LOCUS       NM_019654               4460 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus suppressor of cytokine signaling 5 (Socs5), mRNA.
ACCESSION   NM_019654
VERSION     NM_019654.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4460)
  AUTHORS   Sun,L., Liu,L., Liang,D. and Liu,L.
  TITLE     SOCS5, targeted by miR-155-5p, plays a negative regulatory role in
            pulmonary hypertension through inhibiting JAK2/STAT3 signaling
            pathway
  JOURNAL   BMC Pulm Med 24 (1), 52 (2024)
   PUBMED   38267898
  REMARK    GeneRIF: SOCS5, targeted by miR-155-5p, plays a negative regulatory
            role in pulmonary hypertension through inhibiting JAK2/STAT3
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4460)
  AUTHORS   Lei,Y., He,J., Hu,F., Zhu,H., Gu,J., Tang,L. and Luo,M.
  TITLE     Sequential inspiratory muscle exercise-noninvasive positive
            pressure ventilation alleviates oxidative stress in COPD by
            mediating SOCS5/JAK2/STAT3 pathway
  JOURNAL   BMC Pulm Med 23 (1), 385 (2023)
   PUBMED   37828534
  REMARK    GeneRIF: Sequential inspiratory muscle exercise-noninvasive
            positive pressure ventilation alleviates oxidative stress in COPD
            by mediating SOCS5/JAK2/STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4460)
  AUTHORS   Kedzierski,L., Tan,A.E.Q., Foo,I.J.H., Nicholson,S.E. and
            Fazakerley,J.K.
  TITLE     Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory
            Responses during Alphavirus Infection
  JOURNAL   Viruses 14 (11), 2476 (2022)
   PUBMED   36366574
  REMARK    GeneRIF: Suppressor of Cytokine Signalling 5 (SOCS5) Modulates
            Inflammatory Responses during Alphavirus Infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4460)
  AUTHORS   Fairchild,C.L., Hino,K., Han,J.S., Miltner,A.M., Peinado Allina,G.,
            Brown,C.E., Burns,M.E., La Torre,A. and Simo,S.
  TITLE     RBX2 maintains final retinal cell position in a DAB1-dependent and
            -independent fashion
  JOURNAL   Development 145 (3) (2018)
   PUBMED   29361558
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4460)
  AUTHORS   Hazra,B., Kumawat,K.L. and Basu,A.
  TITLE     The host microRNA miR-301a blocks the IRF1-mediated neuronal innate
            immune response to Japanese encephalitis virus infection
  JOURNAL   Sci Signal 10 (466), eaaf5185 (2017)
   PUBMED   28196914
  REMARK    GeneRIF: Data show that the Japanese encephalitis virus
            (JEV)-induced expression of miR-301a led to inhibition of the
            production of the transcription factor IFN regulatory factor 1
            (IRF1) and the signaling protein suppressor of cytokine signaling 5
            (SOCS5).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4460)
  AUTHORS   Seki,Y., Hayashi,K., Matsumoto,A., Seki,N., Tsukada,J., Ransom,J.,
            Naka,T., Kishimoto,T., Yoshimura,A. and Kubo,M.
  TITLE     Expression of the suppressor of cytokine signaling-5 (SOCS5)
            negatively regulates IL-4-dependent STAT6 activation and Th2
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13003-13008 (2002)
   PUBMED   12242343
  REMARK    GeneRIF: SOCS5 regulates Th1/Th2 cell balance and suppresses IL-4
REFERENCE   7  (bases 1 to 4460)
  AUTHORS   Callus,B.A. and Mathey-Prevot,B.
  TITLE     SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and
            EGF-R signalling in the imaginal wing disc
  JOURNAL   Oncogene 21 (31), 4812-4821 (2002)
   PUBMED   12101419
REFERENCE   8  (bases 1 to 4460)
  AUTHORS   Cooney,R.N.
  TITLE     Suppressors of cytokine signaling (SOCS): inhibitors of the
            JAK/STAT pathway
  JOURNAL   Shock 17 (2), 83-90 (2002)
   PUBMED   11837794
  REMARK    Review article
REFERENCE   9  (bases 1 to 4460)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4460)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053015.1.
            
            On Aug 28, 2003 this sequence version replaced NM_019654.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053015.1, BQ770308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 56.93 cM"
     gene            1..4460
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="suppressor of cytokine signaling 5"
                     /db_xref="GeneID:56468"
                     /db_xref="MGI:MGI:2385459"
     exon            1..369
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /inference="alignment:Splign:2.1.0"
     exon            370..430
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /inference="alignment:Splign:2.1.0"
     exon            431..4394
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..2053
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="cytokine inducible SH2-containing protein 5;
                     SOCS-5"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 5"
                     /protein_id="NP_062628.2"
                     /db_xref="CCDS:CCDS29014.1"
                     /db_xref="GeneID:56468"
                     /db_xref="MGI:MGI:2385459"
                     /translation="MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKS
                     ISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGA
                     TPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSS
                     MQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKC
                     PFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGV
                     DPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQ
                     SRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAE
                     ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSS
                     TVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPS
                     MLQDFLKEYHYKQKVRVRWLEREPVKAK"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="hexamer: AATAAA"
     polyA_site      3437
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="major polyA site"
     regulatory      4370..4375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="hexamer: TATAAA"
     polyA_site      4394
                     /gene="Socs5"
                     /gene_synonym="1810018L08Rik; Cish5; mKIAA0671"
                     /note="major polyA site"
ORIGIN      
        1 cgccggcccg gcaggagcgg aggacgggac gcgcgggcgg tcgcgctcgc cctgtcgctg
       61 actgcgctgc cccggcccat ccttgcctgg ccgcaggtgc cctggatgag gccgccgcgc
      121 gtgtcccggc cgctgagtgt cccccgcggt cgcccggcgc ctgccctcaa gcggccgcct
      181 ctccttgccc gggtccccgt tttcccccgg cgcagtcctc ctccggtggg cgcctccgca
      241 cctcggcgca ggcggcacgg ccctcgggcc gggatggatc cgccgggaag aggaagacaa
      301 gccggggcgt tgagcccctg cgcacggtgc cgccgcgcgt agtgggagct tactcgcagt
      361 aggctctcga aggctcaggt ctgaagcggg aagctgatct tttattacag atattgctgg
      421 cgccgtggag ctcttctaat caatggataa agtggggaaa atgtggaaca acttaaaata
      481 cagatgccag aatctcttca gccacgaggg aggaagccgt aatgagaacg tggagatgaa
      541 ccccaacaga tgtccgtctg tcaaagagaa aagcatcagt ctgggagagg cagctcccca
      601 gcaagagagc agtcccttaa gagaaaatgt tgccttacag ctgggactga gcccttccaa
      661 gaccttttcc aggcggaacc aaaactgtgc cgcagagatc cctcaagtgg ttgaaatcag
      721 catcgagaaa gacagtgact cgggtgccac cccaggaacg aggcttgcac ggagagactc
      781 ctactcgcgg cacgccccgt ggggaggaaa gaagaaacat tcctgttcca caaagaccca
      841 gagttcattg gataccgaga aaaagtttgg tagaactcga agcggccttc agaggcgaga
      901 gcggcgctat ggagtcagct ccatgcagga catggacagc gtttctagcc gcgcggtcgg
      961 gagccgctcc ctgaggcaga ggctccagga cacggtgggt ttgtgttttc ccatgagaac
     1021 ttacagcaag cagtcaaagc cactcttttc caataaaaga aaaatacatc tttctgaatt
     1081 aatgctggag aaatgccctt ttcctgctgg ctcggattta gcacaaaagt ggcatttgat
     1141 taaacagcat accgcccctg tgagcccaca ctcaacattt tttgatacat ttgatccatc
     1201 actggtgtct acagaagatg aagaagatag gcttcgcgag agaagacggc ttagtatcga
     1261 agaaggggtg gatccccctc ccaacgcaca aatacacacc tttgaagcta ctgcacaggt
     1321 caacccattg tataagctgg gaccaaagtt agctcctggg atgacagaga taagtggaga
     1381 tggttctgca attccacaaa cgaattgtga ctcagaagag gattcaacca ccctatgtct
     1441 gcagtcacgg aggcagaagc agcgccaggt gtccggggac agccacgcgc acgttagcag
     1501 acagggagct tggaaagttc atacgcagat cgattacata cactgcctcg tgccagattt
     1561 gcttcagatc acagggaatc cctgttactg gggcgtgatg gaccgatacg aggccgaagc
     1621 ccttctagaa gggaaaccgg aaggcacgtt cttgctcagg gactctgcac aggaggacta
     1681 cctcttctct gtgagcttcc gccgctacaa caggtctctg cacgcccgga tcgagcagtg
     1741 gaaccacaac ttcagcttcg atgcccatga cccctgcgtg tttcactcct ccactgtcac
     1801 ggggcttctc gaacactata aagaccccag ctcttgcatg ttttttgaac cgttgctaac
     1861 gatatcactg aatagaactt tccctttcag cctgcagtat atctgccgcg cagtgatctg
     1921 cagatgcact acgtatgatg ggattgacgg gctcccgcta ccgtcgatgt tacaggattt
     1981 tttaaaagag tatcattata aacaaaaagt tagggttcgc tggttagaac gagaaccagt
     2041 caaagcaaag taactcctgt ccccaaaggg cactaactaa gtctgctcct cccgtgcatc
     2101 agactgcacc cataggaggc agtcagctgc taggatttcc cacccagaat gggagcttag
     2161 tcattagcct ctgccctatg gggtccgctg ttcctcagac aaaggtgcct agggacagca
     2221 agatggcttg caggtgttcg gtgggctgtg acaactgagg gaggcaactc tggggcattt
     2281 gctatgaaga attctatttc ttactgaaga acaaattatt aatattggat gggtatttca
     2341 atagtgtgac taatgtttga aattattttt tctaagaatt tttctataac cttcagaaaa
     2401 agtagtgatg tttgtagtta ctataaatca agctttgaaa gttcaaaaca aacaagtaaa
     2461 taaaagacta ccttcctttt agagaaaaca aatgcaagtt ttccagccac agggcattgt
     2521 gcactgttaa tgtggcttgt agtcagcctc cttttctcct cagagaagga ggctctaaag
     2581 taaaccaggt tttcctagat agttttctta accctgagac tcccagctca gtggtggagt
     2641 tgggtaaaag ccccagtgtg catttcggat gagcacggtg acctgagagc atgcagttgg
     2701 agtttccagt ggggtgtttt tctccaagtt gacatgtgca gtcagtcctc acattgtctc
     2761 atcaaagttg gaaccctttc ctgtgccctt gactatgtga gcccagagga cagcgagact
     2821 aggagatgcc cagacacatc agatagtagt aactccactg gttgacgatg ccaagttgtg
     2881 ttaaactata attaatcgtt tggatgacag tatttatctc tttgttgtaa gctcatagcc
     2941 gaattgctta agtacaattt atattataca gttttagtgc agttaattct taacagaaaa
     3001 cctgaagtct aaattgcaga tttaaaaggt actgtacacc catgctgcct gtaaataact
     3061 ttacttggca ccttttgtca cttaggatag gacgtaatac aacttgagtg aatgcttggg
     3121 acgtgttgtc gagttctagt gttgcttctc gtgttggact gtgttcccgg ttctgtccta
     3181 gccatttgca ctacagtagc caaatccatt cctgtgtgtt gccgtgctct gtaactgctg
     3241 ccgggtgctc ctcggccctc atgccagctg ctgcaggagg ttgctttctg tcccatggct
     3301 attgccaggg cttcctgaaa gaaatgctac atttgtatgc aacagtaacc ctttaactgc
     3361 taaacgtatg tttctgcttg ctgtgccttg ttctggctgc ttttccgtgc taataaagta
     3421 tgtttggtgt tcttgtatat ctgccgtttt atacatttgc cacaatttct cttgtacgtg
     3481 gaatggtttg gggtttttaa ataagcattg acaacttatt gtagtcaatg cagagtcacc
     3541 tacaacctaa tactgacctg tcagaataag ctaaatctaa gttgaatgtt ctctagcttt
     3601 ttaaccctaa tcacattttg tgaaccagtg tctgtagtca ctgcaaatta gtgtatagtt
     3661 tacagcagga cccagagaag tgagaagctg gtgatttctc tgcgcagtag ggagaggctg
     3721 aaaccagcgg taacgttagc agatgagtgt tagaacatcc agccacgcca gaaaccagtg
     3781 acacggagtc tgtgtaccag gacgccacag ctccacttag tggtttaggg accattttaa
     3841 ttgaagataa atgcctgaga tgcagacctt taaccaaaga cttgttcatg tcaatgcaga
     3901 acggggatgg aaggaacttc gatctctctg ttacttgtag tagatgtccc tgaggaacat
     3961 ataccaaagt gtctgagaac gtcatccaaa cctactttca aagcataatg tgcaattaag
     4021 ttgttatgac gtagttatat tgcataattg ttaggtctgt tttcttgagc ttacagtgta
     4081 cctggaagag gaaccccttg aggaaagata agtccatgct gagagctgga ggaagactat
     4141 gatcaggcga tgctgtgaag agaacttgaa actcggagag agccttgatg tttttatatg
     4201 cttgtagtaa actgatgttc tcactatagt tttatagaaa atattaatgc ttttttgtat
     4261 ttcagaactt ttcctgtgta acatgcaagt tgttttaagt gtaactattg agtttatgta
     4321 agcatgtgtc cactgtgcta aaggcactta tgtttcagtt tgtgtacaat ataaatatgc
     4381 aactttgggg ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4441 aaaaaaaaaa aaaaaaaaaa
//
