LOCUS       NP_001366264             181 aa            linear   ROD 24-OCT-2024
DEFINITION  sorting nexin-22 isoform 2 [Mus musculus].
ACCESSION   NP_001366264 XP_030100294
VERSION     NP_001366264.1
DBSOURCE    REFSEQ: accession NM_001379335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 181)
  AUTHORS   Christian,D.A., Adams,T.A. 2nd, Shallberg,L.A., Phan,A.T.,
            Smith,T.E., Abraha,M., Perry,J., Ruthel,G., Clark,J.T.,
            Pritchard,G.H., Aronson,L.R., Gossa,S., McGavern,D.B., Kedl,R.M.
            and Hunter,C.A.
  TITLE     cDC1 coordinate innate and adaptive responses in the omentum
            required for T cell priming and memory
  JOURNAL   Sci Immunol 7 (75), eabq7432 (2022)
   PUBMED   36179012
REFERENCE   3  (residues 1 to 181)
  AUTHORS   Mancino,D.N.J., Lima,A., Roig,P., Garcia Segura,L.M., De
            Nicola,A.F. and Garay,L.I.
  TITLE     Tibolone restrains neuroinflammation in mouse experimental
            autoimmune encephalomyelitis
  JOURNAL   J Neuroendocrinol 34 (1), e13078 (2022)
   PUBMED   34961984
REFERENCE   4  (residues 1 to 181)
  AUTHORS   Kim,S., Bagadia,P., Anderson,D.A. 3rd, Liu,T.T., Huang,X.,
            Theisen,D.J., O'Connor,K.W., Ohara,R.A., Iwata,A., Murphy,T.L. and
            Murphy,K.M.
  TITLE     High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite
            Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell
            Identity
  JOURNAL   Immunity 53 (4), 759-774 (2020)
   PUBMED   32795402
  REMARK    Erratum:[Immunity. 2021 Jul 13;54(7):1622. doi:
            10.1016/j.immuni.2021.05.018. PMID: 34260888]
REFERENCE   5  (residues 1 to 181)
  AUTHORS   Williams,J.W., Zaitsev,K., Kim,K.W., Ivanov,S., Saunders,B.T.,
            Schrank,P.R., Kim,K., Elvington,A., Kim,S.H., Tucker,C.G.,
            Wohltmann,M., Fife,B.T., Epelman,S., Artyomov,M.N., Lavine,K.J.,
            Zinselmeyer,B.H., Choi,J.H. and Randolph,G.J.
  TITLE     Limited proliferation capacity of aortic intima resident
            macrophages requires monocyte recruitment for atherosclerotic
            plaque progression
  JOURNAL   Nat Immunol 21 (10), 1194-1204 (2020)
   PUBMED   32895539
REFERENCE   6  (residues 1 to 181)
  AUTHORS   Hegde,S., Krisnawan,V.E., Herzog,B.H., Zuo,C., Breden,M.A.,
            Knolhoff,B.L., Hogg,G.D., Tang,J.P., Baer,J.M., Mpoy,C., Lee,K.B.,
            Alexander,K.A., Rogers,B.E., Murphy,K.M., Hawkins,W.G.,
            Fields,R.C., DeSelm,C.J., Schwarz,J.K. and DeNardo,D.G.
  TITLE     Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance
            in Pancreatic Cancer
  JOURNAL   Cancer Cell 37 (3), 289-307 (2020)
   PUBMED   32183949
REFERENCE   7  (residues 1 to 181)
  AUTHORS   Brahler,S., Zinselmeyer,B.H., Raju,S., Nitschke,M., Suleiman,H.,
            Saunders,B.T., Johnson,M.W., Bohner,A.M.C., Viehmann,S.F.,
            Theisen,D.J., Kretzer,N.M., Briseno,C.G., Zaitsev,K., Ornatsky,O.,
            Chang,Q., Carrero,J.A., Kopp,J.B., Artyomov,M.N., Kurts,C.,
            Murphy,K.M., Miner,J.H. and Shaw,A.S.
  TITLE     Opposing Roles of Dendritic Cell Subsets in Experimental GN
  JOURNAL   J Am Soc Nephrol 29 (1), 138-154 (2018)
   PUBMED   29217759
REFERENCE   8  (residues 1 to 181)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   9  (residues 1 to 181)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112676.8.
            
            On Mar 30, 2020 this sequence version replaced XP_030100294.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1551693.1,
                                           SRR7652917.1225724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.69 cM"
     Protein         1..181
                     /product="sorting nexin-22 isoform 2"
                     /calculated_mol_wt=20609
     Region          2..115
                     /region_name="PX_SNX22"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 22; cd06880"
                     /db_xref="CDD:132790"
     Site            order(43..45,66..67,79)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132790"
     CDS             1..181
                     /gene="Snx22"
                     /gene_synonym="Gm1120"
                     /coded_by="NM_001379335.1:80..625"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:382083"
                     /db_xref="MGI:MGI:2685966"
ORIGIN      
        1 mlevhipsvg peaegprqsp ekghmvfqve vlysgrrhtv prrysefhal hkrikkrykv
       61 pdfpskrlpn wrtrgleqrr qgletyiqgi lylnqdvpke lleflrlrhf ptdsktssws
      121 sqlhhrpvig fcmdpyvctp speplpevvv dgvlqglygf stspvpaqpe anchpapslv
      181 p
//
