LOCUS       NP_001359271             986 aa            linear   ROD 03-SEP-2024
DEFINITION  sorting nexin-25 isoform 1 [Mus musculus].
ACCESSION   NP_001359271 XP_006509305
VERSION     NP_001359271.1
DBSOURCE    REFSEQ: accession NM_001372342.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 986)
  AUTHORS   Zhang,Y., Yu,Z., Sun,M., Du,R., Gao,H., Dai,Q., Dong,Y., Liu,C.,
            Yin,M., Xu,T., Zhang,X., Liu,J. and Xu,J.
  TITLE     Redox-modulated SNX25 as a novel regulator of GPCR-G protein
            signaling from endosomes
  JOURNAL   Redox Biol 75, 103253 (2024)
   PUBMED   38936254
  REMARK    GeneRIF: Redox-modulated SNX25 as a novel regulator of GPCR-G
            protein signaling from endosomes.
REFERENCE   2  (residues 1 to 986)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 986)
  AUTHORS   Tanaka,T., Okuda,H., Isonishi,A., Terada,Y., Kitabatake,M.,
            Shinjo,T., Nishimura,K., Takemura,S., Furue,H., Ito,T., Tatsumi,K.
            and Wanaka,A.
  TITLE     Dermal macrophages set pain sensitivity by modulating the amount of
            tissue NGF through an SNX25-Nrf2 pathway
  JOURNAL   Nat Immunol 24 (3), 439-451 (2023)
   PUBMED   36703006
REFERENCE   4  (residues 1 to 986)
  AUTHORS   Takemura,S., Isonishi,A., Tanaka,T., Okuda,H., Tatsumi,K.,
            Yamano,M. and Wanaka,A.
  TITLE     Neural expression of sorting nexin 25 and its regulation of
            tyrosine receptor kinase B trafficking
  JOURNAL   Brain Struct Funct 225 (9), 2615-2642 (2020)
   PUBMED   32955616
  REMARK    GeneRIF: Neural expression of sorting nexin 25 and its regulation
            of tyrosine receptor kinase B trafficking.
REFERENCE   5  (residues 1 to 986)
  AUTHORS   Takemura,S., Nagano,M., Isonishi,A., Tanaka,T., Tatsumi,K.,
            Yamano,M., Minami,Y., Shigeyoshi,Y. and Wanaka,A.
  TITLE     Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic
            nucleus
  JOURNAL   Neurosci Lett 727, 134897 (2020)
   PUBMED   32156614
  REMARK    GeneRIF: Circadian rhythms of sorting nexin 25 in the mouse
            suprachiasmatic nucleus.
REFERENCE   6  (residues 1 to 986)
  AUTHORS   Hao,X., Wang,Y., Ren,F., Zhu,S., Ren,Y., Jia,B., Li,Y.P., Shi,Y.
            and Chang,Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114558.18.
            
            On Aug 29, 2019 this sequence version replaced XP_006509305.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.15551.1,
                                           SRR1660821.184400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.03 cM"
     Protein         1..986
                     /product="sorting nexin-25 isoform 1"
                     /calculated_mol_wt=112040
     Region          148..303
                     /region_name="PXA"
                     /note="PXA domain; pfam02194"
                     /db_xref="CDD:460484"
     Region          437..545
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     Region          648..770
                     /region_name="PX_SNX25"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 25; cd06878"
                     /db_xref="CDD:132788"
     Site            order(698..700,727..728,740)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132788"
     Region          847..950
                     /region_name="Nexin_C"
                     /note="Sorting nexin C terminal; pfam08628"
                     /db_xref="CDD:462541"
     CDS             1..986
                     /gene="Snx25"
                     /gene_synonym="Gm1699; Gm173; Sbbi31"
                     /coded_by="NM_001372342.1:286..3246"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS90394.1"
                     /db_xref="GeneID:102141"
                     /db_xref="MGI:MGI:2142610"
ORIGIN      
        1 mhrdatdssg arrgptsaad acraargsad rprtadgpgw gwrgpaavaa lavlalcclv
       61 pgwgpaagtg pgavllrlsl ylscaaaall lgtlvslvcw spraqppdfv sswsrlaatv
      121 rcplrspvyg npqetaqgrr vvishnmdrv lrdvfdysyr dyilswygnl srddgqlyhl
      181 llddfweivk qirqrlshvd vvkvvcndiv kallthfcdl kaatarheeq prpfvlhacl
      241 kdshdevrfl qtcsqvlvlc llpskdiqsl slrtmlaeil ttkvlkpvve llsnpdyinq
      301 mllrqleyre qmsehhkray tyapsyedfi klinsnsdvd flkqlryqiv veiiqattis
      361 sfpqlkrhkg kesaamktdl lrarnmkryi nqltvakkqc ekririlggp aydqqedgas
      421 degegpqsqk ilqfedimtn pfyrerfgty meridkralv gfwesaehlk nankseipql
      481 vsemyqnffv eskeisveks lykeiqqclv gnrgievfsk iqadvsevlr eryypsflvs
      541 dlyeklmree eeeepdaqla sekdelgsgg eageeavegt sgvsdpasfa viklrelnek
      601 leykrqalss iqnapkpdkk iisklkdeil liekectalq lhmartdwwc enlglwrasi
      661 tsaevteeng eqmpcyfvrv nlqevggvet knwtvprrls efqnlhrkls ecvpslkkvq
      721 lpslsklpfk sidhkflgks rnqlnaflqn llsderlfqs ealyaflsps pdylkvidvq
      781 gkktsfslss fleklprdff shqeeeieed sdlsdygddv dgkkdslaep cfmligeife
      841 lrgmfkwvrr tlialvqvtf grtinkqird tvswisseqm lvyyisafrd afwpngklap
      901 ptrirsvaqs qetkqraqqk llenipdtlq slvgqqnarh giikifkalq etkankhlly
      961 vlmellltel cpelrahldq fkagqv
//
