LOCUS       NM_011435               2045 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus superoxide dismutase 3, extracellular (Sod3), mRNA.
ACCESSION   NM_011435
VERSION     NM_011435.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Li,Q., Lv,K., Jiang,N., Liu,T., Hou,N., Yu,L., Yang,Y., Feng,A.,
            Zhang,Y., Su,Z., Sang,X., Feng,Y., Chen,R., Xu,W., Cui,L., Cao,Y.
            and Chen,Q.
  TITLE     SOD3 suppresses early cellular immune responses to parasite
            infection
  JOURNAL   Nat Commun 15 (1), 4913 (2024)
   PUBMED   38851821
  REMARK    GeneRIF: SOD3 suppresses early cellular immune responses to
            parasite infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Xu,K., Fei,W., Gao,W., Fan,C., Li,Y., Hong,Y. and Cui,R.
  TITLE     SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways
  JOURNAL   Free Radic Biol Med 212, 65-79 (2024)
   PUBMED   38141889
  REMARK    GeneRIF: SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways.
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Choi,H., Miller,M.R., Nguyen,H.N., Surratt,V.E., Koch,S.R.,
            Stark,R.J. and Lamb,F.S.
  TITLE     Extracellular SOD modulates canonical TNFalpha signaling and
            alpha5beta1 integrin transactivation in vascular smooth muscle
            cells
  JOURNAL   Free Radic Biol Med 209 (Pt 1), 152-164 (2023)
   PUBMED   37852546
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Sproule,T.J., Philip,V.M., Chaudhry,N.A., Roopenian,D.C. and
            Sundberg,J.P.
  TITLE     Seven naturally variant loci serve as genetic modifiers of Lamc2jeb
            induced non-Herlitz junctional Epidermolysis Bullosa in mice
  JOURNAL   PLoS One 18 (7), e0288263 (2023)
   PUBMED   37437067
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Folz,R.J., Guan,J., Seldin,M.F., Oury,T.D., Enghild,J.J. and
            Crapo,J.D.
  TITLE     Mouse extracellular superoxide dismutase: primary structure,
            tissue-specific gene expression, chromosomal localization, and lung
            in situ hybridization
  JOURNAL   Am J Respir Cell Mol Biol 17 (4), 393-403 (1997)
   PUBMED   9376114
  REMARK    Review article
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Suh,J.G., Takai,S., Yamanishi,T., Kikuchi,T., Folz,R.J., Tanaka,K.,
            Oh,Y.S. and Wada,K.
  TITLE     Sequence analysis, tissue expression and chromosomal localization
            of a mouse secreted superoxide dismutase gene
  JOURNAL   Mol Cells 7 (2), 204-207 (1997)
   PUBMED   9163733
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Ookawara,T., Kizaki,T., Ohishi,S., Yamamoto,M., Matsubara,O. and
            Ohno,H.
  TITLE     Purification and subunit structure of extracellular superoxide
            dismutase from mouse lung tissue
  JOURNAL   Arch Biochem Biophys 340 (2), 299-304 (1997)
   PUBMED   9143334
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Carlsson,L.M., Marklund,S.L. and Edlund,T.
  TITLE     The rat extracellular superoxide dismutase dimer is converted to a
            tetramer by the exchange of a single amino acid
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5219-5222 (1996)
   PUBMED   8643556
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Carlsson,L.M., Jonsson,J., Edlund,T. and Marklund,S.L.
  TITLE     Mice lacking extracellular superoxide dismutase are more sensitive
            to hyperoxia
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6264-6268 (1995)
   PUBMED   7603981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102735.9 and U38261.1.
            
            On Feb 3, 2006 this sequence version replaced NM_011435.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145194.1, U38261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC102735.9         44796-44798
            4-1246              U38261.1           6-1248
            1247-2045           AC102735.9         49932-50730
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6 x CBA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 27.92 cM"
     gene            1..2045
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /note="superoxide dismutase 3, extracellular"
                     /db_xref="GeneID:20657"
                     /db_xref="MGI:MGI:103181"
     exon            1..249
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /inference="alignment:Splign:2.1.0"
     exon            250..2045
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1023
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /EC_number="1.15.1.1"
                     /note="extracellular superoxide dismutase"
                     /codon_start=1
                     /product="extracellular superoxide dismutase [Cu-Zn]
                     precursor"
                     /protein_id="NP_035565.1"
                     /db_xref="CCDS:CCDS19283.1"
                     /db_xref="GeneID:20657"
                     /db_xref="MGI:MGI:103181"
                     /translation="MLAFLFYGLLLAACGSVTMSNPGESSFDLADRLDPVEKIDRLDL
                     VEKIGDTHAKVLEIWMELGRRREVDAAEMHAICRVQPSATLPPDQPQITGLVLFRQLG
                     PGSRLEAYFSLEGFPAEQNASNRAIHVHEFGDLSQGCDSTGPHYNPMEVPHPQHPGDF
                     GNFVVRNGQLWRHRVGLTASLAGPHAILGRSVVVHAGEDDLGKGGNQASLQNGNAGRR
                     LACCVVGTSSSAAWESQTKERKKRRRESECKTT"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /note="hexamer: ATTAAA"
     polyA_site      1816
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /note="major polyA site"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
                     /note="hexamer: AACAAG"
     polyA_site      2006
                     /gene="Sod3"
                     /gene_synonym="EC-SOD"
ORIGIN      
        1 ggaggaagag gaggaggcag caattttacc acaagggaca gccaagctgg ctttgcttct
       61 cttggccagc ccaatgacct tcctcccatt tgctgaccac tcccccgggc tggcctccct
      121 gctgctcgct cacataacag ccagctggac agctctgggg aggcaactca gaggctcttc
      181 ctccggcctc tagctgggtg ctggcctgaa cttcaccaga gggaaagagc tcttgggaga
      241 gcctgacagg tgcagagaac ctcagccatg ttggccttct tgttctacgg cttgctactg
      301 gcggcctgtg gctctgtcac catgtcaaat ccaggggagt ccagcttcga cctagcagac
      361 aggcttgacc cggttgagaa gatagacagg cttgacctgg ttgagaagat aggcgacacg
      421 catgccaaag tgctggagat ctggatggag ctaggacgac gaagggaggt ggatgctgcc
      481 gagatgcatg caatctgcag ggtacaacca tcagccacgc tgccaccgga tcagccgcag
      541 atcaccggct tggttctctt ccggcagctg gggccgggct ccaggcttga ggcctatttc
      601 agtctggagg gcttcccagc tgagcagaac gcctccaacc gtgccatcca cgtgcatgag
      661 ttcggggacc tgagccaggg ctgcgattcc accgggccgc actacaaccc gatggaggtg
      721 ccgcaccctc agcacccggg cgactttggc aacttcgtgg tgcgcaacgg ccagctctgg
      781 aggcatcgcg tcggcctgac cgcgtcgctg gccggaccgc acgccatctt gggccgctct
      841 gtggtggtcc acgccggcga ggacgacctg ggtaaaggtg gcaaccaggc cagcctgcag
      901 aacggcaatg caggtcgccg gctcgcctgc tgcgtggtag gcaccagcag ctccgccgcc
      961 tgggagagcc agacaaagga gcgcaagaag cggcggcggg agagcgagtg caagaccact
     1021 taagcctcac tcagggcctc cgagccccgc cgctgcacgc atagatgtct ccaggcgccc
     1081 ccagacgcct ctagtcaccc cagaggcctc taggcgtcct agacagaggc ctcccagaca
     1141 cctcagtcgc ctctgcgctt ccatgcacgc cagacacctc tgtatggccc ccagatgcct
     1201 ccacgaacct ccgcgcaccc tagatgttct cccatgtccc ggacaccgtt cctctgtgtc
     1261 caggacacct tagttaaccc agaaatcttt tcacgcccta tgcacttcca cagacccaga
     1321 tccttaatgc tctagatcca tcccgagccc ctttgtgtcc caagacaatc ccacaagccc
     1381 ctagtctttg agtctgctct cagagaaccc cctcttcctc cccagagatc gcatgtgctc
     1441 agatactctc ctcctctgag gacttcccag tgagcacctt tgagagtact cccttggggt
     1501 atactgaaat atcgcccacc ccatttcctt ctgccccctt ttgttttctt cctgtcccca
     1561 tagcacccga gactcctctc ttccctagag acctcttttt tcttcccttt gttcctccga
     1621 ggcgctctgg gaccactctg acaccctcac ccccaccccc aagttccatg ttcccgatca
     1681 cctcctgcgg aggccccagg ttctgttttc atctgtttcc catatggtgc ctgcacccca
     1741 gggagagcag ctccttagag agagtatttg ggaaccttta tgttgctcat taaaaacata
     1801 gcaattcaca acacaatgca ctggccttgt gtactttttt gagactttgc agcttagttt
     1861 tgttttgttt ttgttttttt tttcttcccg cccccaaaat atccctgaga atttgcaggt
     1921 ctcctcctct aatgaaagaa gtttctatca ttaattgcta tgcctttttg gaggactgag
     1981 gacattaaca aggacgctta aatgtgcatg tgtgtggctt ctttacaaaa ggacaccgac
     2041 acagc
//
