LOCUS       NM_017472               1377 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sorting nexin 3 (Snx3), mRNA.
ACCESSION   NM_017472
VERSION     NM_017472.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Lu,J., Xu,S., Huo,Y., Sun,D., Hu,Y., Wang,J., Zhang,X., Wang,P.,
            Li,Z., Liang,M., Wu,Z. and Liu,P.
  TITLE     Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3
  JOURNAL   Cell Death Differ 28 (10), 2871-2887 (2021)
   PUBMED   33947971
  REMARK    GeneRIF: Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3.
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Brown,H.M., Murray,S.A., Northrup,H., Au,K.S. and Niswander,L.A.
  TITLE     Snx3 is important for mammalian neural tube closure via its role in
            canonical and non-canonical WNT signaling
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33214242
  REMARK    GeneRIF: Snx3 is important for mammalian neural tube closure via
            its role in canonical and non-canonical WNT signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Chen,C., Garcia-Santos,D., Ishikawa,Y., Seguin,A., Li,L.,
            Fegan,K.H., Hildick-Smith,G.J., Shah,D.I., Cooney,J.D., Chen,W.,
            King,M.J., Yien,Y.Y., Schultz,I.J., Anderson,H., Dalton,A.J.,
            Freedman,M.L., Kingsley,P.D., Palis,J., Hattangadi,S.M.,
            Lodish,H.F., Ward,D.M., Kaplan,J., Maeda,T., Ponka,P. and Paw,B.H.
  TITLE     Snx3 regulates recycling of the transferrin receptor and iron
            assimilation
  JOURNAL   Cell Metab 17 (3), 343-352 (2013)
   PUBMED   23416069
  REMARK    GeneRIF: Snx3 regulates recycling of the transferrin receptor and
            iron assimilation.
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Tai,G., Lu,L., Wang,T.L., Tang,B.L., Goud,B., Johannes,L. and
            Hong,W.
  TITLE     Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in
            transport from the early/recycling endosome to the trans-Golgi
            network
  JOURNAL   Mol Biol Cell 15 (9), 4011-4022 (2004)
   PUBMED   15215310
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Chalhoub,N., Benachenhou,N., Rajapurohitam,V., Pata,M., Ferron,M.,
            Frattini,A., Villa,A. and Vacher,J.
  TITLE     Grey-lethal mutation induces severe malignant autosomal recessive
            osteopetrosis in mouse and human
  JOURNAL   Nat Med 9 (4), 399-406 (2003)
   PUBMED   12627228
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Abrahams,B.S., Mak,G.M., Berry,M.L., Palmquist,D.L., Saionz,J.R.,
            Tay,A., Tan,Y.H., Brenner,S., Simpson,E.M. and Venkatesh,B.
  TITLE     Novel vertebrate genes and putative regulatory elements identified
            at kidney disease and NR2E1/fierce loci
  JOURNAL   Genomics 80 (1), 45-53 (2002)
   PUBMED   12079282
REFERENCE   10 (bases 1 to 1377)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013183.1, DN176987.1 and AK007798.1.
            
            On Apr 2, 2008 this sequence version replaced NM_017472.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007798.1, AK013183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AK013183.1         27-136
            111-202             DN176987.1         80-171
            203-1377            AK007798.1         14-1188
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.89 cM"
     gene            1..1377
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /note="sorting nexin 3"
                     /db_xref="GeneID:54198"
                     /db_xref="MGI:MGI:1860188"
     exon            1..439
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..766
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /codon_start=1
                     /product="sorting nexin-3"
                     /protein_id="NP_059500.2"
                     /db_xref="CCDS:CCDS23812.1"
                     /db_xref="GeneID:54198"
                     /db_xref="MGI:MGI:1860188"
                     /translation="MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRG
                     RFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLP
                     FRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIR
                     HA"
     exon            440..535
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..660
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1377
                     /gene="Snx3"
                     /gene_synonym="SDP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcgcct cagccccacc ccgcagtgtc cctcggggcc gccgcggggc ctgcgaaccg
       61 ggcgcggcgt tcaggccagt cagctgtttc tccctgggca gagggcggaa gcccgagcag
      121 cctggggcgg agcttcgcgc ggaacgaacg cccacccgtc ctacgtgctc gttcgtctcc
      181 gttcgctgcg cgcgagccgg gagtccccgc ggcgggcggc ggtggcgttg gcggaaggcg
      241 gtggagagaa gcccgcggct gccgcggcga cagcgaaatg gcggagacgg tagcggacac
      301 ccggcggctc atcaccaagc cgcagaatct gaatgacgcc tacgggccgc ccagcaactt
      361 cctcgagatc gacgtgagca acccgcagac cgtgggggtc ggccggggcc gcttcaccac
      421 ctacgagatc agggtcaaga caaatcttcc tatcttcaag ctgaaggaat ctactgttag
      481 aagaagatac agtgactttg agtggcttcg aagtgaacta gaaagagaga gcaaggttgt
      541 agttccccca ctccctggga aagcattttt gcggcagctt ccttttagag gagacgatgg
      601 aatatttgat gacaatttca tcgaggaaag gaagcaaggg ctggaacagt tcataaacaa
      661 ggtcgctggt catcctctgg cccagaatga acgttgtctt cacatgtttt tacaggatga
      721 aattatagat aaaagctata ctccatctaa aataagacat gcctgagttt ggtgagaaga
      781 agcaaaaccc gagaccatta atgattcatc cgcaccaatg aagaagttgt aactaactag
      841 catgctgcgc agacactggc atagcatgcc ctgggtacac taacactcac ctgctccctt
      901 tcgttccgct tgtcttggca gttgacaaga cattcgtttg ctttagtgaa actccctcgc
      961 tccagcctct ctaagtagct cttcccgctg tgtccgtgtg cacactgtag ccccacagcc
     1021 ccgtagaacc tgcagtgtcc tgactaaagc tgccgacttg ctctcatttg cagtttctgt
     1081 gtcatgtttg cttcttgaat ctgattgact agaatatttc tcccccctgc cccttgatgt
     1141 gtgatgtcac cacctggtcc taatttatgt gcaggagcac gacaccactt gtctccagcg
     1201 ccacacatcc gaggtgtact ttgtgtgcag aatgtgtctt ccttctggcc tgtaatcccc
     1261 ttcccatgaa agattaatga gggaaatctt tatattctgt ataaaaacaa aatcaaattt
     1321 atatactaaa atcatttgtc taaaatttaa gttgttttca aataaaagtt gaaatgc
//
