LOCUS       NM_001403055            8184 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus sorbin and SH3 domain containing 1 (Sorbs1),
            transcript variant 6, mRNA.
ACCESSION   NM_001403055 XM_036161474
VERSION     NM_001403055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8184)
  AUTHORS   Aye,C.C., Hammond,D.E., Rodriguez-Cuenca,S., Doherty,M.K.,
            Whitfield,P.D., Phelan,M.M., Yang,C., Perez-Perez,R., Li,X.,
            Diaz-Ramos,A., Peddinti,G., Oresic,M., Vidal-Puig,A., Zorzano,A.,
            Ugalde,C. and Mora,S.
  TITLE     CBL/CAP Is Essential for Mitochondria Respiration Complex I
            Assembly and Bioenergetics Efficiency in Muscle Cells
  JOURNAL   Int J Mol Sci 24 (4), 3399 (2023)
   PUBMED   36834818
  REMARK    GeneRIF: CBL/CAP Is Essential for Mitochondria Respiration Complex
            I Assembly and Bioenergetics Efficiency in Muscle Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8184)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8184)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8184)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   5  (bases 1 to 8184)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   6  (bases 1 to 8184)
  AUTHORS   Mandai,K., Nakanishi,H., Satoh,A., Takahashi,K., Satoh,K.,
            Nishioka,H., Mizoguchi,A. and Takai,Y.
  TITLE     Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized
            at cell-cell and cell-matrix adherens junctions
  JOURNAL   J Cell Biol 144 (5), 1001-1017 (1999)
   PUBMED   10085297
REFERENCE   7  (bases 1 to 8184)
  AUTHORS   Ribon,V., Herrera,R., Kay,B.K. and Saltiel,A.R.
  TITLE     A role for CAP, a novel, multifunctional Src homology 3
            domain-containing protein in formation of actin stress fibers and
            focal adhesions
  JOURNAL   J Biol Chem 273 (7), 4073-4080 (1998)
   PUBMED   9461600
REFERENCE   8  (bases 1 to 8184)
  AUTHORS   Ribon,V., Printen,J.A., Hoffman,N.G., Kay,B.K. and Saltiel,A.R.
  TITLE     A novel, multifuntional c-Cbl binding protein in insulin receptor
            signaling in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 18 (2), 872-879 (1998)
   PUBMED   9447983
REFERENCE   9  (bases 1 to 8184)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 8184)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142101.4, AC144949.5 and AC170187.2.
            
            On Mar 25, 2022 this sequence version replaced XM_036161474.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.53130.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC142101.4         83118-83190
            74-158              AC142101.4         145463-145547
            159-211             AC144949.5         195206-195258       c
            212-280             AC144949.5         191490-191558       c
            281-370             AC144949.5         188627-188716       c
            371-499             AC144949.5         186336-186464       c
            500-526             AC144949.5         175704-175730       c
            527-639             AC144949.5         175469-175581       c
            640-781             AC144949.5         166424-166565       c
            782-954             AC144949.5         157942-158114       c
            955-1018            AC144949.5         156150-156213       c
            1019-1066           AC144949.5         145466-145513       c
            1067-1196           AC144949.5         145225-145354       c
            1197-1311           AC144949.5         142847-142961       c
            1312-1395           AC144949.5         137304-137387       c
            1396-1461           AC144949.5         133633-133698       c
            1462-1563           AC144949.5         132993-133094       c
            1564-1613           AC144949.5         129934-129983       c
            1614-1786           AC144949.5         120398-120570       c
            1787-3253           AC144949.5         118419-119885       c
            3254-3339           AC144949.5         117695-117780       c
            3340-3507           AC144949.5         114741-114908       c
            3508-3554           AC144949.5         110970-111016       c
            3555-3669           AC144949.5         107565-107679       c
            3670-3795           AC144949.5         107312-107437       c
            3796-3990           AC144949.5         104617-104811       c
            3991-4743           AC144949.5         102529-103281       c
            4744-4803           AC144949.5         93191-93250         c
            4804-4994           AC144949.5         92411-92601         c
            4995-5107           AC170187.2         191181-191293       c
            5108-8184           AC170187.2         186689-189765       c
FEATURES             Location/Qualifiers
     source          1..8184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.25 cM"
     gene            1..8184
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /note="sorbin and SH3 domain containing 1"
                     /db_xref="GeneID:20411"
                     /db_xref="MGI:MGI:700014"
     exon            1..73
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            74..158
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            159..211
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..5175
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /note="isoform 6 is encoded by transcript variant 6;
                     ponsin; sorbin and SH3 domain-containing protein 1; SH3
                     domain protein 5; c-Cbl-associated protein"
                     /codon_start=1
                     /product="sorbin and SH3 domain-containing protein 1
                     isoform 6"
                     /protein_id="NP_001389984.1"
                     /db_xref="GeneID:20411"
                     /db_xref="MGI:MGI:700014"
                     /translation="MSSECDVGSSKAVVNGLASGNHGPDKADPFRARSISAVKIIPVK
                     TVKSPSGLVLPPDMDPTKICTGKGTVTLRASSSYRGTPSSSPVSPQESPKHESKSGLE
                     PEDPSADEWKLSSSADTNGNAQPSPLAAKGYRSVHPSLSADKPQGSPLLNEVSSSHIE
                     TDSQDFPPTSRPSSAYPSTTIVNPTIVLLQHNRDPASERRAGEQDPVPTPAELTSPGR
                     ASERRAKDASRRVVRSTQDLSDVSTDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDS
                     DVHSPRYSFSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLPLPARSSSLKSSPERND
                     WEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE
                     LEFGRPPPKKIWDYTPGDCSILPREDRKTNLEKDLSFCQAELEADLEKVETVNKSPSA
                     NSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYKSVLEGG
                     DIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHSRTFHTSNALGPGCKHKKPLS
                     AAKACISEILPSKFKPRLSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLR
                     VGGSIENLLMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQIN
                     RAGLSLGSISSSSVRDLASHFERSRLTLARGELGASQEGSEHIPKHTVSSRITAFEQL
                     IQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPREMDGMDSGGVY
                     ASPTCSNMADHALSFRSLVPSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFPKHRL
                     NKCKGTCPASYTRFTTIRKHEQQSSRQSDWRSDSRGDKNSLLRNIHLMSPLPFRLKKP
                     LQQHPRQPPPSDSSESPAGQKADLPCHDPQDQPHSAGKPLVPARLSSRHTMARLSHNL
                     EPPLDRPAGLEDCTRAINNGNPVPYSDHGLDRNNNPQSELAAAHGDSESPRHFIPADY
                     LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL
                     LNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDVVYIYRQIDQNWYEGEHHGR
                     VGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL
                     LRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDLPYSSSPSRSATVSP
                     QYTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLTVGVPGRRSLAMTPPLPPLPE
                     ASVYDMDRLALSARARPSLPLSLPYSSWSDHSTLRPVVSPMALPPPHKAYSLAPSVQA
                     PLHVNGDGGIHIRQDGFSQPPPGNSDRVISELSDAFSSQSKRQPWREDGPYDRKAESE
                     AGERYPGGPKISKKSCLKPSDVVRCLSSEQRLSEFHTPEDSQSCKPLGGPFPAWETGP
                     PELHRAVEADRKAAQSGVSQPSHHSLSAGPDLTESEKNYVEAVCNEIINIAEKSVHYC
                     STVSHPLDFHHKVPPSDNKSSLIISQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQ
                     NDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL"
     exon            212..280
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            281..370
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            371..499
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            500..526
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            527..639
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            640..781
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            782..954
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1018
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1066
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1196
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1311
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1395
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1461
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1563
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1613
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1786
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..3253
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3339
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3507
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3554
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3669
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3795
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3990
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4743
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4744..4803
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4994
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..5107
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..8184
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8157..8162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /note="hexamer: AATAAA"
     polyA_site      8184
                     /gene="Sorbs1"
                     /gene_synonym="2310065E01Rik; 9530001P15Rik; CAP;
                     mKIAA1296; Sh3d5; SH3P12"
                     /note="major polyA site"
ORIGIN      
        1 agagcggggc tgactgtagc gtggagcgcg agccgggctg gacgcgcgca agcccttgcc
       61 ggggacccgc gaggagttgg catccattgg aagaccctga gatcctctca gctcagaact
      121 ccaggaccga tgcatcttcc caccaccttg aagcactgag ccctccagag ctgcatctgg
      181 gaagactcgc ctgcctccag catgagttct gaatgtgatg ttggaagctc taaagctgtg
      241 gtgaatggct tggcatctgg caaccatgga ccagacaaag ccgacccttt ccgtgctcgc
      301 tctatatctg ctgttaaaat aattcccgtg aagacagtga aaagcccttc aggcctagta
      361 ctccctccag acatggaccc taccaaaatc tgcactggga aaggaacagt gactcttcgg
      421 gcctcgtctt cctacagggg aaccccaagc agcagccctg tgagccccca ggaatctccg
      481 aagcatgaaa gcaagtcagg cctggagcca gaggaccctt cagcagatga atggaaactt
      541 tcttccagtg cagataccaa tggcaacgcc cagccctccc cacttgctgc caagggctat
      601 agaagtgtgc atcccagcct ttctgctgac aagccccagg gcagtccttt actaaacgaa
      661 gtttcttctt cccacattga aaccgattcc caagacttcc ctccaacaag cagaccttcg
      721 tctgcctacc cctccaccac catcgtcaac cctaccattg tgctcctgca gcacaatcga
      781 gatcctgcct cagagagaag agcgggtgag caggacccag taccaacccc agcagaactc
      841 acttcgcccg gcagggcttc tgagagaagg gcaaaggatg ctagcagacg ggtggtgagg
      901 agcacacagg acctgagcga tgtgtctaca gatgaagtgg gcatcccact ccggaatacc
      961 gagcgatcga aagactggta caaaactatg tttaaacaga tccacaaact gaacagagat
     1021 gatgattctg atgtccattc ccctcgatat tccttctctg acgacacaaa gtctcccctt
     1081 tctgtgcctc gctcaaaaag tgagatgaac tacatcgaag gggagaaagt ggttaagagg
     1141 tccgccacac tcccgctccc agcccgctcc tcctcactca agtccagccc ggaaagaaac
     1201 gactgggagc ccccagataa gaaagtggat acgagaaaat accgagcaga gcccaaaagc
     1261 atttacgaat atcagccggg caagtcttcg gtcctgacca atgagaagat gagtcgggat
     1321 ataagcccag aagagataga tttaaagaat gaaccttggt ataaattctt ttcggaattg
     1381 gagtttggga gaccgcctcc caaaaagata tgggactata ctcctggaga ctgctctatc
     1441 cttcctagag aggatagaaa gactaatcta gagaaagatc tcagcttctg ccaagcagag
     1501 ttagaggcag atttagagaa agtggagacc gttaataaat cacccagtgc aaactcgcca
     1561 cagagctcag cagtcagccc gactccagac attacgtcag agcctcctgg atatatctat
     1621 tcttccaact tccatgcagt gaagagagaa tcggacggga cccccggggg tctcgctagc
     1681 ttggagaatg agaggcagat ctataagagt gtcttggaag gtggcgacat ccctcttcag
     1741 ggcctcagtg ggctcaagcg accttccagc tcagcttcca ctaaagtgga tcgtaaaggc
     1801 gggaatgctc acatgatttc ttcatcatca gttcatagcc gaacgtttca cactagcaat
     1861 gctttaggcc ctgggtgtaa gcacaagaaa cccctgtcgg ctgcgaaagc ctgcatttcg
     1921 gagatccttc cttctaaatt caaacccagg ctctctgctc ccagcgctct tttgcaggaa
     1981 cagaagagtg tcctgttacc ctcagagaag gctcagagct gtgagaacct ctgtgtgtct
     2041 ttgaatgatt ccaaaagagg cctcccactc cgggttgggg ggagcatcga gaacctgctc
     2101 atgcgctccc ggcgggatta cgatagcaag tccagtagta ccatgagcct gcaggagtac
     2161 ggcaccagct ccaggaggcc ctgccctctc tccagaaagg ctggactgca cttctccatg
     2221 ttctaccggg acatgcacca gatcaaccga gctggcctct ccctgggctc catctcctcc
     2281 tcaagtgtgc gagatcttgc ctcccacttt gaaaggagca gactgacgtt agccaggggt
     2341 gagctgggcg ctagccaaga gggctcagag catatcccca agcacaccgt gtcctcccgc
     2401 atcacggcct ttgagcagct cattcagcgg tcccggtcca tgccgtccct ggacttctct
     2461 ggccggctga gcaagtcccc gacccctgtg ctctctagaa gcggcctgac ctcagctcgt
     2521 tcagcggaat ccctcctcga gtctaccaag ctccgtccca gagagatgga cgggatggac
     2581 tccggagggg tctatgcgtc gcccacgtgt agcaatatgg cggaccacgc cttgagcttc
     2641 cggagccttg tgccctctga gcctctttcc atctgctcag atgagctaga ccactgctca
     2701 aatgtttcta acgacagcag ggagggcagc gggggcagtg ttcatggaga cttccccaaa
     2761 catcgcctca acaagtgcaa gggcacctgc ccggcttcat acacccggtt caccactatc
     2821 cgcaagcatg agcagcagtc gtccaggcag tcagactggc gctcggattc caggggggac
     2881 aagaacagtc tcctcagaaa catccacctg atgagtcccc tcccttttcg attgaaaaag
     2941 cccctccaac agcaccccag acagcctccc cccagtgact cctcagagtc ccctgctggc
     3001 cagaaagcag accttccctg ccacgaccct caggaccagc cccactctgc ggggaaaccc
     3061 ctggtccctg ctcgcctgtc ttcccgacat accatggcaa ggcttagcca caacctagaa
     3121 ccccctctgg acagacccgc aggcctggag gactgcacaa gggccattaa taacgggaac
     3181 cctgtgccct actcagacca tggcttggac aggaacaaca acccacaaag tgaactggca
     3241 gcggcccatg gagattcaga gtcaccaaga cattttatac cagctgatta cttggagtcc
     3301 acagaagaat ttattcggag acggcacgat gataaagaga aacttttagc ggaccagaga
     3361 cgacttaagc gcgagcaaga agaggccgat attgcagctc gccgccacac aggtgtcatc
     3421 ccgactcatc atcagtttat cactaatgag cgctttgggg acctcctcaa tatagatgat
     3481 acggccaaaa ggaaatctgg gttagagatg agacctgctc gagccaaatt tgactttaaa
     3541 gcccagaccc tgaaggagct gcctctgcag aagggagacg ttgtttacat ctacagacag
     3601 attgaccaga actggtatga aggtgaacac catggccggg tgggaatctt cccacgcacc
     3661 tatatcgagc ttcttcctcc agctgagaag gctcagccca gaaagttggc acccgtacaa
     3721 gttttggaat atggagaagc cattgcgaag tttaacttta atggagatac acaagtagaa
     3781 atgtctttcc gaaaggggga gaggatcacg ctgctccgac aggtggatga gaactggtac
     3841 gaagggagga ttcctgggac atctcgccaa ggcattttcc ctatcaccta tgtagatgtg
     3901 cttaagaggc cattggtgaa aacccctgtg gattacatcg acctgcctta ttcttcttcc
     3961 ccaagtcgca gtgccactgt gagcccacag tatactagtc acagcaagct catcatgcca
     4021 gccccttcat ctctacccca cccccgccga gccctgtccc ctgagatgca cgccatcacc
     4081 tccgagtgga tctctctgac tgtcggggtc ccaggcaggc gttctctggc catgacacca
     4141 cccttgcctc ctctgcctga ggcttctgtc tatgacatgg accgcctggc cttgtcagca
     4201 agggcccgtc cctccttgcc tctcagcctc ccctattcaa gttggtcaga tcactccacc
     4261 ctgcgcccag tggtctcccc gatggccctg cctccacccc acaaagccta ctcactggca
     4321 cccagtgtcc aggctcctct tcacgtcaat ggagatggtg gtattcacat tcgccaagat
     4381 ggcttctccc agccaccacc tgggaactct gatagggtca tctcagagct tagtgacgcc
     4441 tttagcagcc agagcaagag acagccctgg cgagaagatg gaccatatga caggaaagca
     4501 gagagcgagg caggtgagag ataccctggt ggacccaaga tctctaagaa gagctgcttg
     4561 aaaccttcag acgtggtcag gtgcctgagt tctgagcaga gactctcaga gttccacact
     4621 cctgaggaca gtcagtcctg caagcccctg ggtggccctt tcccagcctg ggagactggg
     4681 ccaccagagc tgcacagagc tgtcgaggct gacaggaagg ctgctcagag tggtgtgagc
     4741 cagccttctc atcattcatt gagcgcagga cctgatctca cagaatctga aaagaactat
     4801 gtggaagcgg tttgcaatga gatcataaac attgcggaga aatctgttca ttactgcagc
     4861 actgtctctc atccccttga cttccatcac aaggtacccc cttctgacaa taaatcatct
     4921 ttaatcattt ctcagcaacc tcaagcccag cagcgaagag tcaccccaga caggagtcag
     4981 ccctcactgg atttgtgtag ctaccaagcg ttatatagtt atgtgccaca gaacgatgat
     5041 gagttggaac tccgagatgg agatattgtt gatgtcatgg aaaaatgtga cgatggatgg
     5101 tttgttggca cttcgagaag gacgaggcag tttggtactt ttccaggcaa ctatgtaaaa
     5161 cctttatatc tataagaaga ctaaaaagca cagagattat tttttatcgg aggatgaagc
     5221 atcattcatg aactggtctc tttatttaag tactgagtca gtaagaaaac taatgcagtt
     5281 ggtaaagaaa gaattcaaag aaggaacaga gaagtgtgtt tgaaacccat tgtgtatcag
     5341 ggattaacta tctgctgaag acatctgtat ttacatgact gcttctggga gctgctctag
     5401 cccccgctgc ttggggaatc tgatctggag catgtccatg agcaacatta gccaaaaaaa
     5461 aaaaaaaaaa atgtgcccag tctttaccca ctcccatttt aaagaggtcc cttggggcta
     5521 gataagtcag tccccatccg tgttccacag gtcatagcct gagcatcact gacaactcct
     5581 gcctctgttc ctgagtatcc cagagccagc agacctcaag tgctgctaga ggctggtctg
     5641 gttttgaagt tttccttcag caccatgact tgatgaagtc taggggaaga aatggtggca
     5701 gaccaggtgc cctagcactc agccttctgg gtgatattgc ctcttactgc cctgatactc
     5761 agacagaaag ccatgccatg tgtgtcccga gcttgggagc aggtggcctg gcagatgggc
     5821 tacatttgtg tctccacatg attaagccac accttggggc tctggaagtc acttggagtg
     5881 tgttcttctc ctggtcacta ccactggcta gccagggtta gctgtgcctt tcttctctgg
     5941 cttagtatgg gcttgataca cttgagccca tagaatacag cctggtttcc aggagctctc
     6001 ttagcatgta tagatgcaag ctggctgctt gggcaccgtg agtaagatac tcgctcgcag
     6061 acctaggagg gactctgcct cctgggttgt ccgtggagtc tgaacgccac ccagaatatt
     6121 gtgttctctg gtccttcccc ctcctcctct ccacctcagg ccagggtgtc ctggtgcaca
     6181 tggtgaggcc tccattcaga gctcaggtat tgctcactgg cctgggtatg aggcagcaat
     6241 cctccttttg gtggcagctg tgagtctgtc ttctgtgagc cccagttatg aggagggggc
     6301 cctttgacac ctgggtatcc ctagttgaca tgaagataag tgtggccctg ttcccagagc
     6361 tgagcctgcc agggtctcag ctgagtggac aacataggag aagccaatct agagagacca
     6421 tgatacgtgc agagggtgtg agaggaaggg acgcatttct cctacgaggg actctagaaa
     6481 gcagtcaggg ttccctctcc cttggctcac ttctgaacaa ccggggtgct gggagaccct
     6541 ttgtctgagg gcagtttatg tctggaaata ttgagatttt ttttcttttc cagattctgg
     6601 tattcttctt ctacccaaaa ttacatgcac taggccacaa ataccaggga ttgtaggtga
     6661 tatggggtat atactgaaac cctggctctc tgcatagagt tcagaatcac cccaaccact
     6721 atactgtccc aaagtctgga gtctttacaa gtccattctt ccgtgaccgc ctgctgtctt
     6781 agatagcatg ggaccctaac tccccctgcc ccccaaccac caccagtcag ccacaattct
     6841 ccgaggaggc tctcggggaa actgccacag gttgattcac actgaaatat aaatggctga
     6901 tggggaaata aatgtgttgc ctcttcccgg agacatcctt tttaactgag acagagcaga
     6961 gcctttaatc ccaagggaaa atggtagaag cttcctgggc agaaagaccc ggcgagtcta
     7021 tgacctgttg ctttgcaagc tcagcttccc cagccagctg cactgcttgc ttttttgact
     7081 ttgtccctct cgaagggaac ataggacaaa taaataaaag tgcatatgtg cgttttttta
     7141 cttttctgga atgcagcctt tgctctctcc gagatgccag ccacggctag tgcgattgta
     7201 tctaaatttc ctgaggggtg ttttttgatt aagtaggtaa tgtcaaacac ccctttaact
     7261 acagctagaa aataaaacca ttttataaag ccacccttgc atcccctgcg agcctcacac
     7321 agagcatctc tccaaatcca ggtatgccag ccaccttgaa taaaatctct tccgcttccg
     7381 acgtatgaaa agcaaaaatg aaaagaggga aggttcccag ttactctttt gtcttcagac
     7441 atttagtaat ataaagtacc tatttttatg ctgaaatgtt tatacaggtt tattaacagc
     7501 aagcgcaact aactggcggc atgccgtgca gctcgttttg atatattagc catgcttgca
     7561 gataaaggca agccccaaac tactcacctt ttgcagtctc tctgggatca ggaaaagaaa
     7621 aagcaatcac atgtttgaga agtgggactg taaatatgta atgtatattt aactttgtgt
     7681 agcccatgta cctaccttgt atagaaaaat aatttttaaa acctgagcag aaaaggagta
     7741 aaatgaggga gtcatgaagg gtcccccccc acacttttat ttaaatgaag gaatttcaaa
     7801 taattcacct gcagactttt agcacaaaaa tagtccttgg aaattgttaa catattcggt
     7861 tgttctttgg ggaagagaag accactataa taccatttac ttttcttttc gaggttctat
     7921 ttatctgcag tagtattaag tcatattgct ggaataggtt actacccccc caaaagatat
     7981 tattgagaaa aaataaaaat ggtctatgta acctatgaaa gtattgcatt taaattgcac
     8041 accaagcgca tgtactacgc agacacaggt ttttctgttc atctaatttt tttccttatt
     8101 gcagtggatt gatttgatag acatgttgag ttactacttt gctgtacata ttatttaata
     8161 aactttattc ggaattgcgt ggca
//
