LOCUS       NM_172277               2683 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus sorting nexin 8 (Snx8), mRNA.
ACCESSION   NM_172277 NM_178018
VERSION     NM_172277.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Hu,Y., He,W., Huang,Y., Xiang,H., Guo,J., Che,Y., Cheng,X., Hu,F.,
            Hu,M., Ma,T., Yu,J., Tian,H., Tian,S., Ji,Y.X., Zhang,P., She,Z.G.,
            Zhang,X.J., Huang,Z., Yang,J. and Li,H.
  TITLE     Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8
            as a Therapeutic Target for NAFLD
  JOURNAL   Hepatology 74 (5), 2508-2525 (2021)
   PUBMED   34231239
  REMARK    GeneRIF: Fatty Acid Synthase-Suppressor Screening Identifies
            Sorting Nexin 8 as a Therapeutic Target for NAFLD.
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Guo,W., Wei,J., Zhong,X., Zang,R., Lian,H., Hu,M.M., Li,S.,
            Shu,H.B. and Yang,Q.
  TITLE     SNX8 modulates the innate immune response to RNA viruses by
            regulating the aggregation of VISA
  JOURNAL   Cell Mol Immunol 17 (11), 1126-1135 (2020)
   PUBMED   31511639
  REMARK    GeneRIF: SNX8 modulates the innate immune response to RNA viruses
            by regulating the aggregation of VISA.
            Erratum:[Cell Mol Immunol. 2021 Jun;18(6):1613-1614. doi:
            10.1038/s41423-021-00682-z.. PMID: 33958747]
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Wei,J., Guo,W., Lian,H., Yang,Q., Lin,H., Li,S. and Shu,H.B.
  TITLE     SNX8 mediates IFNgamma-triggered noncanonical signaling pathway and
            host defense against Listeria monocytogenes
  JOURNAL   Proc Natl Acad Sci U S A 114 (49), 13000-13005 (2017)
   PUBMED   29180417
  REMARK    GeneRIF: SNX8 mediates IFNG-triggered non-canonical signaling
            pathway and host defense against Listeria monocytogenes.
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Van Dyck,F., Braem,C.V., Chen,Z., Declercq,J., Deckers,R.,
            Kim,B.M., Ito,S., Wu,M.K., Cohen,D.E., Dewerchin,M., Derua,R.,
            Waelkens,E., Fiette,L., Roebroek,A., Schuit,F., Van de Ven,W.J. and
            Shivdasani,R.A.
  TITLE     Loss of the PlagL2 transcription factor affects lacteal uptake of
            chylomicrons
  JOURNAL   Cell Metab 6 (5), 406-413 (2007)
   PUBMED   17983586
REFERENCE   8  (bases 1 to 2683)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131670.5 and AK148429.1.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_172277.4.
            
            On Sep 13, 2016 this sequence version replaced NM_172277.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.264084.1, AK148429.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC131670.5         104353-104421       c
            70-1754             AK148429.1         2-1686
            1755-2683           AC131670.5         55406-56334         c
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.95 cM"
     gene            1..2683
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /note="sorting nexin 8"
                     /db_xref="GeneID:231834"
                     /db_xref="MGI:MGI:2443816"
     exon            1..161
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1447
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /codon_start=1
                     /product="sorting nexin-8"
                     /protein_id="NP_758481.1"
                     /db_xref="CCDS:CCDS39356.1"
                     /db_xref="GeneID:231834"
                     /db_xref="MGI:MGI:2443816"
                     /translation="MTGRAMDPLPSPAVAAAAEAEADEEADPPATGPRTSQVTEWRAL
                     DPGRMQMPQGNPLLLSYTLQELLAKDTVQVELIPEKKGLFLKHVEYEVSSQRFKSSVY
                     RRYNDFVVFHEVLLHKFPYRMVPALPPKRVLGADREFIEGRRRALKRFINLVARHPPF
                     SEDVLLKLFLSFSGSDVQHKLKEAAQCVGDEFMNCKLAARAKDFLPADIQTQFAMSRE
                     LIRNVYNSFYKLRDRAERIASRAIDNAADLLIFGKELSALGSDTTPLPSWAALHLSTW
                     GSLKQALKGLSVEFALLADRAAQQGKKEENDVVEKLNLFLDLLQSYKDLCERHEKGVL
                     HKHQRALHKYGLMKRQMMSAAHGREPESVEQLESRIVEQENVIQTMELRNYFSLYCLH
                     QETQLVHVYLPLTSHILGAFVNSQIQGHKEMSKVWNDLKPKLSCLFAGPHSVLTPPRS
                     PQEDGVCPH"
     exon            162..352
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            353..470
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            471..592
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            593..673
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            674..834
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..967
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1036
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1183
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1333
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2683
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2675
                     /gene="Snx8"
                     /gene_synonym="B130023O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagagctggc gtgggcgggg ctggccgggc gggcgcggga ggaagtcacg tgggcgagcg
       61 ggctcacatg actggccgcg cgatggaccc gctgccctcg ccggcagtcg ctgcagctgc
      121 tgaggcggag gctgacgagg aggcggatcc gccggcgaca ggcccacgaa catcccaggt
      181 cactgagtgg agggccctgg accccgggcg aatgcagatg ccgcagggga acccactgct
      241 gctgtcctac accctgcagg agctgctggc caaggacacg gtgcaggtgg agctcatccc
      301 tgagaagaag ggcctcttcc ttaagcatgt ggagtacgag gtttccagcc agcgcttcaa
      361 gtcctccgtg tacagacgct acaatgactt cgtggtcttc catgaagtgc tgcttcacaa
      421 gttcccgtac cgcatggttc cagctcttcc gcccaagaga gtgctgggag ccgacaggga
      481 gttcatcgag ggccgccgga gggccctgaa gcgcttcatc aacctggtgg cccggcaccc
      541 acccttctct gaggacgtgc tccttaaact cttcctctcc ttcagtggct cggatgttca
      601 gcacaagctc aaggaggcgg cccagtgcgt gggagatgag ttcatgaact gtaagctggc
      661 tgctagggcc aaggacttcc tcccagctga catccagact caatttgcca tgagccggga
      721 gctgattcga aatgtctaca acagcttcta caagcttcga gacagagccg agcggattgc
      781 gtcccgggcc attgacaacg ctgctgatct tctcatattt ggaaaggagc ttagtgcttt
      841 gggctccgac accacccctc tgccctcctg ggctgctctg cacctcagca catggggctc
      901 cctgaagcaa gcgctcaagg gcctctccgt ggagtttgca ctgctggcgg acagagctgc
      961 acagcagggc aagaaggagg agaatgatgt agtggagaag ctgaacctct tcttggattt
     1021 gttgcagtcc tacaaagacc tgtgtgagcg gcacgagaag ggcgtgcttc acaaacacca
     1081 gcgggcactg cacaagtacg gcctgatgaa gaggcagatg atgagtgcag cgcacggccg
     1141 agaacctgag tctgtggagc agctggagtc acgaatcgtg gagcaggaga acgtgatcca
     1201 gactatggaa ctccgaaact acttctccct ctactgcctg caccaggaga cgcagctcgt
     1261 ccacgtctac ctgcctctca cctcgcacat cctgggggcc ttcgtgaact cccagatcca
     1321 agggcacaag gagatgagca aggtgtggaa tgacctgaag ccgaagctga gctgcctctt
     1381 cgctggacct cacagtgtgt tgacgccacc gcgctccccg caggaggatg gcgtgtgtcc
     1441 ccactagtgg caagacccac gacagagctc ccggtggcct cactaaaacc tcttttcaaa
     1501 cagtgtgttc ctggctgatt ccctccaggc agcagccgtt cccctgagct gcctgtgggc
     1561 tgccggcggt ctttgtgtct ccctgttctt gttgtaggag gtctttgtgc ccccagtctg
     1621 ccccttggcc tgttgatcag gtcggtagtg ggaagttagg gtgctttgga ctggattgtg
     1681 cccggtgccc gcagtgttaa gggccttttg tacccagtaa gtggtttcta ggggagccta
     1741 ggggttcacc tagcagcaaa gggatgggag gactggcctg tcctgtggcc tggcaaagag
     1801 ctggtcaatc tctcagagtg ggcagtgact ctagccttgg gcctacagac attctgggag
     1861 gagcatttga agccaggcgg aggtctgatg caagggggag gtgagtgtgc agtgcttgga
     1921 gctttggagg acatctttca cttcagtgcg atccttggag ctctggtcca gggcctgtca
     1981 aggtccacag tggatgaagg ctcagggtct ttttgtgttg ggtttggagg gtgggagtga
     2041 ggaggggttg tggggaagca ctggaggtgg gcatccctgt tgggtgccca ggcctcaggc
     2101 tgtcaggccg caggctccac ctggatgtga gccgtttcct ttaccagccc gctcaccagc
     2161 ctctgtgctc tagtgctctg ggtcccccac gcctgcaata gagcctgcct tttctcacat
     2221 agtctttccc tgactggact gtgggtgcct gactccaaac ttgaggttcc actcctaggg
     2281 ttcagaggaa ccaagggtcc ccctaccctt ctgggtatcg tgctgtctga gcctgtgttg
     2341 tgccccagcc acgcttgggg ctgccagaaa gacagagaag cacaagaggc accggatctc
     2401 ccgcctgctt gtccctttcc ctggcctgag tggggcccag cggtagcctt aactggacag
     2461 tcctggggcc atcagagtgg gagtgaaggg aaggggtttt ttttggtgct ccctacttgg
     2521 tgttagccac cctggttgaa gaagctagac agggcagtgg gtctctgggc taagggagtc
     2581 aagctggtgc tatgggattc ggctcgatga atgaagcact ttatggactg cggggatcag
     2641 ttactgccac acccaataaa ctggaagtgt ttacagatgg ttt
//
