LOCUS       NM_018821               5921 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus suppressor of cytokine signaling 6 (Socs6), mRNA.
ACCESSION   NM_018821
VERSION     NM_018821.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5921)
  AUTHORS   Zhang,P., Guan,P., Ye,X., Lu,Y., Hang,Y., Su,Y. and Hu,W.
  TITLE     SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis
            and Is Negatively Regulated by Quaking-Mediated miR-19b
  JOURNAL   Oxid Med Cell Longev 2022, 1121323 (2022)
   PUBMED   35126805
  REMARK    GeneRIF: SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte
            Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5921)
  AUTHORS   Fairchild,C.L., Hino,K., Han,J.S., Miltner,A.M., Peinado Allina,G.,
            Brown,C.E., Burns,M.E., La Torre,A. and Simo,S.
  TITLE     RBX2 maintains final retinal cell position in a DAB1-dependent and
            -independent fashion
  JOURNAL   Development 145 (3) (2018)
   PUBMED   29361558
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5921)
  AUTHORS   Lawrenson,I.D., Krebs,D.L., Linossi,E.M., Zhang,J.G.,
            McLennan,T.J., Collin,C., McRae,H.M., Kolesnik,T.B., Koh,K.,
            Britto,J.M., Kueh,A.J., Sheikh,B.N., El-Saafin,F., Nicola,N.A.,
            Tan,S.S., Babon,J.J., Nicholson,S.E., Alexander,W.S., Thomas,T. and
            Voss,A.K.
  TITLE     Cortical Layer Inversion and Deregulation of Reelin Signaling in
            the Absence of SOCS6 and SOCS7
  JOURNAL   Cereb Cortex 27 (1), 576-588 (2017)
   PUBMED   26503265
  REMARK    GeneRIF: Results suggest: 1) SOCS6 and SOCS7 bind
            tyrosine-phosphorylated DAB1 and commit it to ubiquitination and
            proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6
            and SOCS7 terminates reelin signaling and allows a new cycle of
            reelin signaling to commence. 3) Repeated cycles of reelin
            signaling 'ON' and 'OFF' drive the fundamentally cyclic process of
            cell migration in the cortex.
REFERENCE   4  (bases 1 to 5921)
  AUTHORS   Galic,S., Sachithanandan,N., Kay,T.W. and Steinberg,G.R.
  TITLE     Suppressor of cytokine signalling (SOCS) proteins as guardians of
            inflammatory responses critical for regulating insulin sensitivity
  JOURNAL   Biochem J 461 (2), 177-188 (2014)
   PUBMED   24966052
  REMARK    Review article
REFERENCE   5  (bases 1 to 5921)
  AUTHORS   Teckchandani,A., Laszlo,G.S., Simo,S., Shah,K., Pilling,C.,
            Strait,A.A. and Cooper,J.A.
  TITLE     Cullin 5 destabilizes Cas to inhibit Src-dependent cell
            transformation
  JOURNAL   J Cell Sci 127 (Pt 3), 509-520 (2014)
   PUBMED   24284072
  REMARK    GeneRIF: Our results show that endogenous Cul5 suppresses
            epithelial cell transformation by several pathways, including
            inhibition of Src-Cas-induced ruffling through SOCS6
REFERENCE   6  (bases 1 to 5921)
  AUTHORS   Li,L., Gronning,L.M., Anderson,P.O., Li,S., Edvardsen,K.,
            Johnston,J., Kioussis,D., Shepherd,P.R. and Wang,P.
  TITLE     Insulin induces SOCS-6 expression and its binding to the p85
            monomer of phosphoinositide 3-kinase, resulting in improvement in
            glucose metabolism
  JOURNAL   J Biol Chem 279 (33), 34107-34114 (2004)
   PUBMED   15123678
  REMARK    GeneRIF: SOCS-6 expression is induced by insulin, which regulates
            its binding to the p85 monomer of phosphoinositide 3-kinase
REFERENCE   7  (bases 1 to 5921)
  AUTHORS   Bayle,J., Letard,S., Frank,R., Dubreuil,P. and De Sepulveda,P.
  TITLE     Suppressor of cytokine signaling 6 associates with KIT and
            regulates KIT receptor signaling
  JOURNAL   J Biol Chem 279 (13), 12249-12259 (2004)
   PUBMED   14707129
  REMARK    GeneRIF: SOCS6 has a role as a negative regulator of receptor
            tyrosine kinases
REFERENCE   8  (bases 1 to 5921)
  AUTHORS   Jegalian,A.G. and Wu,H.
  TITLE     Differential roles of SOCS family members in EpoR signal
            transduction
  JOURNAL   J Interferon Cytokine Res 22 (8), 853-860 (2002)
   PUBMED   12396724
  REMARK    GeneRIF: SOCS4 expression, in contrast, does not appear to be EPO
            inducible.SOCS4 is ineffective at counteracting EPO-mediated
            events.
REFERENCE   9  (bases 1 to 5921)
  AUTHORS   Krebs,D.L., Uren,R.T., Metcalf,D., Rakar,S., Zhang,J.G., Starr,R.,
            De Souza,D.P., Hanzinikolas,K., Eyles,J., Connolly,L.M.,
            Simpson,R.J., Nicola,N.A., Nicholson,S.E., Baca,M., Hilton,D.J. and
            Alexander,W.S.
  TITLE     SOCS-6 binds to insulin receptor substrate 4, and mice lacking the
            SOCS-6 gene exhibit mild growth retardation
  JOURNAL   Mol Cell Biol 22 (13), 4567-4578 (2002)
   PUBMED   12052866
  REMARK    GeneRIF: SOCS-6 binds to insulin receptor substrate 4, and mice
            lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
REFERENCE   10 (bases 1 to 5921)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122398.2.
            
            On Feb 9, 2019 this sequence version replaced NM_018821.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031164.1, AK142069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC122398.2         137433-137478
            47-171              AC122398.2         144307-144431
            172-5921            AC122398.2         160722-166471
FEATURES             Location/Qualifiers
     source          1..5921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 58.66 cM"
     gene            1..5921
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="suppressor of cytokine signaling 6"
                     /db_xref="GeneID:54607"
                     /db_xref="MGI:MGI:1924885"
     exon            1..46
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /inference="alignment:Splign:2.1.0"
     exon            47..171
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..5921
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1902
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="cytokine inducible SH2-containing protein 4;
                     suppressor of cytokine signaling 4; cytokine inducible
                     SH2-containing protein CIS4; SH2 domain containing SOCS
                     box protein SOCS6; CIS-4; cytokine-inducible SH2 protein
                     4"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 6"
                     /protein_id="NP_061291.2"
                     /db_xref="CCDS:CCDS29389.1"
                     /db_xref="GeneID:54607"
                     /db_xref="MGI:MGI:1924885"
                     /translation="MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFG
                     SCYGKDMASCDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSS
                     ASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASP
                     GPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDY
                     LQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPE
                     ILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHM
                     AESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEA
                     EGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHT
                     SIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQ
                     YTRIDLIQKLPLPNKMKDYLQEKHY"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="hexamer: AACAAA"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="hexamer: AATATA"
     polyA_site      2595
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="major polyA site"
     polyA_site      2603
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
     regulatory      2844..2849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="hexamer: ATTAAA"
     polyA_site      2868
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
     regulatory      5900..5905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
                     /note="hexamer: AATAAA"
     polyA_site      5919
                     /gene="Socs6"
                     /gene_synonym="1500012M23Rik; 5830401B18Rik; Cis4; Cish4;
                     HSPC060; SOCS-4; SOCS-6; Socs4; SSI4; STAI4; STATI4"
ORIGIN      
        1 ggcagtcgcg ccgccgcggg gaggaagcag agcccgcggc tgcagggttt tcatttcata
       61 tgggggaatg gtagtatgct ggtcagattt ttgtcaactg gacacaagct acagttattt
      121 ggaaagaaga actctaaatt gagaaaatgc ctccataaga tttgcctgta gaaaatagct
      181 tcagaggtta aatgaagcca ggcagaatac acccatgagg catcgcagcc cctcccgatg
      241 tttgggcata actgctccag aaccaaattg acccatttgg attagttaac ttttgtcaaa
      301 atgaagaaaa tcagtctgaa gaccttcagg aaatctttta acctgagtaa aagcaaagac
      361 gaaactgagt tcatggtggt tcagccccag tcccttgctg gtgacttcgt gaaagatgac
      421 tctttattcg ggagctgtta tggcaaagac atggccagtt gtgacattgg cagcgaggat
      481 gagaaaggga agaacagatc caaaagcgag agcctgatgg gcactttgaa gaggcggttg
      541 tccgccaagc agaagaccaa gggcaagggc ggcactgcgt ctacagatga ggacaccttc
      601 tcctcagctt cagctcctgg tgggctcaag gatgtgcgtg ctccgcggcc catccgctcc
      661 acatcactga gaagccacca ttatagcccc acgccctggc cgctgcgtcc caccagctcg
      721 gaggagacgt gcatcaagat ggagatgcga gtgaaagcac tggtgcatgc tgccagccca
      781 ggaccagtca acggtgtgcg caaggatctg cgggagctac agcccaggga gctgcgagac
      841 ctgcagccag agccgcgccc tgagtcccgc tgcagcccca gctcacccgg ggacctgagc
      901 ctccacctgg aggaacacgt gcctgtagta atcggactca tgtctcagga ctaccttcag
      961 tacaccgtgc ctttagatga cgggatgtgc cctcttgaag ggccgcgcag ctgctgcctg
     1021 gatacgtctt ctcccatgga ggtgtcagcc gtacccctgc cgggggcgag tggtgccttc
     1081 tccgaagacg acagtcatgt ggaccaggac ctggttgtag gcccagagat ccttgtggat
     1141 tcatcagtga acaatttgtt gattggcacc acaggagtca tgttgcagag ccctagagga
     1201 ggtcatgatg acgcccctcc cctctcacca ttgctacctc caatgcagaa taacccaatc
     1261 caaaggaact tcagtggcct ctcgggccca gacttgcaca tggccgaaag tgttcgctgt
     1321 catttgaatt tcgatcccaa ctctgcgcct ggggttgcta gagtttatga ctcggtgcaa
     1381 agtagtggcc ccatggttgt tacaagtctt acggaggagc tgaagaagct tgcaaaacag
     1441 gggtggtatt ggggccccat cacacgctgg gaggcagagg ggaagttggc aaatgtgcca
     1501 gatggttctt ttcttgtaag ggatagttct gatgaccgtt accttttaag cctgagcttt
     1561 cgttcccatg gtaaaacact tcacactaga attgagcact caaatggtag attcagcttt
     1621 tatgaacagc cagatgtgga agggcataca tctatagttg acttaatcga gcattcaatc
     1681 agggactctg aaaatggagc attttgttat tcaagatctc gattgcctgg atcagcaact
     1741 tacccagtca gactgaccaa tccagtgtca cgattcatgc aggtgcgctc gctgcagtac
     1801 ctgtgccgct ttgttatccg tcagtacacc agaatagact taattcagaa actgcctttg
     1861 ccaaacaaaa tgaaggatta tttgcaggag aagcactact gagagatttg gagccctgtt
     1921 tcttgcactt tggggttcag aaacaagact tgagtacagt ttacagactt acatcgccat
     1981 tgaagtcttt gctgccataa cttttagttt ttatgtgtga gagtcatcaa tttgttcaag
     2041 ggtggggaag tgtctgcaag gcgtcctgag tttattttgg ttcttgaaaa gggatgcctt
     2101 tagggtttag aagtgtgagt tatctttcct taatgtgcag aataatcaca atgtgaatga
     2161 ccagattctc tttaatgccc cttccagtcc tttgctgcta tccactgtga ttcttatgca
     2221 ttaaagcaca tttcatgtgt attcaaccct aagtaaagtt gaatgaaact taaatataaa
     2281 ttgctatgat gttaaatggc ccagttgaat aaacgtgtgg gataaaacat ttacatatac
     2341 actgaaaact gatttttttt aagtctcaca ctttaaaagt gatttgttca gaattatgaa
     2401 ttaatacaat gttgataaat ggaatgcaaa tctgcaacat cttttaaaat acttttctaa
     2461 attatttttt aaggatgtga taattgtttt ggttgggaga agttgaattg ttctgttgcc
     2521 ttcattttca tcttgtggtt tgtctctttt gataaattgc cttacattaa aaattgtaaa
     2581 caaatatata cccaatttag aaattgttgc cttttctgtc attaaactcg ggtacaaatt
     2641 ggcgtaactt aaaagctctg taaagcccaa acaattgtta caaaagtaag ataaccctgg
     2701 tttttgtgag gtgtgtgtgt gttcgtgtgt gtaagagaga gagagatttt tcagttacat
     2761 attttatcta tgatttcttt agtagatatt ttcttccata aacttgacaa aacaagtttc
     2821 ataaatgagt tgtattttct tacattaaag tttatataaa gttgtaaact gatctgaata
     2881 gaaaggttat tttaaagttg tcttgacttt cttctgtata atctttacag tgtgctgtgt
     2941 ttgaccattc taactctaaa ccaacaacct tgaatgacat cagctaaata attaaaaatt
     3001 gtgatacatt atgtgagaaa aattgtaaaa ctatgtctga taccagaaat agtttcctgc
     3061 ttgtgactac cctttgagga tagcattttg gtttatttta aattggttaa tttgtaagta
     3121 gtctggcacc tctacttact tatcattgtg ttagagaatg atgagaccag gttttaaaag
     3181 ttattttgga atgtagactg ttgattcagt tcaaagttct gcagtggtgt tattaaaact
     3241 attaagcgat agtatttaaa gatttctcca ttcagaaaat atttccagct gcacatgctt
     3301 ttaaaaaaat cagggtaaac atcttaggtc agacctgctg gctttgtcat ccaaacatat
     3361 ctatagcttt acatttttcc tctttttcta gggtcaaaat tgagatattg caggaaaagg
     3421 ctcagtgcca acatgttaaa gagttgtggc atcttgactt ataaggagca aggcacttac
     3481 ttttgatgga atgttacaaa gaatttcatt ttctgatatg tttcatctaa tatgatagat
     3541 gaattatatg gagatagtgt aagcattcac tattggatta agaactattg gagaagtgta
     3601 ggcttgtgtg caaaataatg caagacactt aactattttt ttgtaaaact ttatttttaa
     3661 acaactgaag ctatatctag tgtgagttga cagtccccac atctacatta gatggcaggt
     3721 gttgtcacat agtcactgta ttaatgatga aggttgagat gacttcatgt ttcaaaaata
     3781 tgcacatgtc ctggcaatca tggctcatag aagtctcagg actgtcccca acatgtttca
     3841 agtaaacata gcttgtttcc tactcttccc catggtgccg tgtggttagg atctacccat
     3901 taaatgtcaa gagtattctt atctttatct aaatatttct aataatcaat ttgtgctatt
     3961 ctgtaggaca aatctttatt atgaaaacaa caacccttga tgaatttcca tttacatgct
     4021 ttatatgacc tgtccaactc aatttgaaat gattaggttc tgatacttga tgaataaaaa
     4081 tcaaagcatt tattgagaaa tcagatttgc aaatggtaaa atattgccaa tatttttgtg
     4141 tttttgtagc caagacatcc atctgacaga agtgggaaac aatgggaaat actgactttt
     4201 gtatgacact gtctgataaa aatgaagaga tttaagtctc tgtcttctag tatcatggcc
     4261 tagattgaag ttggttaact ttctggcttt tttgaactta gatgatacaa acataacctc
     4321 taagccattc tgtgtgtgtg tgtgtgtgtg tgtgaaataa tttttgttac ttttaatttt
     4381 ttgcatatat tacatcctga ccacagtttt cagtaccttt cctcttccca gtgctctttc
     4441 ccaacttccc ctgtcctcta gatccacttc tccttttccc ttcaaaacaa aacaaaacaa
     4501 aacaaaacaa aacaaaacaa aaaaaacaaa gagcaggcct cacagggata ttaacagaac
     4561 ctggcataac aaattccatt aagactagga acaaaccctc atatcaaggc tggatgaagg
     4621 aaaagggccc caagtatagg caagagattc agtggcacct ccaacccttg cttttagggg
     4681 tccaacaaaa acaccaacta tataactata aggcgtatgc agaggcacta gctcagaaca
     4741 catttagaat tcctacatta aggcaagaca aaagcaagca gaaaaactat ctgtgagagt
     4801 gaatcagatt tttttttttt ttactgtata ctccaccacc agaaatgctg gaggctgagg
     4861 gttaatttgg ggcttcataa gacacttaac acatttttat aaataagaga gctatggaga
     4921 gtacttgaaa aaaaatgcct tgctttctcc aaggaagact gttctctttt tacatggtgc
     4981 aatactctga aaaattagaa agtcacgtat cacagtaaat aaccacaaaa ctgaaaaatt
     5041 taaggaaacc agccacacag agcgacagtt ttctgttgaa taaaatgatg tgccaaatag
     5101 gctaactcgt tagcattaag gaaatgaaac acataaagta ttcattgtag tttctgagcc
     5161 agtattactg aagacaaaag ttattgaaat cttacaggtt tatgcagttt ttttcctagt
     5221 gctaagcatc tctaactgct ttcaggaatg tcaacttgac tgtacatttc atgtcatata
     5281 tgaaagaaac ttttatgaat gaatcaaaat aacattttga tttctatctg aatgtctttc
     5341 attgaatatg atgtgttaat tagaaactga aataacacta ccagcaatag acagtttttt
     5401 tgaataatga acaatagcca gttccacaaa taactaaaat tctaaagtta ttggtatatt
     5461 agtaataaaa atttgctttc tttaaatact tttttagtcc tgtaaagaaa aaattttata
     5521 acatttttat tgaccagtcg tgatataaca aggcaaatat gaatttgttt ttgaaaagtg
     5581 atgcaagttc tccaaccaga aaggatgaga tggagtctta gaatctccta acagtatatt
     5641 gtcatgttgg ggtaaggaag tctcatagtt gatatgccat gaaattaata cctgcaacct
     5701 agattgctgt agtttacact ttgtatgttt caaatcaggt atatactgtt tgtactgaga
     5761 acaccacaga atgaattatc caaagtccac cgatttaata tgtgttttgg tttgtaagtg
     5821 aattatagta atttcttgca cattttttgg aaatcaattg tataaaaatt tatgtatctg
     5881 cttctagata cagtatgtaa ataaaagttt tgttcataac a
//
