LOCUS       NM_001408819            6043 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sorting nexin 13 (Snx13), transcript variant 6, mRNA.
ACCESSION   NM_001408819 XM_017315016
VERSION     NM_001408819.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6043)
  AUTHORS   Zheng,B., Tang,T., Tang,N., Kudlicka,K., Ohtsubo,K., Ma,P.,
            Marth,J.D., Farquhar,M.G. and Lehtonen,E.
  TITLE     Essential role of RGS-PX1/sorting nexin 13 in mouse development and
            regulation of endocytosis dynamics
  JOURNAL   Proc Natl Acad Sci U S A 103 (45), 16776-16781 (2006)
   PUBMED   17077144
  REMARK    GeneRIF: Snx13-null embryos are defective in nutrient uptake and
            transport, which may contribute to the other developmental
            abnormalities observed.
REFERENCE   3  (bases 1 to 6043)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140376.3 and AC122314.4.
            
            On Jun 29, 2022 this sequence version replaced XM_017315016.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.12614.1,
                                           SRR10223970.15141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC140376.3         76638-76857         c
            221-310             AC140376.3         38021-38110         c
            311-432             AC140376.3         37065-37186         c
            433-554             AC140376.3         32565-32686         c
            555-656             AC140376.3         32379-32480         c
            657-745             AC140376.3         31136-31224         c
            746-829             AC140376.3         25736-25819         c
            830-968             AC140376.3         23372-23510         c
            969-1057            AC140376.3         22940-23028         c
            1058-1157           AC140376.3         20909-21008         c
            1158-1351           AC140376.3         18749-18942         c
            1352-1456           AC140376.3         17232-17336         c
            1457-1589           AC140376.3         16493-16625         c
            1590-1627           AC140376.3         13388-13425         c
            1628-1697           AC140376.3         11545-11614         c
            1698-1870           AC140376.3         4144-4316           c
            1871-1978           AC140376.3         1024-1131           c
            1979-2089           AC122314.4         150193-150303       c
            2090-2251           AC122314.4         142551-142712       c
            2252-2323           AC122314.4         141353-141424       c
            2324-2469           AC122314.4         136562-136707       c
            2470-2538           AC122314.4         136265-136333       c
            2539-2651           AC122314.4         134453-134565       c
            2652-6043           AC122314.4         127253-130644       c
FEATURES             Location/Qualifiers
     source          1..6043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.67 cM"
     gene            1..6043
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="sorting nexin 13"
                     /db_xref="GeneID:217463"
                     /db_xref="MGI:MGI:2661416"
     exon            1..220
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2899
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="sorting nexin-13 isoform 6"
                     /protein_id="NP_001395748.1"
                     /db_xref="GeneID:217463"
                     /db_xref="MGI:MGI:2661416"
                     /translation="MLTECLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYV
                     QYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRK
                     AQQRVTEKDDQVKGTAEDLVETFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLL
                     YLLLPPGDFQSKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSNCNYEAF
                     MNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRI
                     QRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTV
                     EGYRVTAQQQLEVLSGRQRDGKQQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYL
                     VAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDP
                     SFRGSDDGDGESFNGSPTGSINLSLDDLSSVTSDDSVQLHAYISDTVYADYDPYAVAG
                     VCNDHGKTYALYAITVHRRNLNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPG
                     KKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHCVYDFLENKAYSKGKGDF
                     ARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGVTKMSDNVGRMSERLGQDIKQSFFKV
                     PPLITKTDSDPEHCRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLL
                     QQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAETVPCRDKAIR
                     MRTRIAGKTKLFAIMPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLE
                     TLFPQYKFRELFNKLHSRSKQMQKYKQKLQSTQAPSLQKR"
     exon            221..310
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..432
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..554
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..656
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..745
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..829
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..968
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1057
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1157
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1351
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1456
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1589
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1627
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1697
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1870
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1978
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2089
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2251
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2323
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2469
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2538
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2651
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..6043
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="hexamer: AATAAA"
     polyA_site      4022
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="major polyA site"
     regulatory      6022..6027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
                     /note="hexamer: AATAAA"
     polyA_site      6043
                     /gene="Snx13"
                     /gene_synonym="mKIAA0713; Rgs-px1"
ORIGIN      
        1 gcggacgtcg ctcttccaag atggcggcgc gtccgtcgcg agcagccggg ccggggggaa
       61 gccagcgaag ccgagtaaag ccgccgcccg ggacaggact gaagcagcag ttgccgccgt
      121 tggcggcggc ccgggcagtt tccgctgctg ctacggctat tgccatgcgg cgaggctagg
      181 gaggacctca ctcccccggg gtgtaatgat gttaacagag tgcttagaag aaatgaaacg
      241 cgaagccagg actataaaga ttgacagaag attgacgggt gccaatataa ttgatgagcc
      301 tctccagcaa gttatccagt tttccttgag ggattatgtc cagtactggt attatacatt
      361 aagtgatgat gagtcatttc ttcttgaaat taggcaaact cttcaaaatg cgctcattca
      421 gtttgctact aggtcaaaag aaatagactg gcagccttat tttactacac gcattgtaga
      481 tgattttggc actcacctac gagtattcag aaaggcccaa cagagagtaa cagagaaaga
      541 cgatcaagta aaaggtacag cagaggatct ggtagaaacc ttttttgaag ttgaagttga
      601 aatggagaag gatgtttgcc gggatctagt gtgcacttct cccaaagatg aagaaggatt
      661 cctaagggat ttgtgtgagg ttttattata tttattgcta cctcctggag atttccagag
      721 caagatcatg cgatactttg tcagggaaat ccttgcacga ggaattcttc ttccattaat
      781 aaatcaactc agtgatcctg attatattaa tcaatatgtc atatggatga tccgtgattc
      841 aaattgcaac tatgaggcct ttatgaacat tattaaatta agtgacaata ttggagagtt
      901 agaggcagtc agagataagg cagcagaaga gctacagtat cttagatcct tagatacagc
      961 cggtgatgat atcaacacta tcaaaaatca aataaatagc ttattatttg taaagaaagt
     1021 atgtgattca agaatacagc ggttacagtc aggcaaagaa ataaatactg tgaagctagc
     1081 agcaaacttt gggaaacttt gtacagtccc cttggacagc attcttgtag acaatgttgc
     1141 actacaattt tttatggatt atatgcagca aactggaggc caagcacatc tcttcttctg
     1201 gatgacagtg gaagggtacc gggttacagc ccagcaacag ctcgaggttc tctcaggtcg
     1261 ccagagagat ggcaaacagc agaccaacca aaccaaaggt cttttaagag cagcagctgt
     1321 tggaatttat gagcagtatt tatctgaaaa ggcatctcca agagttactg ttgatgacta
     1381 tttagtggca aaactagcag atactttgaa tcatgaagac ccaactccag aaatctttga
     1441 tgacattcaa agaaaggtat atgaactgat gctacgagat gaaagatttt atccttcctt
     1501 taggcagaat gcgctctatg tgcgaatgct agctgagctt gacatgttaa aagatcctag
     1561 tttcagagga tcagatgatg gggatggaga atcttttaat gggtctccta caggaagcat
     1621 aaatttgtct ttagatgacc tttcaagtgt gacttctgat gattctgtac aacttcatgc
     1681 ctacatttca gacactgtat atgctgacta tgacccatat gctgtggcag gcgtttgtaa
     1741 tgatcatggc aagacatatg cactatatgc catcactgta caccggcgca acctaaacac
     1801 tgaggagatg tggaaaacct atcggcgtta tagtgacttc catgacttcc acatgagaat
     1861 cactgagcag tttgaaaatc tgtcaagcat attgaagctt cctggtaaaa agacgtttaa
     1921 caatatggat agagattttt tagaaaagag gaaaaaggat ttaaatgcct acttgcagtt
     1981 actcttgact cctgaaatga tgaaggcatc cccggcgctg gctcactgtg tctatgattt
     2041 ccttgagaac aaagcctaca gtaaagggaa gggtgatttt gctcgaaaga tggacacttt
     2101 cgtaaatccg cttcgcaact ctatgaggaa tgtttcaaat gcagtcaaat cccttcctga
     2161 tagcttggca gaaggagtga caaaaatgtc ggacaacgtg ggcagaatgt cagagagatt
     2221 agggcaagac ataaagcagt cattttttaa ggtccctcct ttaattacga agactgattc
     2281 agatcctgaa cattgtcgag tctcagctca gcttgatgat aatgtggatg acaatattcc
     2341 acttagggta atgctgcttc taatggatga ggtgtttgac ttaaaagaga gaaaccagtg
     2401 gttgagaagg aatatcaaga atttactcca gcagcttatt agagctacat atggtgatac
     2461 tattaacaga aaaatagttg accatgttga ctggatgacc tcaccggaac aagtagctga
     2521 ctcggtgaag cgtttcagag atgcattttg gcccaatggc attttagcag agactgtccc
     2581 atgcagagat aaagctattc gaatgagaac aagaattgca ggaaaaacaa aattatttgc
     2641 aattatgcca gatgaactga agcacattat tggagcggag acaacacgga aaggtattct
     2701 tcgcgtgttt gaaatgtttc agcacaacca gctaaatagg agaatggtgt atgtcttctt
     2761 agaaggcttt ttagaaacct tatttccaca gtataaattt cgtgaacttt tcaacaaact
     2821 tcattcaagg tcaaagcaaa tgcagaaata taaacaaaaa cttcaaagta ctcaagcgcc
     2881 ttctttacaa aaaaggtgac actccaacgt gtgaagctgg tgttcatttt gtctaggact
     2941 aatggtgtgg acagatctcc tggggtgtaa ctcccgtact gttgtgtcta taccagtctt
     3001 tccatgtctg aaaacagaat cctagtacat cgtaagactg gttctccttt tcaactgtaa
     3061 tccaccaata ccaagagagt cctgtgtctt acatggtttg ctgcgttatt tgcaacatcg
     3121 agaggatcct gccccgtctc gttcaagaat ggagtcggtc tcttctgttc cagactaatc
     3181 agcattctct cccagtgcca gagtgccaga gtgtgtgtgt gggagctgag ggaagcacaa
     3241 agcaatgggt cacaggtaac ttagctaact agtgtggtgg ctgcagagcg cagctcagag
     3301 ttggagagat ttgtctccct caaggatctt gtggggcatc agcattttgc tatcatgtgg
     3361 gttagcaggt gagtgatctt cagaacaatt gtccagttgt ttccaggtag cctgggcaaa
     3421 gtgagggaaa gaatgccctt agtgcaggaa atcacccttc ccaaattacc gtcctgtgta
     3481 aagcatttta atataaagcc aatcaaaact agcatttgat tggatttatt attcaccgat
     3541 ggaaatgttg gttgattctc tttggtgatg tgctgtatgg gctcggcctt gctcttaggg
     3601 ccctcacctc tccacctctc ctttggcatt ctgtgcagaa gaagcatgtg gtagctctct
     3661 taggagttca cattttttaa tcttttaaca gattactgat tatatagaag ggaaattatt
     3721 tattgtaaga actgccaaat acattgtcct tctaaaaatt ggaaattaaa gcagtactct
     3781 attgaaagtt accatatgat aactttaaat tgtatgatct agacatgcct taggtaacta
     3841 ccaatatagc aaatcaaagg attaatgagc ttctagtcct atgtaaacat acaaatgcct
     3901 aattctacta tgtgtacata tataaaaata aataatgaaa acagaactgt actattttta
     3961 aaaatatgct tttatttata tttcgcataa tgtaaaattc taaataaagc tagtacacaa
     4021 aaccctttgg tgtatacatt taactcccta atattttata tcagtgaaac aaataccttt
     4081 tccagttgtg aagcctttgc atttcctagt gttctctcca ttttgtccat taggaagtct
     4141 tcatatccca tacatgcagg atttctgtac ttttaaatac ttccagtgac taagggtttg
     4201 gatatatcag ctctttttgt tttaaaaata tttaacacta aaaccttaaa atagtgaaac
     4261 tacttttcag accactgagc cagtatcctg atatctaaag aacgtttggg tgcttgttgt
     4321 aaagggacag agtattgata acccagctct ttgggagctt ggagcctgga atgggatttg
     4381 tcttgctgtc tttcagatcc ttcttaccca gtgaagccta gtaataagag ggaagccttc
     4441 ctgtaaggct ctccaatgct caccagtgct gtgtgcatat gtggagtatg cacacactca
     4501 gcatgcgttg catgtctttc agaattacat aagtaaagcc cctttcaaaa cttgcaagtg
     4561 aggaaagatt ctgtttgtct ggcagaagaa atgtttccta tactcatatg ctcctgccct
     4621 gccggccctt cctcggcccc aggcttaaaa ttggatgcat caggtctgtg ggaagcctca
     4681 gcatggccac aagtgcaata atttcataca cagcctcctg tctcagttat attcttacat
     4741 gagtacattt aagtgcatac agaaggattc atgcaagagc ctagtgtgta catgtgaaaa
     4801 taaagtgaga aaactgtcaa ccaggggaaa aagaggtcat acaaaatgca gattcttctt
     4861 ctaacagccc tgcaagacaa ctgcaacctc accaaaacaa aacaaagagc aaaatcagaa
     4921 ctgttcgagg aagtggtctt taaaggaacc tcggctgaga agcttttata tttcaggagc
     4981 agaaatgtca aatggccacg tgtctgtgca cgtctgtgtc ttacaacaga gtgtggtcgt
     5041 tggccctagg cttggtccag ctgtgtagag tgtttaaccg atgagtagag tacagtattc
     5101 tctggttaat aaaattattc tatttagtgc acttgttgca cagatgaaca tagacacaaa
     5161 gaggctatat gtcttctgct gaacactttt aagtcagtag tggtgccttt aggcaaaacc
     5221 gtcaaaatta atcattcttt tgggttttct gatatttttt ttttcaggta gtgtaaaact
     5281 acaaaaaacc catcacagct tattcaccta aaatttgatt gtatgactta aatgtcacac
     5341 ttagatgagc atttcctata gctcaagtgt cccatgcagt tgctggaaac agttgtgcca
     5401 ttgaccagtg gatgcacttt gttagcctta atttaaacaa caacaacaac aaaatttctt
     5461 gaatatatca gtttgatcac tacaagtttg ctgcaggtgt ttggggaaaa aagagttaag
     5521 tgcaatgaaa gtgtaccttt ttttttagaa aaaaattaag aacataattt tcacaatcta
     5581 cagttttaat tttgtgcaat attttcattt aatgcatgtt tgagtaattg tataataact
     5641 acatttttaa tgttttgaga tctaatttaa ctgtcttatt aacccaacaa cttcattccg
     5701 ttgttgctgc accttaatta aggacttgtt ttaaaagtct ttttgtcact ccttgtaaaa
     5761 ttcttttctt agtagaaaat tttgcttatg ggagcatggc tcctgtatta taagggaaaa
     5821 ctaaagagca cattttaggg ttttaattgt taaaaactac cttgtgcata tctctgtata
     5881 taagcgtcga tcgtgcctac cgctctatca atgctctcct ctaaccaagg ggaaagaatc
     5941 agaatgtcag ttacttttat taacgacaga aattaaaatt tttatttggt ttgtgttatg
     6001 ttctgtctgt tagaaaatac taataaagta ttaacaaaca gtt
//
