LOCUS       NM_001347022            2699 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sorting nexin 31 (Snx31), transcript variant 2, mRNA.
ACCESSION   NM_001347022 XM_006520145
VERSION     NM_001347022.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Xu,N., Cai,Y., Li,J., Tao,T., Liu,C., Shen,Y., Li,X., Zhang,L.,
            Zhao,M., Shi,X., Li,J. and Huang,L.
  TITLE     An SNX31 variant underlies dominant familial exudative
            vitreoretinopathy-like pathogenesis
  JOURNAL   JCI Insight 8 (10), e167032 (2023)
   PUBMED   37053012
  REMARK    GeneRIF: An SNX31 variant underlies dominant familial exudative
            vitreoretinopathy-like pathogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Vieira,N., Deng,F.M., Liang,F.X., Liao,Y., Chang,J., Zhou,G.,
            Zheng,W., Simon,J.P., Ding,M., Wu,X.R., Romih,R., Kreibich,G. and
            Sun,T.T.
  TITLE     SNX31: a novel sorting nexin associated with the
            uroplakin-degrading multivesicular bodies in terminally
            differentiated urothelial cells
  JOURNAL   PLoS One 9 (6), e99644 (2014)
   PUBMED   24914955
  REMARK    GeneRIF: These data support a model in which SNX31 mediates the
            endocytic degradation of uroplakins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Yu,Z., Mannik,J., Soto,A., Lin,K.K. and Andersen,B.
  TITLE     The epidermal differentiation-associated Grainyhead gene Get1/Grhl3
            also regulates urothelial differentiation
  JOURNAL   EMBO J 28 (13), 1890-1903 (2009)
   PUBMED   19494835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137871.18.
            
            On Mar 28, 2018 this sequence version replaced NM_001347022.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061007.1, SRR17784646.1393875.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC137871.18        69817-69942         c
            127-201             AC137871.18        69629-69703         c
            202-316             AC137871.18        61150-61264         c
            317-381             AC137871.18        59919-59983         c
            382-492             AC137871.18        53667-53777         c
            493-583             AC137871.18        51878-51968         c
            584-671             AC137871.18        48785-48872         c
            672-741             AC137871.18        45144-45213         c
            742-834             AC137871.18        42055-42147         c
            835-1038            AC137871.18        39944-40147         c
            1039-1152           AC137871.18        37813-37926         c
            1153-1230           AC137871.18        31969-32046         c
            1231-1287           AC137871.18        22069-22125         c
            1288-2699           AC137871.18        18432-19843         c
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.48 cM"
     gene            1..2699
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /note="sorting nexin 31"
                     /db_xref="GeneID:66696"
                     /db_xref="MGI:MGI:1913946"
     exon            1..126
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1380
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-31 isoform 2"
                     /protein_id="NP_001333951.1"
                     /db_xref="CCDS:CCDS84166.1"
                     /db_xref="GeneID:66696"
                     /db_xref="MGI:MGI:1913946"
                     /translation="MKMHFCIPVSQQRPDALGGRYVLYSVYLDGFLFCKVRYSQLHRW
                     DEQLRRVFGNCLPPFPPKYYLAMTTAMAEERRDQLERYLQNVTADPRVTRSDVFTEFL
                     TLVQLHTLNITIQNVELAVFLPDGRSIKVEGLTSDTAERVLEVMAHKLGLQPDLVGYF
                     GLFLIQCFPEGKLSVVKKLADFELPYTSLQSSEMENCKIGLRKWYLDPALDSMLMDCR
                     AAGDLLYMQAVQDIEKEWMKPTQAQREELKALQKKENQTKFLELSQEVRHYGYVQLDP
                     CTCNHPEPGCGAQLSIGNNEISCCITLPNGQIQDIAFQMSRVKCWQVTFLGTLLDTDG
                     PQRTLNQNLELRFQYSEDSCQQWFVIYTKQAFFLSSCLKKMISERMTKLTEQSPEMQI
                     EVPEQGRSKKHPSQPSQQKVYFNFLRKGKMKRSEGDYVWDTLMEEGL"
     exon            127..201
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            202..316
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..381
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            382..492
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            493..583
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            584..671
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            672..741
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            742..834
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1038
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1152
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1230
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1287
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..2699
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2109
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /note="major polyA site"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2355
                     /gene="Snx31"
                     /gene_synonym="4631426E05Rik"
ORIGIN      
        1 agcccagact ctaggcggca ggtcctgttc tccacgctgt ccctggtcat cgccagagcc
       61 atgaagatgc acttctgcat cccggtgtcc cagcagcggc cagacgcgct ggggggccgc
      121 tacgtgttgt actccgtgta cctggacggg ttcctcttct gcaaagtacg ctacagccag
      181 ctgcaccgct gggatgaaca gctgagacgg gtgtttggaa actgcctgcc ccctttccca
      241 cccaagtact acctggcaat gactactgct atggctgaag agaggaggga ccagttggaa
      301 cgctacctgc aaaatgtaac tgcggatccc cgtgtgacaa ggagtgatgt cttcactgag
      361 tttttaacac tggtgcagct gcacacattg aatatcacca tccagaatgt cgagctggct
      421 gtattcctgc ctgatggaag gagcattaaa gtagaaggtc taacatcaga tacggctgaa
      481 agggtcctgg aggtgatggc ccacaaactc ggattgcagc cagatctggt gggctacttc
      541 ggccttttcc ttatccagtg tttcccggag ggcaagctct ctgtggtgaa gaagctggcc
      601 gactttgagc tgccttacac tagtcttcag agttctgaaa tggaaaactg taagatcggg
      661 ctcagaaagt ggtacctgga cccagctctg gactccatgt tgatggactg cagagcagct
      721 ggagacttgc tgtacatgca ggcagtgcag gacattgaaa aagaatggat gaaacccaca
      781 caggctcaga gggaggaact aaaggcactg cagaagaaag agaatcaaac aaagtttttg
      841 gagctgtcgc aggaggtccg gcactatggg tatgttcagc tggatccctg cacctgcaac
      901 cacccggaac ctggctgtgg ggcccagctt tccatcggca ataatgagat cagctgctgt
      961 ataactttgc ctaatggcca gatccaggac attgctttcc agatgagcag agtgaagtgc
     1021 tggcaggtca ctttccttgg aactctgctg gataccgatg ggccccagcg aactctcaac
     1081 cagaacctag agctgagatt tcagtatagt gaagatagtt gccagcagtg gtttgttatt
     1141 tacaccaaac aggctttttt cctgagcagc tgcctgaaga agatgatctc agagaggatg
     1201 acaaagctca ctgagcagag cccagagatg cagatcgagg ttccagaaca aggcagaagt
     1261 aaaaagcacc cgagccaacc tagccagcag aaagtctatt ttaattttct gagaaaaggc
     1321 aagatgaaga gatccgaagg tgactatgtt tgggataccc tgatggaaga aggtctctga
     1381 aggaatctca tctctacggc tgtcttaaga cagtgccagc gcgtgggtgt gggaggtggg
     1441 cttcccacca tccaggcatt tatccacttc tctctttctt tgacattgca gtctcctgtg
     1501 ctgatcagtc taacttcagc actccataac tctcagggct aacatggtgt aggaaccaac
     1561 gctatagagc tgacttaagt ggcaggtggg caggttcaaa tcaaccaatg ggaggtttgt
     1621 tctatcttcc ctctaagata gatgtacctg gctccatgaa gccctttgta tgttctcgta
     1681 ttgcagggat aaaaagcttg ttctaaatta taggaatatg tttggcacca aagtagattc
     1741 accagattgg gaaagtatgg cttctttgac ctatccagag agcaaaagga gctaaaattc
     1801 caatccccac ctttactcac tccttagtct actaaaacga tgaccacaaa gtcccgggct
     1861 gccctggcct gcgtccctca ctgtatggtt ctgttccact attagaagac tgggctctgg
     1921 gctggagaaa cggctcagtg gttaagagca cttgctactt ttgcagagga ctaaattccc
     1981 ttaacccaca tggtacttaa caaccagctg taactccagc tccagaggac ccagtgccct
     2041 cttctggcct cctctggcac ccacacatac acataataaa aataaataaa attgaattct
     2101 gaccaataat catctcgcca atttgaatat ttttcttttg gaaatcaata gtcctgcact
     2161 cgtagcaaat ctcttagctt tacaaatgtg tatttttttt tccacaatag ttttccttaa
     2221 acagcttcag gtgtaccata ctaacgtaat tagatatgga attaagagca aaatagagag
     2281 gggaagataa atatgcaaaa ataactaatg ttcttttctg agttagctaa ttatgaaata
     2341 aatataaaat ccgatgaata cagagtttgc tagtgaaaat ttgtgcatct tttgaaatgt
     2401 ggaatctacg agtcctctaa tatctataaa tcaatgccta tgagtttgag ttttaggctg
     2461 tcgtaggatc tctgcagaga tatctgtgtc acccaggtca gtatgctggc gtcaccatca
     2521 gagttaatgg aagcttatca actgtcacac cgacttaaga ctagtgaggg tccatctaac
     2581 cctgatagca cagcacaggg gccgtctcag acagcaggaa cccagactct gtattgagat
     2641 cagaaggttg aacagtatgt gactgcagct tttgtagatt aaaaaaaaat ctgatgccc
//
