosomes controls
            Nrxn axonal surface polarization required for proper synapse
            development and function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4479)
  AUTHORS   Hermey,G., Hoffmeister-Ullerich,S.A., Merz,B., Gross,D., Kuhl,D.
            and Kins,S.
  TITLE     Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3
            expression in mice
  JOURNAL   Biol Chem 400 (9), 1181-1189 (2019)
   PUBMED   31095505
  REMARK    GeneRIF: SorCS1 and SorLA expression were markedly reduced in the
            frontal cerebral cortex and to a minor extent in the hippocampus,
            whereas SorCS3 expression was solely reduced in the frontal
            cerebral cortex
REFERENCE   3  (bases 1 to 4479)
  AUTHORS   Subkhangulova,A., Malik,A.R., Hermey,G., Popp,O., Dittmar,G.,
            Rathjen,T., Poy,M.N., Stumpf,A., Beed,P.S., Schmitz,D.,
            Breiderhoff,T. and Willnow,T.E.
  TITLE     SORCS1 and SORCS3 control energy balance and orexigenic peptide
            production
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29440124
  REMARK    GeneRIF: our findings identified a novel role for VPS10P domain
            receptors SORCS1 and SORCS3 in hypothalamic control of metabolism
            through regulation of orexigenic peptide production.
REFERENCE   4  (bases 1 to 4479)
  AUTHORS   Knight,E.M., Ruiz,H.H., Kim,S.H., Harte,J.C., Hsieh,W., Glabe,C.,
            Klein,W.L., Attie,A.D., Buettner,C., Ehrlich,M.E. and Gandy,S.
  TITLE     Unexpected partial correction of metabolic and behavioral
            phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of
            diabetes/Alzheimer's-related Sorcs1
  JOURNAL   Acta Neuropathol Commun 4, 16 (2016)
   PUBMED   26916443
  REMARK    GeneRIF: Male mice with either the APP/PSEN1 or Sorcs1 -/- genotype
            displayed earlier onset and persistent impairment in both glucose
            homeostasis and in learning behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4479)
  AUTHORS   Savas,J.N., Ribeiro,L.F., Wierda,K.D., Wright,R.,
            DeNardo-Wilke,L.A., Rice,H.C., Chamma,I., Wang,Y.Z., Zemla,R.,
            Lavallee-Adam,M., Vennekens,K.M., O'Sullivan,M.L., Antonios,J.K.,
            Hall,E.A., Thoumine,O., Attie,A.D., Yates,J.R. 3rd, Ghosh,A. and de
            Wit,J.
  TITLE     The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and
            AMPA Receptors
  JOURNAL   Neuron 87 (4), 764-780 (2015)
   PUBMED   26291160
  REMARK    GeneRIF: SorCs1 is a global protein trafficking regulator,
            including AMPA receptors and neurexins.
REFERENCE   6  (bases 1 to 4479)
  AUTHORS   Goodarzi,M.O., Lehman,D.M., Taylor,K.D., Guo,X., Cui,J.,
            Quinones,M.J., Clee,S.M., Yandell,B.S., Blangero,J., Hsueh,W.A.,
            Attie,A.D., Stern,M.P. and Rotter,J.I.
  TITLE     SORCS1: a novel human type 2 diabetes susceptibility gene suggested
            by the mouse
  JOURNAL   Diabetes 56 (7), 1922-1929 (2007)
   PUBMED   17426289
REFERENCE   7  (bases 1 to 4479)
  AUTHORS   Hermey,G., Schaller,H.C. and Hermans-Borgmeyer,I.
  TITLE     Transient expression of SorCS in developing telencephalic and
            mesencephalic structures of the mouse
  JOURNAL   Neuroreport 12 (1), 29-32 (2001)
   PUBMED   11201086
REFERENCE   8  (bases 1 to 4479)
  AUTHORS   Hermey,G. and Schaller,H.C.
  TITLE     Alternative splicing of murine SorCS leads to two forms of the
            receptor that differ completely in their cytoplasmic tails
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 350-354 (2000)
   PUBMED   10760602
REFERENCE   9  (bases 1 to 4479)
  AUTHORS   Hermey,G., Riedel,I.B., Hampe,W., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     Identification and characterization of SorCS, a third member of a
            novel receptor family
  JOURNAL   Biochem Biophys Res Commun 266 (2), 347-351 (1999)
   PUBMED   10600506
REFERENCE   10 (bases 1 to 4479)
  AUTHORS   Casademunt,E., Carter,B.D., Benzel,I., Frade,J.M., Dechant,G. and
            Barde,Y.A.
  TITLE     The zinc finger protein NRIF interacts with the neurotrophin
            receptor p75(NTR) and participates in programmed cell death
  JOURNAL   EMBO J 18 (21), 6050-6061 (1999)
   PUBMED   10545116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100726.7, AC158463.7, AC101745.9 and AC131103.4.
            
            On Mar 31, 2022 this sequence version replaced NM_001252501.1.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon, and it thus differs in the 3' coding region and 3'
            UTR, compared to variant 1. The encoded isoform (2) has a distinct
            C-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030440.1, SRR17784644.1111533.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AC100726.7         76270-77086         c
            818-885             AC158463.7         26705-26772
            886-985             AC158463.7         123161-123260
            986-1144            AC101745.9         131600-131758       c
            1145-1218           AC101745.9         111107-111180       c
            1219-1283           AC101745.9         86230-86294         c
            1284-1402           AC101745.9         60390-60508         c
            1403-1492           AC101745.9         57895-57984         c
            1493-1672           AC101745.9         50675-50854         c
            1673-1819           AC101745.9         40089-40235         c
            1820-1922           AC101745.9         30756-30858         c
            1923-1999           AC101745.9         30412-30488         c
            2000-2091           AC101745.9         28352-28443         c
            2092-2199           AC101745.9         26341-26448         c
            2200-2317           AC101745.9         24883-25000         c
            2318-2448           AC101745.9         23240-23370         c
            2449-2562           AC131103.4         209041-209154       c
            2563-2734           AC131103.4         197567-197738       c
            2735-2921           AC131103.4         176939-177125       c
            2922-3055           AC131103.4         169571-169704       c
            3056-3179           AC131103.4         168320-168443       c
            3180-3292           AC131103.4         162977-163089       c
            3293-3424           AC131103.4         161968-162099       c
            3425-3524           AC131103.4         155437-155536       c
            3525-3630           AC131103.4         139972-140077       c
            3631-4479           AC131103.4         130217-131065       c
FEATURES             Location/Qualifiers
     source          1..4479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 45.05 cM"
     gene            1..4479
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="sortilin-related VPS10 domain containing receptor
                     1"
                     /db_xref="GeneID:58178"
                     /db_xref="MGI:MGI:1929666"
     exon            1..817
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..3838
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; VPS10 domain-containing receptor SorCS1; VPS10
                     domain receptor protein SORCS 1"
                     /codon_start=1
                     /product="VPS10 domain-containing receptor SorCS1 isoform
                     2 precursor"
                     /protein_id="NP_001239430.1"
                     /db_xref="CCDS:CCDS84452.1"
                     /db_xref="GeneID:58178"
                     /db_xref="MGI:MGI:1929666"
                     /translation="MGKVGAGDGSSAGLSALLAGAGLLMLLAPGVCSSLSCCPPQHPS
                     STPRRTLTPRGFPHPGPLGRAPATPPPLFMRPLFAVAPGDRALFLERAGGSRVSVATA
                     ARSGRRRRSGTEPEKIEPGEGASRSRRDMLKDGGQQGLGTGARDPDKATRFRMEELRL
                     TSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYE
                     KLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQS
                     LLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQESVVPNRFYWSVMGSSKEPDLVHL
                     EARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYV
                     SYRRSPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTL
                     ALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPD
                     ADLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELSDSDI
                     SMFVSSDAGNTWRQIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYS
                     FTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQ
                     LHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNG
                     QCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPR
                     GLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIK
                     HVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLW
                     PSQVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGNAILQDTKTIAV
                     YEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPT
                     AAELFVLPYQDGTRENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTA
                     APLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRGWRDRSAVKNIGCSCRGPGFNS
                     QHQQGGSQASVTSVPRDPTPSSDLHGHQEHTWCTDIHPGKTPIHIK"
     exon            818..885
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            886..985
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1144
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1218
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1283
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1402
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1492
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1672
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1819
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1922
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1999
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2091
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2199
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2317
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2448
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2562
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2734
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2921
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3055
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3179
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3292
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3424
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3524
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3630
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..4479
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4063..4068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="hexamer: AATAAA"
     polyA_site      4091
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="major polyA site"
     regulatory      4454..4459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="hexamer: ATTAAA"
     polyA_site      4479
                     /gene="Sorcs1"
                     /gene_synonym="mSorCS; Sorcs"
                     /note="major polyA site"
ORIGIN      
        1 agttcggctc cacccccgcg cggcggcggc ggcggcggtg gctcgcagct ccgtcccaac
       61 ccgcgcgctc cgcacaagcc cagcctgggc gagcggcagg cacctgcccg gcgccgcctc
      121 cgcgcgcccc gccgccgccc agcccaactt ggatggagtt gtggtcctga gcgcacgccc
      181 tgccgccgtc agcctgtagc ctcgctccgc tgcctgcctt cggtccggga ccccctctcc
      241 gcttctctac gctccagaga tgggaaaagt tggcgctgga gacggctcct cggccgggct
      301 gagcgcgctc cttgcaggag cggggcttct gatgctctta gcccccggcg tctgcagcag
      361 cctctcttgc tgccctccgc agcaccctag ctcgacccca cgccggaccc ttaccccaag
      421 aggctttcct cacccgggac ctctgggtcg ggctcctgcc acgcccccgc ccctcttcat
      481 gagacccctg ttcgcagtgg cccccgggga ccgtgcgctg tttctggagc gagctggggg
      541 cagcagggtg tcagtggcga ccgctgcacg ctctggccgt aggagacgga gtggaacgga
      601 acccgagaag attgaacccg gagagggtgc gagtcggagc cgccgggaca tgctaaagga
      661 tggagggcag caggggcttg ggactggcgc acgggacccg gacaaagcca cccgcttccg
      721 gatggaggag ctgagactga ccagcaccac atttgctctg acaggagact cagcacacaa
      781 ccaagctatg gtccactggt ctggccacaa cagcagcgtg attctcattt tgacaaagct
      841 ctatgactat aacctgggga gtatcaccga gagctcgctt tggaggtcaa ccgattatgg
      901 gactacctat gaaaagttga atgataaagt ggggttgaag acaattttga gctatctcta
      961 tgtgtgtcca accaacaagc gtaagattat gttactcaca gacccggaga ttgagagcag
     1021 tttgttgatc agctcagatg aaggggcaac ctatcaaaag taccggctca acttttacat
     1081 tcagagtttg cttttccatc cgaagcaaga agactggatc ctggcataca gtcaagacca
     1141 aaagttatac agctctgctg agtttggccg aagatggcag cttatccagg aatcagtggt
     1201 accaaatagg ttctactggt ctgtgatggg gtcgagcaaa gaaccagacc ttgtgcatct
     1261 cgaggccagg actgtggatg gtcactcaat atacctaact tgtcggatgc aaaactgcac
     1321 tgaagccaac agaaataagc ctttcccagg ttacatcgac ccggactctt tgattgttca
     1381 ggacgattat gtgtttgttc agctgacatc aggaggaaga ccacattact atgtgtccta
     1441 ccgaagaagc ccgtttgcac aaatgaagct tccgaaatac gctttgccca aggacatgca
     1501 cgtcattagc acagacgaga accaagtgtt tgcagccgtt caagaatgga accagaacga
     1561 cacctacaac ctctacatct cagacacacg aggagtctac ttcacactgg ccttggagaa
     1621 tgtgcagagc agcagaggcc ctgaaggcaa cgtcatgatt gacctttatg aggtagcagg
     1681 gataaaggga atgttcttgg ctaacaagaa gattgacaac caagtgaaga ctttcatcac
     1741 ttacaacaaa ggcagagact ggcggttgct gcaggctcca gatgcagatc taagggggga
     1801 ccctgtgcac tgtttgctgc cctactgttc gctacacctt cacctgaagg tttctgagaa
     1861 tccctacaca tccgggatca ttgccagcag agacacagcc ccaagtatta tagttgcatc
     1921 aggtaacata ggctctgagt tgtcagacag tgacatcagc atgtttgtat cttcagatgc
     1981 agggaacact tggaggcaga tttttgaaga agagcacagc attttgtacc ttgaccaagg
     2041 tggagtcctt gttgctatga aacacacatc tctcccaatt cgacaccttt ggttgagttt
     2101 tgatgaaggg agatcttgga gcaaatacag ctttacatcc attccactct ttgtggatgg
     2161 agtcctgggg gagcctggag aagagacact aatcatgaca gtgtttggac acttcagtca
     2221 tcgttccgaa tggcagctgg tcaaagtgga ctacaagtcc atttttgata gacgctgtgc
     2281 tgaagaagac tacagaccct ggcagttgca tagtcagggg gaagcatgca tcatgggagc
     2341 caagaggata tacaagaaga gaaagtctga gcgcaagtgt atgcaaggaa agtatgcggg
     2401 agcaatggag tctgagcctt gtgtttgtac agaggcagac tttgactgtg actatggcta
     2461 tgagagacat agtaatggac aatgcctgcc agcattttgg ttcaacccat cctcactgtc
     2521 aaaagactgc agcttgggac agagttacct caacagcact gggtatagga aggtggtctc
     2581 caataattgt actgatggag tgagagagca gtataccgcc aaaccacaga agtgtccagg
     2641 gaaggcccct cgtgggctgc ggattgtcac tgcagatggg aaactgacag cagagcaggg
     2701 ccacaatgtc actctcatgg tgcagctgga agagggtgat gtgcagcgga cactcatcca
     2761 agtggacttc ggagatggca ttgcagtatc gtatgtcaac ctcagctcta tggaagacgg
     2821 tatcaagcac gtatatcaga atgtgggcat tttccgagtg accgtgcagg tggacaacag
     2881 tctggggtct gacagcgccg tcctgtactt acatgtaact tgtcccctgg agcatgtgca
     2941 cctgtctctt ccttttgtca caacaaagaa caaagaggtc aatgcaactg cagtgctttg
     3001 gcccagccaa gtgggcactc tcacttacgt gtggtggtat gggaacaaca cagagcccct
     3061 gatcaccttg gagggaagca tatcgttcaa gtttacttct gaaggaatga atactatcac
     3121 agtccaagtc tctgctggga acgccatact gcaagacaca aagaccattg cggtatatga
     3181 ggaatttcgg tctcttcgct tggccttttc tccgaacttg gatgactaca accctgacat
     3241 cccggagtgg aggagggaca tcagccgagt catcaaaaag tctctggtgg aagccacagg
     3301 gattcccagc cagcatatcc tggtggcggt gttacctggc ttacccactg ctgcagagct
     3361 ctttgttttg ccctaccaag atggaaccag agaaaacaaa aggtcgcctg aggacctgga
     3421 gcagatatct gaagttctaa tccacaaact caaccaaaac ttggtgcact tcgagctgaa
     3481 gcctggcgtc caagttcttg tccacgcagc tcacctgaca gcagctccac tggtggacct
     3541 cactcctacc cacagcggat ctgccatgct gatgttgctc tctgtggtgt ttgtggggct
     3601 cgctgtattc gtcatctaca agtttaaaag aggctggaga gatcgctcag cagttaagaa
     3661 cattggctgc tcttgcagag gacccgggtt caattctcag caccaacaag gtggctcaca
     3721 agcatctgta acttcagttc caagagatcc gacaccctct tctgaccttc atgggcacca
     3781 agaacacacg tggtgcacag atatacaccc aggaaaaaca cccatacaca taaaataaaa
     3841 ataaaatgat ttttctaaag tatttagagg aataagaaaa tttttatgag atgtgaagag
     3901 cgggatttaa aatgttacgg ggtgaaataa tagtttgtat gcaaagcaca gggcagagaa
     3961 catctcagtg gtaggcctct aacttgccta caacgcacat tgtcttggat tcaatcacta
     4021 gtactgccat aaaatgtgaa tatatgtata tatacactta taaataaaga agactggacg
     4081 gaaatataaa atatattacc ccttattatt tctaatttcc aaaaccatgg atgttttaat
     4141 tcccctcatc tttgaaataa acatgtagtc ctcatacact tggactaaac atatcttaaa
     4201 tagggtacaa aaggaatgct tataaggaaa tctatatgcc tattaaacca gtcatataat
     4261 tataagctgt gtatatagtt cctaggacga tcacaattat tgcagtgtgt aattattctc
     4321 ttcaaaaact aaaagttaaa caactctgaa tgttattttt atcaattgaa attcatactg
     4381 agatgaaaat attactatgc tgtttttgta tctgtaatcc atgaactttc tgaatatatt
     4441 ctattcattt ttaattaaat ttttaggtta tcatgcaaa
//
