LOCUS       NM_001271408            2945 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus sorbin and SH3 domain containing 3 (Sorbs3),
            transcript variant 3, mRNA.
ACCESSION   NM_001271408
VERSION     NM_001271408.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Park,S.J., Frake,R.A. and Rubinsztein,D.C.
  TITLE     Increased SORBS3 expression in brain ageing contributes to
            autophagic decline via YAP1-WWTR1/TAZ signaling
  JOURNAL   Autophagy 19 (3), 943-944 (2023)
   PUBMED   35822241
  REMARK    GeneRIF: Increased SORBS3 expression in brain ageing contributes to
            autophagic decline via YAP1-WWTR1/TAZ signaling.
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Park,S.J., Frake,R.A., Karabiyik,C., Son,S.M., Siddiqi,F.H.,
            Bento,C.F., Sterk,P., Vicinanza,M., Pavel,M. and Rubinsztein,D.C.
  TITLE     Vinexin contributes to autophagic decline in brain ageing across
            species
  JOURNAL   Cell Death Differ 29 (5), 1055-1070 (2022)
   PUBMED   34848853
  REMARK    GeneRIF: Vinexin contributes to autophagic decline in brain ageing
            across species.
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Chen,R., Luo,X., Jiang,X. and Deng,S.
  TITLE     Vinexin beta deficiency exacerbates diet-induced obesity,
            hepatosteatosis, insulin resistance and endoplasmic reticulum
            stress in mice
  JOURNAL   Biochem Biophys Res Commun 596, 14-21 (2022)
   PUBMED   35104662
  REMARK    GeneRIF: Vinexin beta deficiency exacerbates diet-induced obesity,
            hepatosteatosis, insulin resistance and endoplasmic reticulum
            stress in mice.
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Hino,N., Ichikawa,T., Kimura,Y., Matsuda,M., Ueda,K. and Kioka,N.
  TITLE     An amphipathic helix of vinexin alpha is necessary for a substrate
            stiffness-dependent conformational change in vinculin
  JOURNAL   J Cell Sci 132 (2) (2019)
   PUBMED   30578314
  REMARK    GeneRIF: these results demonstrate that the H2 helix in vinexin
            alpha plays a critical role in ECM stiffness-dependent regulation
            of vinculin and cell behaviors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Kuroda,M., Ueda,K. and Kioka,N.
  TITLE     Vinexin family (SORBS) proteins regulate mechanotransduction in
            mesenchymal stem cells
  JOURNAL   Sci Rep 8 (1), 11581 (2018)
   PUBMED   30068914
  REMARK    GeneRIF: These observations reveal a critical role of vinexin alpha
            and CAP in mechanotransduction and MSC differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2945)
  AUTHORS   Suwa,A., Mitsushima,M., Ito,T., Akamatsu,M., Ueda,K., Amachi,T. and
            Kioka,N.
  TITLE     Vinexin beta regulates the anchorage dependence of ERK2 activation
            stimulated by epidermal growth factor
  JOURNAL   J Biol Chem 277 (15), 13053-13058 (2002)
   PUBMED   11825889
  REMARK    GeneRIF: regulates the anchorage dependence of ERK2 activation
            stimulated by epidermal growth factor
REFERENCE   7  (bases 1 to 2945)
  AUTHORS   Kawauchi,T., Ikeya,M., Takada,S., Ueda,K., Shirai,M., Takihara,Y.,
            Kioka,N. and Amachi,T.
  TITLE     Expression of vinexin alpha in the dorsal half of the eye and in
            the cardiac outflow tract and atrioventricular canal
  JOURNAL   Mech Dev 106 (1-2), 147-150 (2001)
   PUBMED   11472845
REFERENCE   8  (bases 1 to 2945)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (bases 1 to 2945)
  AUTHORS   Kioka,N., Sakata,S., Kawauchi,T., Amachi,T., Akiyama,S.K.,
            Okazaki,K., Yaen,C., Yamada,K.M. and Aota,S.
  TITLE     Vinexin: a novel vinculin-binding protein with multiple SH3 domains
            enhances actin cytoskeletal organization
  JOURNAL   J Cell Biol 144 (1), 59-69 (1999)
   PUBMED   9885244
REFERENCE   10 (bases 1 to 2945)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151836.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus, compared to isoform a.
            Variants 2 and 3 encode the same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165689.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC151836.3         202446-202590       c
            146-290             AC151836.3         201239-201383       c
            291-408             AC151836.3         200898-201015       c
            409-602             AC151836.3         199316-199509       c
            603-666             AC151836.3         197249-197312       c
            667-705             AC151836.3         193890-193928       c
            706-799             AC151836.3         193380-193473       c
            800-890             AC151836.3         191828-191918       c
            891-977             AC151836.3         191528-191614       c
            978-1031            AC151836.3         191373-191426       c
            1032-1118           AC151836.3         190574-190660       c
            1119-1180           AC151836.3         190053-190114       c
            1181-1323           AC151836.3         189400-189542       c
            1324-1376           AC151836.3         189115-189167       c
            1377-1423           AC151836.3         188983-189029       c
            1424-1538           AC151836.3         188695-188809       c
            1539-1664           AC151836.3         184826-184951       c
            1665-1973           AC151836.3         182795-183103       c
            1974-2074           AC151836.3         181974-182074       c
            2075-2181           AC151836.3         181633-181739       c
            2182-2945           AC151836.3         178435-179198       c
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.27 cM"
     gene            1..2945
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /note="sorbin and SH3 domain containing 3"
                     /db_xref="GeneID:20410"
                     /db_xref="MGI:MGI:700013"
     exon            1..145
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            146..290
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2243
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /note="isoform b is encoded by transcript variant 3;
                     SH3-containing adapter molecule 1; SH3 domain-containing
                     protein SH3P3; SH3 domain protein 4; vinexin beta; vinexin
                     alpha"
                     /codon_start=1
                     /product="vinexin isoform b"
                     /protein_id="NP_001258337.1"
                     /db_xref="CCDS:CCDS88702.1"
                     /db_xref="GeneID:20410"
                     /db_xref="MGI:MGI:700013"
                     /translation="MQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNF
                     QFHDPAPRTVCNGCPPPRRDGSLNPDPAWYQTWPGPGSRPSMSPKPPASQHAQNWSAT
                     WTKDSKRQDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLD
                     WTLEDPPKVVSARASSAEPRHLGTLQRPASRPGTTETSSGRNWNHSEETSRNTFNYNF
                     RPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLVDDPVEKPAQPI
                     EVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRP
                     NSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKK
                     RKAARLKFDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPA
                     DEIPKPIKPPTYQVLEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRIT
                     GTGRQGIFPASYVQINREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDW
                     GGRTSPRRSAFPFPITLQEPRSQTQSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWT
                     PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV"
     exon            291..408
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            409..602
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            603..666
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            667..705
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            706..799
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            800..890
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            891..977
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1031
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1118
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1180
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1323
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1376
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1423
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1538
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1664
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1973
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2074
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2181
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2945
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /note="hexamer: AATACA"
     polyA_site      2482
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /note="hexamer: AATAAA"
     polyA_site      2945
                     /gene="Sorbs3"
                     /gene_synonym="SCAM-1; Sh3d4; SH3P3; vinexin-g"
                     /note="major polyA site"
ORIGIN      
        1 cctgccctcc cccaccccat cacattcaca gcactgaaca tatcctacca cacacaggac
       61 accacctggg atatctggtg tcctttcttg gaacccccac aaaccccaca ggcacataca
      121 agcctgattt ggcccagtcc aaaagagtac acacgaagga gcagctggca catcctgcgt
      181 cctccaacct tgacccaagc atgcaaggcc tccctgctgg gctcagcctg gatgatttca
      241 tccctggtca cctccgaacc catataggct catcctcccg ggggacaagg gtgccagtga
      301 tccggaatgg tggctccaac acccttaatt tccagtttca tgaccctgcg cccaggactg
      361 tgtgcaatgg ctgcccccca cccaggagag atggttcctt gaatccagac ccagcatggt
      421 atcagacctg gccaggccct gggagccggc cctctatgag cccgaagcca cctgcttccc
      481 agcatgccca gaactggtca gccacatgga ccaaggacag caagcgacag gacaagcgct
      541 gggtgaagta cgagggaatc gggcccgtgg atgagagcgg catgcccatt gccccccgat
      601 ctagtgttga cagccccaga gactggtatc gaagaatgtt ccagcaaatt caccggaaaa
      661 tgccagacct gcagctggac tggaccttgg aagacccacc caaagtggtt tccgcacgcg
      721 cctcttctgc agaacccagg catctaggga ccctgcaaag acctgcctcc aggcctggca
      781 caactgagac ttctagcgga agaaactgga accactctga agagacatct agaaacacct
      841 ttaactataa ttttagacca tcctcttcag ggcttcatcc cccaaatcag gtgcctagac
      901 atcgagagaa agtagagaat gtctggacag aagattcctg gaaccagttt ctgcacgaac
      961 tagaaactgg gcataagcct aagaaaccac tggtggatga ccctgttgag aagcctgcac
     1021 agcccattga ggtcctgcta gagagagaac tggccaagct gagcgcagag ctggacaagg
     1081 acctgcgggc cattgagacc cgcctgccgt cccccaagaa ctctcaggct ccacgacggc
     1141 cccttgagca gcccggcttg gagcagcagc cctcagcccg tctgtcctca gcctggaggc
     1201 ccaactcacc gcatgcacct tacttcagtt cctcccgacc cctgagcccc cacagaatgg
     1261 cagatggagg aggaagcccc tttctgggac gtagagattt tgtctaccct tcctcagccc
     1321 gagagcctag cgcctctgaa aggggtagca gcccttcgag gaaagaagag aagaagagga
     1381 aggccgcccg gctcaagttt gacttccagg cacagtcccc caaggagctg tctctgcaga
     1441 agggtgacat tgtctatatc cataaggaag tggacaagaa ctggctggag ggggaacacc
     1501 atggccggct gggcatcttc ccagctaatt atgtggaggt tctgcctgcc gatgagattc
     1561 ccaagcccat caagccgccc acataccagg tgctggagta tggcgatgca gtagcccagt
     1621 ataccttcaa gggagacctg gaggtagaac tgtccttccg aaagggagaa cgcatctgcc
     1681 tgatccgcaa ggtgaacgaa cattggtatg aggggcgcat cactggcact ggacgccagg
     1741 gcatcttccc tgccagctac gtgcagataa accgagagcc ccggctcagg ctttgtgatg
     1801 atggtcccca gctccctgca tcacctaacc cgacaaccac tgctcaccta agcagccact
     1861 cccacccctc ctcaatacct gtggacccca ctgactgggg aggtcgaacc tcccctcgac
     1921 gctccgcctt tcccttcccc atcaccctcc aggagcccag atcccaaacc cagagtctca
     1981 atacccctgg accaaccctg tcccatcctc gagccaccag ccgtcccata aacctgggac
     2041 cctcctcccc aaacacagag atacactgga ctccgtaccg ggccatgtac cagtacaggc
     2101 cccagaatga ggacgagctg gaacttcgag agggggaccg tgtggatgtc atgcagcaat
     2161 gtgacgatgg ctggtttgtg ggtgtctccc ggcgaactca gaaatttggg acattccctg
     2221 gaaattatgt agccccagtg tgagtggtct ccatggcagt ttggagccaa cgaggatcgg
     2281 gaggggagca gtagcactat gggagggaga gaggccttcc atagcctcct ccccaggacc
     2341 tgtgctccca gcttctgcag agaccccagc aactttccct ccaagcctcc ttgaagtccg
     2401 attcccaccc cgcaagtcac aggcattcct ttgacagccc ccttcaccgc ccctcaaata
     2461 cagacatctg ctttcatgtg gagactgtct ccaggcctta ttgagaccag acccctaagc
     2521 ctccaacccc ccagcatgtc ccctaatggg gactggctct cgcttcaccc ccatggggtt
     2581 cctctaataa ggaccagcct tctaccctgg tggagaccaa aggcctcctc ccgtttctca
     2641 tcagcttgcc tgctaccact ttgccttctg gcctccagct gggccaggaa gcaaggtggg
     2701 aacacctcct cggccttgaa ggcccaatga caggccttgc ctcaaggcct ttccttctca
     2761 gagcctcctg aacccctggg tagggcctcc ccatgtaccc tgccgactga ctgaggcaca
     2821 caacttccct ggcttatcag aagattcatt tacagggaga caagcttgct gccctaattc
     2881 ccagctctcc ccagtgtcca gatcctctct ggaagagact ataaaataaa cgtgggtgcc
     2941 aggga
//
