LOCUS       NM_178880               8451 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus Son DNA binding protein (Son), transcript variant 1,
            mRNA.
ACCESSION   NM_178880
VERSION     NM_178880.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8451)
  AUTHORS   Vukadin,L., Park,B., Mohamed,M., Li,H., Elkholy,A.,
            Torrelli-Diljohn,A., Kim,J.H., Jeong,K., Murphy,J.M., Harvey,C.A.,
            Dunlap,S., Gehrs,L., Lee,H., Kim,H.G., Sah,J.P., Lee,S.N.,
            Stanford,D., Barrington,R.A., Foote,J.B., Sorace,A.G., Welner,R.S.,
            Hildreth,B.E. 3rd, Lim,S.S. and Ahn,E.E.
  TITLE     A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals
            indispensable SON functions in organ development and hematopoiesis
  JOURNAL   JCI Insight 9 (5), e175053 (2024)
   PUBMED   38290089
  REMARK    GeneRIF: A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome
            reveals indispensable SON functions in organ development and
            hematopoiesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8451)
  AUTHORS   Luo,H., Cortes-Lopez,M., Tam,C.L., Xiao,M., Wakiro,I., Chu,K.L.,
            Pierson,A., Chan,M., Chang,K., Yang,X., Fecko,D., Han,G., Ahn,E.E.,
            Morris,Q.D., Landau,D.A. and Kharas,M.G.
  TITLE     SON is an essential m6A target for hematopoietic stem cell fate
  JOURNAL   Cell Stem Cell 30 (12), 1658-1673 (2023)
   PUBMED   38065069
  REMARK    GeneRIF: SON is an essential m[6]A target for hematopoietic stem
            cell fate.
REFERENCE   4  (bases 1 to 8451)
  AUTHORS   Ueda,M., Matsuki,T., Fukada,M., Eda,S., Toya,A., Iio,A., Tabata,H.
            and Nakayama,A.
  TITLE     Knockdown of Son, a mouse homologue of the ZTTK syndrome gene,
            causes neuronal migration defects and dendritic spine abnormalities
  JOURNAL   Mol Brain 13 (1), 80 (2020)
   PUBMED   32448361
  REMARK    GeneRIF: Knockdown of Son, a mouse homologue of the ZTTK syndrome
            gene, causes neuronal migration defects and dendritic spine
            abnormalities.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8451)
  AUTHORS   Dillman,A.A., Hauser,D.N., Gibbs,J.R., Nalls,M.A., McCoy,M.K.,
            Rudenko,I.N., Galter,D. and Cookson,M.R.
  TITLE     mRNA expression, splicing and editing in the embryonic and adult
            mouse cerebral cortex
  JOURNAL   Nat Neurosci 16 (4), 499-506 (2013)
   PUBMED   23416452
REFERENCE   6  (bases 1 to 8451)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 8451)
  AUTHORS   Wynn,S.L., Fisher,R.A., Pagel,C., Price,M., Liu,Q.Y., Khan,I.M.,
            Zammit,P., Dadrah,K., Mazrani,W., Kessling,A., Lee,J.S. and
            Buluwela,L.
  TITLE     Organization and conservation of the GART/SON/DONSON locus in mouse
            and human genomes
  JOURNAL   Genomics 68 (1), 57-62 (2000)
   PUBMED   10950926
REFERENCE   8  (bases 1 to 8451)
  AUTHORS   Kai,N., Mishina,M. and Yagi,T.
  TITLE     Molecular cloning of Fyn-associated molecules in the mouse central
            nervous system
  JOURNAL   J Neurosci Res 48 (5), 407-424 (1997)
   PUBMED   9185665
REFERENCE   9  (bases 1 to 8451)
  AUTHORS   Soteriou,B., Fisher,R.A., Khan,I.M., Kessling,A.M., Archard,L.C.
            and Buluwela,L.
  TITLE     Conserved gene sequences for species identification: PCR analysis
            of the 3' UTR of the SON gene distinguishes human and other
            mammalian DNAs
  JOURNAL   Forensic Sci Int 73 (3), 171-181 (1995)
   PUBMED   7657183
REFERENCE   10 (bases 1 to 8451)
  AUTHORS   Cheng,S., Lutfalla,G., Uze,G., Chumakov,I.M. and Gardiner,K.
  TITLE     GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21
            and mouse chromosome 16
  JOURNAL   Mamm Genome 4 (6), 338-342 (1993)
   PUBMED   8318737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ088081.1, BC061113.1, AC131691.4, AK040621.1, AK122418.1 and
            CB849818.2.
            
            On Feb 1, 2007 this sequence version replaced NM_178880.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CJ088081.1         1-61
            62-416              BC061113.1         18-372
            417-5566            AC131691.4         97829-102978
            5567-6459           AK040621.1         570-1462
            6460-7023           AK122418.1         821-1384
            7024-7522           CB849818.2         122-620
            7523-8451           AK122418.1         4639-5567
FEATURES             Location/Qualifiers
     source          1..8451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.22 cM"
     gene            1..8451
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /note="Son DNA binding protein"
                     /db_xref="GeneID:20658"
                     /db_xref="MGI:MGI:98353"
     exon            1..161
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..7419
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SON; negative regulatory element-binding protein;
                     NRE-binding protein; Son cell proliferation protein"
                     /codon_start=1
                     /product="protein SON isoform 1"
                     /protein_id="NP_849211.3"
                     /db_xref="CCDS:CCDS37399.1"
                     /db_xref="GeneID:20658"
                     /db_xref="MGI:MGI:98353"
                     /translation="MAADIEQVFRSFVVSKFREIQQELSSGRSEGQLNGETNPPIEGN
                     QAGDTAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEASRKSRCVSVQTDPTDE
                     VPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKLKSHHDGNLESDSFLKFDSEP
                     SAAALEHPVRAFGLSEASETALVLEPPVVSMEVQESHVLETLKPATKAAELSVVSTSV
                     ISEQSEQPMPGMLEPSMTKILDSFTAAPVPMSTAALKSPEPVVTMSVEYQKSVLKSLE
                     TMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEVHPEPSPSTMDFPESSTTDVQRL
                     PEQPVEAPSEIADSSMTRPQESLELPKTTAVELQESTVASALELPGPPATSILELQGP
                     PVTPVPELPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVTPVPQLSQELPG
                     PPAPSMGLEPPQEVPEPPVMAQELSGVPAVSAAIELTGQPAVTVAMELTEQPVTTTEF
                     EQPVAMTTVEHPGHPEVTTATGLLGQPEAAMVLELPGQPVATTALELSGQPSVTGVPE
                     LSGLPSATRALELSGQSVATGALELPGQLMATGALEFSGQSGAAGALELLGQPLATGV
                     LELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTV
                     AQELPTTLVGETSVTVGVDPLMAQESHMLASNTMETHMLASNTMDSQMLASNTMDSQM
                     LASNTMDSQMLASSTMDSQMLASSTMDSQMLATSTMDSQMLATSSMDSQMLATSSMDS
                     QMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSM
                     DSQMLASGAMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMMGSKSPDPYRLAQD
                     PYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRVSPRPYRIAPRSY
                     RIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMS
                     AYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMM
                     SSYSAADRSMMSSYSAADRSMMSSYTDRSMMSMAADSYTDSYTDSYTEAYMVPPLPPE
                     EPPTMPPLPPEEPPMTPPLPPEEPPEGPALSTEQSALTADNTWSTEVTLSTGESLSQP
                     EPPVSQSEISEPMAVPANYSMSESETSMLASEAVMTVPEPAREPESSVTSAPVESAVV
                     AEHEMVPERPMTYMVSETTMSVEPAVLTSEASVISETSETYDSMRPSGHAISEVTMSL
                     LEPAVTISQPAENSLELPSMTVPAPSTMTTTESPVVAVTEIPPVAVPEPPIMAVPELP
                     TMAVVKTPAVAVPEPLVAAPEPPTMATPELCSLSVSEPPVAVSELPALADPEHAITAV
                     SGVSSLEPSVPILEPAVSVLQPVMIVSEPSVPVQEPTVAVSEPAVIVSEHTQITSPEM
                     AVESSPVIVDSSVMSSQIMKGMNLLGGDENLGPEVGMQETLLHPGEEPRDGGHLKSDL
                     YENEYDRNADLTVNSHLIVKDAEHNTVCATTVGPVGEASEEKILPISETKEITELATC
                     AAVSEADIGRSLSSQLALELDTVGTSKGFEFVTASALISESKYDVEVSVTTQDTEHDM
                     VISTSPSGGSEADIEGPLPAKDIHLDLPSTNFVCKDVEDSLPIKESAQAVAVALSPKE
                     SSEDTEVPLPNKEIVPESGYSASIDEINEADLVRPLLPKDMERLTSLRAGIEGPLLAS
                     EVERDKSAASPVVISIPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKK
                     RDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR
                     SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKAARARSRTPSRRSRSHT
                     PSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRR
                     RRSRSAVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKA
                     QLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQ
                     SKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPKSQVTLT
                     KEFPVSSGSQHRKKEADSVYGEWVPVEKNGEESKDDDNVFSSSLPSEPVDISTAMSER
                     ALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTG
                     AQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGL
                     VAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHF
                     LFRVLRNGSPYQPNCMFFLNRY"
     exon            162..328
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            329..6298
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            6299..6459
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            6460..6606
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            6607..6795
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            6796..6906
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            6907..7023
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            7024..7171
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            7172..7243
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            7244..7359
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
     exon            7360..8451
                     /gene="Son"
                     /gene_synonym="2900011L12Rik; mKIAA1019; nrebp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattggccg ctgcgcctcc tcccgaggca tgctgggagc ctggaggact agcgaggagt
       61 agttgagaga acggagcgga cgccatggcg gccgacatcg agcaggtttt caggtctttc
      121 gtggtcagta aattccggga aatacaacag gagctttcca gtggaaggag tgaaggccag
      181 ctgaatggtg aaacaaatcc acccattgaa gggaaccagg caggtgacac agctgcctct
      241 gcaaggagtc tcccaaatga agaaatagtg cagaagatag aggaggtcct ctctggggtc
      301 ttagatacgg agctgcggta caagcccgac ttgaaagagg cctccagaaa aagtagatgc
      361 gtatctgtgc aaacagatcc tactgatgaa gtgcccacca aaaagtcaaa gaagcataaa
      421 aagcacaaaa acaaaaagaa gaaaaagaag aaagaaaaag aaaaaaaata taaaagacaa
      481 ccagaagaat ctgagtccaa gctgaaatct catcatgatg ggaatctaga atctgattcc
      541 ttcttaaagt ttgattctga accttcagca gcggcactgg aacatcctgt aagagcgttt
      601 ggcttatctg aggccagtga gaccgcctta gtgctggaac ctccagtagt ctcaatggag
      661 gttcaggagt cacacgttct agagactctg aagccagcta caaaagctgc agaactgtca
      721 gttgtgtcta catcagtaat ctcagagcag tctgagcagc ctatgccagg tatgctggaa
      781 ccatcaatga caaagatcct ggattccttc acagcagcac cagtgcctat gtcaacagcg
      841 gcgctgaagt cacctgagcc cgttgtaaca atgtcagtgg aatatcagaa gtctgtgctg
      901 aaatctttgg agactatgcc tccagagacg tcaaagacca cgctggtaga gcttcccata
      961 gcaaaagtgg ttgagccatc agaaaccctc acgatagtgt cagagacacc tactgaggtg
     1021 caccctgaac caagcccatc aacaatggat tttccagagt catctacaac tgacgtgcaa
     1081 agattgccag agcagcctgt agaagcacca tcggagattg cagattcatc catgacaaga
     1141 cctcaggagt cactggagct gcctaagacc acagcggtgg agctgcagga gtcgacggtg
     1201 gcctcagctc tggagttgcc ggggccacct gcgacctcca ttctggagtt gcaggggccc
     1261 cctgtgactc cagtgccaga gttgcctggg ccctctgcca ccccagtgcc agagttgtca
     1321 gggccccttt ctaccccagt gcctgagttg ccagggcccc ctgcgacagt ggtccctgag
     1381 ttgccggggc cctctgtgac accagtgcca cagttgtcgc aggaattgcc agggcctcca
     1441 gcaccatcca tggggttgga gccaccacag gaggtaccag agccacctgt gatggcacag
     1501 gagttatcag gggtgcctgc agtgtcggca gcgatagagt tgacagggca acctgcagta
     1561 acagtagcaa tggagttgac cgaacaacct gtgacgacga cagagttcga gcagcctgtg
     1621 gcgatgacaa cggtggagca tcctgggcat cctgaggtga caacagctac agggttgctg
     1681 gggcagccag aggcagcaat ggtgctggag ttgccaggcc agccagtggc aaccacagcg
     1741 ctggagttgt ctgggcagcc ttcggtgact ggggtgccag agttgtcagg gctgccttcg
     1801 gcaactaggg cactggagtt gtcagggcag tctgtggcaa ctggggcatt agagttgcct
     1861 ggtcagctca tggcaactgg ggcactggag ttttcggggc agtctggggc agctggagca
     1921 ctggagcttt tggggcagcc cctagcaacg ggggtgctag agttaccagg gcagcctgga
     1981 gcgccagagt tgcctgggca gcctgtggca actgtggcgc tggagatctc tgttcagtct
     2041 gtggtgacaa catcggagct gtcaacgatg accgtgtcgc agtccctgga ggtgccctcg
     2101 acgacagcgc tggaatccta taatacggta gcacaggagc tgcctactac attggtgggg
     2161 gagacttctg taacagtagg agtggacccc ttgatggccc aagaatccca tatgctagct
     2221 tctaacacca tggagaccca tatgttagca tccaatacca tggactccca gatgctagca
     2281 tccaacacta tggattctca gatgctagca tccaatacca tggactccca gatgttagcc
     2341 tctagcacca tggactccca gatgttagcc tctagcacca tggactccca gatgttagca
     2401 actagcacca tggactccca gatgttagca actagctcta tggactccca gatgttagca
     2461 actagctcta tggactccca gatgttagca accagcagta tggactccca gatgttagca
     2521 accagcagta tggactccca gatgttagca accagctcca tggactccca gatgttagca
     2581 accagcagta tggactccca gatgttagca accagcagta tggactccca gatgttagca
     2641 accagttcca tggactccca gatgttagca tctggtgcta tggattctca gatgttagct
     2701 tctggcacta tggatgctca gatgttagca tctggtacta tggatgccca aatgttagca
     2761 tctagtaccc aggattctgc tatgatgggt tcaaagtctc ctgatcccta taggttagct
     2821 caggatcctt acagattagc tcaggatccc tataggttgg gtcatgaccc ctacaggtta
     2881 ggccatgatg cttacaggtt aggacaagac ccttatagat taggccatga tccctacaga
     2941 ctaactccgg atccctatag ggtatcacct aggccctata gaatagcacc caggtcctat
     3001 aggatagcac ctaggccata caggttagca cctagaccct tgatgttagc atctagacgt
     3061 tctatgatga tgtcctatgc tgcagaacgt tccatgatgt catcttatga gcgctctatg
     3121 atgtcttatg aacgctctat gatgtcccct atggctgaac gctctatgat gtcggcctat
     3181 gagcgctcca tgatgtcagc ttatgagcgc tccatgatgt ctcctatggc tgagcgttct
     3241 atgatgtcag cttatgagcg ctctatgatg tcagcttatg agcgctccat gatgtctcct
     3301 atggctgatc gatccatgat gtccatgggt gccgaccggt ctatgatgtc atcgtactct
     3361 gcagctgacc ggtctatgat gtcatcgtac tctgcagctg atcgatcaat gatgtcatct
     3421 tacactgatc gatcaatgat gtctatggca gctgattctt acactgattc ttatactgat
     3481 tcctatacgg aggcatatat ggtgccacct ttgcctcctg aagagccccc aacaatgcca
     3541 ccattgccac ccgaggaacc accaatgaca cccccattac ctcctgagga accaccagag
     3601 ggtccagcat tatcaacaga gcagtcagca ttaacagctg acaatacttg gtctacagag
     3661 gtgacattat ctactggaga atctctatca cagcctgagc ctcctgtgag tcaaagtgag
     3721 atttcagagc ctatggcagt acctgctaat tattcaatgt cagaatcaga aacttcaatg
     3781 ttagcatcag aggctgttat gactgttcca gaacctgcac gagagcccga gtcttcagtt
     3841 acatcagcac cagttgagtc tgctgtagta gcagaacatg aaatggttcc agagagaccg
     3901 atgacttaca tggtttctga gactaccatg tcagtcgagc cagctgtgtt aacatcagag
     3961 gcttctgtta tatcagagac atcagaaaca tatgattcca tgagaccttc aggacatgct
     4021 atctcagagg taactatgtc actcttggag ccagcagtaa ctatttcaca gccagcagag
     4081 aacagtctag agctcccatc catgactgtc ccagcacctt ctactatgac taccacagaa
     4141 tctccagttg ttgctgtcac agaaattcct cctgtggctg tcccagaacc tcccattatg
     4201 gctgttccag aactccccac catggctgta gtaaaaaccc ccgctgtggc tgtcccagaa
     4261 cctcttgtgg ctgctccaga gcctcctacc atggctactc cagaactttg ctccttatct
     4321 gtctcagaac ctcctgtggc tgtctcggag cttccagctt tggctgaccc agagcatgct
     4381 atcactgcag tgtcaggtgt ttcttccctg gagccttctg tgcctatttt ggaaccagca
     4441 gtatcagtcc ttcaacctgt tatgattgtt tcagaaccgt ctgttcctgt ccaggaacct
     4501 accgtggcag tgtcagaacc tgctgtcata gtctcagagc acacgcaaat aacatcacct
     4561 gagatggctg tagagtcttc accagtaata gtggactcta gtgttatgtc atcacagatt
     4621 atgaaaggaa tgaatttgct tggtggtgat gaaaatcttg gtccagaggt tggcatgcag
     4681 gagactctgt tgcatccagg tgaagagcca cgtgatggag gacacttgaa aagtgacttg
     4741 tatgaaaatg agtatgatag aaatgcagac cttactgtaa acagtcattt aattgttaaa
     4801 gatgcagagc ataacacagt gtgtgctact accgttggtc ctgttggtga agcaagtgaa
     4861 gagaaaattt tgcctattag tgagactaag gaaatcacag aattggctac ctgtgctgcc
     4921 gtcagcgaag ctgacatagg cagaagtctg tcttctcagc ttgctctgga gctggataca
     4981 gtaggaacta gtaaggggtt tgaatttgtc actgcatctg cactcatttc agagagtaaa
     5041 tatgatgttg aagtatctgt aactactcaa gatactgaac atgacatggt aatttccacc
     5101 agccccagtg gtggcagcga agcagacata gagggacctt tgcctgctaa agacattcat
     5161 cttgatttgc catcaactaa ttttgtttgt aaggatgtag aagactcgtt acctatcaaa
     5221 gagagtgccc aggcagtggc agtggctctt agccctaaag agagcagtga agatacagaa
     5281 gtacctcttc ccaataaaga aatagttcct gagtcaggat attctgccag cattgatgaa
     5341 attaatgaag ctgacttagt gagaccatta cttcctaagg acatggagcg tcttacaagc
     5401 cttagagctg gcattgaagg acctttactt gctagtgagg ttgaacgtga caagtcagct
     5461 gccagtccag ttgtaattag cataccagaa agagcttcag agtcatcttc agaggaaaag
     5521 gatgattatg aaatttttgt caaagttaag gacacacatg aaaaaagcaa gaaaaacaaa
     5581 aaccgtgaca aaggtgagaa ggagaagaaa agggactctt cattacggtc tcggagtaag
     5641 cgttccaagt cttctgaaca taagtcacgc aagcgcacca gtgagtcgcg ttctagagca
     5701 aggaagaggt cgtccaagtc caaatctcac cgttctcaga cacggtcacg gtcacgctca
     5761 agacgcagga ggaggagtag ccgatcaaga tctaagtcta gaggaagacg gtctgtatca
     5821 aaagagaaac gcaaaaggtc tccaaagcat agatccaagt ccagggaaag gaaaaggaaa
     5881 agatcaagct cacgagacaa ccggaaagca gctcgagctc ggagtcgaac cccgagtcgg
     5941 cggagtagga gccacactcc tagtcggagg agacggtcta gatctgttgg tagaaggaga
     6001 agttttagca tttcccccag ccgcaggagc cgaaccccca gccgcaggag cagaaccccc
     6061 agccgcagga gccgaacccc cagccgcagg agccgaaccc ccagccgcag gagccgaacc
     6121 cccagccgtc ggagaagatc acggtctgcg gtaagaagac gaagcttcag tatatcaccg
     6181 gtcagattaa ggcgatcaag aacacctttg agaagaaggt ttagtagatc tcccattcgg
     6241 cggaaaagat ccaggtcttc agaaagaggc agatcgccca aacgtctaac agatttggat
     6301 aaggctcaat tacttgaaat agccaaagct aatgcagctg ccatgtgtgc taaggctggt
     6361 gttcctttac caccaaacct aaagcctgca cctccaccta caatagaaga gaaagttgct
     6421 aaaaagtctg gaggagctac catagaagaa ctaactgaga aatgcaaaca gattgcacag
     6481 agtaaagaag atgatgatgt aatagtgaat aaacctcatg tttcggatga agaggaagaa
     6541 gaacctcctt tttatcatca tccctttaaa ctcagtgaac ccaagcccat ttttttcaat
     6601 ttgaatattg ctgcagcaaa gccaactcca ccgaaaagcc aagtaacatt aacaaaggag
     6661 tttcctgtgt catccggatc tcaacatcgg aaaaaggaag cggatagtgt ttatggagag
     6721 tgggttccag tcgagaaaaa tggtgaagaa agcaaagatg atgataatgt tttcagcagc
     6781 agcttgccct cagagcctgt ggacatttca acagcaatga gtgaacgggc acttgctcag
     6841 aagaggctca gtgagaatgc atttgacctt gaagccatga gtatgttaaa ccgagctcaa
     6901 gaacggattg acgcctgggc tcagttgaat tctatccctg ggcagttcac agggagcaca
     6961 ggagtgcagg tcctgacaca ggagcagctg gctaatactg gggcccaagc ctggattaaa
     7021 aaggatcagt tcttaagagc agccccagtg actggaggaa tgggagctgt tttgatgaga
     7081 aaaatgggct ggagagaagg agaaggatta ggaaagaaca aagaaggaaa taaggaaccc
     7141 atccttgttg attttaagac agaccgaaaa ggtcttgttg cagtaggaga gagagcacaa
     7201 aagcgttctg ggaacttctc tgctgcaatg aaagacttat caggcaaaca tcctgtgtct
     7261 gccttgatgg aaatctgtaa taagagaagg tggcaaccac ctgaatttct cttggtccat
     7321 gacagtggcc ctgaccatcg caaacatttc ctctttaggg tattgagaaa tggaagccct
     7381 taccagccca attgtatgtt tttcttgaat aggtattgat aaatggaagc gcttaccagc
     7441 ccagctttgc cagccctaat aagaagcatg ctaaagccac agcagcaact gtggttcttc
     7501 aagcaatggg ccttgtacca aaggacctca tggctaatgc cacttgcttc aggagtgcct
     7561 cacgtagata gattgaggtt ttatattaat cattcagata attttactct gcatcacaat
     7621 gtatttcctc cttaatgttg taaatatttc acaatttaag acattgtgta aaaagcaatc
     7681 tgtacaaaca tctccaggct ttcgtttttg taccatggaa attgtattta accatacagg
     7741 gttttggtat gtttatattg tttaccttag tgatgtattt gtttaagtgg ctaacatcca
     7801 aacaattgtt tgagggcatc agtaatattc agtgtggaat gttaaataac gcttttatac
     7861 tgtattttgt actatgatgt aacttccctt ccttacggct aggctgctgt aacacttgcc
     7921 tgtaatcagt gaagggctgt gcaccttgta ctatttcaca atgggttctg ctggacagat
     7981 actgggccag tgttattaag gcaatgaagc aagatctgtt ccacagggct atgccaccat
     8041 ctcccccttt ttgtagagat tatgaaaaga aagtgataca ttgtgtcatg atcagtacta
     8101 agtcctgcat tcccattaaa gccacttgac ttgggtcata agaaggaagt caaaatggaa
     8161 gtccaacttc agaggccaag tacatattag tatggcttca gttgtgatat agttttactt
     8221 tgatgtgcat tttgaatttc agctacacct agatagacgt aaataaaaat gctgtaaccg
     8281 acttatctaa taaaaattgg cacccagccg ctattttgtt gactgaggaa gtttatgtta
     8341 attttttagg gtctgataga atattcatgt gtattacagt ggtattcata tgctatgtct
     8401 ctaaacttta ttttcaaaag cttaaggccc aaatacaaac ttctctggaa t
//
