LOCUS       NP_083150                997 aa            linear   ROD 02-MAY-2024
DEFINITION  sorting nexin-19 [Mus musculus].
ACCESSION   NP_083150 XP_134648
VERSION     NP_083150.1
DBSOURCE    REFSEQ: accession NM_028874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 997)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 997)
  AUTHORS   Mas,C., Norwood,S.J., Bugarcic,A., Kinna,G., Leneva,N., Kovtun,O.,
            Ghai,R., Ona Yanez,L.E., Davis,J.L., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for different phosphoinositide specificities of
            the PX domains of sorting nexins regulating G-protein signaling
  JOURNAL   J Biol Chem 289 (41), 28554-28568 (2014)
   PUBMED   25148684
  REMARK    GeneRIF: SNX19 and SNX14 PX domains reveal key differences in
            spatial control of RGS-PX proteins in cell signaling and
            trafficking.
REFERENCE   3  (residues 1 to 997)
  AUTHORS   Harashima,S., Horiuchi,T., Wang,Y., Notkins,A.L., Seino,Y. and
            Inagaki,N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   4  (residues 1 to 997)
  AUTHORS   Kan,A., Ikeda,T., Saito,T., Yano,F., Fukai,A., Hojo,H.,
            Ogasawara,T., Ogata,N., Nakamura,K., Chung,U.I. and Kawaguchi,H.
  TITLE     Screening of chondrogenic factors with a real-time
            fluorescence-monitoring cell line ATDC5-C2ER: identification of
            sorting nexin 19 as a novel factor
  JOURNAL   Arthritis Rheum 60 (11), 3314-3323 (2009)
   PUBMED   19877062
  REMARK    GeneRIF: The ATDC5-C2ER cell line system can be used for efficient
            monitoring of chondrogenic differentiation by fluorescence
            analysis. A novel chondrogenic factor (SNX19) is identified for
            elucidating the molecular network of chondrogenic differentiation.
REFERENCE   5  (residues 1 to 997)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC160339.2 and
            CU024910.10.
            
            On Jan 1, 2004 this sequence version replaced XP_134648.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063262.1, AK122231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.04 cM"
     Protein         1..997
                     /product="sorting nexin-19"
                     /calculated_mol_wt=109677
     Region          95..273
                     /region_name="PXA"
                     /note="Domain associated with PX domains; smart00313"
                     /db_xref="CDD:214611"
     Region          313..333
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T1.1)"
     Region          413..437
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T1.1)"
     Region          537..664
                     /region_name="PX_SNX19"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 19; cd06893"
                     /db_xref="CDD:132803"
     Site            order(587..589,623..624,634)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132803"
     Region          697..728
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P4T1.1)"
     Region          843..950
                     /region_name="Nexin_C"
                     /note="Sorting nexin C terminal; pfam08628"
                     /db_xref="CDD:462541"
     CDS             1..997
                     /gene="Snx19"
                     /gene_synonym="3526401K03Rik; mKIAA0254"
                     /coded_by="NM_028874.2:240..3233"
                     /db_xref="CCDS:CCDS22944.1"
                     /db_xref="GeneID:102607"
                     /db_xref="MGI:MGI:1921581"
ORIGIN      
        1 mkaqtvsptq gtisessyvh snlwssrklm ivgvlvgwll vihllvnmwl lillcaslva
       61 lggwlgstai lgasgqlhle rfitittcpp cpeaerqleq einrtiqmii rdfvlswyrs
      121 vshepafeae meaamkglvq elrrrmsivd shaltqrvlt lcgchlqsyi qakeatakeq
      181 scpvqpsqlw daycqvtaph pamscpttev tyargivnli lkelvpkphl etrtgrhvvv
      241 evitcnvilp lisklsdpdw ihlilvsifs kyrhdaaqgt kppcsssvle qpsvptslpl
      301 iveveslpvg kasspatapv hltssepaps peieegheav egdlpgmlee kkvgnssshf
      361 lqpdirgplf lcedselesp lselsketil lmtpgnflsd riqdalcald dsgalepkdg
      421 egsecmegae aeeapgtdte tgmlvsvlnc peiqidtadk eveqgddtsl talleepekp
      481 cplrpscldk dlasgvcsle pamppvplss sppgplssat fsfeslsspd gpvviqnlri
      541 tgtitarehs gtgfhpytly tvkyetvlng enssglqqla yhtvnrryre flnlqtrlee
      601 kpdlrkfikn vkgpkklfpd lpfgnmdsdr vearkslles flkqlcaipe ignseevqef
      661 lalntdaria fvkkpfmvsr idkmvvsaiv dtlktafprs epqspteels eaeneskpqt
      721 egkkasksrl rfssskiapa lsiaeaqdki lyclqegnse sevlsmsgme sfiekqtkll
      781 riqpaevpdk dpqqvpkeyv dsglldkavv aqelnksgpg teteladtaf dlillllmeq
      841 wkwlctesmq kflhiifgtl vqrwlevqva nltcpqrwaq ylhllresiw pggvlpkfpr
      901 pgrtqaqkaa tekqalqslm dllpdflvei lgvnkcrlsw slvlesfqqp linrhliycl
      961 gdiilelldl sasveecapa tsasdspgsl kkmavst
//
