LOCUS       NM_001199188            2399 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus sorting nexin 5 (Snx5), transcript variant 1, mRNA.
ACCESSION   NM_001199188
VERSION     NM_001199188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Li,Y., Wang,X., Bi,Y., Zhang,M., Xiong,W., Hu,X., Zhang,Y. and
            He,F.
  TITLE     SNX5-Rab11a protects against cardiac hypertrophy through regulating
            LRP6 membrane translocation
  JOURNAL   J Mol Cell Cardiol 194, 46-58 (2024)
   PUBMED   38950816
  REMARK    GeneRIF: SNX5-Rab11a protects against cardiac hypertrophy through
            regulating LRP6 membrane translocation.
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Dong,X., Yang,Y., Zou,Z., Zhao,Y., Ci,B., Zhong,L., Bhave,M.,
            Wang,L., Kuo,Y.C., Zang,X., Zhong,R., Aguilera,E.R.,
            Richardson,R.B., Simonetti,B., Schoggins,J.W., Pfeiffer,J.K.,
            Yu,L., Zhang,X., Xie,Y., Schmid,S.L., Xiao,G., Gleeson,P.A.,
            Ktistakis,N.T., Cullen,P.J., Xavier,R.J. and Levine,B.
  TITLE     Sorting nexin 5 mediates virus-induced autophagy and immunity
  JOURNAL   Nature 589 (7842), 456-461 (2021)
   PUBMED   33328639
  REMARK    GeneRIF: Sorting nexin 5 mediates virus-induced autophagy and
            immunity.
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Zhou,Q., Wang,Z., Nayak,N., Subler,M. and Zhang,Z.
  TITLE     Sorting nexin-5 is not required for normal spermatogenesis and male
            fertilization in mice
  JOURNAL   Mol Reprod Dev 87 (12), 1202-1205 (2020)
   PUBMED   33118244
  REMARK    GeneRIF: Sorting nexin-5 is not required for normal spermatogenesis
            and male fertilization in mice.
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808123.9 and AL824710.10.
            
            On Jan 6, 2022 this sequence version replaced NM_001199188.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169786.1, AK078776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL808123.9         10134-10226         c
            94-176              AL808123.9         9810-9892           c
            177-281             AL824710.10        82724-82828         c
            282-392             AL824710.10        81529-81639         c
            393-514             AL824710.10        79861-79982         c
            515-638             AL824710.10        78674-78797         c
            639-734             AL824710.10        77904-77999         c
            735-840             AL824710.10        76303-76408         c
            841-916             AL824710.10        76144-76219         c
            917-956             AL824710.10        75707-75746         c
            957-1043            AL824710.10        75530-75616         c
            1044-1203           AL824710.10        74466-74625         c
            1204-1289           AL824710.10        73249-73334         c
            1290-2399           AL824710.10        70927-72036         c
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.98 cM"
     gene            1..2399
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="sorting nexin 5"
                     /db_xref="GeneID:69178"
                     /db_xref="MGI:MGI:1916428"
     exon            1..93
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            94..176
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1340
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /codon_start=1
                     /product="sorting nexin-5"
                     /protein_id="NP_001186117.1"
                     /db_xref="CCDS:CCDS16815.1"
                     /db_xref="GeneID:69178"
                     /db_xref="MGI:MGI:1916428"
                     /translation="MAAVPELLEQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                     VKFTVHTKTTLSTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAPTKPDFDGP
                     REKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSTHEVFLQRLSSHPVLSKDR
                     NFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKNFLIN
                     YYNRIKDSCAKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKL
                     RKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSK
                     DVKLAETHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVS
                     LLQSCIDLFKNN"
     exon            177..281
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            282..392
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            393..514
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            515..638
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            639..734
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            735..840
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            841..916
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            917..956
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1043
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1203
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1289
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..2399
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="major polyA site"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="hexamer: AAGAAA"
     polyA_site      2399
                     /gene="Snx5"
                     /gene_synonym="0910001N05Rik; 1810032P22Rik; D2Ertd52e"
                     /note="major polyA site"
ORIGIN      
        1 ctttctcgag gcgtgcctcg ccggcggagg gttcggagcc cgcgttcccg tcgcggccct
       61 ccggtgctgg tgtccgcgtg gcgcggagcg aggccacacg gcccctgctc gaggcccgcg
      121 tcgccatggc cgcggttccc gagttgctgg agcagcagga ggaggaccgc agcaagttaa
      181 gatctgtgtc tgtggacctg aatgttgacc catcgcttca gatcgacata cctgatgcac
      241 tcagtgagag agataaggtc aagtttacag tgcacaccaa gaccacactg tccacatttc
      301 agagcccaga gttttctgtt acaaggcaac atgaagactt tgtgtggctg catgacactc
      361 ttactgaaac aacggattat gctggcctta ttatccctcc tgctcctaca aagccagact
      421 ttgatggccc tcgagagaag atgcagaaac tgggagaagg ggaaggatct atgacaaaag
      481 aagagtttgc caagatgaag caagaactgg aagctgagta tctcgctgtc tttaagaaga
      541 ctgtgtccac ccatgaagtc tttcttcagc ggctttcttc tcaccctgtt ctcagtaaag
      601 accgcaactt tcatgttttc ttggaatatg atcaggatct aagtgttaga cggaagaata
      661 ccaaggagat gtttggaggc ttttttaaaa gtgtggtgaa gagcgccgat gaggtccttt
      721 tttctggagt taaggaggtg gatgacttct ttgagcaaga gaagaatttc cttattaact
      781 attacaacag gatcaaggat tcctgtgcta aagcagacaa aatgaccaga tctcacaaaa
      841 atgttgctga cgactatatc cacactgcag cctgcttgca tagcctggcc ttggaagaac
      901 ccacagtcat caaaaagtac ctgttgaaag ttgcagagct atttgaaaaa cttaggaaag
      961 tggaaggtcg agtctcatca gatgaagact taaaactgac agagctcctc cgatactaca
     1021 tgctcaacat agaggctgca aaggatctct tgtatagacg taccaaagcc ctaattgact
     1081 atgagaattc aaacaaagct ttggacaagg cccggttaaa aagcaaagat gtcaagttgg
     1141 cagagactca tcagcaggaa tgctgccaga agtttgaaca gctttctgaa tctgcaaaag
     1201 aagagctgat aaacttcaaa cggaagagag tggcagcatt tcgaaagaac ctaatcgaaa
     1261 tgtctgaact ggaaataaag catgccagaa acaacgtctc cctgttgcag agctgcatcg
     1321 acttattcaa gaacaactga cctgtctact ctgaaggaca ccaatgtgaa agccagcatc
     1381 acttgcactt aaatcattac tgcaaaagaa atagctttga ctagtttaaa atcatgtgaa
     1441 taaatatttt gatttctaaa aatcttaaca cttaaccatg ttggtttaaa aatattttca
     1501 ttgcatgtta cttggacata actaatcctt ttcttatgca tttaatacct caaagtaggt
     1561 agaatctaac agattctcct atagactgtc aggaattact aagaaatggt atggagatgt
     1621 gtgccttctg gaaatgagaa gcaatagcct ggcccatgtc tgtctgaaca tttcctgtgt
     1681 ctgctcctac agacatgtca ggtgtgaatt acagcaaaca gtgactgctt gtgggcaggt
     1741 ggcagacact cttctttatt taggtagatt ttgctccctc ttgtcaagat cacttcagat
     1801 gcttgtacgg taacaagcaa gaagatctca tatgtctttt tacatccttt acagctccat
     1861 ttttgtaact gggatataaa tacttgagag aaaggagaat ctagagttct gacactccct
     1921 gatggtgggg catgtgtgtt tgtgctttgg atgtttttat aaagtatata ataaagataa
     1981 tccatgttac catatggagt gcttttgtag aaaactagac ctcaagaatg ctggcagctc
     2041 cacaggtgga aagggttcat tagctgccct cttgtaacct ttactaacat cttagggatt
     2101 gagccagggc tttgtgcaaa ccattgacag tgcttagccc tcagtactcc tttgaaacag
     2161 gatttggctc tgaacccagg actccactga ctcagcttta cagcctctgg agttctgcag
     2221 ttatggtata ccaacatatc tggctcagtc ccaggtttga agactgagtc ttggctctgt
     2281 ttgctgtata tgaatacttg ggggggggtg ggtcctatct aaactggttt gtttgtattg
     2341 attccatagc acaaattgat ggaagtctgg atttatttaa gaaaagattt cacaacaaa
//
