LOCUS       NM_001379335            2552 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus sorting nexin 22 (Snx22), transcript variant 2, mRNA.
ACCESSION   NM_001379335 XM_030244434
VERSION     NM_001379335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Christian,D.A., Adams,T.A. 2nd, Shallberg,L.A., Phan,A.T.,
            Smith,T.E., Abraha,M., Perry,J., Ruthel,G., Clark,J.T.,
            Pritchard,G.H., Aronson,L.R., Gossa,S., McGavern,D.B., Kedl,R.M.
            and Hunter,C.A.
  TITLE     cDC1 coordinate innate and adaptive responses in the omentum
            required for T cell priming and memory
  JOURNAL   Sci Immunol 7 (75), eabq7432 (2022)
   PUBMED   36179012
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Mancino,D.N.J., Lima,A., Roig,P., Garcia Segura,L.M., De
            Nicola,A.F. and Garay,L.I.
  TITLE     Tibolone restrains neuroinflammation in mouse experimental
            autoimmune encephalomyelitis
  JOURNAL   J Neuroendocrinol 34 (1), e13078 (2022)
   PUBMED   34961984
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Kim,S., Bagadia,P., Anderson,D.A. 3rd, Liu,T.T., Huang,X.,
            Theisen,D.J., O'Connor,K.W., Ohara,R.A., Iwata,A., Murphy,T.L. and
            Murphy,K.M.
  TITLE     High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite
            Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell
            Identity
  JOURNAL   Immunity 53 (4), 759-774 (2020)
   PUBMED   32795402
  REMARK    Erratum:[Immunity. 2021 Jul 13;54(7):1622. doi:
            10.1016/j.immuni.2021.05.018. PMID: 34260888]
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Williams,J.W., Zaitsev,K., Kim,K.W., Ivanov,S., Saunders,B.T.,
            Schrank,P.R., Kim,K., Elvington,A., Kim,S.H., Tucker,C.G.,
            Wohltmann,M., Fife,B.T., Epelman,S., Artyomov,M.N., Lavine,K.J.,
            Zinselmeyer,B.H., Choi,J.H. and Randolph,G.J.
  TITLE     Limited proliferation capacity of aortic intima resident
            macrophages requires monocyte recruitment for atherosclerotic
            plaque progression
  JOURNAL   Nat Immunol 21 (10), 1194-1204 (2020)
   PUBMED   32895539
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Hegde,S., Krisnawan,V.E., Herzog,B.H., Zuo,C., Breden,M.A.,
            Knolhoff,B.L., Hogg,G.D., Tang,J.P., Baer,J.M., Mpoy,C., Lee,K.B.,
            Alexander,K.A., Rogers,B.E., Murphy,K.M., Hawkins,W.G.,
            Fields,R.C., DeSelm,C.J., Schwarz,J.K. and DeNardo,D.G.
  TITLE     Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance
            in Pancreatic Cancer
  JOURNAL   Cancer Cell 37 (3), 289-307 (2020)
   PUBMED   32183949
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Brahler,S., Zinselmeyer,B.H., Raju,S., Nitschke,M., Suleiman,H.,
            Saunders,B.T., Johnson,M.W., Bohner,A.M.C., Viehmann,S.F.,
            Theisen,D.J., Kretzer,N.M., Briseno,C.G., Zaitsev,K., Ornatsky,O.,
            Chang,Q., Carrero,J.A., Kopp,J.B., Artyomov,M.N., Kurts,C.,
            Murphy,K.M., Miner,J.H. and Shaw,A.S.
  TITLE     Opposing Roles of Dendritic Cell Subsets in Experimental GN
  JOURNAL   J Am Soc Nephrol 29 (1), 138-154 (2018)
   PUBMED   29217759
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112676.8.
            
            On Mar 30, 2020 this sequence version replaced XM_030244434.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1551693.1,
                                           SRR7652917.1225724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC112676.8         169181-169334       c
            155-238             AC112676.8         168749-168832       c
            239-343             AC112676.8         168261-168365       c
            344-438             AC112676.8         167702-167796       c
            439-506             AC112676.8         167088-167155       c
            507-2552            AC112676.8         164749-166794       c
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.69 cM"
     gene            1..2552
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="sorting nexin 22"
                     /db_xref="GeneID:382083"
                     /db_xref="MGI:MGI:2685966"
     exon            1..154
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..625
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-22 isoform 2"
                     /protein_id="NP_001366264.1"
                     /db_xref="GeneID:382083"
                     /db_xref="MGI:MGI:2685966"
                     /translation="MLEVHIPSVGPEAEGPRQSPEKGHMVFQVEVLYSGRRHTVPRRY
                     SEFHALHKRIKKRYKVPDFPSKRLPNWRTRGLEQRRQGLETYIQGILYLNQDVPKELL
                     EFLRLRHFPTDSKTSSWSSQLHHRPVIGFCMDPYVCTPSPEPLPEVVVDGVLQGLYGF
                     STSPVPAQPEANCHPAPSLVP"
     exon            155..238
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     exon            239..343
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     exon            344..438
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     exon            439..506
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     exon            507..2552
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="hexamer: CATAAA"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="hexamer: AATAAA"
     polyA_site      2540
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="major polyA site"
     polyA_site      2552
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /note="major polyA site"
ORIGIN      
        1 agggctgctt ggctgctcca gggagttcgg gtgcccaagc gctcgatccg ggagaggctg
       61 cagccgggtc ggggcgcgga tgctggaagt tcacattccc tcggtggggc ccgaggccga
      121 agggcccagg cagagtccag agaaaggcca catggtgttc caagtggagg tgctgtacag
      181 cggacgcaga cacaccgtgc cgcggcgcta cagcgagttc cacgctctac acaagcggat
      241 caagaaacgg tacaaagtgc ctgactttcc ctcaaaacgc ctgcccaact ggaggaccag
      301 aggactggaa cagcgccggc agggattaga gacctacatc cagggcatcc tgtacctgaa
      361 tcaggatgtg cccaaggagt tactggaatt cttgagactt agacatttcc ctacagactc
      421 caagaccagc agctggagct cccagctgca ccaccggccg gtcattggct tctgtatgga
      481 tccctacgtt tgcacccctt ccccagaacc tctcccagaa gtggtggtgg acggcgtgct
      541 ccagggtctt tatggcttca gcaccagccc ggtaccagcc cagccagagg ctaactgtca
      601 tcctgctcca tcactagtgc cctgactagc ccaggcattg ggccaccttt caggacagct
      661 atgtgcctca gtctcaggaa aatgggtctt cccttggact agactcaggt gtaactggct
      721 gaggctcaga tgtgcccatc cccactcaaa gctctgagcc tggtttgcac tgacagctgt
      781 agctggtaga actcaagact cttaaaagcc caggggtcgt ggcgaagtca agataaagag
      841 aaaggtgtga ggtaatttca gaggtaggct gagaagagtc aggtgtattt tctagcccag
      901 cctgacaggt gtaagcttaa gatgaggcac aggagctagc tagaaagtct ctgcctggtg
      961 agtgggtggg ttgcactagt acaggctaag gcaggaaccc gggggaggag catgcgtcca
     1021 tcagcacaga agagtcccac acagggacac acactcagga caggtgttat atacaccccc
     1081 aaacacagcc cacacccaag ctataaaaaa aacccacttt attgatcagc attggtagtt
     1141 ttttataaaa atcaggcctg tggaatgtga ggggtgtggt caccccatca gatggaagca
     1201 ctagggccag ggtggcacag aaccttgtga ctggctacct tcgtctgtgt ggggattgac
     1261 aggacccaca cagacagctg cttagaggga tgaggtcccc caggctctct actccttggc
     1321 aatggcgaag ggtttctcca cttcgatctt gccggagtcg acaatgatga catccttcag
     1381 tggcttgtcc cggctgtctg tcttggtgct ctccaccttc cgtaccacat cctagacagg
     1441 aaaggcagga gaggagaggt tgagcggggg tcaagaggca cactcctggg agagagcccc
     1501 acataggtga acacagaaca cgatgctgga cagctgatcc aacgctgctc agacgtgatt
     1561 ccgaacaccc ctgactccat gagtgaccaa acaggacccc gcagccggac aaactcagcc
     1621 aggtcttctg gatgggttgt ctggggccta ggacttagag ccttgggggc acggagctcc
     1681 gattgtggtg ctggggatta actcagggcc gcaagcattc caggttaagc ctctcacaga
     1741 gccaaccaca cgggcactct caaacgtggt cccaggttgt ccagcctaga ctctgactcc
     1801 cgagttcaag tgatccccta gcctcagcct cctgaaagct aggaccatag gcatgtgcga
     1861 ggcacctggc caggctgttt attcttgaca ctccccacct ccatgccagg ttaggaagaa
     1921 ccagtgcccc tgacctgtct gtatctgtgg cttaggcgcc tttggggaaa agatttccta
     1981 cttgaagccc ttgcccgttc cagctggatc cttggtgagg actaccgagg tttaacctcc
     2041 acattttaac ttaccatgcc ctctagaact ttgccgaaaa ccacatgctt gccatccagc
     2101 caggaggtct tgactgtggt tatgaagaac tgtgagccat tggtgtcttt gcctgcattg
     2161 gccatgctca cccagccagg cccgtagtgc ttcagcttga agttctcatc tgggaagcgc
     2221 tcaccataga tgctctttcc taggaagagg cagagcaggt cagggagggg gggctgaccc
     2281 caaacagcag gtgcctgggc gaggatctgt ccttgttagg ctaggctttg gtggcaaaca
     2341 aggacagatg tcttctgtct tctacccaag ctgtcaggac caagaccacc tagggtgtga
     2401 ggccaggctg ggggcgtggg tgtagaatcc ttcagaaaag ggctgctgta accttcccag
     2461 ggttacaaaa caggtgcagc ttcgggggga ggggggagtt agaactccta tttgttttta
     2521 ccaaggaaca taaaataaaa gatgcccatg aa
//
