LOCUS       NM_001359958            3109 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus sorting nexin 14 (Snx14), transcript variant 2, mRNA.
ACCESSION   NM_001359958 XM_006511183
VERSION     NM_001359958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3109)
  AUTHORS   Zhou,Y., Sanchez,V.B., Xu,P., Roule,T., Flores-Mendez,M.,
            Ciesielski,B., Yoo,D., Teshome,H., Jimenez,T., Liu,S., Henne,M.,
            O'Brien,T., He,Y., Mesaros,C. and Akizu,N.
  TITLE     Altered lipid homeostasis is associated with cerebellar
            neurodegeneration in SNX14 deficiency
  JOURNAL   JCI Insight 9 (10), e168594 (2024)
   PUBMED   38625743
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3109)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3109)
  AUTHORS   Bryant,D., Seda,M., Peskett,E., Maurer,C., Pomeranz,G., Ghosh,M.,
            Hawkins,T.A., Cleak,J., Datta,S., Hariri,H., Eckert,K.M.,
            Jafree,D.J., Walsh,C., Demetriou,C., Ishida,M., Aleman-Charlet,C.,
            Vestito,L., Seselgyte,R., McDonald,J.G., Bitner-Glindzicz,M.,
            Hemberger,M., Rihel,J., Teboul,L., Henne,W.M., Jenkins,D.,
            Moore,G.E. and Stanier,P.
  TITLE     Diverse species-specific phenotypic consequences of loss of
            function sorting nexin 14 mutations
  JOURNAL   Sci Rep 10 (1), 13763 (2020)
   PUBMED   32792680
  REMARK    GeneRIF: Diverse species-specific phenotypic consequences of loss
            of function sorting nexin 14 mutations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3109)
  AUTHORS   Ha,C.M., Park,D., Kim,Y., Na,M., Panda,S., Won,S., Kim,H., Ryu,H.,
            Park,Z.Y., Rasenick,M.M. and Chang,S.
  TITLE     SNX14 is a bifunctional negative regulator for neuronal 5-HT6
            receptor signaling
  JOURNAL   J Cell Sci 128 (9), 1848-1861 (2015)
   PUBMED   25795301
  REMARK    GeneRIF: SNX14 is a dual endogenous negative regulator in
            5-HT6R-mediated signaling pathway.
REFERENCE   5  (bases 1 to 3109)
  AUTHORS   Huang,H.S., Yoon,B.J., Brooks,S., Bakal,R., Berrios,J.,
            Larsen,R.S., Wallace,M.L., Han,J.E., Chung,E.H., Zylka,M.J. and
            Philpot,B.D.
  TITLE     Snx14 regulates neuronal excitability, promotes synaptic
            transmission, and is imprinted in the brain of mice
  JOURNAL   PLoS One 9 (5), e98383 (2014)
   PUBMED   24859318
  REMARK    GeneRIF: These data reveal a role for monoallelic Snx14 expression
            in maintaining normal neuronal excitability and synaptic
            transmission.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3109)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   7  (bases 1 to 3109)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   8  (bases 1 to 3109)
  AUTHORS   Carroll,P., Renoncourt,Y., Gayet,O., De Bovis,B. and Alonso,S.
  TITLE     Sorting nexin-14, a gene expressed in motoneurons trapped by an in
            vitro preselection method
  JOURNAL   Dev Dyn 221 (4), 431-442 (2001)
   PUBMED   11500980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025673.8 and AC116713.8.
            
            On May 20, 2019 this sequence version replaced NM_001359958.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.123028.1,
                                           SRR13422600.1839791.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               CT025673.8         126673-126934
            263-383             AC116713.8         266845-266965       c
            384-460             AC116713.8         264696-264772       c
            461-539             AC116713.8         264198-264276       c
            540-583             AC116713.8         259619-259662       c
            584-671             AC116713.8         257428-257515       c
            672-756             AC116713.8         254505-254589       c
            757-913             AC116713.8         251273-251429       c
            914-989             AC116713.8         249187-249262       c
            990-1034            AC116713.8         248646-248690       c
            1035-1115           AC116713.8         248458-248538       c
            1116-1230           AC116713.8         248251-248365       c
            1231-1386           AC116713.8         247212-247367       c
            1387-1511           AC116713.8         246091-246215       c
            1512-1570           AC116713.8         245867-245925       c
            1571-1597           AC116713.8         244670-244696       c
            1598-1730           AC116713.8         242186-242318       c
            1731-1932           AC116713.8         238314-238515       c
            1933-2016           AC116713.8         235709-235792       c
            2017-2117           AC116713.8         231158-231258       c
            2118-2229           AC116713.8         229667-229778       c
            2230-2270           AC116713.8         227917-227957       c
            2271-2390           AC116713.8         227706-227825       c
            2391-2514           AC116713.8         226025-226148       c
            2515-2679           AC116713.8         225667-225831       c
            2680-2775           AC116713.8         225429-225524       c
            2776-2867           AC116713.8         224117-224208       c
            2868-2924           AC116713.8         223457-223513       c
            2925-3109           AC116713.8         220702-220886       c
FEATURES             Location/Qualifiers
     source          1..3109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..3109
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /note="sorting nexin 14"
                     /db_xref="GeneID:244962"
                     /db_xref="MGI:MGI:2155664"
     exon            1..262
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            263..383
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            384..460
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            461..539
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            540..583
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            584..671
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            672..756
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            757..913
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            914..989
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1034
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1115
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1230
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1386
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1511
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1570
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1597
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1730
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1932
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2016
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2117
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2229
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2270
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2390
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2514
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2679
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2775
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2867
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2924
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3109
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3090..3095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /note="hexamer: AATAAA"
     polyA_site      3109
                     /gene="Snx14"
                     /gene_synonym="B830022K16; C330035N22Rik; YR-14"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggctga gtctagctgt gaagctgggt ggtgggtggc aatgtggctc cgccgccggg
       61 gtttgggggt gccctccgcc tctgcctctg agggcggcac gtcctcccct gcgtggactg
      121 agatggggtc ttgggtgcgg acgatctgcg ggaggctgaa gcagcggctg cggctggacg
      181 tggggcgcga gatttgccgt cagtatccgc tgttctgctt tctgctgctc tgcctcagcg
      241 tcgcctcgct gctcctcaac aggtatctgc atgtcttaat gatcttctgg tcgtttgttg
      301 ctggagttgt gacattctac tgttcattag gacccgattc cctcttacca aatatattct
      361 tcacaataaa atacaaaccc aagcaattag gacttcaaga gttatttccg caaggacata
      421 gctgtgctgt ttgtggtaaa gtgaaatgta aacggcatag gccttccttg ctccttgaaa
      481 actatcagcc ctggctagac ctgaaagttt cttcgaaggt agatgcatct ctctcagagg
      541 ttcttgaatt agtgttggaa aactttgtct atccatggta cagggatgtg acggatgatg
      601 agtcctttgt tgatgagctg aggatcacct tacggttttt tgcatctgtc ttggtgcgaa
      661 gaattcacaa ggtggatatt ccatctatta taaccaagaa actattaaaa gcagcaatga
      721 aacatataga agtgattgtt aaagcaagac agaaagtaaa gaacacggag tatttacaac
      781 aagccgcttt agaagaatat ggtccagagc ttcatgtggc cctgagaagt cgaagagatg
      841 aattacagta tttaaggaag cttactgagt tactttttcc ttatattttg cctcctaaag
      901 caacagactg caggtccctg acattactca taagagagat tctgtctggt tctgtgcttc
      961 ttccttcttt ggatttccta gctgatccag atactgtcaa tcatttgctt atcatcttca
     1021 tagacgacag ccctcctgaa aaagcaactg aaccagcttc ccctttggtt ccattcctgc
     1081 agaaatttgc agaacctaga aataaaaagc catccgtgct gaagttagag ctgaaacaaa
     1141 tcagagaaca gcaggacctt ttgttccgct ttatgaactt cctgaaacaa gaaggggccg
     1201 tgcacgtcct gcagttctgt ctgacagtcg aggaatttaa tgatagaatt ttgcgtccag
     1261 agttatcaaa tgatgaaatg ctatctctcc atgaagaatt gcagaagatt tataagacct
     1321 actgcttgga tgaaagcatt gacaaaattc gctttgatcc cttcattgtc gaagagattc
     1381 aaagaattgc tgaaggccca tacatagatg ttgtgaagct gcaaactatg aggtgtcttt
     1441 ttgaagcata tgagcacgtc ctttccctgt tggagaacgt gtttaccccc atgttctgcc
     1501 acagtgatga gtattttagg caacttttaa gaggtgcaga atcgcccaca cgcaattcca
     1561 aattcaacag aggtagccta agtttggatg atttccgaag cacacaaaaa agaggagaat
     1621 cgtttggaat cagcagaata ggtagcaaaa ttaaaggcgt attcaagagt acgacaatgg
     1681 agggagctgt gctgcctaat tacggggtgg ctgaaggcga agatgacttt attgaagaag
     1741 ggattgtggt aatggaggat gactctccag tagaagctgt gagcacacct aacactcctc
     1801 gaaaccttgc tgcctggaaa attagcattc cgtatgtaga cttttttgaa gatccctcct
     1861 ctgaaaggaa agagaagaag gagagaattc ctgtgttttg tatcgatgtt gaaagaaacg
     1921 acagacgagc agttggacac gagcctgagc attggtctgt ctatagaaga tatcttgaat
     1981 tctatgttct tgaatcaaaa ctaacagaat ttcatggcac atttcctgat gctcagcttc
     2041 catccaaaag gatcattggc cccaaaaact atgagttttt gaagtcgaag agagaggagt
     2101 tccaggagta tctgcagaaa cttgtgcagc acccggagct gagtaacagc cagcttctgg
     2161 ctgactttct ctcccccaac ggtggggaga cacagtttct agataagata cttccagatg
     2221 taaatcttgg aaaaattata aagtctgttc ctgggaaact aatgaaagag aaaggtcagc
     2281 atttggagcc attcatcatg agtttcatta attcttgcga atctcccaaa cctaaaccga
     2341 gtcggccaga actgacgatt ctcagcccca cttccgaaaa caacaagaag cttttcaacg
     2401 atctgtttaa gaataatgca aaccgcgctg agaacacaga gcgaaagcaa aatcagaact
     2461 acttcatgga ggtgatgact gtggacggag tctatgatta cctgatgtat gtagggcgag
     2521 tagtttttca agtcccagac tggcttcatc atcttctaat gggaactcga atcctcttta
     2581 agaacaccct ggaaatgtac acagactact acctccagtg caagctggag cagctgtttc
     2641 aggagcaccg gctggtctcc ctcatcaccc ttctcagaga tgctatattt tgtgaaaata
     2701 ctgaacctcg ctctctccaa gataagcaaa aaggagcaaa acagactttt gaagaaatga
     2761 tgaattacat tccagatctg atagtcaagt gtatcggtga agaaaccaag tacgaaagca
     2821 tcagactcct gtttgatggc ctgcagcagc cagtgctcaa caagcagctg acctatgtgt
     2881 tgctggacat tgtgatacag gagctgtttc cagagctaaa taaggtacaa aaggaagcta
     2941 cctccatgac atcctggatg taaacacttg gtatagaata acataccaga ataatagaaa
     3001 tgtacttttc actttgtata tttttataaa tatcatgtac tttagtgttt ggaatatatt
     3061 ttttgtttta ataaagacta acaaatagca ataaaaagtg gtttaggta
//
