LOCUS       NM_013671               3824 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus superoxide dismutase 2, mitochondrial (Sod2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_013671
VERSION     NM_013671.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3824)
  AUTHORS   Reed,E.C., Silva,V.A., Giebel,K.R., Natour,T., Lauten,T.H.,
            Jojo,C.N., Schlieker,A.E. and Case,A.J.
  TITLE     Hemoglobin alpha is a redox-sensitive mitochondrial-related protein
            in T-lymphocytes
  JOURNAL   Free Radic Biol Med 227, 1-11 (2025)
   PUBMED   39586383
REFERENCE   2  (bases 1 to 3824)
  AUTHORS   Papinska,J.A., Durslewicz,J., Bagavant,H. and Deshmukh,U.S.
  TITLE     Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland
            Ductal Epithelial Cells Recapitulates Non-Sjogren's Sicca Syndrome
  JOURNAL   Int J Mol Sci 25 (11), 5983 (2024)
   PUBMED   38892170
  REMARK    GeneRIF: Deleting Mitochondrial Superoxide Dismutase 2 in Salivary
            Gland Ductal Epithelial Cells Recapitulates Non-Sjogren's Sicca
            Syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3824)
  AUTHORS   Tamagawa,S., Sakai,D., Nojiri,H., Nakamura,Y., Warita,T.,
            Matsushita,E., Schol,J., Soma,H., Ogasawara,S., Munesada,D.,
            Koike,M., Shimizu,T., Sato,M., Ishijima,M. and Watanabe,M.
  TITLE     SOD2 orchestrates redox homeostasis in intervertebral discs: A
            novel insight into oxidative stress-mediated degeneration and
            therapeutic potential
  JOURNAL   Redox Biol 71, 103091 (2024)
   PUBMED   38412803
  REMARK    GeneRIF: SOD2 orchestrates redox homeostasis in intervertebral
            discs: A novel insight into oxidative stress-mediated degeneration
            and therapeutic potential.
REFERENCE   4  (bases 1 to 3824)
  AUTHORS   Li,Y., Wang,T., Li,X., Li,W., Lei,Y., Shang,Q., Zheng,Z., Fang,J.,
            Cao,L., Yu,D., Meng,Z., Zhang,S., Liu,R., Liu,C., Xu,C., Ding,Y.,
            Chen,Y., Candi,E., Melino,G., Wang,Y., Shi,Y. and Shao,C.
  TITLE     SOD2 promotes the immunosuppressive function of mesenchymal stem
            cells at the expense of adipocyte differentiation
  JOURNAL   Mol Ther 32 (4), 1144-1157 (2024)
   PUBMED   38310354
  REMARK    GeneRIF: SOD2 promotes the immunosuppressive function of
            mesenchymal stem cells at the expense of adipocyte differentiation.
REFERENCE   5  (bases 1 to 3824)
  AUTHORS   Schraps,N., Tirre,M., Pyschny,S., Reis,A., Schlierbach,H.,
            Seidl,M., Kehl,H.G., Schanzer,A., Heger,J., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Cardiomyocyte maturation alters molecular stress response
            capacities and determines cell survival upon mitochondrial
            dysfunction
  JOURNAL   Free Radic Biol Med 213, 248-265 (2024)
   PUBMED   38266827
REFERENCE   6  (bases 1 to 3824)
  AUTHORS   Cebra-Thomas,J.A., Tsai,J.Y., Pilder,S.H., Copeland,N.G.,
            Jenkins,N.A. and Silver,L.M.
  TITLE     Localization of the Mas proto-oncogene to a densely marked region
            of mouse chromosome 17 associated with genomic imprinting
  JOURNAL   Genomics 13 (2), 444-446 (1992)
   PUBMED   1612602
  REMARK    Erratum:[Genomics 1992 Sep;14(1):208]
REFERENCE   7  (bases 1 to 3824)
  AUTHORS   Pilder,S.H., Hammer,M.F. and Silver,L.M.
  TITLE     A novel mouse chromosome 17 hybrid sterility locus: implications
            for the origin of t haplotypes
  JOURNAL   Genetics 129 (1), 237-246 (1991)
   PUBMED   1936961
REFERENCE   8  (bases 1 to 3824)
  AUTHORS   Barlow,D.P., Stoger,R., Herrmann,B.G., Saito,K. and Schweifer,N.
  TITLE     The mouse insulin-like growth factor type-2 receptor is imprinted
            and closely linked to the Tme locus
  JOURNAL   Nature 349 (6304), 84-87 (1991)
   PUBMED   1845916
REFERENCE   9  (bases 1 to 3824)
  AUTHORS   Forejt,J., Vincek,V., Klein,J., Lehrach,H. and Loudova-Mickova,M.
  TITLE     Genetic mapping of the t-complex region on mouse chromosome 17
            including the Hybrid sterility-1 gene
  JOURNAL   Mamm Genome 1 (2), 84-91 (1991)
   PUBMED   1799792
REFERENCE   10 (bases 1 to 3824)
  AUTHORS   Howard,C.A., Gummere,G.R., Lyon,M.F., Bennett,D. and Artzt,K.
  TITLE     Genetic and molecular analysis of the proximal region of the mouse
            t-complex using new molecular probes and partial t-haplotypes
  JOURNAL   Genetics 126 (4), 1103-1114 (1990)
   PUBMED   2076813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137511.1, AK135435.1 and AL589878.12.
            
            On Sep 26, 2005 this sequence version replaced NM_013671.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135435.1, SRR1660819.195833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               BY137511.1         1-360
            361-1306            AK135435.1         350-1295
            1307-3824           AL589878.12        18527-21044         c
FEATURES             Location/Qualifiers
     source          1..3824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.75 cM"
     gene            1..3824
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /note="superoxide dismutase 2, mitochondrial"
                     /db_xref="GeneID:20656"
                     /db_xref="MGI:MGI:98352"
     exon            1..230
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..876
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /EC_number="1.15.1.1"
                     /note="superoxide dismutase [Mn], mitochondrial; manganese
                     SOD; manganese superoxide dismutase"
                     /codon_start=1
                     /product="superoxide dismutase [Mn], mitochondrial
                     precursor"
                     /protein_id="NP_038699.2"
                     /db_xref="CCDS:CCDS28399.1"
                     /db_xref="GeneID:20656"
                     /db_xref="MGI:MGI:98352"
                     /translation="MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINA
                     QIMQLHHSKHHAAYVNNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFW
                     TNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQ
                     IAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYT
                     ACKK"
     exon            231..433
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..550
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..730
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..3824
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1059
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /note="major polyA site"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1316
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
     polyA_site      2188
                     /gene="Sod2"
                     /gene_synonym="MnSOD; Sod-2"
ORIGIN      
        1 aggggagacg ttgccttccc aggatgccgc tccgttatgc gccgggccgt ccgtgtcgcc
       61 gtcctcccct ccgctgatgg gcgctgcggg cagggtcacc gcttcgctgt gtccttgcgg
      121 acgccgggcg gacgctgcct agcagacgcg cgcctgcgag cgaacggccg tgttctgagg
      181 agagcagcgg tcgtgtaaac ctcaataatg ttgtgtcggg cggcgtgcag cacgggcagg
      241 aggctgggcc ctgtggccgg tgccgcgggc tcccggcaca agcacagcct cccagacctg
      301 ccttacgact atggcgcgct ggagccacac attaacgcgc agatcatgca gctgcaccac
      361 agcaagcacc acgcggccta cgtgaacaat ctcaacgcca ccgaggagaa gtaccacgag
      421 gctctggcca agggagatgt tacaactcag gtcgctcttc agcctgcact gaagttcaat
      481 ggtgggggac atattaatca caccattttc tggacaaacc tgagccctaa gggtggtgga
      541 gaacccaaag gagagttgct ggaggctatc aagcgtgact ttgggtcttt tgagaagttt
      601 aaggagaagc tgacagccgt gtctgtggga gtccaaggtt caggctgggg ctggcttggc
      661 ttcaataagg agcaaggtcg cttacagatt gctgcctgct ctaatcagga cccattgcaa
      721 ggaacaacag gccttattcc gctgctgggg attgacgtgt gggagcacgc ttactacctt
      781 cagtataaaa acgtcagacc tgactatctg aaagctattt ggaatgtaat caactgggag
      841 aatgttactg aaagatacac agcttgcaag aagtgaaacc tcactcacgg ccacattgag
      901 tgccaggctc cgggctggtt tatagtagtg tagagcattg cagcactatg actggggtgc
      961 tgtagtcttt attgatgtct ttccacatac ctgataattc tatgataatt tcttatttta
     1021 attaaatcta ttcttaggca actatttgag aacagcgcat actctgtgtg aattgctctt
     1081 gattgaacat tttcgttaga gccttgaatt gcttggatgc tatagctgtc attataagac
     1141 catcagaaat atcccatctc tgttttgggg ggcctgtagg agagtctgta atcctgttct
     1201 actgcagtta gaaaaaaagt tgagttgttc ccccctgccc cctgagttgt tgaatagtga
     1261 aatagagaac caaatagttc tcttttctat taaaaattgc tattttttgt aagtaatcct
     1321 ctatttagtg gacatcacct agtagtcttt gtttatggtc acagtttcac agtacaccat
     1381 ttttttcact caaactctgt aactcaaggc tgtgaatgga gttcagtggt agagccttgc
     1441 ctgtcttatg caaggccctg ggctctacct cagtaatgaa aaaaggtcaa cagacatagc
     1501 tttgctcctg cttgaggagt gcttattatg agaggaaggt aatggtgcct ctgggttttc
     1561 tataggcaga catgcaaaaa cagctaatct tgtctttaca aaccaacagt gtgctgtatg
     1621 aatgtgttca agatggacaa agtaggtagg gcctgtccga tgatgtcagc catgggcact
     1681 aggccacagg gcattctggg aagccattca gccccatgaa ttgtatatct ctggagaact
     1741 ggaccctggg tgtggtggca cctttctcag tagcggcaaa tgggtttctg agtgaggtca
     1801 gtagggtgtc ttcagaacat tagtttttag agacacagat ttttcatttt tctttagttt
     1861 caagaactta cagtcacaag agggcctttg tattgttatt caatagaagg ctgccctttc
     1921 cctgacaagg tgacacagtg cttctgactg tgttcctgtg cactgtggag atatctgtca
     1981 caggggtcct tagtgaattt gccttttcac attcgtctca ccatcttcct gtcatcctta
     2041 atgtccatgt gatgttttat cggttgctca atagtcaata gtttgttggt gtttaattgt
     2101 tgtttattac caaaaaggcc gtgggcgcct ctcatgcatg caaatccttg ttagtggagt
     2161 attttttaaa ggtttgtttt ctttttaatt atgcatgtct gtgtatgttc tgttcattgt
     2221 gcccatggaa gacagaagag cttgttgggt ctgggtccct tagagctgga gaagttacag
     2281 gtggccttga gcggggactt ggatcatctg tgagagcaat aagcacttgc ccgctgagcc
     2341 atctttccag cccccggaat tttttttttt tttttaatat tgattgtttt cttaaacgta
     2401 ttttgtaatt tgtcccaagt tttttttttt tttttttttt ttggcttttt gagacagggt
     2461 ttcattgtgt atccctggca gtcctggaac tcactttgta gaccaggctg gcctcgaact
     2521 cagaaatccg cctgcctctg cctcccgagt gctgggatta aaggcgtgtg ccaccacacc
     2581 ctgctctttt tcttttttta aaaaagattt attttattca tatgagtgca atgtagctgt
     2641 cttcagccac accagaagaa ggcattggat cccattacag atggttgtgt gccactctgt
     2701 gtttgctggg aattgaactc aggacctttg gaagagcagt cagtgctttt aaccgttgag
     2761 tcatctctcc agcctggacc ctcttttttt tttttcccct aattgaaaat acttcttttt
     2821 atacaatata ttctgatcat gttttccctt ctccaactcc tctcagatcc tccctacctc
     2881 cccacccacc caaatccaca ccttttcttt ctccctccca ttagaaaaca gttaacaaca
     2941 cacacacaca catgaatagg acaaaacaga cctttttatt attttaaaca gagaatctca
     3001 gtgctcactc gtgtcatctt ttcctttctt agagtagatt ttgataaaaa gatagtcata
     3061 caagcacagg cagcttttat atgcccaaac ctatcgtgtc catttggaat tttaatactt
     3121 ggatttctga ctggcagcat ttagggttcc cttgctttta atctagtggc aagttgtttc
     3181 ataacagtac agcatactgt taattcctga gtgtgtatac gtttctttgg ctcattgggt
     3241 ccttgttata tttaatgttg tagacagcat tactgaactg ttttgatggt gtactatttt
     3301 taaccattta gtgaaatagg cttactatta aacattaatt tataaggaca ttacaattca
     3361 gacaaggaat tataattcct aagtatgtga atttgtaata agatctcttt agatcagcga
     3421 agcccctgtt tatctgagag gcgccgcctg ccatgagtac catggacagt gattttactg
     3481 agtctaatgt ttaggccttc cagtgtttaa aactgtttta ttgcaagttt ggcagagatg
     3541 acctcggtga gttcatggtg cagttaacgt gatttttatg ccatatttgc tgatttttac
     3601 agattaaatt taaaaaatta catttacaaa attgttgttt tgaggaatat tgttgttgat
     3661 tttgtttgtt ttgttttgag tgactgttag tattcttgaa tactgttaga cctgacagga
     3721 ttagctgtag taaattatca gttttaaagg tgagtgttgt tttattgtaa aatgcatgtt
     3781 ttagatattt ggaaaatact aataaaagca aaggtaacaa agta
//
