LOCUS       NM_080557               2442 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus sorting nexin 4 (Snx4), mRNA.
ACCESSION   NM_080557
VERSION     NM_080557.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Vazquez-Sanchez,S., Gonzalez-Lozano,M.A., Walfenzao,A., Li,K.W. and
            van Weering,J.R.T.
  TITLE     The endosomal protein sorting nexin 4 is a synaptic protein
  JOURNAL   Sci Rep 10 (1), 18239 (2020)
   PUBMED   33106523
  REMARK    GeneRIF: The endosomal protein sorting nexin 4 is a synaptic
            protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Kim,N.Y., Cho,M.H., Won,S.H., Kang,H.J., Yoon,S.Y. and Kim,D.H.
  TITLE     Sorting nexin-4 regulates beta-amyloid production by modulating
            beta-site-activating cleavage enzyme-1
  JOURNAL   Alzheimers Res Ther 9 (1), 4 (2017)
   PUBMED   28109317
  REMARK    GeneRIF: Results indicate that SNX4-mediated regulation of the
            steady-state levels and trafficking of BACE1, as well as the
            subsequent increase in BACE1-mediated cleavage, may be relevant to
            Alzheimer's disease progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Leprince,C., Le Scolan,E., Meunier,B., Fraisier,V., Brandon,N., De
            Gunzburg,J. and Camonis,J.
  TITLE     Sorting nexin 4 and amphiphysin 2, a new partnership between
            endocytosis and intracellular trafficking
  JOURNAL   J Cell Sci 116 (Pt 10), 1937-1948 (2003)
   PUBMED   12668730
  REMARK    GeneRIF: Sorting nexin 4 and amphiphysin 2 have roles in
            endocytosis and intracellular trafficking
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145198.3.
            
            On Nov 17, 2006 this sequence version replaced NM_080557.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016599.1, AK135356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC145198.3         96043-96188         c
            147-268             AC145198.3         83264-83385         c
            269-404             AC145198.3         80759-80894         c
            405-554             AC145198.3         79477-79626         c
            555-602             AC145198.3         77941-77988         c
            603-658             AC145198.3         70647-70702         c
            659-731             AC145198.3         66939-67011         c
            732-793             AC145198.3         63173-63234         c
            794-859             AC145198.3         61592-61657         c
            860-949             AC145198.3         59863-59952         c
            950-1049            AC145198.3         57446-57545         c
            1050-1195           AC145198.3         55758-55903         c
            1196-1310           AC145198.3         52889-53003         c
            1311-2442           AC145198.3         48082-49213         c
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.77 cM"
     gene            1..2442
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /note="sorting nexin 4"
                     /db_xref="GeneID:69150"
                     /db_xref="MGI:MGI:1916400"
     exon            1..146
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1358
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /codon_start=1
                     /product="sorting nexin-4"
                     /protein_id="NP_542124.1"
                     /db_xref="CCDS:CCDS28129.1"
                     /db_xref="GeneID:69150"
                     /db_xref="MGI:MGI:1916400"
                     /translation="MEQAPPDPEKLLQPGPLEPLGGPGAVLEAAVGEENEGTREDGSG
                     VDTMTGNNFWLKKIEISVSEAEKRTGRNAVNMQETYTAYLIETRSVEHADGQSVLTDS
                     LWRRYSEFELLRNYLLVYYPHVVVPPLPEKRAEFVWHKLSADNMDPDFVERRRVGLEN
                     FLLRVASHPVLCRDKIFYSFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDK
                     RFTELRHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGL
                     QSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLETAAQD
                     LAAKKQQCEELATGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSK
                     NLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
                     "
     exon            147..268
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..404
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            405..554
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..602
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            603..658
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..731
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..793
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..859
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            860..949
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1049
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1195
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1310
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2442
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2415..2420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2442
                     /gene="Snx4"
                     /gene_synonym="1810036H14Rik"
                     /note="major polyA site"
ORIGIN      
        1 cagctatgga gcaggcacct ccggaccccg agaagctctt gcagcctgga cccctggagc
       61 cgctgggtgg ccctggcgct gtgctggagg ccgcggtcgg tgaggagaac gagggcaccc
      121 gagaagacgg ctcaggggtc gacacgatga cgggaaataa tttttggttg aagaaaatag
      181 aaatcagtgt ttcagaagca gagaagagaa ccggaaggaa cgccgtgaac atgcaagaaa
      241 cgtacactgc ctacctcatc gagactcggt cagttgagca tgccgatggt cagagtgtgc
      301 tcacagactc gctgtggagg cggtacagtg agttcgagtt gttgagaaac taccttctag
      361 tgtactaccc acatgttgtt gtgccacctc tcccagaaaa gcgggcagag ttcgtgtggc
      421 ataaactctc tgctgacaac atggacccag actttgtgga gagacgacgc gtgggcttag
      481 aaaacttcct cttgagggtt gcttcacatc ctgtcctttg tagagacaaa atcttctatt
      541 catttttaac ccaggaaggt aactggaagg agactgtgaa tgagactgga tttcagctga
      601 aggcagactc caggttaaaa gcgcttaatg caacattcag agtgaaaaac ccagacaaga
      661 ggtttactga gctgaggcac tacagtgatg agctgcagtc tgtcatctcg catctccttc
      721 gagtcagagc tagagtagca gatcgactct atggtgtata taaagtacat gggaattatg
      781 ggagagtttt tagtgaatgg agtgccatcg aaaaagaaat gggggatggg ctgcagagtg
      841 ctgggcatca catggacgtg tatgcatctt ctattgatga tattttggaa gatgaagagc
      901 actatgcaga tcagctgaag gagtatctgt tttatgcaga agcacttcgg gctgtgtgca
      961 ggaagcatga gcttatgcag tatgacctgg agacagctgc tcaagacctg gctgccaaga
     1021 agcagcagtg cgaggagctg gccaccggga ctgtgagaac attctcgttg aagggaatga
     1081 ctaccaaact ctttggtcaa gaaactccag agcaaagaga agccaggata aaggtgctag
     1141 aggagcagat aaatgaaggg gaacagcagc tgaagtctaa aaatctggaa ggcagagaat
     1201 ttgtgaaaaa tgcatgggct gatattgaac gcttcaaaga acaaaagaac cgggacctaa
     1261 aggaagctct catcagctat gctgtcatgc agatcagcat gtgcaaaaag ggaattcagg
     1321 tttggaccaa tgctaaagaa tgcttcagca agatgtaacc ccatgaagtg acttttctct
     1381 gcaatcaaag ccccaaaacg aagcacaagt aaaagaaaat ctattgctac cttatacata
     1441 gaagcatact gtacatggaa caaatcagct ttctttaagc atagttgtgt tcatatagca
     1501 caaatgatac attttaatga agaataaata ttataatttg aagttttggg gactggtgct
     1561 gattccaaaa aagttaattt aataagataa ccaacagatt gttagtcagg ctcctgatcc
     1621 agtgcctccg tcaggatgtg agttaatctc catgtgcacc tctcagtgcc cactgtccag
     1681 atctcttcac gggcagttct tcccagacca gacgcccaga tttactttgt aggacccact
     1741 tctgctatac agttatttta tcttgcctta gagttgagct gtttggtttg acaaagctca
     1801 gcagaaactt gttgtgaagt ctaaggtttt cttctgtgtt cctagatcct gtaccatctg
     1861 caacactaga aaatgccttc agtttgtgtc tcaccaaaat tttgatactg gtcagaaatt
     1921 ttatactgcc aacaacgaag tctcagcttc tcagatttgc agtggaatag atacattatt
     1981 ataatctaga aattgctata tagagagtat taatttaaca ttattattct cagataagaa
     2041 gtgttaactt cggcagcagc ctccatttct tctgctcggc tctgtgctca tggcgtttca
     2101 gggtacgagg tgtagcatct ccatgtgtga gacactcgta gtgagcacat gtgagcggta
     2161 ccgtcaccat taatgtgcgt ttctgttgcc tggctgtgat ttttgtaaag ataaatgatg
     2221 ttgttgtgct ttagtgtgtg tttcatggca catgttcaga agccaagcac actctctgcc
     2281 agcttgcaga ctcctcctaa ccgtgcactc attatttcta atgttttaaa actatactca
     2341 gtactgtttg acatttgact tttttacatg tttaaaatgt tgctggattt ttgtgctgtt
     2401 tgccaaactt atataataaa ggaagtgttg tgtttatttc ca
//
