LOCUS       NM_001372342            3727 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus sorting nexin 25 (Snx25), transcript variant 1, mRNA.
ACCESSION   NM_001372342 XM_006509242
VERSION     NM_001372342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Zhang,Y., Yu,Z., Sun,M., Du,R., Gao,H., Dai,Q., Dong,Y., Liu,C.,
            Yin,M., Xu,T., Zhang,X., Liu,J. and Xu,J.
  TITLE     Redox-modulated SNX25 as a novel regulator of GPCR-G protein
            signaling from endosomes
  JOURNAL   Redox Biol 75, 103253 (2024)
   PUBMED   38936254
  REMARK    GeneRIF: Redox-modulated SNX25 as a novel regulator of GPCR-G
            protein signaling from endosomes.
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Tanaka,T., Okuda,H., Isonishi,A., Terada,Y., Kitabatake,M.,
            Shinjo,T., Nishimura,K., Takemura,S., Furue,H., Ito,T., Tatsumi,K.
            and Wanaka,A.
  TITLE     Dermal macrophages set pain sensitivity by modulating the amount of
            tissue NGF through an SNX25-Nrf2 pathway
  JOURNAL   Nat Immunol 24 (3), 439-451 (2023)
   PUBMED   36703006
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Takemura,S., Isonishi,A., Tanaka,T., Okuda,H., Tatsumi,K.,
            Yamano,M. and Wanaka,A.
  TITLE     Neural expression of sorting nexin 25 and its regulation of
            tyrosine receptor kinase B trafficking
  JOURNAL   Brain Struct Funct 225 (9), 2615-2642 (2020)
   PUBMED   32955616
  REMARK    GeneRIF: Neural expression of sorting nexin 25 and its regulation
            of tyrosine receptor kinase B trafficking.
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Takemura,S., Nagano,M., Isonishi,A., Tanaka,T., Tatsumi,K.,
            Yamano,M., Minami,Y., Shigeyoshi,Y. and Wanaka,A.
  TITLE     Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic
            nucleus
  JOURNAL   Neurosci Lett 727, 134897 (2020)
   PUBMED   32156614
  REMARK    GeneRIF: Circadian rhythms of sorting nexin 25 in the mouse
            suprachiasmatic nucleus.
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Hao,X., Wang,Y., Ren,F., Zhu,S., Ren,Y., Jia,B., Li,Y.P., Shi,Y.
            and Chang,Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114558.18.
            
            On Aug 29, 2019 this sequence version replaced XM_006509242.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.15551.1,
                                           SRR1660821.184400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               AC114558.18        17564-18223
            661-745             AC114558.18        45859-45943
            746-962             AC114558.18        53607-53823
            963-1135            AC114558.18        64714-64886
            1136-1322           AC114558.18        66304-66490
            1323-1393           AC114558.18        89713-89783
            1394-1575           AC114558.18        101768-101949
            1576-1707           AC114558.18        111407-111538
            1708-1983           AC114558.18        113882-114157
            1984-2145           AC114558.18        115525-115686
            2146-2277           AC114558.18        120508-120639
            2278-2418           AC114558.18        122574-122714
            2419-2532           AC114558.18        124706-124819
            2533-2697           AC114558.18        125873-126037
            2698-2815           AC114558.18        128571-128688
            2816-2882           AC114558.18        131484-131550
            2883-3064           AC114558.18        134286-134467
            3065-3165           AC114558.18        135503-135603
            3166-3727           AC114558.18        136183-136744
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.03 cM"
     gene            1..3727
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /note="sorting nexin 25"
                     /db_xref="GeneID:102141"
                     /db_xref="MGI:MGI:2142610"
     exon            1..660
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            661..745
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            746..962
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1135
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1322
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1393
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1575
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1707
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1983
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2145
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2277
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2418
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2532
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2697
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2815
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2882
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3064
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3165
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3727
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /note="hexamer: AATAAA"
     polyA_site      3722
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /note="major polyA site"
ORIGIN      
        1 agtccccctc gcggtcccgc tacctgggcg cgcccggtcg gcgggcagct gcgggcccgg
       61 cgcggggcgg cggcaccgag gcgggagggg gggcgcggcg gtgtctgttg gagcggttcc
      121 cgctcagggc cgccggcgag ggcatgagcg cgggctgccc ttgcctcgcg agcggcggcg
      181 ggagcggcga ggcggcgggg cgccgcgcac aggccacggc ccggggcggc gccggggggc
      241 tgcgggccgg gagatgagcc tgtcgccagc ggcccaggaa gcagcatgca ccgcgatgcc
      301 accgacagca gcggcgcccg ccgcggcccc acgtccgccg cagacgcctg ccgcgctgcc
      361 cggggctccg cggaccggcc gcggacggcg gacggcccgg gctggggctg gcgggggccc
      421 gcggccgtgg ccgccctggc agtgctggcg ctgtgctgcc tggtcccagg ctggggaccg
      481 gcggcgggca cggggccggg cgccgtgctg ctgcgcctca gcctgtacct gagctgcgcc
      541 gcggccgcct tgctgctggg gacactggtc tcgctcgtct gctggagccc gcgcgcccag
      601 ccgccggact tcgtctcttc ctggagccgg ctggcggcga ccgtccgctg tccgctgcgg
      661 agccctgtat atggaaatcc acaggagaca gctcagggca gaagagtggt catttctcac
      721 aacatggatc gtgttctgag agatgtgttc gactacagtt acagagacta tattctctcc
      781 tggtacggga acctcagcag agatgacgga cagctctacc atctgctctt agatgacttc
      841 tgggaaattg tcaagcagat tcgccagagg ctgagtcacg tggatgtggt taaagttgtc
      901 tgtaatgata ttgtaaaggc tttgctcact cacttctgtg acctgaaggc tgctactgcc
      961 agacatgaag aacagccaag gccttttgtg ttgcatgcat gcttgaagga ttcacatgat
     1021 gaagtaagat tccttcaaac atgttctcag gttctggtgt tatgccttct cccttctaag
     1081 gatatccagt ctctcagctt acgtacaatg ctcgcagaaa ttcttacgac aaaagtcttg
     1141 aagccagtag tggaattgct gagtaaccct gactacatta accaaatgct gctcaggcag
     1201 ttggagtaca gagagcagat gagtgagcat cacaagcgag cctacacgta cgcgccttcc
     1261 tacgaggact ttatcaagct catcaacagc aactctgatg tggacttcct gaagcagctc
     1321 aggtatcaaa ttgtagtgga gataatccaa gcaactacaa tcagcagctt tccccagctg
     1381 aagagacaca agggtaagga atcagctgcc atgaaaactg atctcttgag ggccaggaac
     1441 atgaaaaggt acattaacca gctgactgtg gcaaagaagc agtgtgagaa gagaatccga
     1501 atcctgggag gtcctgccta tgaccagcaa gaggatggag cctcggatga aggggaaggg
     1561 cctcagagcc aaaagattct tcagtttgaa gatattatga ccaatccttt ctaccgagag
     1621 cgctttggaa catacatgga acggatagac aagcgggctc tagttggctt ttgggagtct
     1681 gccgaacacc tgaagaatgc taacaagagt gaaattccac aattagttag tgaaatgtat
     1741 cagaatttct tcgtggaaag caaggaaatc tccgtggaaa agtcacttta caaagaaatc
     1801 cagcagtgtc ttgtgggaaa cagaggcatc gaggtgttca gcaaaatcca agccgatgtg
     1861 tccgaggtgc tgagggagcg gtattacccc tccttcctcg tcagcgacct gtatgagaag
     1921 ctcatgcgtg aggaagaaga ggaggagcct gacgctcagc tggcctctga gaaggatgag
     1981 ctgggttcag gaggtgaggc tggtgaggag gctgtagaag gcaccagtgg ggtcagtgat
     2041 ccagccagct ttgctgtaat caaactccga gagctaaatg agaaacttga atacaaaagg
     2101 caagctctaa gttctattca gaatgcacca aaacctgata agaagattat ttccaagttg
     2161 aaggatgaaa tacttctgat agagaaagaa tgcacggctc ttcagctgca catggcgaga
     2221 acagattggt ggtgtgagaa cctgggcctg tggagagcat ccatcaccag cgcagaggtg
     2281 acagaagaga atggcgagca aatgccttgt tactttgtca gggtaaatct acaagaagtt
     2341 ggaggagttg aaactaagaa ctggaccgtc ccaagaaggc tcagtgagtt tcagaattta
     2401 catcggaaac ttagtgagtg tgtcccttct ttaaaaaaag tccagttgcc ttctctcagt
     2461 aagctgcctt tcaaatctat agatcacaag ttcctgggaa agtcaagaaa tcagttaaat
     2521 gcatttctac agaacctgct ttcagatgaa agactgttcc agagcgaagc actttatgcc
     2581 tttttgagcc cttctcctga ctacctcaag gtcattgatg tacaggggaa aaagacctcc
     2641 ttctcattgt cttcatttct ggaaaaactt cctcgtgact tcttctccca tcaggaggag
     2701 gagatagaag aggacagcga cctgtccgat tacggggatg atgtggacgg gaagaaggat
     2761 tccttggctg aaccgtgttt catgctgatc ggggagattt tcgaacttcg aggaatgttt
     2821 aaatgggtgc gaagaacatt aatcgctctt gttcaggtca cgtttggaag aaccatcaac
     2881 aagcaaatcc gcgacacggt gagctggatc tccagcgagc agatgctggt ctactacatc
     2941 agtgctttcc gggatgcctt ttggccaaac gggaaactgg cacctccaac aagaatccga
     3001 agcgtggcac agagtcagga gacgaagcag agagcacagc agaagctgct cgagaacatt
     3061 ccagatacac ttcagagcct tgttggacag caaaatgccc gccatggtat aataaaaata
     3121 ttcaaggcgc tgcaagagac aaaggccaac aaacacctgc tctatgtgct gatggagctg
     3181 ctgctgacag agctctgccc tgagctgagg gctcacctgg atcagttcaa agctggccaa
     3241 gtctgagagc gcacagagca gccgccagag aaatgtctgt gtaaaaatag acattaaata
     3301 ttttcctctt ttgcacagag ggcctgacaa gaaccatatg atttttattt ccgagcctcc
     3361 ctctagctgt acgtgaagtg agcagagtca gagggaggag gacagatgct gtggtaggca
     3421 atagaaatca gactttaaaa gctcaacatg ttgattgaaa tacaaatgtt aatatgtgat
     3481 aagaacatag gaaatatttt aaatatttat gaaaacagtt ttgttgttaa atgacaaact
     3541 cagaatattg tacagttaat ctcctcactg aggattctga acattcctgt gtctcacatg
     3601 tattgaagac cactgttgtg caatgcttga tgtaaagtta ttgtgaaact tttattgttt
     3661 ttatttttac caaagatttc ccatagtttg aagcatttga agcaataaaa tataaaaatg
     3721 aatcaca
//
