LOCUS       NM_026386               2092 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus sorting nexin 2 (Snx2), transcript variant 1, mRNA.
ACCESSION   NM_026386
VERSION     NM_026386.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Zhang,A., He,X., Zhang,L., Yang,L., Woodman,P. and Li,W.
  TITLE     Biogenesis of lysosome-related organelles complex-1 subunit 1
            (BLOS1) interacts with sorting nexin 2 and the endosomal sorting
            complex required for transport-I (ESCRT-I) component TSG101 to
            mediate the sorting of epidermal growth factor receptor into
            endosomal compartments
  JOURNAL   J Biol Chem 289 (42), 29180-29194 (2014)
   PUBMED   25183008
  REMARK    GeneRIF: BLOS1 interacts with sorting nexin 2 and the ESCRT-I
            component TSG101 to mediate the sorting of EGFR into endosomal
            compartments
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Wallingford,M.C. and Giachelli,C.M.
  TITLE     Loss of PiT-1 results in abnormal endocytosis in the yolk sac
            visceral endoderm
  JOURNAL   Mech Dev 133, 189-202 (2014)
   PUBMED   25138534
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Rhee,S., Guerrero-Zayas,M.I., Wallingford,M.C., Ortiz-Pineda,P.,
            Mager,J. and Tremblay,K.D.
  TITLE     Visceral endoderm expression of Yin-Yang1 (YY1) is required for
            VEGFA maintenance and yolk sac development
  JOURNAL   PLoS One 8 (3), e58828 (2013)
   PUBMED   23554936
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Griffin,C.T., Trejo,J. and Magnuson,T.
  TITLE     Genetic evidence for a mammalian retromer complex containing
            sorting nexins 1 and 2
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15173-15177 (2005)
   PUBMED   16214895
  REMARK    GeneRIF: Data describe a functional interaction between Hbeta58,
            sorting nexin 1 (SNX1), and SNX2 and strongly suggest that SNX2
            plays a more critical role than SNX1 in retromer activity during
            embryonic development.
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Schwarz,D.G., Griffin,C.T., Schneider,E.A., Yee,D. and Magnuson,T.
  TITLE     Genetic analysis of sorting nexins 1 and 2 reveals a redundant and
            essential function in mice
  JOURNAL   Mol Biol Cell 13 (10), 3588-3600 (2002)
   PUBMED   12388759
  REMARK    GeneRIF: Data show that mice lacking sorting nexin 1 or sorting
            nexin 2 are viable and fertile, whereas embryos deficient in both
            proteins arrest at midgestation.
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Yuan,L., Liu,J.G. and Hoog,C.
  TITLE     Rapid cDNA sequencing in combination with RNA expression studies in
            mice identifies a large number of male germ cell-specific sequence
            tags
  JOURNAL   Biol Reprod 52 (1), 131-138 (1995)
   PUBMED   7536044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127421.3, AK145840.1, AK002692.1 and AC148020.3.
            
            On Oct 28, 2017 this sequence version replaced NM_026386.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002692.1, AK075929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC127421.3         158739-158762
            25-73               AK145840.1         3-51
            74-2086             AK002692.1         1-2013
            2087-2092           AC148020.3         154251-154256       c
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.99 cM"
     gene            1..2092
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /note="sorting nexin 2"
                     /db_xref="GeneID:67804"
                     /db_xref="MGI:MGI:1915054"
     exon            1..196
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1648
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-2 isoform 1"
                     /protein_id="NP_080662.1"
                     /db_xref="CCDS:CCDS37821.1"
                     /db_xref="GeneID:67804"
                     /db_xref="MGI:MGI:1915054"
                     /translation="MAAEREPPPLGDVKPTDFEELEDGEDLFTSTVSTLESSPSSPEP
                     ASLPAEDISANSNGSKPVEVVLDDDREDLFAEATEEVSLDSPERELILSSEPSPAVTP
                     VTPTTLIAPRIESKSISAPVIFDRSRDEIEEEANGDIFDIEIGVSDPEKVGDGMNAYM
                     AYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTK
                     VKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQAL
                     SGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHASVEALVCHR
                     KELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSEL
                     LSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKPDKIQQAKNEI
                     REWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKAVIIKYLESLVQTQQQLIKYW
                     EAFLPEAKAIA"
     exon            197..314
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            315..478
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            479..545
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..589
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            590..731
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..810
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..886
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1000
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1094
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1300
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1444
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1525
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1597
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2092
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /note="major polyA site"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2091
                     /gene="Snx2"
                     /gene_synonym="0610030A03Rik"
ORIGIN      
        1 gggtcggcgc gccagcccag ccttgcgtgc tcacgtgaca ggtccgcgag gccccggctc
       61 ttgcagacgt ccaggccaag aggcgaagat ggcggccgag agggagcctc ctccgctggg
      121 ggacgtgaag cccacagact ttgaggagct ggaggacgga gaggacctgt tcaccagcac
      181 cgtctccacc cttgagtcaa gtccatcatc tcccgaacca gccagtctcc ctgcagaaga
      241 tatcagtgca aactctaatg gctccaaacc tgtagaagtt gtcctagacg atgacagaga
      301 agatcttttc gcagaagcca cagaagaggt gtccttggac agtcccgaaa gagagctcat
      361 cctgtcctcc gagccgtctc ctgcggtcac ccctgtcact cccaccacac tcattgctcc
      421 tagaatcgaa tcaaagagta tctctgctcc agtcatcttt gacagatcca gggacgagat
      481 tgaagaagaa gcaaatggag atatttttga tatagaaatt ggtgtgtcag atccggaaaa
      541 agttggtgat ggcatgaatg cttacatggc atatagagta acaacaaaga cttctctttc
      601 catgttcagt aagagtgaat tttcagtcaa aagaagattc agtgactttc ttggtttgca
      661 tagcaaatta gcaagcaaat atttacatgt tggttacatc gtgccacccg ctccagaaaa
      721 gagtatagta ggtatgacca aggtcaaagt aggtaaagaa gattcatcat ccactgagtt
      781 tgtagaaaaa cgaagagcgg cactggagag gtatcttcag agaacagtaa agcatccgac
      841 attgcttcag gatcctgact taaggcagtt tttggaaagc tcagagctgc cgagagcagt
      901 taatacgcag gctctgagtg gagcaggaat attgaggatg gtgaacaagg ctgccgacgc
      961 tgtcaacaaa atgacaatca agatgaatga atcggatgca tggtttgaag aaaagcaaca
     1021 gcaatttgag aatcttgacc agcaacttcg gaaacttcat gccagtgttg aagccttggt
     1081 ctgtcataga aaagaacttt cagccaacac agccgccttt gctaagagtg ctgccatgct
     1141 aggtaattct gaggaccaca ctgcgctctc tagagctttg tctcagctgg cagaggttga
     1201 ggagaagata gaccagttac atcaagagca agcttttgct gacttttaca tgttctcaga
     1261 acttcttagt gactacattc gtctcattgc tgcagtgaaa ggtgtgtttg accatcggat
     1321 gaagtgctgg cagaaatggg aagatgctca aattaccttg ctcaaaaaac gtgaaactga
     1381 ggcaaaaatg atggttgcta acaagccaga taaaattcaa caagctaaaa acgagataag
     1441 agagtgggag gcgaaagtac aacaaggaga gagagatttt gagcagatct ctaaaacaat
     1501 tcgaaaagaa gtgggaagat ttgagaaaga acgagtgaaa gattttaaag ctgttatcat
     1561 caagtacttg gagtcattag tacaaacaca gcaacagctg ataaagtact gggaggcatt
     1621 cctacctgaa gccaaagcca ttgcctagcc ttacccctgt gaaggagaca ttggattccc
     1681 cagtgagatc atctagaaac catctaaata aaccactcta tattttatga attacatgtg
     1741 ggttttttat atataaaaac atatgcgctg acattttatt acaagctgca tgtcctgacc
     1801 ttctttgaat taagtggact gtggcatgac attctgcaat attttgctga attgaacact
     1861 attgtgtctt aaatacttgc actaaaaaag tgcactgcaa ggccagaaaa ttttacaatc
     1921 ttctttcttt tatgttctgt agtgtgttta ccctcattat gaagcaaatt agcaatgcat
     1981 tgattaatgt tcacttatac attcctgtac agaaattatg atttttgtga ttatagtaat
     2041 aaaatgatat tacttgtgaa atattagtaa taaattattt gagtatataa ac
//
