LOCUS       NM_001001714            1376 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus spermatogenesis and oogenesis specific basic
            helix-loop-helix 1 (Sohlh1), transcript variant 1, mRNA.
ACCESSION   NM_001001714 XM_130180
VERSION     NM_001001714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1376)
  AUTHORS   Hughes,C.H.K., Smith,O.E., Meinsohn,M.C., Brunelle,M., Gevry,N. and
            Murphy,B.D.
  TITLE     Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the
            ovarian reserve
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2220849120 (2023)
   PUBMED   37494420
REFERENCE   2  (bases 1 to 1376)
  AUTHORS   Rodriguez-Escriba,M., Rodriguez-Alonso,B., Belur,S. and Rajkovic,A.
  TITLE     Sohlh1 loss of function male and female infertility model impacts
            overall health beyond gonadal dysfunction in micedagger
  JOURNAL   Biol Reprod 108 (4), 619-628 (2023)
   PUBMED   36723967
  REMARK    GeneRIF: Sohlh1 loss of function male and female infertility model
            impacts overall health beyond gonadal dysfunction in micedagger.
REFERENCE   3  (bases 1 to 1376)
  AUTHORS   Nakagawa,T., Jorg,D.J., Watanabe,H., Mizuno,S., Han,S., Ikeda,T.,
            Omatsu,Y., Nishimura,K., Fujita,M., Takahashi,S., Kondoh,G.,
            Simons,B.D., Yoshida,S. and Nagasawa,T.
  TITLE     A multistate stem cell dynamics maintains homeostasis in mouse
            spermatogenesis
  JOURNAL   Cell Rep 37 (3), 109875 (2021)
   PUBMED   34686326
REFERENCE   4  (bases 1 to 1376)
  AUTHORS   Sorrenti,M., Klinger,F.G., Iona,S., Rossi,V., Marcozzi,S. and DE
            Felici,M.
  TITLE     Expression and possible roles of extracellular signal-related
            kinases 1-2 (ERK1-2) in mouse primordial germ cell development
  JOURNAL   J Reprod Dev 66 (5), 399-409 (2020)
   PUBMED   32418930
REFERENCE   5  (bases 1 to 1376)
  AUTHORS   Wang,Z., Liu,C.Y., Zhao,Y. and Dean,J.
  TITLE     FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse
            oocyte growth and differentiation
  JOURNAL   Nucleic Acids Res 48 (7), 3525-3541 (2020)
   PUBMED   32086523
  REMARK    GeneRIF: findings substantiate a major role for FIGLA, LHX8 and
            SOHLH1 as multifunctional regulators of networks necessary for
            oocyte maintenance and differentiation during early
            folliculogenesis.
REFERENCE   6  (bases 1 to 1376)
  AUTHORS   Choi,Y., Yuan,D. and Rajkovic,A.
  TITLE     Germ cell-specific transcriptional regulator sohlh2 is essential
            for early mouse folliculogenesis and oocyte-specific gene
            expression
  JOURNAL   Biol Reprod 79 (6), 1176-1182 (2008)
   PUBMED   18753606
REFERENCE   7  (bases 1 to 1376)
  AUTHORS   Huang,X., Andreu-Vieyra,C.V., York,J.P., Hatcher,R., Lu,T.,
            Matzuk,M.M. and Zhang,P.
  TITLE     Inhibitory phosphorylation of separase is essential for genome
            stability and viability of murine embryonic germ cells
  JOURNAL   PLoS Biol 6 (1), e15 (2008)
   PUBMED   18232736
REFERENCE   8  (bases 1 to 1376)
  AUTHORS   Ballow,D., Meistrich,M.L., Matzuk,M. and Rajkovic,A.
  TITLE     Sohlh1 is essential for spermatogonial differentiation
  JOURNAL   Dev Biol 294 (1), 161-167 (2006)
   PUBMED   16564520
  REMARK    GeneRIF: Sohlh1 represents the first testis-specific bHLH
            transcription factor that is essential for spermatogonial
            differentiation.
REFERENCE   9  (bases 1 to 1376)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8090-8095 (2006)
   PUBMED   16690745
  REMARK    GeneRIF: Sohlh1 and Lhx8 are two germ cell-specific, critical
            regulators of oogenesis
REFERENCE   10 (bases 1 to 1376)
  AUTHORS   Rajkovic,A., Pangas,S.A., Ballow,D., Suzumori,N. and Matzuk,M.M.
  TITLE     NOBOX deficiency disrupts early folliculogenesis and
            oocyte-specific gene expression
  JOURNAL   Science 305 (5687), 1157-1159 (2004)
   PUBMED   15326356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731682.20.
            
            On Nov 8, 2022 this sequence version replaced NM_001001714.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY623913.1, BC139189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AL731682.20        47629-47833         c
            206-340             AL731682.20        47216-47350         c
            341-488             AL731682.20        46707-46854         c
            489-613             AL731682.20        46151-46275         c
            614-747             AL731682.20        45760-45893         c
            748-934             AL731682.20        44984-45170         c
            935-1011            AL731682.20        44422-44498         c
            1012-1376           AL731682.20        43493-43857         c
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.21 cM"
     gene            1..1376
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /note="spermatogenesis and oogenesis specific basic
                     helix-loop-helix 1"
                     /db_xref="GeneID:227631"
                     /db_xref="MGI:MGI:2684956"
     exon            1..205
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1214
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis- and oogenesis-specific basic
                     helix-loop-helix-containing protein 1; helix-loop-helix
                     protein NOHLH"
                     /codon_start=1
                     /product="spermatogenesis- and oogenesis-specific basic
                     helix-loop-helix-containing protein 1 isoform 1"
                     /protein_id="NP_001001714.1"
                     /db_xref="CCDS:CCDS15793.1"
                     /db_xref="GeneID:227631"
                     /db_xref="MGI:MGI:2684956"
                     /translation="MASGGHERANEDYRVSGITGCSKTPQPETQDSLQTSSQSSALCT
                     APVAAANLGPSLRRNVVSERERRRRISLSCEHLRALLPQFDGRREDMASVLEMSVYFL
                     QLAHSMDPSWEQLSVPQPPQEMWHMWQGDVLQVTLANQIADSKPDSGIAKPSAVSRVQ
                     DPPCFGMLDTDQSQATERESELLERPSSCPGHRQSALSFSEPESSSLGPGLPPWIPHS
                     WQPATPEASDIVPGGSHQVASLAGDPESSGMLAEEANLVLASVPDARYTTGAGSDVVD
                     GAPFLMTTNPDWWLGSVEGRGGPALARSSPVDGAEPSFIGDPELCSQELQAGPGELWG
                     LDFGSPGLALKDEADSIFPDFFP"
     exon            206..340
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            341..488
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            489..613
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            614..747
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            748..934
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1011
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1376
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1340..1345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /note="hexamer: ATTAAA"
     polyA_site      1376
                     /gene="Sohlh1"
                     /gene_synonym="Gm110; Nohlh"
                     /note="major polyA site"
ORIGIN      
        1 gcataagagt gggcacccag gtgctggttg gatgcagagc tcctggggta ggcacagtgt
       61 gggtgagagg gcgggctggt gggcctagct aagggctatc tgcggcttcc ggcttgttgc
      121 ttccctccaa cttcgtgcca atggcgtccg gtggccacga gcgggccaat gaggattaca
      181 gagtctctgg cattacggga tgcagcaaga ctcctcagcc tgagactcag gacagcttgc
      241 agacctcatc acaaagctca gctctctgca cagctcctgt ggctgctgca aacttgggcc
      301 ccagtcttcg gagaaacgtg gtcagcgaga gagaacgcag gaggcggatc tcgttgagct
      361 gtgagcactt gcgggctcta ctgcctcagt ttgatggccg acgggaggac atggcatctg
      421 tcctggagat gtctgtgtac ttcctccagc ttgcccacag catggaccct agctgggagc
      481 aactctctgt tcctcagcct ccccaggaga tgtggcacat gtggcagggt gatgttctgc
      541 aggtaaccct ggcgaatcag attgcagaca gcaagccaga ctccggtata gccaaaccat
      601 ctgctgtgtc tcgggtacag gatcccccat gctttgggat gctggataca gaccagagcc
      661 aggctactga gagagagtca gagctgctgg agagaccttc ctcctgccct ggtcatcgcc
      721 agagcgcgtt gtcattcagt gagccagagt cttccagctt gggtcctggg ctcccaccct
      781 ggatccctca ctcatggcag ccagccactc ccgaggcaag tgacattgtt cctggtgggt
      841 cacaccaggt ggcatccctg gccggggacc ctgaatcttc cggcatgctg gctgaggagg
      901 ccaacttggt cttggcatct gtgcctgatg ccaggtacac cacaggggca gggtccgatg
      961 tggtggatgg agcacccttt ctgatgacca ccaatcctga ctggtggttg gggtcggtgg
     1021 agggcagagg aggcccagcc cttgccagga gcagcccagt ggatggggca gagccaagct
     1081 tcatcggaga ccctgagctt tgctcccagg agctccaggc tggtcctgga gagctgtggg
     1141 gtttggattt tggcagccct ggcctggccc tgaaggatga agcggacagc atcttccctg
     1201 actttttccc ctgatagctg agtcccccag agtttagttt gctggggagc tgtcctgtgc
     1261 ctgggtgttg tattttgggc ttggtttgca gctgaggcct aatttgaggg agcctggcag
     1321 ggctgtgagt ggagtttgta ttaaagagga aagtggtttt tctggcagaa acaaaa
//
