LOCUS       NM_007706               2222 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus suppressor of cytokine signaling 2 (Socs2), transcript
            variant 1, mRNA.
ACCESSION   NM_007706
VERSION     NM_007706.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2222)
  AUTHORS   Guzylack-Piriou,L., Gausseres,B., Tasca,C., Hassel,C., Tabouret,G.
            and Foucras,G.
  TITLE     A loss of function mutation in SOCS2 results in increased
            inflammatory response of macrophages to TLR ligands and
            Staphylococcus aureus
  JOURNAL   Front Immunol 15, 1397330 (2024)
   PUBMED   39185412
  REMARK    GeneRIF: A loss of function mutation in SOCS2 results in increased
            inflammatory response of macrophages to TLR ligands and
            Staphylococcus aureus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2222)
  AUTHORS   Ivanova,E., Hue-Beauvais,C., Castille,J., Laubier,J., Le
            Guillou,S., Aujean,E., Lecardonnel,J., Lebrun,L., Jaffrezic,F.,
            Rousseau-Ralliard,D., Pechoux,C., Letheule,M., Foucras,G.,
            Charlier,M. and Le Provost,F.
  TITLE     Mutation of SOCS2 induces structural and functional changes in
            mammary development
  JOURNAL   Development 151 (6) (2024)
   PUBMED   38391249
  REMARK    GeneRIF: Mutation of SOCS2 induces structural and functional
            changes in mammary development.
REFERENCE   3  (bases 1 to 2222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2222)
  AUTHORS   Santos,M.R.G., Chaves,I.M., Queiroz-Junior,C.M., Cramer,A.T.,
            Anestino,T.A., Dos Santos,A.C.P.M., Leite,P.G., Macari,S.,
            Barrioni,B.R., Pereira,M.M., Teixeira,M.M., de Souza,D.D.G.,
            Madeira,M.F.M. and Machado,F.S.
  TITLE     SOCS2 regulates alveolar bone loss in Aggregatibacter
            actinomycetemcomitans-induced periodontal disease
  JOURNAL   Inflamm Res 72 (4), 859-873 (2023)
   PUBMED   36912916
  REMARK    GeneRIF: SOCS2 regulates alveolar bone loss in Aggregatibacter
            actinomycetemcomitans-induced periodontal disease.
REFERENCE   5  (bases 1 to 2222)
  AUTHORS   Cabrera-Galvan,J.J., Araujo,E., de Mirecki-Garrido,M.,
            Perez-Rodriguez,D., Guerra,B., Aranda-Tavio,H.,
            Guerra-Rodriguez,M., Brito-Casillas,Y., Melian,C.,
            Martinez-Martin,M.S., Fernandez-Perez,L. and Recio,C.
  TITLE     SOCS2 protects against chemical-induced hepatocellular carcinoma
            progression by modulating inflammation and cell proliferation in
            the liver
  JOURNAL   Biomed Pharmacother 157, 114060 (2023)
   PUBMED   36455458
REFERENCE   6  (bases 1 to 2222)
  AUTHORS   Dilts,R.B., Famula,T.R. and Bradford,G.E.
  TITLE     Ovulation rate and pre- and postimplantation survival in mice with
            a major gene for rapid postweaning gain
  JOURNAL   J Anim Sci 69 (9), 3590-3596 (1991)
   PUBMED   1938644
REFERENCE   7  (bases 1 to 2222)
  AUTHORS   Medrano,J.F., Pomp,D., Sharrow,L., Bradford,G.E., Downs,T.R. and
            Frohman,L.A.
  TITLE     Growth hormone and insulin-like growth factor-I measurements in
            high growth (hg) mice
  JOURNAL   Genet Res 58 (1), 67-74 (1991)
   PUBMED   1936984
REFERENCE   8  (bases 1 to 2222)
  AUTHORS   Calvert,C.C., Famula,T.R., Bernier,J.F., Khalaf,N. and
            Bradford,G.E.
  TITLE     Efficiency of growth in mice with a major gene for rapid
            postweaning gain
  JOURNAL   J Anim Sci 62 (1), 77-85 (1986)
   PUBMED   3957811
REFERENCE   9  (bases 1 to 2222)
  AUTHORS   Bradford,G.E.
  TITLE     Growth and reproduction in mice selected for rapid body weight gain
  JOURNAL   Genetics 69 (4), 499-512 (1971)
   PUBMED   5168371
REFERENCE   10 (bases 1 to 2222)
  AUTHORS   Bradford,G.E.
  TITLE     Selection for litter size in mice in the presence and absence of
            gonadotropin treatment
  JOURNAL   Genetics 58 (2), 283-295 (1968)
   PUBMED   5664389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY069559.1, AK137403.1 and AC167222.4.
            
            On Dec 12, 2009 this sequence version replaced NM_007706.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137403.1, AK162591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BY069559.1         1-121
            122-1679            AK137403.1         2-1559
            1680-1697           AC167222.4         132769-132786       c
            1698-2222           AK137403.1         1577-2101
FEATURES             Location/Qualifiers
     source          1..2222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 49.35 cM"
     gene            1..2222
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /note="suppressor of cytokine signaling 2"
                     /db_xref="GeneID:216233"
                     /db_xref="MGI:MGI:1201787"
     exon            1..240
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..601
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1059
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /note="CIS-2; cytokine inducible SH2-containing protein 2;
                     cytokine-inducible SH2 protein 2; STAT-induced STAT
                     inhibitor 2"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 2"
                     /protein_id="NP_031732.1"
                     /db_xref="CCDS:CCDS24136.1"
                     /db_xref="GeneID:216233"
                     /db_xref="MGI:MGI:1201787"
                     /translation="MTLRCLEPSGNGADRTRSQWGTAGLPEEQSPEAARLAKALRELS
                     QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDG
                     KFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSA
                     PTLQHFCRLAINKCTGTIWGLPLPTRLKDYLEEYKFQV"
     exon            602..2222
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /note="hexamer: AATAAA"
     regulatory      2192..2197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /note="hexamer: AACAAA"
     polyA_site      2208
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
                     /note="major polyA site"
     polyA_site      2211
                     /gene="Socs2"
                     /gene_synonym="8030460M17; CIS2; Cish2; D130043N08Rik; hg;
                     JAB; SOCS-2; SSI-2"
ORIGIN      
        1 ggagcgaggg aggcgcgtcg ggctgggaag tcgcgcgcac actcggctcc ggggacagac
       61 ggttaactct tgccaagtct cgccgcctct gcggctcccg ggccttgggc ttcccccctg
      121 aagcatgagc ctttcctccc gcagccgcca acgctgcgcg ggtctcggac agtgcgcgcc
      181 gggactccag gcgcgcgccc tcaagatccc ttgtgcccgg agcccggaag cttgcggcag
      241 gcgatctgtg ggtgacagtg tctgcgagag actttgccac accattctgc cggaatttgg
      301 agaaaaagaa ccagccgctt ccagtcccct ccccctccgc caccatttcg gacaccctgc
      361 acactctcgt tttggggtac cctgtgactt ccaggcagca cgcgaggtcc actggcccca
      421 gctcgggcga ccagctgtct gggacgtgtt gactcatctc ccatgaccct gcggtgcctg
      481 gagccctccg ggaatggagc ggacaggacg cggagccagt gggggaccgc ggggttgccg
      541 gaggaacagt cccccgaggc ggcgcgtctg gcgaaagccc tgcgcgagct cagtcaaaca
      601 ggatggtact ggggaagtat gactgttaat gaagccaaag agaaattaaa agaggctcca
      661 gaaggaactt tcttgattag agatagttcg cattcagact acctactaac tatatccgtt
      721 aagacgtcag ctggaccgac taacctgcgg attgagtacc aagatgggaa attcagattg
      781 gattctatca tatgtgtcaa gtccaagctt aaacagtttg acagtgtggt tcatctgatt
      841 gactactatg tccagatgtg caaggataaa cggacaggcc cagaagcccc acggaatggg
      901 actgttcacc tgtacctgac caaacctctg tatacatcag cacccactct gcagcatttc
      961 tgtcgactcg ccattaacaa atgtaccggt acgatctggg gactgccttt accaacaaga
     1021 ctaaaagatt acttggaaga atataaattc caggtataag tatttctctc tctttttcgt
     1081 ttttttttaa aaaaaaaaaa aacacatgcc tcatatagac tatctccgaa tgcagctatg
     1141 tgaaagagaa cccagaggcc ctcctctgga taactgcgca gaattctctc ttaaggacag
     1201 ttgggctcag tctaacttaa aggtgtgaag atgtagctag gtattttaaa gttcccctta
     1261 ggtagtttta gctgaatgat gctttctttc ctatggctgc tcaagatcaa atggcccttt
     1321 taaatgaaac aaaacaaaac aaaacaaaac aaaacaaaaa caaaatgtcc caaggaaagg
     1381 caagagaata ttcctgtcag aatgacttgc ctttgttttt tgggttccta tgcactgggt
     1441 caaaagtcca agctccatag gagagaaaga aaggcttcca tttccaggag gacagctgaa
     1501 ggagggaaag accctggctg acccaggctt cagctccact tctagacgcc tggggttcag
     1561 tctgtgttag aacctgttat agtttgcatc ctgatgtatc tagtaggagt tccgttaagc
     1621 tgaccatgct tgtatttatc cctcgtctta tgcaactaat caaatcaacc aaaaaaagga
     1681 aaaaaaaaaa aaaaaaagaa acgaaaaaag aaccatcacc atgagatcct gtatttgtct
     1741 ttttttacta cacgtatgac ctcccccgtg agtgagtact gtagtcctcc atctcaaggc
     1801 agccttactt cagacacatt tcaaactggt gcaaacagaa aagacttctc tcttttcttc
     1861 tgaggctaaa gacaagaatg tcacgctata caggtgcaac tcaatccttg aaaacagaaa
     1921 ccaatgcaga cagagacatt ttaccccttg atgtagctgt gagtcccaac ctagtgccat
     1981 tgtttttatt tttattttta tttttggaaa tggctttaga actttccaag ttatccttga
     2041 attgtctgac cacggacatc aacagctgcc tcccttctac catgtagaat cctatgactt
     2101 aacttttctt ccagatatag aggggtacct gcctgttttt caaagtgttt atttactgct
     2161 gttactattt gattagaatg tatcaaataa aaacaaacct gacttttaca agttgcactc
     2221 at
//
