LOCUS       NM_007707               2742 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus suppressor of cytokine signaling 3 (Socs3), mRNA.
ACCESSION   NM_007707
VERSION     NM_007707.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Delpech,C., Schaeffer,J., Vilallongue,N., Delaunay,A., Benadjal,A.,
            Blot,B., Excoffier,B., Plissonnier,E., Gascon,E., Albert,F.,
            Paccard,A., Saintpierre,A., Gasnier,C., Zagar,Y., Castellani,V.,
            Belin,S., Chedotal,A. and Nawabi,H.
  TITLE     Axon guidance during mouse central nervous system regeneration is
            required for specific brain innervation
  JOURNAL   Dev Cell 59 (24), 3213-3228 (2024)
   PUBMED   39353435
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Dellorusso,P.V., Proven,M.A., Calero-Nieto,F.J., Wang,X.,
            Mitchell,C.A., Hartmann,F., Amouzgar,M., Favaro,P., DeVilbiss,A.,
            Swann,J.W., Ho,T.T., Zhao,Z., Bendall,S.C., Morrison,S.,
            Gottgens,B. and Passegue,E.
  TITLE     Autophagy counters inflammation-driven glycolytic impairment in
            aging hematopoietic stem cells
  JOURNAL   Cell Stem Cell 31 (7), 1020-1037 (2024)
   PUBMED   38754428
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Gallo,R., Teijeiro,A., Angulo-Aguado,M. and Djouder,N.
  TITLE     IL-17A produced by POMC neurons regulates diet-induced obesity
  JOURNAL   iScience 27 (7), 110259 (2024)
   PUBMED   39027371
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Wang,T., Kaneko,S., Kriukov,E., Alvarez,D., Lam,E., Wang,Y., La
            Manna,S., Marasco,D., Fernandez-Gonzalez,A., Mitsialis,S.A.,
            Kourembanas,S., Stahl,A., Chen,M., Xu,H., Baranov,P., Cai,G., von
            Andrian,U.H. and Sun,Y.
  TITLE     SOCS3 regulates pathological retinal angiogenesis through
            modulating SPP1 expression in microglia and macrophages
  JOURNAL   Mol Ther 32 (5), 1425-1444 (2024)
   PUBMED   38504518
  REMARK    GeneRIF: SOCS3 regulates pathological retinal angiogenesis through
            modulating SPP1 expression in microglia and macrophages.
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Ahn,B.Y., Zhang,Y., Wei,S., Jeong,Y., Park,D.H., Lee,S.J.,
            Leem,Y.E. and Kang,J.S.
  TITLE     Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in
            postmenopausal cardiomyopathy
  JOURNAL   Exp Mol Med 56 (3), 711-720 (2024)
   PUBMED   38486105
  REMARK    GeneRIF: Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in
            postmenopausal cardiomyopathy.
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Minamoto,S., Ikegame,K., Ueno,K., Narazaki,M., Naka,T.,
            Yamamoto,H., Matsumoto,T., Saito,H., Hosoe,S. and Kishimoto,T.
  TITLE     Cloning and functional analysis of new members of STAT induced STAT
            inhibitor (SSI) family: SSI-2 and SSI-3
  JOURNAL   Biochem Biophys Res Commun 237 (1), 79-83 (1997)
   PUBMED   9266833
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Starr,R., Willson,T.A., Viney,E.M., Murray,L.J., Rayner,J.R.,
            Jenkins,B.J., Gonda,T.J., Alexander,W.S., Metcalf,D., Nicola,N.A.
            and Hilton,D.J.
  TITLE     A family of cytokine-inducible inhibitors of signalling
  JOURNAL   Nature 387 (6636), 917-921 (1997)
   PUBMED   9202125
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591433.6, AK152514.1 and BC052031.1.
            
            On Oct 9, 2009 this sequence version replaced NM_007707.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052031.1, AK152441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AL591433.6         145530-145709       c
            181-204             AK152514.1         1-24
            205-2742            BC052031.1         1-2538
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..2742
                     /gene="Socs3"
                     /gene_synonym="Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3"
                     /note="suppressor of cytokine signaling 3"
                     /db_xref="GeneID:12702"
                     /db_xref="MGI:MGI:1201791"
     exon            1..492
                     /gene="Socs3"
                     /gene_synonym="Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3"
                     /inference="alignment:Splign:2.1.0"
     exon            493..2732
                     /gene="Socs3"
                     /gene_synonym="Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..1258
                     /gene="Socs3"
                     /gene_synonym="Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3"
                     /note="CIS-3; cytokine inducible SH2-containing protein 3;
                     STAT-induced STAT inhibitor 3; E2a-Pbx1 target gene in
                     fibroblasts 10"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 3"
                     /protein_id="NP_031733.1"
                     /db_xref="CCDS:CCDS25697.1"
                     /db_xref="GeneID:12702"
                     /db_xref="MGI:MGI:1201791"
                     /translation="MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                     GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSF
                     SLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSLPPTEPSSEVPEQPPAQALPGST
                     PKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFL
                     DQYDAPL"
ORIGIN      
        1 cggcgggtcc tggaggcccc agctccaagc ccgccctccg cggcccctcc ctcgccctcc
       61 gcgcacagcc tttcagtgca gagtagtgac taaacattac aagaagaccg gccgggcagt
      121 tccaggaatc ggggggcggg gcgtactggc cgggtaaata cccgcgcgcg cggcctccga
      181 ggcggctcta actctgactc tacactcgcc tgctcttacg accgctgtct ctccgggctc
      241 ccggacgccc ccttcccggc ccagctctcc gtcgaggtcc ctcgcccagg tcctttgcct
      301 gattcgccca ggagtgcgcc tcatcggccc ggggagcagc gaagccagag ggggcgcacg
      361 cacggggagc ccctttgtag acttcacggc tgccaacatc tgggcgcagc gcgagccact
      421 gctggccgcc gcctcgcctc ggggaccata ggaggcgcag ccccaaggcc ggagatttcg
      481 cttcgggact agctccccgg gatgcggtag cggccgctgt gcggaggccg cgaagcagct
      541 gcagccaccg ccgcgcagat ccacgctggc tccgtgcgcc atggtcaccc acagcaagtt
      601 tcccgccgcc gggatgagcc gccccctgga caccagcctg cgcctcaaga ccttcagctc
      661 caaaagcgag taccagctgg tggtgaacgc cgtgcgcaag ctgcaggaga gcggattcta
      721 ctggagcgcc gtgaccggcg gcgaggcgaa cctgctgctc agcgccgagc ccgcgggcac
      781 ctttcttatc cgcgacagct cggaccagcg ccacttcttc acgttgagcg tcaagaccca
      841 gtcggggacc aagaacctac gcatccagtg tgaggggggc agcttttcgc tgcagagtga
      901 cccccgaagc acgcagccag ttccccgctt cgactgtgta ctcaagctgg tgcaccacta
      961 catgccgcct ccagggaccc cctccttttc tttgccaccc acggaaccct cgtccgaagt
     1021 tccggagcag ccacctgccc aggcactccc cgggagtacc cccaagagag cttactacat
     1081 ctattctggg ggcgagaaga ttccgctggt actgagccga cctctctcct ccaacgtggc
     1141 caccctccag catctttgtc ggaagactgt caacggccac ctggactcct atgagaaagt
     1201 gacccagctg cctggaccca ttcgggagtt cctggatcag tatgatgctc cactttaagg
     1261 agcaaaaggg tcagaggggg gcctgggtcg gtcggtcgcc tctcctccga ggcacatggc
     1321 acaagcacaa aaatccagcc ccaacggtcg gtagctccca gtgagccagg ggcagattgg
     1381 cttcttcctc aggccctcca ctcccgcaga gtagagctgg caggacctgg aattcgtctg
     1441 aggggagggg gagctgccac ctgctttccc ccctccccca gctccagctt ctttcaagtg
     1501 gagccagccg gcctggcctg gtgggacaat acctttgaca agcggactct cccctcccct
     1561 tcctccacac cccctctgct tcccaaggga ggtggggaca cctccaagtg ttgaacttag
     1621 aactgcaagg ggaatcttca aactttcccg ctggaacttg tttgcgcttt gatttggttt
     1681 gatcaagagc aggcacctgg gggaaggatg gaagagaaaa gggtgtgtga agggttttta
     1741 tgctggccaa agaaataacc actcccactg cccaacctag gtgaggagtg gtggctcctg
     1801 gctctgggga gagtggcaag gggtgacctg aagagagcta tactggtgcc aggctcctct
     1861 ccatggggca gctaatgaaa cctcgcagat cccttgcacc ccagaaccct ccccgttgtg
     1921 aagaggcagt agcatttaga agggagacag atgaggctgg tgagctggcc gccttttcca
     1981 acaccgaagg gaggcagatc aacagatgag ccatcttgga gcccaggttt ccctggagca
     2041 gatggagggt tctgctttgt ctctcctatg tggggctagg agactcgcct taaatgccct
     2101 ctgtcccagg gatggggatt ggcacacaag gagccaaaca cagccaatag gcagagagtt
     2161 gagggattca cccaggtggc tacaggccag gggaagtggc tgcaggggag agacccagtc
     2221 actcaggaga ctcctgagtt aacactggga agacattggc cagtcctagt catctctcgg
     2281 tcagtaggtc cgagagcctc caggccctgc acagccctcc cttctcacct ggggggaggc
     2341 aggaggtgat ggagaagcct tcccatgccg ctcacagggg cctcacggga atgcagcagc
     2401 catgcaatta cctggaactg gtcctgtgtt ggggagaaac aagttttctg aagtcaggta
     2461 tggggctggg tggggcagct gtgtgttggg gtggcttttt tctctctgtt ttgaataatg
     2521 tttacaattt gcctcaatca cttttataaa aatccacctc cagcccgccc ctctccccac
     2581 tcaggccttc gaggctgtct gaagatgctt gaaaaactca accaaatccc agttcaactc
     2641 agactttgca catatattta tatttatact cagaaaagaa acatttcagt aatttataat
     2701 aaaagagcac tattttttaa tgaaaaaaaa aaaaaaaaaa aa
//
