LOCUS       NM_009896               1220 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript
            variant 2, mRNA.
ACCESSION   NM_009896 XM_619417
VERSION     NM_009896.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Yu,J., Mei,J., Zuo,D., Zhang,M., Yu,S., Li,F., Wang,J., Bi,D.,
            Ma,S., Wang,J. and Yin,Z.J.
  TITLE     Inflammatory factor-mediated miR-155/SOCS1 signaling axis leads to
            Treg impairment in systemic lupus erythematosus
  JOURNAL   Int Immunopharmacol 141, 113013 (2024)
   PUBMED   39213866
  REMARK    GeneRIF: Inflammatory factor-mediated miR-155/SOCS1 signaling axis
            leads to Treg impairment in systemic lupus erythematosus.
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Li,X., Sun,H., Zhang,L., Liang,H., Zhang,B., Yang,J., Peng,X.,
            Sun,J., Zhou,Y., Zhai,M., Jiang,L., Zhu,H. and Duan,W.
  TITLE     GDF15 attenuates sepsis-induced myocardial dysfunction by
            inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling
            pathway
  JOURNAL   Eur J Pharmacol 982, 176894 (2024)
   PUBMED   39147013
  REMARK    GeneRIF: GDF15 attenuates sepsis-induced myocardial dysfunction by
            inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling
            pathway.
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   He,C., Wang,T., Han,Y., Zuo,C. and Wang,G.
  TITLE     Jun-activated SOCS1 enhances ubiquitination and degradation of
            CCAAT/enhancer-binding protein beta to ameliorate cerebral
            ischaemia/reperfusion injury
  JOURNAL   J Physiol 602 (19), 4959-4985 (2024)
   PUBMED   39197117
  REMARK    GeneRIF: Jun-activated SOCS1 enhances ubiquitination and
            degradation of CCAAT/enhancer-binding protein beta to ameliorate
            cerebral ischaemia/reperfusion injury.
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Miao,M., Pan,M., Chen,X., Shen,J., Zhang,L., Feng,X., Chen,M.,
            Cui,G., Zong,H., Zhang,W., Chang,S., Xu,F., Wang,Z., Li,D., Liu,W.,
            Ding,Z., Zhang,S., Chen,B., Zha,X. and Fan,X.
  TITLE     IL-13 facilitates ferroptotic death in asthmatic epithelial cells
            via SOCS1-mediated ubiquitinated degradation of SLC7A11
  JOURNAL   Redox Biol 71, 103100 (2024)
   PUBMED   38484644
  REMARK    GeneRIF: IL-13 facilitates ferroptotic death in asthmatic
            epithelial cells via SOCS1-mediated ubiquitinated degradation of
            SLC7A11.
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Gregorieff,A., Pyronnet,S., Sonenberg,N. and Veillette,A.
  TITLE     Regulation of SOCS-1 expression by translational repression
  JOURNAL   J Biol Chem 275 (28), 21596-21604 (2000)
   PUBMED   10764816
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Schluter,G., Boinska,D. and Nieman-Seyde,S.C.
  TITLE     Evidence for translational repression of the SOCS-1 major open
            reading frame by an upstream open reading frame
  JOURNAL   Biochem Biophys Res Commun 268 (2), 255-261 (2000)
   PUBMED   10679190
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Masuhara,M., Sakamoto,H., Matsumoto,A., Suzuki,R., Yasukawa,H.,
            Mitsui,K., Wakioka,T., Tanimura,S., Sasaki,A., Misawa,H.,
            Yokouchi,M., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of novel CIS family genes
  JOURNAL   Biochem Biophys Res Commun 239 (2), 439-446 (1997)
   PUBMED   9344848
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   Naka,T., Narazaki,M., Hirata,M., Matsumoto,T., Minamoto,S.,
            Aono,A., Nishimoto,N., Kajita,T., Taga,T., Yoshizaki,K., Akira,S.
            and Kishimoto,T.
  TITLE     Structure and function of a new STAT-induced STAT inhibitor
  JOURNAL   Nature 387 (6636), 924-929 (1997)
   PUBMED   9202127
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Endo,T.A., Masuhara,M., Yokouchi,M., Suzuki,R., Sakamoto,H.,
            Mitsui,K., Matsumoto,A., Tanimura,S., Ohtsubo,M., Misawa,H.,
            Miyazaki,T., Leonor,N., Taniguchi,T., Fujita,T., Kanakura,Y.,
            Komiya,S. and Yoshimura,A.
  TITLE     A new protein containing an SH2 domain that inhibits JAK kinases
  JOURNAL   Nature 387 (6636), 921-924 (1997)
   PUBMED   9202126
REFERENCE   10 (bases 1 to 1220)
  AUTHORS   Starr,R., Willson,T.A., Viney,E.M., Murray,L.J., Rayner,J.R.,
            Jenkins,B.J., Gonda,T.J., Alexander,W.S., Metcalf,D., Nicola,N.A.
            and Hilton,D.J.
  TITLE     A family of cytokine-inducible inhibitors of signalling
  JOURNAL   Nature 387 (6636), 917-921 (1997)
   PUBMED   9202125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010583.8 and AF120490.1.
            
            On Feb 8, 2006 this sequence version replaced NM_009896.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF120490.1, U88325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 10764816
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CT010583.8         75138-75164         c
            28-1220             AF120490.1         1-1193
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.81 cM"
     gene            1..1220
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /note="suppressor of cytokine signaling 1"
                     /db_xref="GeneID:12703"
                     /db_xref="MGI:MGI:1354910"
     exon            1..106
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      51..155
                     /regulatory_class="uORF"
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10764816]"
                     /note="this uORF is predicted to encode a 34 aa peptide
                     (PMID:10764816)"
     exon            107..1220
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      123..155
                     /regulatory_class="uORF"
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10764816]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:10764816)"
     CDS             157..795
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /note="cytokine inducible SH2-containing protein 1;
                     cytokine inducible SH2-containing protein 7; JAK2-binding
                     protein; STAT-induced STAT inhibitor 1"
                     /codon_start=1
                     /product="suppressor of cytokine signaling 1"
                     /protein_id="NP_034026.1"
                     /db_xref="CCDS:CCDS27952.1"
                     /db_xref="GeneID:12703"
                     /db_xref="MGI:MGI:1354910"
                     /translation="MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCP
                     AVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTF
                     LVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPR
                     RMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="Socs1"
                     /gene_synonym="Cish1; Cish7; JAB; SOCS-1; SSI-1"
                     /note="major polyA site"
ORIGIN      
        1 agcagagaga actgcggccg tggcagcggc acggctccca gccccggagc atgcgcgaca
       61 gccgccccgg agcccccagc cgcggctccc cgcgtcctgc cgccagcgca gccccggacg
      121 ctatggccca cccctccagc tggcccctcg agtaggatgg tagcacgcaa ccaggtggca
      181 gccgacaatg cgatctcccc ggcagcagag ccccgacggc ggtcagagcc ctcctcgtcc
      241 tcgtcttcgt cctcgccagc ggcccccgtg cgtccccggc cctgcccggc ggtcccagcc
      301 ccagcccctg gcgacactca cttccgcacc ttccgctccc actccgatta ccggcgcatc
      361 acgcggacca gcgcgctcct ggacgcctgc ggcttctatt ggggacccct gagcgtgcac
      421 ggggcgcacg agcggctgcg tgccgagccc gtgggcacct tcttggtgcg cgacagtcgc
      481 caacggaact gcttcttcgc gctcagcgtg aagatggctt cgggccccac gagcatccgc
      541 gtgcacttcc aggccggccg cttccacttg gacggcagcc gcgagacctt cgactgcctt
      601 ttcgagctgc tggagcacta cgtggcggcg ccgcgccgca tgttgggggc cccgctgcgc
      661 cagcgccgcg tgcggccgct gcaggagctg tgtcgccagc gcatcgtggc cgccgtgggt
      721 cgcgagaacc tggcgcgcat ccctcttaac ccggtactcc gtgactacct gagttccttc
      781 cccttccaga tctgaccggc tgccgctgtg ccgcagcatt aagtgggggc gccttattat
      841 ttcttattat taattattat tatttttctg gaaccacgtg ggagccctcc ccgcctgggt
      901 cggagggagt ggttgtggag ggtgagatgc ctcccacttc tggctggaga cctcatccca
      961 cctctcaggg gtgggggtgc tcccctcctg gtgctccctc cgggtccccc ctggttgtag
     1021 cagcttgtgt ctggggccag gacctgaatt ccactcctac ctctccatgt ttacatattc
     1081 ccagtatctt tgcacaaacc aggggtcggg gagggtctct ggcttcattt ttctgctgtg
     1141 cagaatatcc tattttatat ttttacagcc agtttaggta ataaacttta ttatgaaagt
     1201 ttttttttaa aagaaacaaa
//
