LOCUS       NM_153680               1955 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus sorting nexin 17 (Snx17), transcript variant 1, mRNA.
ACCESSION   NM_153680
VERSION     NM_153680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Cui,Q., Liang,S., Li,H., Guo,Y., Lv,J., Wang,X., Qin,P., Xu,H.,
            Huang,T.Y., Lu,Y., Tian,Q. and Zhang,T.
  TITLE     SNX17 Mediates Dendritic Spine Maturation via p140Cap
  JOURNAL   Mol Neurobiol 61 (3), 1346-1362 (2024)
   PUBMED   37704928
  REMARK    GeneRIF: SNX17 Mediates Dendritic Spine Maturation via p140Cap.
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   He,X., Zhou,S., Ji,Y., Zhang,Y., Lv,J., Quan,S., Zhang,J., Zhao,X.,
            Cui,W., Li,W., Liu,P., Zhang,L., Shen,T., Fang,H., Yang,J.,
            Zhang,Y., Cui,X., Zhang,Q. and Gao,F.
  TITLE     Sorting nexin 17 increases low-density lipoprotein receptor-related
            protein 4 membrane expression: A novel mechanism of acetylcholine
            receptor aggregation in myasthenia gravis
  JOURNAL   Front Immunol 13, 916098 (2022)
   PUBMED   36311763
  REMARK    GeneRIF: Sorting nexin 17 increases low-density lipoprotein
            receptor-related protein 4 membrane expression: A novel mechanism
            of acetylcholine receptor aggregation in myasthenia gravis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Wu,Y., Zhou,Y., Huang,J., Ma,K., Yuan,T., Jiang,Y., Ye,M. and Li,J.
  TITLE     The Role of Sorting Nexin 17 in Cardiac Development
  JOURNAL   Front Cardiovasc Med 8, 748891 (2021)
   PUBMED   34988124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Dhawan,K., Naslavsky,N. and Caplan,S.
  TITLE     Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology
            domain protein 1 (EHD1)-mediated fission machinery
  JOURNAL   J Biol Chem 295 (12), 3837-3850 (2020)
   PUBMED   32041776
  REMARK    GeneRIF: Sorting nexin 17 (SNX17) links endosomal sorting to Eps15
            homology domain protein 1 (EHD1)-mediated fission machinery.
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Lee,J., Retamal,C., Cuitino,L., Caruano-Yzermans,A., Shin,J.E., van
            Kerkhof,P., Marzolo,M.P. and Bu,G.
  TITLE     Adaptor protein sorting nexin 17 regulates amyloid precursor
            protein trafficking and processing in the early endosomes
  JOURNAL   J Biol Chem 283 (17), 11501-11508 (2008)
   PUBMED   18276590
  REMARK    GeneRIF: SNX17 regulates amyloid precursor protein trafficking and
            processing in the early endosomes
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Czubayko,M., Knauth,P., Schluter,T., Florian,V. and Bohnensack,R.
  TITLE     Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class
            affinity protein, interacts with the cerebral cavernous
            malformation related protein KRIT1
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1264-1272 (2006)
   PUBMED   16712798
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   van Kerkhof,P., Lee,J., McCormick,L., Tetrault,E., Lu,W.,
            Schoenfish,M., Oorschot,V., Strous,G.J., Klumperman,J. and Bu,G.
  TITLE     Sorting nexin 17 facilitates LRP recycling in the early endosome
  JOURNAL   EMBO J 24 (16), 2851-2861 (2005)
   PUBMED   16052210
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114619.9.
            
            On Mar 17, 2023 this sequence version replaced NM_153680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026571.1, AK156299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC114619.9         134878-135053       c
            177-251             AC114619.9         134400-134474       c
            252-369             AC114619.9         133430-133547       c
            370-434             AC114619.9         132864-132928       c
            435-545             AC114619.9         132487-132597       c
            546-636             AC114619.9         132302-132392       c
            637-724             AC114619.9         132079-132166       c
            725-794             AC114619.9         131793-131862       c
            795-887             AC114619.9         131268-131360       c
            888-1091            AC114619.9         130970-131173       c
            1092-1217           AC114619.9         130597-130722       c
            1218-1295           AC114619.9         130403-130480       c
            1296-1370           AC114619.9         130199-130273       c
            1371-1412           AC114619.9         130066-130107       c
            1413-1955           AC114619.9         129443-129985       c
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.26 cM"
     gene            1..1955
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /note="sorting nexin 17"
                     /db_xref="GeneID:266781"
                     /db_xref="MGI:MGI:2387801"
     exon            1..176
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1526
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-17 isoform a"
                     /protein_id="NP_710147.1"
                     /db_xref="CCDS:CCDS19177.1"
                     /db_xref="GeneID:266781"
                     /db_xref="MGI:MGI:2387801"
                     /translation="MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLH
                     EQLRKEYGANVVPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFL
                     RRAQQETQQVPTEEVSLEVLLSNGQKVLVTVLTSDQTEDVLEAVAAKLDLPDDLIGYF
                     SLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENR
                     VGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDA
                     CVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGT
                     SSPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSI
                     RKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTD
                     ASASAVHGNFAFEGIGDEDL"
     exon            177..251
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            252..369
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            370..434
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            435..545
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            546..636
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            637..724
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            725..794
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            795..887
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1091
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1217
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1295
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1370
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1412
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1955
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /note="hexamer: ATTAAA"
     polyA_site      1955
                     /gene="Snx17"
                     /gene_synonym="5830447M19Rik; b2b1625.1Clo; D5Ertd260e;
                     mKIAA0064"
                     /note="major polyA site"
ORIGIN      
        1 ggagttcagg cccaccaaaa tggcgagctg ggctgcggag acgcgctgag tggcagaggc
       61 aagcgagcag aggcgctgcg aacctggtag tacggagctc tgccttaggg aacatgcact
      121 tttccattcc tgaaacggag tcccgcagtg gggacagcgg cggctccgcc tacgtggcct
      181 ataacattca cgtgaatgga gtcctgcact gtcgggtgcg ctacagccag cttctggggc
      241 tgcacgagca gcttcggaag gagtatgggg ccaacgtggt tcctgcattc cccccaaaga
      301 agctgttctc tttgacccct gcagaggtgg agcagaggag agagcagttg gagaagtaca
      361 tgcaagctgt tcggcaagac ccattgcttg ggagcagtga gacttttaat agctttctac
      421 gtcgggccca acaggagacc caacaggtgc ccacagagga ggtttccttg gaagtgctgc
      481 tcagcaatgg acagaaagtt ctggtaactg tgctaacttc tgaccagaca gaagatgtcc
      541 tggaggctgt ggctgcaaag ctggatcttc cagatgactt gatcggatat tttagtctct
      601 tccttgttcg agaaaaagaa gatggagcct tttcttttgt acggaagctg caggagtttg
      661 aactgcctta tgtttctgtt accagtcttc ggagtcaaga gtataagatt gtgctcagaa
      721 agagttattg ggactctgcc tatgacgacg atgtcatgga gaaccgggtt ggcctgaacc
      781 tgctttatgc tcagacggtg tcagacattg agcatggctg gatcctggtc accaaagagc
      841 agcaccggca gctcaaatct ctgcaagaga aggtctccaa aaaggagttc ttgcggctgg
      901 cccaaactct gcggcactat ggctatctgc gctttgatgc ctgtgtggct gactttccag
      961 agaaggattg ccctgttgtg gtgagcgcag gcaacagtga gctcagtctc cagctgcgac
     1021 taccaggcca gcaactccgt gaaggctctt tccgtgttac ccgaatgcga tgctggcggg
     1081 tcacctcctc tgtgccactc cctagtgggg gcacgagcag tccaagccgg ggtcggggtg
     1141 aggttcgcct ggaactggct tttgaatacc tcatgagcaa ggaccggcta cagtgggtca
     1201 ccatcaccag cccacaggct atcatgatga gcatctgcct gcagtccatg gtagatgagc
     1261 tgatggtgaa gaaatctggg ggcagtatca ggaagatgct gcgccggcgg gtggggggca
     1321 ccctgagacg ttcagacagc cagcaagcag tgaagtcccc accattgctc gagtcaccag
     1381 acgccagccg ggagtccatg gtgaaactct caagtaaact gagtgctgtg agcttgcggg
     1441 ggattggcag tcccagcaca gatgccagtg ccagtgccgt ccacggcaat ttcgccttcg
     1501 agggcattgg agatgaggat ctgtaatctc agctgcctgg atgtctgccc tctacctgag
     1561 aggagattta tacacacttg ccctgtgcct atgctcccac gttaggggag tctcttccta
     1621 ttccctcccc acttctcctt gttcctcttg gccaggggcc tcctaaccat accttccctt
     1681 ttcctgggct ggctacacaa aagatcactg tctctttttt agagctggcc cttgatgcca
     1741 aattagcatt tagtattttg cacaaagtcc aagagactgt ggctacttgc ctcggagagg
     1801 aactctaaca ctccatgggt tgtttctggc ttttgaggaa ctccagcact ccatgggttg
     1861 tttctggctt ttcagggcct gggcaaaggg tgggcagagg tctgtgaatg gtctgagcag
     1921 ctccccatca ttaaactcag cctgattgcc gccta
//
