LOCUS       NM_001408825            5798 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sorting nexin 13 (Snx13), transcript variant 12, mRNA.
ACCESSION   NM_001408825
VERSION     NM_001408825.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5798)
  AUTHORS   Zheng,B., Tang,T., Tang,N., Kudlicka,K., Ohtsubo,K., Ma,P.,
            Marth,J.D., Farquhar,M.G. and Lehtonen,E.
  TITLE     Essential role of RGS-PX1/sorting nexin 13 in mouse development and
            regulation of endocytosis dynamics
  JOURNAL   Proc Natl Acad Sci U S A 103 (45), 16776-16781 (2006)
   PUBMED   17077144
  REMARK    GeneRIF: Snx13-null embryos are defective in nutrient uptake and
            transport, which may contribute to the other developmental
            abnormalities observed.
REFERENCE   3  (bases 1 to 5798)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140376.3 and AC122314.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.226755.1,
                                           SRR1660817.121971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-617               AC140376.3         25736-26352         c
            618-756             AC140376.3         23372-23510         c
            757-845             AC140376.3         22940-23028         c
            846-945             AC140376.3         20909-21008         c
            946-1139            AC140376.3         18749-18942         c
            1140-1244           AC140376.3         17232-17336         c
            1245-1377           AC140376.3         16493-16625         c
            1378-1415           AC140376.3         13388-13425         c
            1416-1485           AC140376.3         11545-11614         c
            1486-1625           AC140376.3         4144-4283           c
            1626-1733           AC140376.3         1024-1131           c
            1734-1844           AC122314.4         150193-150303       c
            1845-2006           AC122314.4         142551-142712       c
            2007-2078           AC122314.4         141353-141424       c
            2079-2224           AC122314.4         136562-136707       c
            2225-2293           AC122314.4         136265-136333       c
            2294-2406           AC122314.4         134453-134565       c
            2407-5798           AC122314.4         127253-130644       c
FEATURES             Location/Qualifiers
     source          1..5798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.67 cM"
     gene            1..5798
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="sorting nexin 13"
                     /db_xref="GeneID:217463"
                     /db_xref="MGI:MGI:2661416"
     exon            1..617
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..2654
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="isoform 11 is encoded by transcript variant 12"
                     /codon_start=1
                     /product="sorting nexin-13 isoform 11"
                     /protein_id="NP_001395754.1"
                     /db_xref="GeneID:217463"
                     /db_xref="MGI:MGI:2661416"
                     /translation="MIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDT
                     AGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVD
                     NVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLSGRQRDGKQQTNQTKGLL
                     RAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRD
                     ERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSSVT
                     SDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNLNTEEMWKTYRRYSDFHDFHMRI
                     TEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHCVY
                     DFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGVTKMSDNVGRM
                     SERLGQDIKQSFFKVPPLITKTDSDPEHCRVSAQLDDNVDDNIPLRVMLLLMDEVFDL
                     KERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPN
                     GILAETVPCRDKAIRMRTRIAGKTKLFAIMPDELKHIIGAETTRKGILRVFEMFQHNQ
                     LNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQSTQAPSLQKR"
     exon            618..756
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..845
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..945
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1139
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1244
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1377
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1415
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1485
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1625
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1733
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1844
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2006
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2078
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2224
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2293
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2406
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..5798
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="hexamer: AATAAA"
     polyA_site      3777
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="major polyA site"
     regulatory      5777..5782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="hexamer: AATAAA"
     polyA_site      5798
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
ORIGIN      
        1 ctgtgaaaat actcaggtag aggagacact tgtgttccag ttatgcagat ttacctaatg
       61 ttgatactac acggtacttg ttccatctca tcacttaaaa taaacataat ctcaagttga
      121 tgtttatctt ctccttttta tttttaaata ctaggttctt gagtctataa acacctttat
      181 tctaatattt tgtcttttag aaattcacta aatactaata agccagaggt gtccttttat
      241 tgtgttttta aaaataattc ccttctaatt gtcatagaga tgtgtttaag ttgatatggt
      301 taattttgtc ttaatttatt ttgatgtgga ggtggtagct caccttttat attttggttg
      361 tgagcctagc cttagcagct gagccatctc tctagcatgg tagctcacct ttttataagg
      421 ctgcagtgag tccatgttcc atgtgtatta tagcgcttac tgttgtttca ggaatccact
      481 gttagatttg agaatatgct aaattcaggt atgtatttta aatttaattt taggaaatcc
      541 ttgcacgagg aattcttctt ccattaataa atcaactcag tgatcctgat tatattaatc
      601 aatatgtcat atggatgatc cgtgattcaa attgcaacta tgaggccttt atgaacatta
      661 ttaaattaag tgacaatatt ggagagttag aggcagtcag agataaggca gcagaagagc
      721 tacagtatct tagatcctta gatacagccg gtgatgatat caacactatc aaaaatcaaa
      781 taaatagctt attatttgta aagaaagtat gtgattcaag aatacagcgg ttacagtcag
      841 gcaaagaaat aaatactgtg aagctagcag caaactttgg gaaactttgt acagtcccct
      901 tggacagcat tcttgtagac aatgttgcac tacaattttt tatggattat atgcagcaaa
      961 ctggaggcca agcacatctc ttcttctgga tgacagtgga agggtaccgg gttacagccc
     1021 agcaacagct cgaggttctc tcaggtcgcc agagagatgg caaacagcag accaaccaaa
     1081 ccaaaggtct tttaagagca gcagctgttg gaatttatga gcagtattta tctgaaaagg
     1141 catctccaag agttactgtt gatgactatt tagtggcaaa actagcagat actttgaatc
     1201 atgaagaccc aactccagaa atctttgatg acattcaaag aaaggtatat gaactgatgc
     1261 tacgagatga aagattttat ccttccttta ggcagaatgc gctctatgtg cgaatgctag
     1321 ctgagcttga catgttaaaa gatcctagtt tcagaggatc agatgatggg gatggagaat
     1381 cttttaatgg gtctcctaca ggaagcataa atttgtcttt agatgacctt tcaagtgtga
     1441 cttctgatga ttctgtacaa cttcatgcct acatttcaga cactggcgtt tgtaatgatc
     1501 atggcaagac atatgcacta tatgccatca ctgtacaccg gcgcaaccta aacactgagg
     1561 agatgtggaa aacctatcgg cgttatagtg acttccatga cttccacatg agaatcactg
     1621 agcagtttga aaatctgtca agcatattga agcttcctgg taaaaagacg tttaacaata
     1681 tggatagaga ttttttagaa aagaggaaaa aggatttaaa tgcctacttg cagttactct
     1741 tgactcctga aatgatgaag gcatccccgg cgctggctca ctgtgtctat gatttccttg
     1801 agaacaaagc ctacagtaaa gggaagggtg attttgctcg aaagatggac actttcgtaa
     1861 atccgcttcg caactctatg aggaatgttt caaatgcagt caaatccctt cctgatagct
     1921 tggcagaagg agtgacaaaa atgtcggaca acgtgggcag aatgtcagag agattagggc
     1981 aagacataaa gcagtcattt tttaaggtcc ctcctttaat tacgaagact gattcagatc
     2041 ctgaacattg tcgagtctca gctcagcttg atgataatgt ggatgacaat attccactta
     2101 gggtaatgct gcttctaatg gatgaggtgt ttgacttaaa agagagaaac cagtggttga
     2161 gaaggaatat caagaattta ctccagcagc ttattagagc tacatatggt gatactatta
     2221 acagaaaaat agttgaccat gttgactgga tgacctcacc ggaacaagta gctgactcgg
     2281 tgaagcgttt cagagatgca ttttggccca atggcatttt agcagagact gtcccatgca
     2341 gagataaagc tattcgaatg agaacaagaa ttgcaggaaa aacaaaatta tttgcaatta
     2401 tgccagatga actgaagcac attattggag cggagacaac acggaaaggt attcttcgcg
     2461 tgtttgaaat gtttcagcac aaccagctaa ataggagaat ggtgtatgtc ttcttagaag
     2521 gctttttaga aaccttattt ccacagtata aatttcgtga acttttcaac aaacttcatt
     2581 caaggtcaaa gcaaatgcag aaatataaac aaaaacttca aagtactcaa gcgccttctt
     2641 tacaaaaaag gtgacactcc aacgtgtgaa gctggtgttc attttgtcta ggactaatgg
     2701 tgtggacaga tctcctgggg tgtaactccc gtactgttgt gtctatacca gtctttccat
     2761 gtctgaaaac agaatcctag tacatcgtaa gactggttct ccttttcaac tgtaatccac
     2821 caataccaag agagtcctgt gtcttacatg gtttgctgcg ttatttgcaa catcgagagg
     2881 atcctgcccc gtctcgttca agaatggagt cggtctcttc tgttccagac taatcagcat
     2941 tctctcccag tgccagagtg ccagagtgtg tgtgtgggag ctgagggaag cacaaagcaa
     3001 tgggtcacag gtaacttagc taactagtgt ggtggctgca gagcgcagct cagagttgga
     3061 gagatttgtc tccctcaagg atcttgtggg gcatcagcat tttgctatca tgtgggttag
     3121 caggtgagtg atcttcagaa caattgtcca gttgtttcca ggtagcctgg gcaaagtgag
     3181 ggaaagaatg cccttagtgc aggaaatcac ccttcccaaa ttaccgtcct gtgtaaagca
     3241 ttttaatata aagccaatca aaactagcat ttgattggat ttattattca ccgatggaaa
     3301 tgttggttga ttctctttgg tgatgtgctg tatgggctcg gccttgctct tagggccctc
     3361 acctctccac ctctcctttg gcattctgtg cagaagaagc atgtggtagc tctcttagga
     3421 gttcacattt tttaatcttt taacagatta ctgattatat agaagggaaa ttatttattg
     3481 taagaactgc caaatacatt gtccttctaa aaattggaaa ttaaagcagt actctattga
     3541 aagttaccat atgataactt taaattgtat gatctagaca tgccttaggt aactaccaat
     3601 atagcaaatc aaaggattaa tgagcttcta gtcctatgta aacatacaaa tgcctaattc
     3661 tactatgtgt acatatataa aaataaataa tgaaaacaga actgtactat ttttaaaaat
     3721 atgcttttat ttatatttcg cataatgtaa aattctaaat aaagctagta cacaaaaccc
     3781 tttggtgtat acatttaact ccctaatatt ttatatcagt gaaacaaata ccttttccag
     3841 ttgtgaagcc tttgcatttc ctagtgttct ctccattttg tccattagga agtcttcata
     3901 tcccatacat gcaggatttc tgtactttta aatacttcca gtgactaagg gtttggatat
     3961 atcagctctt tttgttttaa aaatatttaa cactaaaacc ttaaaatagt gaaactactt
     4021 ttcagaccac tgagccagta tcctgatatc taaagaacgt ttgggtgctt gttgtaaagg
     4081 gacagagtat tgataaccca gctctttggg agcttggagc ctggaatggg atttgtcttg
     4141 ctgtctttca gatccttctt acccagtgaa gcctagtaat aagagggaag ccttcctgta
     4201 aggctctcca atgctcacca gtgctgtgtg catatgtgga gtatgcacac actcagcatg
     4261 cgttgcatgt ctttcagaat tacataagta aagccccttt caaaacttgc aagtgaggaa
     4321 agattctgtt tgtctggcag aagaaatgtt tcctatactc atatgctcct gccctgccgg
     4381 cccttcctcg gccccaggct taaaattgga tgcatcaggt ctgtgggaag cctcagcatg
     4441 gccacaagtg caataatttc atacacagcc tcctgtctca gttatattct tacatgagta
     4501 catttaagtg catacagaag gattcatgca agagcctagt gtgtacatgt gaaaataaag
     4561 tgagaaaact gtcaaccagg ggaaaaagag gtcatacaaa atgcagattc ttcttctaac
     4621 agccctgcaa gacaactgca acctcaccaa aacaaaacaa agagcaaaat cagaactgtt
     4681 cgaggaagtg gtctttaaag gaacctcggc tgagaagctt ttatatttca ggagcagaaa
     4741 tgtcaaatgg ccacgtgtct gtgcacgtct gtgtcttaca acagagtgtg gtcgttggcc
     4801 ctaggcttgg tccagctgtg tagagtgttt aaccgatgag tagagtacag tattctctgg
     4861 ttaataaaat tattctattt agtgcacttg ttgcacagat gaacatagac acaaagaggc
     4921 tatatgtctt ctgctgaaca cttttaagtc agtagtggtg cctttaggca aaaccgtcaa
     4981 aattaatcat tcttttgggt tttctgatat tttttttttc aggtagtgta aaactacaaa
     5041 aaacccatca cagcttattc acctaaaatt tgattgtatg acttaaatgt cacacttaga
     5101 tgagcatttc ctatagctca agtgtcccat gcagttgctg gaaacagttg tgccattgac
     5161 cagtggatgc actttgttag ccttaattta aacaacaaca acaacaaaat ttcttgaata
     5221 tatcagtttg atcactacaa gtttgctgca ggtgtttggg gaaaaaagag ttaagtgcaa
     5281 tgaaagtgta cctttttttt tagaaaaaaa ttaagaacat aattttcaca atctacagtt
     5341 ttaattttgt gcaatatttt catttaatgc atgtttgagt aattgtataa taactacatt
     5401 tttaatgttt tgagatctaa tttaactgtc ttattaaccc aacaacttca ttccgttgtt
     5461 gctgcacctt aattaaggac ttgttttaaa agtctttttg tcactccttg taaaattctt
     5521 ttcttagtag aaaattttgc ttatgggagc atggctcctg tattataagg gaaaactaaa
     5581 gagcacattt tagggtttta attgttaaaa actaccttgt gcatatctct gtatataagc
     5641 gtcgatcgtg cctaccgctc tatcaatgct ctcctctaac caaggggaaa gaatcagaat
     5701 gtcagttact tttattaacg acagaaatta aaatttttat ttggtttgtg ttatgttctg
     5761 tctgttagaa aatactaata aagtattaac aaacagtt
//
