LOCUS       NM_028937               2351 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus spermatogenesis and oogenesis specific basic
            helix-loop-helix 2 (Sohlh2), mRNA.
ACCESSION   NM_028937
VERSION     NM_028937.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Liu,L., Zhang,X., Zhang,R., Wang,L., Zhi,S., Feng,X., Liu,X.,
            Shen,Y. and Hao,J.
  TITLE     Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2
            mediated anti-oxidative signaling pathway
  JOURNAL   Cell Death Dis 14 (10), 698 (2023)
   PUBMED   37875506
  REMARK    GeneRIF: Sohlh2 promotes pulmonary fibrosis via repression of
            p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2351)
  AUTHORS   Graham-Paquin,A.L., Saini,D., Sirois,J., Hossain,I., Katz,M.S.,
            Zhuang,Q.K., Kwon,S.Y., Yamanaka,Y., Bourque,G., Bouchard,M. and
            Pastor,W.A.
  TITLE     ZMYM2 is essential for methylation of germline genes and active
            transposons in embryonic development
  JOURNAL   Nucleic Acids Res 51 (14), 7314-7329 (2023)
   PUBMED   37395395
REFERENCE   3  (bases 1 to 2351)
  AUTHORS   Sorrenti,M., Klinger,F.G., Iona,S., Rossi,V., Marcozzi,S. and DE
            Felici,M.
  TITLE     Expression and possible roles of extracellular signal-related
            kinases 1-2 (ERK1-2) in mouse primordial germ cell development
  JOURNAL   J Reprod Dev 66 (5), 399-409 (2020)
   PUBMED   32418930
REFERENCE   4  (bases 1 to 2351)
  AUTHORS   Shi,J., Gao,Q., Cao,Y. and Fu,J.
  TITLE     Dennd1a, a susceptibility gene for polycystic ovary syndrome, is
            essential for mouse embryogenesis
  JOURNAL   Dev Dyn 248 (5), 351-362 (2019)
   PUBMED   30884041
REFERENCE   5  (bases 1 to 2351)
  AUTHORS   Wanner,N., Vornweg,J., Combes,A., Wilson,S., Plappert,J.,
            Rafflenbeul,G., Puelles,V.G., Rahman,R.U., Liwinski,T., Lindner,S.,
            Grahammer,F., Kretz,O., Wlodek,M.E., Romano,T., Moritz,K.M.,
            Boerries,M., Busch,H., Bonn,S., Little,M.H., Bechtel-Walz,W. and
            Huber,T.B.
  TITLE     DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal
            and Differentiation
  JOURNAL   J Am Soc Nephrol 30 (1), 63-78 (2019)
   PUBMED   30518531
REFERENCE   6  (bases 1 to 2351)
  AUTHORS   Choi,Y., Yuan,D. and Rajkovic,A.
  TITLE     Germ cell-specific transcriptional regulator sohlh2 is essential
            for early mouse folliculogenesis and oocyte-specific gene
            expression
  JOURNAL   Biol Reprod 79 (6), 1176-1182 (2008)
   PUBMED   18753606
  REMARK    GeneRIF: Sohlh2 is a critical factor for maintenance and
            differentiation of the oocyte during early oogenesis
REFERENCE   7  (bases 1 to 2351)
  AUTHORS   Hao,J., Yamamoto,M., Richardson,T.E., Chapman,K.M., Denard,B.S.,
            Hammer,R.E., Zhao,G.Q. and Hamra,F.K.
  TITLE     Sohlh2 knockout mice are male-sterile because of degeneration of
            differentiating type A spermatogonia
  JOURNAL   Stem Cells 26 (6), 1587-1597 (2008)
   PUBMED   18339773
  REMARK    GeneRIF: Knockout of this protein causes degegneration of
            spermatogonia in mice.
REFERENCE   8  (bases 1 to 2351)
  AUTHORS   Kaji,K., Nichols,J. and Hendrich,B.
  TITLE     Mbd3, a component of the NuRD co-repressor complex, is required for
            development of pluripotent cells
  JOURNAL   Development 134 (6), 1123-1132 (2007)
   PUBMED   17287250
REFERENCE   9  (bases 1 to 2351)
  AUTHORS   Ballow,D.J., Xin,Y., Choi,Y., Pangas,S.A. and Rajkovic,A.
  TITLE     Sohlh2 is a germ cell-specific bHLH transcription factor
  JOURNAL   Gene Expr Patterns 6 (8), 1014-1018 (2006)
   PUBMED   16765102
  REMARK    GeneRIF: The expression pattern of SOHLH2 suggests that it may be a
            critical regulator of early germ cell development.
REFERENCE   10 (bases 1 to 2351)
  AUTHORS   Ballow,D., Meistrich,M.L., Matzuk,M. and Rajkovic,A.
  TITLE     Sohlh1 is essential for spermatogonial differentiation
  JOURNAL   Dev Biol 294 (1), 161-167 (2006)
   PUBMED   16564520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ086115.1 and AI413378.1.
            
            On Oct 10, 2007 this sequence version replaced NM_028937.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ086115.1, AK016704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2341              DQ086115.1         1-2341
            2342-2351           AI413378.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 26.53 cM"
     gene            1..2351
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /note="spermatogenesis and oogenesis specific basic
                     helix-loop-helix 2"
                     /db_xref="GeneID:74434"
                     /db_xref="MGI:MGI:1921684"
     exon            1..71
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1427
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /codon_start=1
                     /product="spermatogenesis- and oogenesis-specific basic
                     helix-loop-helix-containing protein 2"
                     /protein_id="NP_083213.2"
                     /db_xref="CCDS:CCDS17358.1"
                     /db_xref="GeneID:74434"
                     /db_xref="MGI:MGI:1921684"
                     /translation="MADRISTGELGRRPGQGRVNLLLVGDATRYFLAGSMQKFFPSTA
                     QITLTISNVKKVAVLLAANSFDIIFLKVTSTLTAEEQEAAKLIRSGKKKNTHLLFAFV
                     IPERLKGYVSEYGADISFSEPLTLEKVNTVIHYWKTYFTNTDMENTELPPECRLYFQT
                     SRSELGGRFSTDMFLCSELLKNDARLGLKAPLSSLDKSKQASFLHSTKEKLRRERIKS
                     CCEQLRTLLPYVKGRKSDVASVIEATVDYVKQVRESLSPAIMAQVTEAIQNNRRFSKR
                     QMPIELFLPFSATSQREDAMLTSAFSPVQEIQLLADRGLNVYSMTAAGGALEGAVRGQ
                     PGSVSESSIEDLYKTRVPSTARSLNSFHSVKYTSGTVSPHEAAARTNQNISTYLPPTA
                     PSVSNFIPQHCNAMLCPARPTSPNCLCTPGHELAASSRAASASIFRGFRAASASDHQA
                     SQPPALPSPQPHDSSYF"
     exon            72..286
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..348
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..453
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..550
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..661
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..809
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..898
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1020
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1277
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..2348
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /note="hexamer: AATAAA"
     polyA_site      2348
                     /gene="Sohlh2"
                     /gene_synonym="4933406N12Rik; Sosf2"
                     /note="major polyA site"
ORIGIN      
        1 gaagctgcag agcagtagac gccatggccg accggatcag cactggggag ctaggccgga
       61 ggcctgggca gggcagagta aatcttttgc tggttggaga tgccacaaga tacttcctgg
      121 ctggctctat gcagaaattc tttcctagca cagcacagat caccctgacc atcagcaatg
      181 tgaagaaggt cgccgtgctt ttggctgcta actcgtttga cataattttc ttgaaggtga
      241 cttccactct aactgcagag gagcaggagg ctgccaagtt aattagatct ggcaagaaga
      301 aaaacacaca tttgctgttt gcttttgtaa tacctgaaag acttaaaggc tatgtttcag
      361 aatatggagc tgacattagt ttcagtgagc cgctgacctt ggaaaaagtg aacacggtga
      421 tacactactg gaaaacgtat ttcacaaata cggatatgga aaacactgag ttgcctccag
      481 aatgccggct gtactttcag acgtcccgca gtgaactcgg agggcgtttt tctacagata
      541 tgtttctttg ctctgaactg ctgaagaatg acgctagact tggattaaag gccccgttgt
      601 cgagtctaga caaaagcaaa caggcgtctt ttcttcactc aaccaaagaa aagctgagac
      661 gagaacgcat caagtcttgc tgtgagcagc tgcgcacgct cctgccatac gtcaagggga
      721 ggaagagcga tgtggcatca gttatcgagg ccacagttga ttatgtgaag caggtccggg
      781 agtctctctc tccagccatt atggcccagg ttacagaagc cattcagaac aatagaaggt
      841 tttctaagag acagatgccc atcgagctgt tccttccatt ctcagccaca tcacagaggg
      901 aagatgccat gctgaccagc gctttctcac ctgtgcaaga gattcagctc ctggctgatc
      961 ggggcctgaa cgtgtattcc atgactgctg caggaggagc tttggaggga gcagtgagag
     1021 gtcagccagg ctctgtttcc gagagctcta ttgaggatct gtataagact cgcgtcccca
     1081 gcacagcccg atctctgaat tccttccact ctgtcaaata cacttctgga actgtctctc
     1141 cccatgaggc agctgccagg acaaatcaga acatttccac ttatttgcca cccactgcac
     1201 ccagtgtgtc caactttatt cctcagcact gcaatgccat gctttgccca gcacgcccaa
     1261 ccagtcccaa ctgcctgtgc actccgggcc atgagcttgc agccagttct cgcgctgcct
     1321 cagccagcat ctttcgtgga ttccgtgcgg cgtcagcttc ggatcaccag gcctctcagc
     1381 cacctgctct gccatctcca cagcctcacg acagtagtta cttttaagaa acattaatat
     1441 ttgaaaatat gtaggtttgg ttgcctgaag ttagctttat taactttcat gatgcagaca
     1501 tgcatttgtg acgttgtaag aatgggctaa actcaattaa tgtgcacttc tccctccaac
     1561 agtctgggtc gtattaacgg tccatgtgtg gggctcatat tctagatcac atgccgggca
     1621 cagttgttca gttgaggaag aagggacaaa gaaagatact tgaaatctgc tgcccccgtt
     1681 gtctgataaa tgtgctagaa ccatccaaag gtacctagaa agattgttga cgacagtgag
     1741 aaccttgtgt tctcaggcat cttcatccat gttgggattt ccctggccag tgagctgcaa
     1801 gcagcgcagc ctaagtgacc cacacacaca ttaattctac caaaaagtaa ttgtgacgtt
     1861 actgtgaaaa ccatactaca aagaaggccc atgtgggtgt aagcttctac aaccaggcag
     1921 gccagcacgc acggctcctg cagcctggtg attggctctg tcattgattt ctgttggtat
     1981 cttttctaga ttggcatttg aaagagcccc cttcttccat catcatccaa actaagataa
     2041 gcaggctata aggagcggca gccctgccct cttggcgatg tgggtagatt gctgtgcttt
     2101 ccgctgggtt tgcaggcttg tgagtagaat ggcagccagg aggggcattg ctttccttgc
     2161 tgaacccaca catttctgtc cttgccttaa cagggtgttt gagcaactgt tggaaacaag
     2221 gggagagaag gatggctgtt ttatatttca ctgaaatgtt cttacacaaa cattttattg
     2281 ttaaagtgtc taggtttacc ctgcaatcca ttgttttgtt taataaaatg ttttctcttt
     2341 tataataaaa a
//
