LOCUS       NM_001402663            6536 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus sorbin and SH3 domain containing 2 (Sorbs2),
            transcript variant 5, mRNA.
ACCESSION   NM_001402663 XM_017312688
VERSION     NM_001402663.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6536)
  AUTHORS   Ban,Y., Yang,X., Tan,D., Gong,C., Gao,Y., Yuan,J., Chen,Y., Wang,Y.
            and Xu,T.
  TITLE     Sorbs2 regulates seizure activity by influencing AMPAR-mediated
            excitatory synaptic transmission in temporal lobe epilepsy
  JOURNAL   Neurochem Int 176, 105727 (2024)
   PUBMED   38555055
  REMARK    GeneRIF: Sorbs2 regulates seizure activity by influencing
            AMPAR-mediated excitatory synaptic transmission in temporal lobe
            epilepsy.
REFERENCE   2  (bases 1 to 6536)
  AUTHORS   Sun,X., Lee,H.C. and Lu,T.
  TITLE     Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes
  JOURNAL   Circ Res 134 (7), 858-871 (2024)
   PUBMED   38362769
  REMARK    GeneRIF: Sorbs2 Deficiency and Vascular BK Channelopathy in
            Diabetes.
REFERENCE   3  (bases 1 to 6536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6536)
  AUTHORS   Jia,Y., Pan,H., Liu,J., Huang,T., Han,K., Mei,Q., Zeng,L., Zhou,J.
            and Zhang,Y.
  TITLE     MiR-484 promotes nonalcoholic fatty liver disease progression in
            mice via downregulation of Sorbs2
  JOURNAL   Obesity (Silver Spring) 31 (12), 2972-2985 (2023)
   PUBMED   37752619
  REMARK    GeneRIF: MiR-484 promotes nonalcoholic fatty liver disease
            progression in mice via downregulation of Sorbs2.
REFERENCE   5  (bases 1 to 6536)
  AUTHORS   McLendon,J.M., Zhang,X., Matasic,D.S., Kumar,M., Koval,O.M.,
            Grumbach,I.M., Sadayappan,S., London,B. and Boudreau,R.L.
  TITLE     Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in
            Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice
  JOURNAL   J Am Heart Assoc 11 (13), e025687 (2022)
   PUBMED   35730644
  REMARK    GeneRIF: Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in
            Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.
REFERENCE   6  (bases 1 to 6536)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   7  (bases 1 to 6536)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   8  (bases 1 to 6536)
  AUTHORS   Fagman,H., Amendola,E., Parrillo,L., Zoppoli,P., Marotta,P.,
            Scarfo,M., De Luca,P., de Carvalho,D.P., Ceccarelli,M., De
            Felice,M. and Di Lauro,R.
  TITLE     Gene expression profiling at early organogenesis reveals both
            common and diverse mechanisms in foregut patterning
  JOURNAL   Dev Biol 359 (2), 163-175 (2011)
   PUBMED   21924257
REFERENCE   9  (bases 1 to 6536)
  AUTHORS   Lamberti,A., Sanges,C., Chambery,A., Migliaccio,N., Rosso,F., Di
            Maro,A., Papale,F., Marra,M., Parente,A., Caraglia,M.,
            Abbruzzese,A. and Arcari,P.
  TITLE     Analysis of interaction partners for eukaryotic translation
            elongation factor 1A M-domain by functional proteomics
  JOURNAL   Biochimie 93 (10), 1738-1746 (2011)
   PUBMED   21689717
REFERENCE   10 (bases 1 to 6536)
  AUTHORS   Matsuyama,M., Mizusaki,H., Shimono,A., Mukai,T., Okumura,K.,
            Abe,K., Shimada,K. and Morohashi,K.
  TITLE     A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene
            expression through activation of MAPK cascade in mouse fetal gonad
  JOURNAL   Genes Cells 10 (5), 421-434 (2005)
   PUBMED   15836771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158351.4, AC116747.10 and AC113469.9.
            
            On Mar 21, 2022 this sequence version replaced XM_017312688.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.79773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               AC158351.4         150594-151149
            557-695             AC116747.10        85549-85687         c
            696-745             AC116747.10        8288-8337           c
            746-838             AC116747.10        2911-3003           c
            839-865             AC113469.9         36658-36684
            866-990             AC113469.9         36955-37079
            991-1129            AC113469.9         50291-50429
            1130-1302           AC113469.9         54257-54429
            1303-1369           AC113469.9         61067-61133
            1370-1544           AC113469.9         63772-63946
            1545-1659           AC113469.9         66827-66941
            1660-1818           AC113469.9         74040-74198
            1819-1868           AC113469.9         81214-81263
            1869-2056           AC113469.9         84019-84206
            2057-3637           AC113469.9         86216-87796
            3638-3726           AC113469.9         90948-91036
            3727-3773           AC113469.9         92203-92249
            3774-3888           AC113469.9         94870-94984
            3889-4017           AC113469.9         95071-95199
            4018-4218           AC113469.9         96891-97091
            4219-4268           AC113469.9         110957-111006
            4269-4375           AC113469.9         114967-115073
            4376-6536           AC113469.9         116983-119143
FEATURES             Location/Qualifiers
     source          1..6536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.44 cM"
     gene            1..6536
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /note="sorbin and SH3 domain containing 2"
                     /db_xref="GeneID:234214"
                     /db_xref="MGI:MGI:1924574"
     exon            1..556
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..695
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..745
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             736..4437
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     sorbin and SH3 domain-containing protein 2;
                     Arg/Abl-interacting protein ArgBP2; arg/Abl-interacting
                     protein 2; arg-binding protein 2; Arg/Abl-binding protein
                     2"
                     /codon_start=1
                     /product="sorbin and SH3 domain-containing protein 2
                     isoform 5"
                     /protein_id="NP_001389592.1"
                     /db_xref="GeneID:234214"
                     /db_xref="MGI:MGI:1924574"
                     /translation="MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSA
                     WRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITINGNSGGAVSPVS
                     YYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEE
                     EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPY
                     SAQSHPAAKTQTYRPLSKSHSDNGTDAFKEVPSPVPPPHVPPRPRDQSSTLKHDWDPP
                     DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPPTPTPVPREPSRKPLSVSPSTD
                     GLRSPSPPPRSCVPAPRPSAPDLSPTRVSIYQSSIDRSLERPSSSASMAGDFRKRRKS
                     EPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGDDSKMCPP
                     LCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETV
                     SPKIKSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVCGN
                     SRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLH
                     GWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRF
                     SIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDH
                     SDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYT
                     RFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKILTPQKQTEKAKCK
                     ASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSP
                     MHQPFHPLPPDGASHCPLYQNDCGRMPHSASFPDVDTTSNYHAQDYGSALSLQDHESP
                     RSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID
                     QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNV
                     ELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLP
                     HSYSSDRIYTLSSNKPQRPGFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVM
                     EKCDDGWFVGTSRRTKFFGTFPGNYVKRL"
     exon            746..838
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..865
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..990
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1129
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1302
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1369
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1544
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1659
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1818
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1868
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2056
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..3637
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3726
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3773
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3888
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4017
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4218
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..4268
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4375
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..6536
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6516..6521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /note="hexamer: AATAAA"
     polyA_site      6536
                     /gene="Sorbs2"
                     /gene_synonym="2010203O03Rik; 9430041O17Rik; A530071H08;
                     Argbp2; mKIAA0777; nArgBP2"
                     /note="major polyA site"
ORIGIN      
        1 gagaggacca gccattttac ttatggaaag cagtgtggca tagagcttag ctgtggaaga
       61 agcatttaaa aagagaaaaa tctttggaga gccacaatgg gcatgctagt gcacagttat
      121 tgcagccacg tgtgcccgca agctggccct gcgacaagct gttgactggt gttgcaatta
      181 gctgattgga gaacggggac tgcggggtga taatgctgcg tatccgctcg cgggcagcag
      241 gaaagggttt tgtctcggga aagcaagcct gccctgcacg gctatctctg cagctcccca
      301 gctgagagaa ctcggggttc taaagggagg ggtcgccctc tgccagcaca gattctgtgc
      361 caggctgttg cttatgagct gcaggtctgg gaaagcaggt gtgtgctcgg atgggcactg
      421 ggctggaacg caggcggacg ctctagtgtt cacctgcttc ctgttaacag actggttggc
      481 tcacagagca tctgctccta cacgctgaag ctgcagctga gaaaggggtt ccgggcatcc
      541 cacttgactg acggagacgc ttggattgga cttaatctta aacctctgga ggtcaagacc
      601 ttttaaaaag ggctaaataa acactctcta catgtaaaag gccagcgact cctacttcct
      661 ctgttggagc aactgaggag ttcggcctct tctaggaaaa ctgaagaagt taataacaaa
      721 cccttcaagg tgaaaatgaa tacagatagc ggtgggtgtg ctcgcaaacg tgccgccatg
      781 tctgttacgt taacatctgt gaagagagtt caaagttctc caaacctatt ggctgcaggg
      841 cgtgagtctc agtctccaga ttcagcttgg agatcttaca atgatcggaa tccagagaca
      901 ctgaacggag atgccacata ttcctctctt gcagcaaaag gttttagaag cgttcggcca
      961 aacctgcaag acaaaagatc accgacccag agccagatca ctatcaatgg caactctggt
     1021 ggcgccgtga gtccagtgag ttactatcag aggccattct ccccttctgc atactccctc
     1081 ccagcctcgc tgaactccag cattatcatg cagcacggca ggtctcttga ttctgcagag
     1141 acatattccc agcatgccca gtccctggat ggcaccatgg gaagctccat cccgctctat
     1201 agatcctccg aggaagagaa gagggtcacg gtcatcaaag ccccgcatta cccagggatc
     1261 ggccctgtgg atgagtctgg aatccccaca gccattagga cgactgtcga caggccaaag
     1321 gactggtaca agacaatgtt caagcaaatc cacatggtac acaagccggg tctgtacaac
     1381 tcgccctaca gtgctcagtc ccacccggct gcgaagactc agacctacag acctctttcg
     1441 aaaagccact cagacaatgg caccgatgcg tttaaggagg tgccctcccc agtgcctccc
     1501 ccacacgtcc caccacgacc aagagatcag tcttcaacac taaagcatga ctgggaccct
     1561 ccagacagaa aggtggacac caggaaattt cgatcggagc caaggagtat ttttgaatat
     1621 gagcctggga agtcgtccat tctgcagcac gaaagacccc cccctctccc accaactccg
     1681 acacctgttc ccagggaacc cagccggaag cctctctcag tgtcaccctc aacagatggc
     1741 ctgcgtagcc cttcccctcc gcccaggagc tgtgtccccg caccccgtcc gagtgcccca
     1801 gatctctctc ccacccgggt ctccatctat cagtcctcca tagacagaag cctggaaaga
     1861 cccagcagct ctgcaagcat ggccggtgac tttaggaaac ggaggaagag cgaacctgca
     1921 gtgggcccac tccggggctt gggggatcag agttcaagca ggaccagccc tggccgggcg
     1981 gacctcccag gatcaagttc cacctttacg aagtctttca ttagctcttc tccttcctct
     2041 ccctcgagag cacaaggtgg ggatgatagc aaaatgtgtc cgcccctttg cagttactcg
     2101 gggctcaatg gcaccccctc tggtgagtta gagtgctgca acgcttacag acaacatttg
     2161 gacgtccccg gggactcgca aagggccatc actttcaaga atggctggca aatggcccgg
     2221 caaaatgcag agatctggag tagcactgaa gagaccgttt cccccaaaat caaatcacgt
     2281 agctgcgatg atctcctgaa tgacgactgc gacagcttcc cagaccctaa aaccaagtca
     2341 gagagtatgg gttctctgtt atgtgaagaa gactccaaag agagctgccc catgacatgg
     2401 gcgtccccct acatccagga agtgtgcggg aacagcagat ctaggctcaa acacaggtca
     2461 gcccataatg ccccaggctt cctcaaaatg tacaagaaaa tgcatcgcat caaccgcaag
     2521 gacttgatga attcagaggt catttgctcg gtgaaatcca ggatcctgca gtacgagaag
     2581 gagcaacagc acagggggct gctgcacgga tggagccagt cttccaccga ggaggtgccc
     2641 agggacgtgg tgcccactcg catttcggaa tttgaaaagc tgattcagaa gtcgaagtct
     2701 atgcccaatc taggagatga aatgttatct cctataaccc tagaaccccc acaaaatggt
     2761 ttgtgtccca agaggcgatt ttctatcgag tctctgctgg aggaagaaac tcaggttcgt
     2821 cacccttctc agggtcagcg aagctgcaag tctaacaccc tggtgcccat ccacatcgag
     2881 gtcaccagcg acgagcaacc tagaacacac atggagtttt ccgacagtga ccaagatggg
     2941 gttgtgtccg accacagcga ctacgttcac gtcgaagggt cgtccttttg tagtgaaagt
     3001 gactttgacc acttttcatt cacatcctct gaaagcttct acggatcgag ccatcaccac
     3061 caccatcacc atcaccatca ccgacacctc atcagctcct gcaaaggccg atgcccggct
     3121 tcttacactc gatttaccac aatgctaaaa catgaaagag ctaagcatga aaacatggac
     3181 cgacccagaa ggcaagaaat ggatcctggc ctgtctaagc ttgcatttct agtcagccct
     3241 gtgcctttcc gaaggaaaaa aatcctgact ccccaaaaac agactgaaaa ggcaaaatgc
     3301 aaagcctcag tagttgaagc tctggactct gccctgaaag acatttgcga ccaaataaaa
     3361 gccgaaaagc ggaggggaag cttgccagac aacagcatcc tgcacaggct tatcagtgaa
     3421 ctgctgccac agattcctga aaggaattca tctcttcatg ctctcaaaag gagccccatg
     3481 caccagcctt tccacccact gcctccagat ggtgctagtc attgtcccct gtaccaaaat
     3541 gattgtggga gaatgcctca cagtgcctct ttccctgacg tggacacaac cagcaactac
     3601 cacgcacagg actatgggag tgcactgagc ctccaagatc acgagtcccc tagaagttac
     3661 tcatctactc tgactgactt gggcagaagt gcatcacggg aacgaagggg aactccagaa
     3721 aaagagaaat tgcctgcaaa agctgtctat gatttcaaag ctcagacatc taaggagctg
     3781 tcatttaaga aaggagacac tgtctacatc ctcaggaaaa ttgaccaaaa ctggtatgag
     3841 ggggaacacc acggcagagt gggcattttc ccaatctcat acgtagagaa actaacaccc
     3901 ccggaaaaag cgcagcccgc aagaccacca cccccagtcc agcccggaga gattggagaa
     3961 gccatagcca agtacaactt caatgcagac acaaatgtgg aactctccct gcgaaagggc
     4021 gacaggatta ttcttcttaa aagagttgac caaaactggt acgaaggtaa aatcccagga
     4081 accaacagac aaggcatctt ccccgtgtcc tatgtcgagg ttgtcaagag gaacgcaaaa
     4141 ggtgctgagg actacccaga ccctcctctg ccccacagct actccagtga cagaatttac
     4201 accctaagct ccaataagcc acagcgtcct gggttctctc atgaaaacat tcaaggtggg
     4261 ggagaaccgt ttcaggctct gtataactat actcctagga acgaagatga gctggaactc
     4321 agagaaagtg atgtcgttga tgtcatggaa aagtgtgacg acggatggtt tgtgggaact
     4381 tcaagaagaa ccaaattctt tggtactttt cccggaaact atgtcaaaag gctgtgactc
     4441 acctcactcc tactttatgc cacatttcag ccacacatct gcattaaccc acctgaaaca
     4501 tcccagcagg ccccttgctg ccatgcctta tggttcccaa tcagccatta ccatctccac
     4561 ctgccgccag ccaccaaatc accagcagga gggtctgcct gccactggga gccttgggga
     4621 ggctgggagc cttagagaaa cgcaagctca cgccttcata aatatgcagt ttcctgcttt
     4681 ctgccctgaa ctttgaaatg cctgtgtaag gaatcaaaat gaacatgatc gtacttttta
     4741 aaagtgaaat aattaaggaa gaaagaaaga ggaaaaaaag agagagagac tctccaggag
     4801 actgtctggt gtcatgactg aatcgccacc tctctggaag gtgtaccgtc ctcaggaagc
     4861 cagaaggttt tgttttgttt ttttctatgg ttctcatttt caccctcagc ttggcagttc
     4921 attttctttt cacgagtttg cctagtgctc tggtttacac tatatgacaa ctatacttca
     4981 gctgttcttt gcctgcactt attatataca ttgtttcatg cacagttatt acaaatcagg
     5041 agcgtttgga aagttcactg ggacgagtgt gattttttgt tgagtgcatt acatcttcac
     5101 atgggggcgg ggaggtcttt tccctgccca tgtttttttg tgcttattag aggtgcaaac
     5161 agcgagcgat taagaactgt tggtcaactg ttacgagact ataaaaggct tagccacact
     5221 acgggacaaa ttgtgttgtg aattcgcatt gctgttttgt gtactaaaac gtaaccattg
     5281 gcattgtgaa caacaagctc ttagtggtgt atttacctgt taaaacttaa aagcagtgtt
     5341 agtgagttag gcagagagat gaaagtaata cagtcagtaa gtttcactgc gtgcacactg
     5401 acacgtttga gattgtagga ggacatataa ttcatatgct atgttgtaca ttttatggaa
     5461 atataaaaga atcccacatt attttataga gtacttcagg agcatcctaa gtgttaaggc
     5521 tggctttagc aaggattatg atcaatacaa ctatttttac tacaataatt atttttcttc
     5581 tatgagaccc agaatcctga ctccatttgc agacaggaat atatatgtgt tgagcctgat
     5641 tttttttctg gtgtgtgtaa aatacttcct aggaatacac tgggcacttt tggaaataat
     5701 gtttaaatca ttcaggttgt gttcctgtcc ccaaaacaga tctacaaaat aataccaaac
     5761 ctgaaagatt ccatggattt acggtgcctg cattccacat agccagagac ttagctttgt
     5821 atttcaaatg aatttgcata aaacctgttc atctttagca ccttatagac aaaacttttt
     5881 atggcttttc tcccatgggc aatgcttgat cttatacaac acttacactc tagaatattt
     5941 tgtacatatg tttgttcttt tttttttttt ttttgtacag actatttact tgttcaaaaa
     6001 aaacagtaag atctcccaat ttgttcttta tcctgcactt aaactgagtt taaactcttt
     6061 cagcagatct cccttcgtgg tatcttcaca gatcacaagt aaatgtgaat ctgaaagata
     6121 gcatccacac aaaattctat aatcggaaag atctttgtaa ctaatctgaa atacacataa
     6181 atgtcagtta cagaggaaca ttgttggggg caggaggtaa agaaacatct tagagaaatc
     6241 cactttacta tcaagttcac aaccagtttt atattcgaaa cgcttggagt cagccagcca
     6301 gccacatgca gctttgctga taaatggata ccttttcaca ccatttatga aaacaaaatt
     6361 tcaactctgt tgcctgttct atttaagaaa aattgctgtt tctactctct gtatctgatt
     6421 ttaaaaggaa aaaaaaattc acacctggct ttcaggtaac tgactttgga ttcttacaag
     6481 caaaggtcat tgtgtttttt cttgagtaga tacctaataa attttgcttg aaagta
//
