LOCUS       NM_028874               5541 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sorting nexin 19 (Snx19), mRNA.
ACCESSION   NM_028874 XM_134648
VERSION     NM_028874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5541)
  AUTHORS   Mas,C., Norwood,S.J., Bugarcic,A., Kinna,G., Leneva,N., Kovtun,O.,
            Ghai,R., Ona Yanez,L.E., Davis,J.L., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for different phosphoinositide specificities of
            the PX domains of sorting nexins regulating G-protein signaling
  JOURNAL   J Biol Chem 289 (41), 28554-28568 (2014)
   PUBMED   25148684
  REMARK    GeneRIF: SNX19 and SNX14 PX domains reveal key differences in
            spatial control of RGS-PX proteins in cell signaling and
            trafficking.
REFERENCE   3  (bases 1 to 5541)
  AUTHORS   Harashima,S., Horiuchi,T., Wang,Y., Notkins,A.L., Seino,Y. and
            Inagaki,N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   4  (bases 1 to 5541)
  AUTHORS   Kan,A., Ikeda,T., Saito,T., Yano,F., Fukai,A., Hojo,H.,
            Ogasawara,T., Ogata,N., Nakamura,K., Chung,U.I. and Kawaguchi,H.
  TITLE     Screening of chondrogenic factors with a real-time
            fluorescence-monitoring cell line ATDC5-C2ER: identification of
            sorting nexin 19 as a novel factor
  JOURNAL   Arthritis Rheum 60 (11), 3314-3323 (2009)
   PUBMED   19877062
  REMARK    GeneRIF: The ATDC5-C2ER cell line system can be used for efficient
            monitoring of chondrogenic differentiation by fluorescence
            analysis. A novel chondrogenic factor (SNX19) is identified for
            elucidating the molecular network of chondrogenic differentiation.
REFERENCE   5  (bases 1 to 5541)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC160339.2 and
            CU024910.10.
            
            On Nov 17, 2006 this sequence version replaced NM_028874.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063262.1, AK122231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1928              AC160339.2         139207-141134
            1929-2067           AC160339.2         144113-144251
            2068-2168           AC160339.2         145208-145308
            2169-2288           AC160339.2         145414-145533
            2289-2419           AC160339.2         147690-147820
            2420-2516           AC160339.2         148653-148749
            2517-2697           AC160339.2         149228-149408
            2698-2827           AC160339.2         151974-152103
            2828-3012           AC160339.2         174109-174293
            3013-3100           CU024910.10        38814-38901
            3101-5541           CU024910.10        39880-42320
FEATURES             Location/Qualifiers
     source          1..5541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.04 cM"
     gene            1..5541
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /note="sorting nexin 19"
                     /db_xref="GeneID:102607"
                     /db_xref="MGI:MGI:1921581"
     exon            1..1928
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..3233
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /codon_start=1
                     /product="sorting nexin-19"
                     /protein_id="NP_083150.1"
                     /db_xref="CCDS:CCDS22944.1"
                     /db_xref="GeneID:102607"
                     /db_xref="MGI:MGI:1921581"
                     /translation="MKAQTVSPTQGTISESSYVHSNLWSSRKLMIVGVLVGWLLVIHL
                     LVNMWLLILLCASLVALGGWLGSTAILGASGQLHLERFITITTCPPCPEAERQLEQEI
                     NRTIQMIIRDFVLSWYRSVSHEPAFEAEMEAAMKGLVQELRRRMSIVDSHALTQRVLT
                     LCGCHLQSYIQAKEATAKEQSCPVQPSQLWDAYCQVTAPHPAMSCPTTEVTYARGIVN
                     LILKELVPKPHLETRTGRHVVVEVITCNVILPLISKLSDPDWIHLILVSIFSKYRHDA
                     AQGTKPPCSSSVLEQPSVPTSLPLIVEVESLPVGKASSPATAPVHLTSSEPAPSPEIE
                     EGHEAVEGDLPGMLEEKKVGNSSSHFLQPDIRGPLFLCEDSELESPLSELSKETILLM
                     TPGNFLSDRIQDALCALDDSGALEPKDGEGSECMEGAEAEEAPGTDTETGMLVSVLNC
                     PEIQIDTADKEVEQGDDTSLTALLEEPEKPCPLRPSCLDKDLASGVCSLEPAMPPVPL
                     SSSPPGPLSSATFSFESLSSPDGPVVIQNLRITGTITAREHSGTGFHPYTLYTVKYET
                     VLNGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPFG
                     NMDSDRVEARKSLLESFLKQLCAIPEIGNSEEVQEFLALNTDARIAFVKKPFMVSRID
                     KMVVSAIVDTLKTAFPRSEPQSPTEELSEAENESKPQTEGKKASKSRLRFSSSKIAPA
                     LSIAEAQDKILYCLQEGNSESEVLSMSGMESFIEKQTKLLRIQPAEVPDKDPQQVPKE
                     YVDSGLLDKAVVAQELNKSGPGTETELADTAFDLILLLLMEQWKWLCTESMQKFLHII
                     FGTLVQRWLEVQVANLTCPQRWAQYLHLLRESIWPGGVLPKFPRPGRTQAQKAATEKQ
                     ALQSLMDLLPDFLVEILGVNKCRLSWSLVLESFQQPLINRHLIYCLGDIILELLDLSA
                     SVEECAPATSASDSPGSLKKMAVST"
     exon            1929..2067
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2168
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2288
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2419
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2516
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2697
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2827
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3012
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3100
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..5541
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4534..4539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /note="hexamer: ATTAAA"
     polyA_site      4557
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /note="major polyA site"
     regulatory      5535..5540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /note="hexamer: AATATA"
     polyA_site      5541
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
ORIGIN      
        1 gccggcaaag ttttcctcat ctcggctgga acaggctagt tgatgggccc tgtcgacaga
       61 agcgagcggg agaagcagag ctttttctgt cgctctgcag tgccagtagt atcgaaggtc
      121 cagagttcac tcagtagcag ctggacttgt tctcttcggt gacagttcat gctcccactc
      181 ctgacaccaa aataaaatcg gaggctgtca tctgtggaaa catacctgtc ctttcaacca
      241 tgaaggcaca aacagtgtcc cctacccagg ggactatctc cgagtccagt tatgtccaca
      301 gcaatctatg gagtagccgg aagctaatga tcgtgggggt cttggtgggc tggctactgg
      361 tcatccacct tctggtcaac atgtggcttc tgatccttct atgtgcatcg ctggtagcgc
      421 tgggaggatg gctgggctcc actgccatcc taggggcttc aggtcaattg cacctggaac
      481 gattcattac catcaccacc tgtcctccat gtcccgaggc agaaaggcag ctggaacagg
      541 agattaaccg cactatccag atgattatcc gagacttcgt gttatcctgg tatcgttctg
      601 tgagccatga gccggccttc gaggcagaga tggaggcagc catgaaaggg ttggttcagg
      661 agcttcgaag gcggatgagc atagtggaca gccatgctct tacccagagg gttctgactc
      721 tctgtggttg tcacctgcag agctatattc aggcaaagga ggctactgca aaggagcaga
      781 gctgtccagt tcagccctcc cagctgtggg atgcttactg ccaggttaca gctccccatc
      841 ctgccatgag ctgtcccacc acggaggtca cttatgcacg tggcattgtg aacttgatac
      901 taaaagagtt agtgcccaag ccccacctgg agacgaggac tggacgccac gttgtggttg
      961 aagttattac ttgcaatgtc atcttaccac tgatcagcaa gctatcagat cctgactgga
     1021 tccaccttat tcttgtgagt atcttttcca agtacagaca tgatgcagca cagggaacta
     1081 aacccccctg ctcatccagt gtcctagagc agccctcggt gcccacatct ctgccattga
     1141 ttgttgaagt agagagtctg ccagtaggaa aagcatcttc tccagcaaca gccccagtac
     1201 acttgacctc cagtgagcca gccccttccc cagagattga agaaggccat gaagctgtag
     1261 agggagattt gcctgggatg ctcgaagaaa aaaaagtagg aaatagctca tcccattttc
     1321 tacagccaga tatccgaggc cccttgttct tatgtgaaga ctcagaactg gagtcaccac
     1381 tgtctgaact gagcaaagaa accatcctgc taatgacccc aggcaacttc ctttctgaca
     1441 ggattcaaga tgctctgtgt gccctagacg actccggggc tctggagcct aaggatggcg
     1501 agggatctga atgtatggaa ggagcagagg ccgaggaggc cccagggaca gacacagaga
     1561 caggcatgct ggtctccgtg cttaattgcc cagagatcca gattgacaca gcagacaagg
     1621 aggtggagca aggagatgac acctctctta cagctttgct ggaggaacca gaaaaaccct
     1681 gccccctacg gccctcatgt ttagacaaag atctcgccag tggtgtgtgc tcccttgaac
     1741 ctgctatgcc cccagtgcct ctttcctcct ctccacctgg tcctctcagc tcagccacct
     1801 tcagcttcga gtccctgagc agtccagacg gcccggttgt catccagaac cttcgaatca
     1861 ctggcaccat cactgcccga gagcacagtg ggactggatt ccacccatac acactgtaca
     1921 ctgtgaagta cgagactgtc cttaatggcg agaacagcag cggcctacag cagctggcct
     1981 atcacaccgt gaaccgccgc taccgggagt tcttgaatct gcagacccgc ctggaggaga
     2041 aaccagatct acgaaagttt atcaaaaatg tgaagggtcc aaaaaagctc tttccagatc
     2101 ttccgtttgg aaacatggat agtgacagag tagaagccag gaagagcctc ctggagtcat
     2161 tcctgaagca actctgcgcc attcctgaga ttggcaacag tgaggaggtg caggagttcc
     2221 ttgctctgaa cacagatgct cggattgcct ttgtcaagaa accattcatg gtctctagga
     2281 tagacaagat ggtggtgagt gctatcgtgg acaccttgaa gacagcattt cctcgctctg
     2341 aaccccagag tcccacagag gagctgagtg aagcagagaa tgaaagcaag ccccagacag
     2401 aaggcaagaa ggctagcaag tccagactga ggttttcatc cagtaaaatt gcccctgcac
     2461 tgagtatagc cgaggcacag gacaagattc tgtactgcct ccaggaaggc aattcggagt
     2521 cagaagtcct gtccatgtct gggatggagt ctttcattga aaaacagaca aagttactga
     2581 gaatccagcc agcagaagtc ccggataaag atccccagca agtgcccaaa gaatatgtgg
     2641 atagcggtct gctggacaaa gctgtggtag cccaagagct caacaagagt ggcccgggaa
     2701 cggagacaga gttagccgac acggcctttg atctgatcct cctgctgttg atggagcaat
     2761 ggaagtggct gtgtactgaa agcatgcaga agttcctcca cattattttt ggcacactag
     2821 ttcagaggtg gctagaagtg caggtggcta atctaacatg tccccagcgc tgggcacagt
     2881 acctccatct tcttcgggaa tctatctggc ctggtggagt gctgcccaag tttccacggc
     2941 ctggaaggac gcaggcacag aaagcagcta cggagaagca ggctttgcag agcttgatgg
     3001 atctccttcc agattttttg gtagaaatcc tgggagtgaa caagtgtcgg ctgagctgga
     3061 gtcttgtctt ggagtcattc cagcagcccc tcatcaacag acatttgatt tactgccttg
     3121 gagacattat cctggagttg ctggacctca gtgcctctgt tgaagagtgt gccccagcta
     3181 cctctgcctc agattcccca ggaagcctca agaagatggc tgtctccact tagctaaaac
     3241 accatctcca aaggcttgaa aaagagagct gttcagcttc cagaaacagc taagatacct
     3301 gtgccctctg gagctaagct agcttagcta gcctccatct caggggctca gttcccctac
     3361 caggtctccc ttagtagcac atgacggagc tacatagcct atttgcatgt gtacctgttt
     3421 ccatagtctt tggcatgtgg attgctgcgg agaggaggtc ttgtttcctt gagaacagaa
     3481 gctgtgaagc aaaggctatt tatccctttg ccttctcacc atcacggttt gccaacagca
     3541 tggccctgcg catgcgtgaa cctaatccac aaatgtgcaa gtggcaggtg acacaggaga
     3601 aacaatggag ccagatttcc tggggggaga agcagtctcc tgagctctct tttcctagct
     3661 ggaaaccaaa cgttcattca ggatcactcc cttaccctgc ccagttccca acaattccag
     3721 aagaagaggg aaggaaagtg tgtctccagg gacttgctct ttggctattt tctgacacag
     3781 tggacttcta aaggatgtca agaaggctgc ttcctagggt ggctatactt ttcctgtcca
     3841 gaggcttcaa agcacactgt caaacttctg gtaaagccac tccacccttc acaccctttc
     3901 ctgcgaggga ttagacagca gatttcctta actttcctcc cagcccctac ccaaaagcaa
     3961 atgcgttttg gatttgtaac tttccttcta tcaacagaat tgcatggcaa gttacgtatt
     4021 tggtctcagt atttccaaag agaaaggaaa gtacttgttc catggctgag ggtgtacaaa
     4081 gaatagaagt caggggatga gtggggatcc ctccacaaga ttctggcaag aataatatag
     4141 caaacttgcg gatacagatt ttactttctg ttccttaaat attgaattag tccttaggag
     4201 gccaggaata aaggcagaac agtctgtgtc cactggaaag atggagcaac tgagagcagc
     4261 tgttagaaga aaagggagtt ggagggaaag tcacaaggtg agtgctgctg cccagtgagt
     4321 gcacatgagt agctggcatc cccagggtac ccatgagaga ccatagccaa ccctcagctc
     4381 aggaggtctg tgttgtgtag ctctagcctt gctatactca actacagaac ccacagggat
     4441 ggaggtcatg gggaaagcct ggtaagaact gggaaggcat caagagccag catcaaagtt
     4501 gtcacagact ctgaagtgtg tgatgaacac acaattaaag ttgttcatag aaaaaaaggt
     4561 tgtgaaattg ttttagtctc ctgtcctgag aggctcgtaa ctgtacatta cactctgatg
     4621 tgactgggag ggttctggct taaaaagaaa aaacagtgaa tgagataaag ttttatggcc
     4681 tcttctggcc ttgaagcttg acttgatggc tccatagttt ttgaagtatc cccttcccta
     4741 gaccctcaga ggcaaagata attcaacatg tcctctgagt gcctgctagg gatatggttt
     4801 caaggggatg ccttagaact gatcctgtgg ctcctagggt aaaggccact ttattctgta
     4861 ttggcggaat gagcaaccct gatttctgaa caggcttctc tcccaacacc cacccccttc
     4921 gcatgaccac agccacctgt gtccacttga atctgctacc agtcctggta cacatgtgca
     4981 caagcactgt taacccaaca caccacgagt tcctgtggca atgaagtcta agggatcttt
     5041 tcatgcctgc agcccagaga acttccctat gcttcatttt atataagagg acacactttt
     5101 actccacctg ccttcaaaag ataagccatc ctcaagaggg aaataataaa tataaccaag
     5161 gatatatcaa aacctctctg acttggaaaa aggttagtag caggctccaa cctcaagatc
     5221 atgagcatgt gggagagcca cgggtgttgg ggtgatgctc caggctggga gtgggaacgg
     5281 agggagaact gagccacact agtccacttg atttcttccc tgtttgtttg gctttttaag
     5341 gacccagttt gttcatttaa ttgagaatat tagtacctga agtaagacca acacccattc
     5401 tgtcttgatt gcacatttgt aagaagagga gagatgggtg gatactgagc tctttctggc
     5461 aatttctaaa tgccatcctt gctgtcattt attaaagttc aagatcgctg tatataatta
     5521 tacaatttta tataaatata a
//
