LOCUS       NM_025664               3338 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus sorting nexin 9 (Snx9), mRNA.
ACCESSION   NM_025664 XM_973143 XM_984215
VERSION     NM_025664.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Kawasaki,T., Sugihara,F., Fukushima,K., Matsuki,T., Nabeshima,H.,
            Machida,T., Mitsui,Y., Fujimura,S., Sagawa,R., Gaheun,L.,
            Kuniyoshi,K., Tanaka,H., Narazaki,M., Kumanogoh,A., Akira,S. and
            Satoh,T.
  TITLE     Loss of FCHSD1 leads to amelioration of chronic obstructive
            pulmonary disease
  JOURNAL   Proc Natl Acad Sci U S A 118 (26) (2021)
   PUBMED   34168078
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Liu,C., Zhai,X., Du,H., Cao,Y., Cao,H., Wang,Y., Yu,X., Gao,J. and
            Xu,Z.
  TITLE     Sorting nexin 9 (SNX9) is not essential for development and
            auditory function in mice
  JOURNAL   Oncotarget 7 (42), 68921-68932 (2016)
   PUBMED   27655699
  REMARK    GeneRIF: Snx9-deficient mice do not show defects in development as
            well as auditory function, suggesting that SNX9 is not essential
            for mice development and hearing
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Nandez,R., Balkin,D.M., Messa,M., Liang,L., Paradise,S., Czapla,H.,
            Hein,M.Y., Duncan,J.S., Mann,M. and De Camilli,P.
  TITLE     A role of OCRL in clathrin-coated pit dynamics and uncoating
            revealed by studies of Lowe syndrome cells
  JOURNAL   Elife 3, e02975 (2014)
   PUBMED   25107275
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Cao,H., Yin,X., Cao,Y., Jin,Y., Wang,S., Kong,Y., Chen,Y., Gao,J.,
            Heller,S. and Xu,Z.
  TITLE     FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and
            cuticular plate and regulate actin polymerization in vitro
  JOURNAL   PLoS One 8 (2), e56516 (2013)
   PUBMED   23437151
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Schimenti,J.C., Reynolds,J.L. and Planchart,A.
  TITLE     Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated
            male mouse sterility but not transmission ratio distortion
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3342-3347 (2005)
   PUBMED   15722415
REFERENCE   7  (bases 1 to 3338)
  AUTHORS   MaCaulay,S.L., Stoichevska,V., Grusovin,J., Gough,K.H.,
            Castelli,L.A. and Ward,C.W.
  TITLE     Insulin stimulates movement of sorting nexin 9 between cellular
            compartments: a putative role mediating cell surface receptor
            expression and insulin action
  JOURNAL   Biochem J 376 (Pt 1), 123-134 (2003)
   PUBMED   12917015
REFERENCE   8  (bases 1 to 3338)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168063.3 and AK155830.1.
            
            On Feb 9, 2019 this sequence version replaced NM_025664.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170339.1, AK155830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC168063.3         83298-83319
            23-2596             AK155830.1         2-2575
            2597-3338           AC168063.3         173189-173930
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.51 cM"
     gene            1..3338
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /note="sorting nexin 9"
                     /db_xref="GeneID:66616"
                     /db_xref="MGI:MGI:1913866"
     exon            1..223
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1999
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /codon_start=1
                     /product="sorting nexin-9"
                     /protein_id="NP_079940.2"
                     /db_xref="CCDS:CCDS57041.1"
                     /db_xref="GeneID:66616"
                     /db_xref="MGI:MGI:1913866"
                     /translation="MATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKN
                     NKGEQGLVPTDYVEILPNDGKDPFSCGNSVADQAFLDSLTASTAQTNSSSANSNNQVG
                     GGNDPWTAWNAPKPGNWDSSDAWGSRTDGTSAQRNSSANNWDTGFGHPQAYQGPATGD
                     DDEWDEDWDDPKSSSPYFKDSEPAEAGGIQRGNSRAGASSMKLPLNKFPGFAKPGMEQ
                     YLLAKQLAKPKEKIAIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTP
                     TNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAW
                     MTRMCRHPVVSESEVFQQFLNFRDEKEWKTGKRKAEKDELVGVMIFSTMEPEAPDLDL
                     IEIEQKCDAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLAAVFS
                     SSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIG
                     AHKGAIEKVKESDKLVATSKITPQDKQTMVKRVGTMSYALQAEMNHFHSNRIYDYNSV
                     IRLYLEQQVQFYETIAEKLRQALSRFPVM"
     exon            224..310
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..385
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..511
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..680
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..831
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..916
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1042
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1160
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1291
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1395
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1499
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1577
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1654
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1744
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1859
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1951
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3338
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3315..3320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /note="hexamer: AATAAA"
     polyA_site      3338
                     /gene="Snx9"
                     /gene_synonym="2700073N08Rik; SDP1; SH3PX1"
                     /note="major polyA site"
ORIGIN      
        1 agccgggact ttcaggaact gcaggcgcgg gcggcggcgg gagtcgccga gccgcggggg
       61 ccggagcgcc gagagcagga ctgaggcgga gccgccgcgc cgggccgcag ccaccgaacc
      121 gcagacggag tcgacctccc cgcccgctta gggccgaagc tccgcagcac gggagaccag
      181 ccggcccgcc ggggccgggg aaccgcccgc catggccacc aaggctcggg tcatgtacga
      241 ctttgctgct gagcctggaa acaatgagct gaccgttact gaaggagaaa tcatcacagt
      301 tacaaacccg aatgttggtg gaggatggct ggaaggaaag aacaacaaag gagagcaggg
      361 gcttgttcct actgactacg tggaaatttt accaaacgat ggaaaagatc cgttttcttg
      421 tgggaattca gtagccgacc aagctttcct cgattccctg acagctagca cagctcaaac
      481 caactcatct tctgccaaca gcaataacca ggttggtggt ggcaatgacc cctggacagc
      541 ctggaatgct cccaaacctg ggaactggga cagctccgat gcctggggct ccaggacaga
      601 cggaactagc gctcagagga acagcagcgc caacaactgg gacacgggct ttggccaccc
      661 acaggcctac caaggaccag caactggtga tgatgacgaa tgggatgaag actgggacga
      721 ccccaagtcc tcctcacctt acttcaagga ttcagaacca gctgaagcag ggggcatcca
      781 gcggggaaac agtcgtgcgg gtgcctcctc catgaagctg ccccttaaca aatttcctgg
      841 atttgcaaaa cctggcatgg agcagtactt gttggccaag cagctagcaa aacccaaaga
      901 gaaaatcgcc atcatcgttg gagattatgg ccctatgtgg gtttatccta cctctacgtt
      961 tgactgtgtg gtagctgatc cccggaaagg ttccaaaatg tacggtctga agagctacat
     1021 tgagtatcag ctaacaccca ctaacactaa ccgatctgta aaccacagat ataagcactt
     1081 tgattggtta tatgagcgtc tcctggttaa gtttgggtct gccattccga tcccttctct
     1141 tccagacaag caggtcacag gtcgctttga agaggaattt atcaaaatgc ggatggagcg
     1201 gctccaggcc tggatgacca ggatgtgccg gcacccggtg gtgtcagaaa gtgaagtttt
     1261 ccagcagttc ctgaatttcc gagatgagaa ggaatggaag actggaaaga ggaaggctga
     1321 gaaagacgaa ctggtgggag tgatgatatt ttccaccatg gaaccagagg ctcctgactt
     1381 ggatttgata gaaatagaac agaagtgtga cgctgtgggg aagttcacca aggccatgga
     1441 tgacggcgtg aaggagctgc tgacggtggg gcaggagcac tggaagcgct gcacagggcc
     1501 cttacccaag gagtatcaga agatagggaa ggctctgcag agcttagcgg cagtgttcag
     1561 ctccagcggt tatcaaggag agaccgacct taacgatgca atcacagaag ctgggaagac
     1621 gtatgaggag atcgccagcc ttgtggcaga gcagccaaag aaggacctcc acttcctgat
     1681 ggagtgcaac catgagtaca aaggctttct cggctgcttc ccggacatca ttggtgccca
     1741 caagggagca atagaaaaag tgaaagaaag tgataagctg gttgcaacta gtaaaattac
     1801 tccccaagac aagcagacca tggtgaagag agttggcacc atgtcttacg ctctgcaagc
     1861 tgagatgaat cactttcaca gtaaccggat ctatgattac aacagtgtca tccgcctcta
     1921 cctggagcag caagtgcagt tctatgaaac aatcgcagaa aagctgaggc aggccctcag
     1981 ccgcttcccg gttatgtaaa ccagaatgga acacaagaga actccgaagt gcttcattta
     2041 cctggggcaa tgcgattcaa ttccctcccc tccccgcccc ccatcataag agagagaaaa
     2101 ggaagaaaac caaaaagaaa gaagttgaca aaccctgttt tggtcgttag ccacctacgt
     2161 gcgctgttgc ccaggatggc ctttcttgtt catttcagcc tattagttac ccagtgaaaa
     2221 tgtctatttt tggaaaatac ttaaatttat caagattttg aatgaagaaa taggggttct
     2281 tcctcctggt attttacata gaatcgtaat ttatatatta cctgtgatct tccagttctt
     2341 acccaatgtc agataattaa tactaattgc tttcttaaaa atatgaaaaa cggcagaata
     2401 aaaagtatat ctttgtatat ttttataact ctttcagtcc tttggggatc gttgtctgtt
     2461 tgggggagtc tgtacaccct cactggcata gctacagtta agtgctcccg ggatagggaa
     2521 atagagtcct cagatcacct acaccctcaa acttggtggt gggtagccca tcagaggtcc
     2581 cagtaggtgg gcacagcagg caagaagacc ctgcctccct actgctgccc aggttggttc
     2641 cctgtgctga ggtaaattca gcattctttg cactccctcc tagctcatag cacaggtgga
     2701 agctcccacc ctcgcacgca cgctctccat ccctcagcgg ctgagaggag aggagctgtg
     2761 gcctggtttg gagcagcagg ctggtcagta ttctctcaga agcagagttc agcgcctgtt
     2821 ccctcccaca gactgggaaa gttaaggact agagtaagtg ggaggacatg cggtagcaag
     2881 ctggtgacaa gcagagaatg gctctgtctg tgactgtgtc ccagccttca tgactggaga
     2941 gcacagagcg cacgccatct cctccctgca gacacagtgg tccccttcca cagttgcctt
     3001 atgatgtgac cctctgctgc cactttcctg acctgacgtt atattataga gatgggaagt
     3061 ctgggccaac agaaatgaat gaaaccaaaa ataagtagct gagaaaatcc aatgagcgtg
     3121 agcatgacaa cttcctgtcc ttgacatcag ggctttgtta atgttttcta agtcattttt
     3181 ccctacctga cttttctttt atacaattcc atagaacagt gtttatgata cagccattta
     3241 atatatgtac aaattgtaaa gaacatgtat aaatatttta cataaatgtg agagcatgta
     3301 gaaaccaata tataaataaa ttgtttttaa aaactgta
//
