LOCUS       NM_080843               6888 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus suppressor of cytokine signaling 4 (Socs4), mRNA.
ACCESSION   NM_080843
VERSION     NM_080843.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6888)
  AUTHORS   Kedzierski,L., Er Qi Tan,A., Jia Hui Foo,I., Narayanan,D.,
            Moily,N., McQuilten,H.A., Nicholson,S.E. and Fazakerley,J.K.
  TITLE     In Semliki Forest virus encephalitis, suppressor of cytokine
            signaling 4 (SOCS4) is an essential modulator of immune responses
            that mediates the balance between immunopathology and virus
            clearance
  JOURNAL   Immunol Cell Biol 101 (4), 333-344 (2023)
   PUBMED   36702633
  REMARK    GeneRIF: In Semliki Forest virus encephalitis, suppressor of
            cytokine signaling 4 (SOCS4) is an essential modulator of immune
            responses that mediates the balance between immunopathology and
            virus clearance.
REFERENCE   3  (bases 1 to 6888)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6888)
  AUTHORS   Fairchild,C.L., Hino,K., Han,J.S., Miltner,A.M., Peinado Allina,G.,
            Brown,C.E., Burns,M.E., La Torre,A. and Simo,S.
  TITLE     RBX2 maintains final retinal cell position in a DAB1-dependent and
            -independent fashion
  JOURNAL   Development 145 (3) (2018)
   PUBMED   29361558
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6888)
  AUTHORS   Kedzierski,L., Tate,M.D., Hsu,A.C., Kolesnik,T.B., Linossi,E.M.,
            Dagley,L., Dong,Z., Freeman,S., Infusini,G., Starkey,M.R.,
            Bird,N.L., Chatfield,S.M., Babon,J.J., Huntington,N., Belz,G.,
            Webb,A., Wark,P.A., Nicola,N.A., Xu,J., Kedzierska,K., Hansbro,P.M.
            and Nicholson,S.E.
  TITLE     Suppressor of cytokine signaling (SOCS)5 ameliorates influenza
            infection via inhibition of EGFR signaling
  JOURNAL   Elife 6, e20444 (2017)
   PUBMED   28195529
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6888)
  AUTHORS   Simo,S. and Cooper,J.A.
  TITLE     Rbx2 regulates neuronal migration through different cullin 5-RING
            ligase adaptors
  JOURNAL   Dev Cell 27 (4), 399-411 (2013)
   PUBMED   24210661
REFERENCE   7  (bases 1 to 6888)
  AUTHORS   Feng,Z.P., Chandrashekaran,I.R., Low,A., Speed,T.P., Nicholson,S.E.
            and Norton,R.S.
  TITLE     The N-terminal domains of SOCS proteins: a conserved region in the
            disordered N-termini of SOCS4 and 5
  JOURNAL   Proteins 80 (3), 946-957 (2012)
   PUBMED   22423360
  REMARK    GeneRIF: Identified is a conserved region of about 70 residues in
            the N-terminal domains of Socs4 and 5 that is predicted to be more
            ordered than the surrounding sequence.
REFERENCE   8  (bases 1 to 6888)
  AUTHORS   Sutherland,J.M., Keightley,R.A., Nixon,B., Roman,S.D., Robker,R.L.,
            Russell,D.L. and McLaughlin,E.A.
  TITLE     Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian
            primordial follicle activation
  JOURNAL   J Cell Physiol 227 (3), 1188-1198 (2012)
   PUBMED   21604262
  REMARK    GeneRIF: Negative regulation of the JAK/STAT pathway is controlled
            by SOCS4, which target members of negative feedback loops, to
            suppress follicle growth and development.
REFERENCE   9  (bases 1 to 6888)
  AUTHORS   Ferguson,J.E. 3rd, Wu,Y., Smith,K., Charles,P., Powers,K., Wang,H.
            and Patterson,C.
  TITLE     ASB4 is a hydroxylation substrate of FIH and promotes vascular
            differentiation via an oxygen-dependent mechanism
  JOURNAL   Mol Cell Biol 27 (18), 6407-6419 (2007)
   PUBMED   17636018
  REMARK    GeneRIF: Socs4 is a hydroxylation substrate of FIH and promotes
            vascular differentiation via an oxygen-dependent mechanism.
REFERENCE   10 (bases 1 to 6888)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156016.2, CJ121925.1, AK014115.1, AW046781.1 and BG083279.2.
            
            On Mar 28, 2020 this sequence version replaced NM_080843.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.1325608.1, AK014115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC156016.2         87419-87429         c
            12-224              CJ121925.1         1-213
            225-1189            AK014115.1         33-997
            1190-1211           AW046781.1         383-404
            1212-1827           AK014115.1         1019-1634
            1828-2377           BG083279.2         98-647
            2378-6888           AC156016.2         68247-72757         c
FEATURES             Location/Qualifiers
     source          1..6888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..6888
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="suppressor of cytokine signaling 4"
                     /db_xref="GeneID:67296"
                     /db_xref="MGI:MGI:1914546"
     exon            1..302
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /inference="alignment:Splign:2.1.0"
     exon            303..6888
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1706
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="suppressor of cytokine signaling 7; suppressor of
                     cytokine signalling 4; SOCS-4; SOCS-7"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 4"
                     /protein_id="NP_543119.2"
                     /db_xref="CCDS:CCDS26985.1"
                     /db_xref="GeneID:67296"
                     /db_xref="MGI:MGI:1914546"
                     /translation="MAENNSKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESCS
                     ESEAIGTVENVEIPLRSQERQLSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPI
                     KNCSGRHSPGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTVPMSPNSDEWVS
                     ADLSERKLRDAQLKRRNTEDDIPCFSHTNGQPCVITANSASCTGGHITGSMMNLVTNN
                     SIEDSDMDSEDEIITLCTSSRKRNKPRWEMEEEILQLEAPPKFHTQIDYVHCLVPDLL
                     QISNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQ
                     WNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRT
                     VICNCTTYDGIDALPIPSPMKLYLKEYHYKSKVRLLRIDVPEQQ"
     regulatory      6856..6861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="hexamer: AATAAA"
     regulatory      6876..6881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="hexamer: ATTAAA"
     polyA_site      6881
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="major polyA site"
     polyA_site      6888
                     /gene="Socs4"
                     /gene_synonym="3110032M18Rik; A730004F22Rik; Socs7"
                     /note="major polyA site"
ORIGIN      
        1 gtcagaagcg cgccgcctcg aagccgagag ctggtggctg gggccgctct gaaagaaaag
       61 gtgggagccg aacccggaag tggcggcggt ccctggagag caggcggagg cagcggcaag
      121 tctgactctg ggctgaccgt ggagccgggg cgggggctga cagccaggcc tccgcctggc
      181 gggagccgca cgaggagcgg gagtggccgg gcctctcttc cgcgcttgag cgagcgccgg
      241 gtgatggcgg tggtgatggc ggcaggcgct cggacagctc cgcttgagct gagctcggag
      301 agatccgtcc agaaagtgcc cagaagaaac ttcctcttag aaaagctgaa aacacaatat
      361 ttataacact ggaaattgta aagaatttgt ttaaaatggc tgaaaacaat agtaaaaatg
      421 tagatgtacg gcctaaaaca agtcggagtc gaagtgctga caggaaggat ggttatgtgt
      481 ggagtggaaa gaagttgtct tggtccaaaa agagtgagag ttgttctgaa tctgaagcca
      541 taggtactgt tgagaatgtt gaaattcctc taagaagcca agaaaggcag cttagctgtt
      601 cgtccattga gttggactta gatcattcct gtgggcatag atttttaggc cgatccctta
      661 aacagaaact gcaagatgcg gtggggcagt gttttccaat aaagaattgt agtggccgac
      721 actctccagg gcttccatct aaaagaaaga ttcatatcag tgaactcatg ttagataagt
      781 gccctttccc acctcgctca gatttagcct ttaggtggca ttttattaaa cgacacactg
      841 ttcctatgag tcccaactca gatgaatggg tgagtgcaga cctgtctgag aggaaactga
      901 gagatgctca gctgaaacga agaaacacag aagatgacat accctgtttc tcacatacca
      961 atggccagcc ttgtgtcata actgccaaca gtgcttcgtg tacaggtggt cacataactg
     1021 gttctatgat gaacttggtc acaaacaaca gcatagaaga cagtgacatg gattcagagg
     1081 atgaaattat aacgctgtgc acaagctcca gaaaaaggaa taagcccagg tgggaaatgg
     1141 aagaggagat cctgcagttg gaggcacctc ctaagttcca cacccagatc gactacgtcc
     1201 actgccttgt tccagacctc cttcagatca gtaacaatcc gtgctactgg ggtgtcatgg
     1261 acaaatatgc agccgaagct ctgctggaag gaaagccaga gggcaccttt ttacttcgag
     1321 attcagcgca ggaagattat ttattctctg ttagttttag acgctacagt cgttctcttc
     1381 atgctagaat tgagcagtgg aatcataact ttagctttga tgcccatgat ccttgtgtct
     1441 tccattctcc tgatattact gggctcctgg aacactataa ggaccccagt gcctgtatgt
     1501 tctttgagcc gctcttgtcc actcccttaa tccggacgtt ccccttttcc ttgcagcata
     1561 tttgcagaac ggttatttgt aattgtacga cttacgatgg catcgatgcc cttcccattc
     1621 cttcgcctat gaaattgtat ctgaaggaat accattataa atcaaaagtt aggttactca
     1681 ggattgatgt gccagagcag cagtgatgcg gagaggttag aatgtcgacc tgcatacata
     1741 ttttcattta atattttatt tttcttatgc ctctttgaat ttttgtacaa aggcagttga
     1801 atcaaataaa actgtgccct aagttttaat tccagatcaa tttatttttt ttatgataca
     1861 cttgttatat atttttaagc aggtgtttgg ttttgttttt accatataaa tttacatatg
     1921 gtccaggcat atttacaatt tcaaggcatt gcatatacat ttgaatattc tgtatttttt
     1981 aaataatctt ttgttctttc ctatgtgtga aatattttgc taatctatgc tatcagtatt
     2041 cttgtatgac cgaatagtta cctattctct tttcatcttg aagattttca gtaaagagtg
     2101 ttgtaatcaa tccattataa tgtaattgac ttttgtaatt tgccaatagg agtgttaaac
     2161 aacaaaatga tttaaaatga aacttaatgt attttcattt taaatattaa ctaaaccaag
     2221 tttgtttgtt agttattcta gccaataaga aaagagaatg tagcatccta gaggtgtatt
     2281 tgttctgcag tttggcagga ccgtcagtta gtccaaataa acatcccctc agcgtggagg
     2341 cgaatggaac ctgtgctcct ttcttacggg aagctttgca aagcaaaata gcagggttac
     2401 aagcttggag ttgttaaggc aactagagtt ttctctatta atttatagac tgttgttgca
     2461 cctacttagc tcttttttgg gaactctagt tcccagggga aaatacatag tttctaaaca
     2521 gctcctggat ccaccaataa caaaaaactg tctcattatt ttaaattgat cttaaataaa
     2581 gatgaaaaca aaaacatggc tcaatattta ggaagcttaa cattgctttt ggtatttaca
     2641 acctaaatag tcatttctgt cctcagaact aacatgaatt ttatgtggtg tggcagtagc
     2701 tccatgacat gacgtcacag gcctagagta acaaacagtg gaggggtgcc ctgtttcttc
     2761 agtgactgac cttgacagag tgcccagttt tccttgtggg agctatctgc ctcttttaaa
     2821 tattgtacta attattttac ttatcttttt ctgtgtgtaa cagtgtttct ccatgtagcc
     2881 taggctgacc tcaaatttga gctccttcag cctgaatttc agattactgg tttaacccac
     2941 catgaacagc tagtgatgga tggatagatt ttttcctttc cttccttcct tcctttctct
     3001 ttttctttgt ttttgttgtt gttgttgcta tttgcttagc ttggattggt ttggttgttt
     3061 agttggttgg attttgtttg tttttttttt tttaaacagt ctctctgtgt aatcctggct
     3121 atcctgtagc ttgctgagtc gaccaggctg tcatcaaact ctgagaaata ctactgcctt
     3181 tgcctcccaa gtactgtctt aaaggcatct gacaccatgc atggctaata attcctccct
     3241 ccctccctcc ctccctccct ccctctttct ttctttcttt ctttctttct ttctttcttt
     3301 ctttctttct ttctttcttt ctttctttct ttctatgatg tatttcttga tgttagttca
     3361 gctgtgtaag gaaatttgct tcagcctgat tgaaagaaca ttaactcata catttctgag
     3421 ttagaacaaa tgtttctctt tgacatggtg atacatgcct ctaatcctag cacttgaaaa
     3481 ccagagggat ggggattgct gcaagtttaa gccagtcaga gctgtgtgct gagaatttgt
     3541 ctccaaaaag aagccttatt cttgttgcat atatgttaaa gtagcctttc ccagccttga
     3601 ggatctgtta atgtaaaaac atgcttcagc aatagctttc actgaatata gcagttcatg
     3661 cctgtattcc caaaacttgg gagactgagg cagaaggatc accatgagtt ctggaataac
     3721 ctaggctaca gagtgagacc ctatctcaat atccctgccc cccaccctgc aaagaaacta
     3781 acagttttaa attcttcaac aattacaaag ttaaatggga aaaatctttt accattctct
     3841 tctagaattt tttctcagcg gtctaaagat cgtgtgatcc ctgtgagagg tagccactca
     3901 aggtgtacct cttagagttg tactgaggct caggctgtga acaccagtgt cagggtaact
     3961 taagtgtttg aagctgatgc tgacctccct gacagtagac aggccgacta cctcatctcg
     4021 ctgtggcact tttgtagtta ctgagatgct catcttatta accagtgcga tatttcctaa
     4081 gtgtccatct ttgctgaaag aaaaattata gtgtggtaag actctactca taattacagc
     4141 tctatatcag aatttgataa aaccttttgt ttctgtgaaa caattatttt taacattttt
     4201 cttttaaaag taacttttta tcagtacaga actatctaag ggatgactag cttatgaata
     4261 ttctgttaaa aggtagtttt ataaagaaaa gtgaaatatg tcttttatag tggtaaaact
     4321 aagtatttat atgaaagtca aaatcagtag cttttaatat acttcagact ggttgcttat
     4381 gatatatttt ctctggcttt tttattcttt tcaattttta ggtattaaca actgttaata
     4441 ttttcaaaat actgccatat gtgtagcttt gaaatgtgta ttaaatgagg acaagagagc
     4501 gacttgtata ctctgaaatg ctttgtatct ttcctttggt acttactaca ataaaaagaa
     4561 atttggaaag tagagatata taaagacttg ggaagagaat tatttagtgt gaaggaaaga
     4621 gaagagagta acaaaaaatt agggattgga atgtagagaa attatcactg tgttcttgtg
     4681 atgaacatca gtattcaaaa gtaactcata aaaagtttaa aatatatttg agttaaatag
     4741 ctaaaatgca actaatttat gctaaattag cataaataaa atttaagaag tatgcaagga
     4801 agtctcaatt aaatgaaaat gttaaaactc ttaacttgaa ttgtggaaca tttgaatagt
     4861 attaattcca gttgaaagac tgtctagtgc aggccttgat gcccacagct ttaatcccag
     4921 cactggggac acagaggcag ccgggtccct cagagttgga tgccaacctg gtctacaaag
     4981 tgagtttcag gccagccagg gctacacagt gagacctgtc tcaaaacaaa acaaaagaag
     5041 gaagaaagaa aaggaattga aagaaaagca gttggtatgg gggaactgtg cagagtttat
     5101 ttgtgagaca ggatggagct aaaagaatca agataaaata ttaaaattaa gaatttaggc
     5161 attgcctcag ggaaaaggca gcgagaggga accactttat tgctaatagc tcgtctggag
     5221 cagacgccag ctgctctggg agcctccagc acaaccagga agtgaacttg actttccatt
     5281 tctcctgggg ctttttagga cagacccttc tgctctttgt tagacctgca tcttgagtca
     5341 tgctacgatt gctaaaatat gctgaatgga ttatttttaa aagtttcttt gggtgttttt
     5401 tctatgaaga gttatatgtg atttttctga tatataactg tgtcagtggt ctaaataatg
     5461 aatggagggg atatgttaat ttaaagggga tctgatagga acattaaagg aagcttttag
     5521 tcagcctgtg gctagattta ttgatttggt aagcaaacct gtattgtttg ctgactttca
     5581 gctaatggct aactctggtc aaagaatggc ttttgcttaa ggttttgact tattataaat
     5641 aagattaaga atatcttagt aattaggaat cctttaaaac atagaacaaa tgtgcaaata
     5701 agactcatct ttttataaga aaaacacata agcctttatc acttattcat gagctaaagc
     5761 cattaagata aatcaaatta tcgacgttca atctctgaac tttggatcgt tttctagatc
     5821 catataatag agtacttctt tcctgtgaat ctgatgcttt gagatagatc tcttaccctc
     5881 ttttcattaa aagtatttgt catttttaac tacagtcaca atccagtagg caactatatt
     5941 tttattttgg cagagcaaat ttcagagtcc atacttaatt ataagacaat cctgaagaca
     6001 aaacaatgtt taaaatagcc tatttagcca ggtgtagtgg tacaggcctc tagtcccatc
     6061 acttgggact agatttctgt gagttccagg ccattgttac atcctgtctt gagaaaagaa
     6121 gacgatgaag acatgtaaag taatggctat ctagtggaaa aggctttagg acaaaactaa
     6181 cttcaagaca gtgtgtctat tttgtaattt tgaatggatt gctcaatcct aaatactcct
     6241 ttgccttaat ttcctgtgaa atgtaggtaa tggtcttggt ctcctgaatg ttcagtaaaa
     6301 ggtgtccctt ggatcatagt tgaaaataat agttgctgag tagctattca gtactagttg
     6361 agaatgacac atttttaaag tagcaccttt gtggggcata caaaatcata ttcacttgtc
     6421 tgtaataagc tttcttgact tgctctgata atggagataa tagaacaatt tgggtttatg
     6481 gtttaaaccc tacaattaga taattggagt ttcctcctgc ctttcagaag atctgtgtaa
     6541 actgatgttg gccttatttg gaaagataat cacatctgca ggaaataaag atcattttac
     6601 catggttata aatcaaatct aagctatcag acttaggagt catgatgtaa aactcaagaa
     6661 agtttattta aattatgctg gctttgctag aattggatac atttgtatga gccgagtatg
     6721 aaatatatac acttgaatat cagagtttaa tgatttcaca aagctatgtt gtcaatcatg
     6781 gtgtgtaacc catactgttt cttttcactt tctaatcttg acaaatattt ctgtaggttt
     6841 aaaatttttg atctaaataa attttcgctt aatatattaa atccaaaa
//
