LOCUS       NM_011434                652 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus superoxide dismutase 1, soluble (Sod1), mRNA.
ACCESSION   NM_011434 XM_128337 XM_358882
VERSION     NM_011434.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 652)
  AUTHORS   Zhang,J., Chen,K., Chen,Y., Hua,L., Chen,S., Chen,X., Zou,L.,
            Li,S., Yang,X. and Shen,Y.
  TITLE     Pathology reduction and motor behavior improvement associated with
            ultrasound-mediated delivery of arctiin to the motor cortex in a
            mutant SOD1 mouse model of amyotrophic lateral sclerosis
  JOURNAL   Ultrasonics 144, 107449 (2024)
   PUBMED   39217855
  REMARK    GeneRIF: Pathology reduction and motor behavior improvement
            associated with ultrasound-mediated delivery of arctiin to the
            motor cortex in a mutant SOD1 mouse model of amyotrophic lateral
            sclerosis.
REFERENCE   2  (bases 1 to 652)
  AUTHORS   da Cunha Menezes,E., de Abreu,F.F., Davis,J.B., Maurer,S.V.,
            Roshko,V.C., Richardson,A., Dowell,J., Cassella,S.N. and
            Stevens,H.E.
  TITLE     Effects of gestational hypothyroidism on mouse brain development:
            Gabaergic systems and oxidative stress
  JOURNAL   Dev Biol 515, 112-120 (2024)
   PUBMED   39048051
REFERENCE   3  (bases 1 to 652)
  AUTHORS   Hutchings,A.J., Hambrecht,B., Veh,A., Giridhar,N.J., Zare,A.,
            Angerer,C., Ohnesorge,T., Schenke,M., Selvaraj,B.T., Chandran,S.,
            Sterneckert,J., Petri,S., Seeger,B., Briese,M., Stigloher,C.,
            Bischler,T., Hermann,A., Damme,M., Sendtner,M. and Luningschror,P.
  TITLE     Plekhg5 controls the unconventional secretion of Sod1 by
            presynaptic secretory autophagy
  JOURNAL   Nat Commun 15 (1), 8622 (2024)
   PUBMED   39366938
  REMARK    GeneRIF: Plekhg5 controls the unconventional secretion of Sod1 by
            presynaptic secretory autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 652)
  AUTHORS   Choi,E.S., Hnath,B., Sha,C.M. and Dokholyan,N.V.
  TITLE     Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells
  JOURNAL   Structure 32 (10), 1776-1792 (2024)
   PUBMED   39208794
  REMARK    GeneRIF: Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells.
REFERENCE   5  (bases 1 to 652)
  AUTHORS   Hale,O.J., Wells,T.R., Mead,R.J. and Cooper,H.J.
  TITLE     Mass spectrometry imaging of SOD1 protein-metal complexes in
            SOD1G93A transgenic mice implicates demetalation with pathology
  JOURNAL   Nat Commun 15 (1), 6518 (2024)
   PUBMED   39117623
  REMARK    GeneRIF: Mass spectrometry imaging of SOD1 protein-metal complexes
            in SOD1G93A transgenic mice implicates demetalation with pathology.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 652)
  AUTHORS   de Haan,J.B., Newman,J.D. and Kola,I.
  TITLE     Cu/Zn superoxide dismutase mRNA and enzyme activity, and
            susceptibility to lipid peroxidation, increases with aging in
            murine brains
  JOURNAL   Brain Res Mol Brain Res 13 (3), 179-187 (1992)
   PUBMED   1593944
REFERENCE   7  (bases 1 to 652)
  AUTHORS   Ratty,A.K., Matsuda,Y., Elliott,R.W., Chapman,V.M. and Gross,K.W.
  TITLE     Genetic mapping of two DNA markers, D16Ros1 and D16Ros2, flanking
            the mutation site in the chakragati mouse, a transgenic insertional
            mutant
  JOURNAL   Mamm Genome 3 (1), 5-10 (1992)
   PUBMED   1581634
REFERENCE   8  (bases 1 to 652)
  AUTHORS   Brookes,S., Maccarone,P., de Haan,J.B., Tymms,M., Forrest,G.L.,
            Graves,J.A. and Kola,I.
  TITLE     Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR,
            and CBR--to two different chromosomes in the marsupial species
            Macropus eugenii
  JOURNAL   Cytogenet Cell Genet 61 (1), 25-28 (1992)
   PUBMED   1380419
REFERENCE   9  (bases 1 to 652)
  AUTHORS   Francke,U. and Taggart,R.T.
  TITLE     Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1)
            to a region of chromosome 16 and of Hprt to a region of the X
            chromosome in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5230-5233 (1979)
   PUBMED   291939
REFERENCE   10 (bases 1 to 652)
  AUTHORS   Oberley,L.W., Bize,I.B., Sahu,S.K., Leuthauser,S.W. and Gruber,H.E.
  TITLE     Superoxide dismutase activity of normal murine liver, regenerating
            liver, and H6 hepatoma
  JOURNAL   J Natl Cancer Inst 61 (2), 375-379 (1978)
   PUBMED   210289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048874.1 and BE989579.1.
            
            On Apr 18, 2018 this sequence version replaced NM_011434.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF740594.1, CX568035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               BC048874.1         21-648
            629-652             BE989579.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 51.56 cM"
     gene            1..652
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /note="superoxide dismutase 1, soluble"
                     /db_xref="GeneID:20655"
                     /db_xref="MGI:MGI:98351"
     exon            1..168
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /inference="alignment:Splign:2.1.0"
     exon            169..265
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /inference="alignment:Splign:2.1.0"
     exon            266..335
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /inference="alignment:Splign:2.1.0"
     exon            336..453
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /inference="alignment:Splign:2.1.0"
     exon            454..637
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      611..616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /note="hexamer: ATTAAA"
     polyA_site      625
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /note="major polyA site"
     polyA_site      637
                     /gene="Sod1"
                     /gene_synonym="B430204E11Rik; Cu/Zn-SOD; CuZnSOD; Ipo-1;
                     Ipo1; Sod-1; SODC"
                     /note="major polyA site"
ORIGIN      
        1 cgcggtcctt tcctgcggcg ccttccgtcc gtcggcttct cgtcttgctc tctctggtcc
       61 ctccggagga ggccgccgcg cgtctcccgg ggaagcatgg cgatgaaagc ggtgtgcgtg
      121 ctgaagggcg acggtccggt gcagggaacc atccacttcg agcagaaggc aagcggtgaa
      181 ccagttgtgt tgtcaggaca aattacagga ttaactgaag gccagcatgg gttccacgtc
      241 catcagtatg gggacaatac acaaggctgt accagtgcag gacctcattt taatcctcac
      301 tctaagaaac atggtggccc ggcggatgaa gagaggcatg ttggagacct gggcaatgtg
      361 actgctggaa aggacggtgt ggccaatgtg tccattgaag atcgtgtgat ctcactctca
      421 ggagagcatt ccatcattgg ccgtacaatg gtggtccatg agaaacaaga tgacttgggc
      481 aaaggtggaa atgaagaaag tacaaagact ggaaatgctg ggagccgctt ggcctgtgga
      541 gtgattggga ttgcgcagta aacattccct gtgtggtctg agtctcagac tcatctgcta
      601 ccctcaaacc attaaactgt aatctgaaga gttgtaaaaa aaaaaaaaaa aa
//
