LOCUS       NM_001127349            2469 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus sorting nexin 10 (Snx10), transcript variant 3, mRNA.
ACCESSION   NM_001127349
VERSION     NM_001127349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2469)
  AUTHORS   Barnea-Zohar,M., Stein,M., Reuven,N., Winograd-Katz,S., Lee,S.,
            Addadi,Y., Arman,E., Tuckermann,J., Geiger,B. and Elson,A.
  TITLE     SNX10 regulates osteoclastogenic cell fusion and osteoclast size in
            mice
  JOURNAL   J Bone Miner Res 39 (10), 1503-1517 (2024)
   PUBMED   39095084
  REMARK    GeneRIF: SNX10 regulates osteoclastogenic cell fusion and
            osteoclast size in mice.
REFERENCE   2  (bases 1 to 2469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2469)
  AUTHORS   Wu,D., Wang,Y., Xu,J., Wang,D., Zhang,J., Meng,L., Hu,Y., Wang,P.,
            Lin,J. and Zhou,S.
  TITLE     SNX10 promoted liver IR injury by facilitating macrophage M1
            polarization via NLRP3 inflammasome activation
  JOURNAL   Mol Immunol 166, 79-86 (2024)
   PUBMED   38271879
  REMARK    GeneRIF: SNX10 promoted liver IR injury by facilitating macrophage
            M1 polarization via NLRP3 inflammasome activation.
REFERENCE   4  (bases 1 to 2469)
  AUTHORS   Bao,W., You,Y., Ni,J., Hou,H., Lyu,J., Feng,G., Wang,Y., You,K.,
            Zhang,S., Zhang,L., Cao,X., Wang,X., Li,H., Li,H., Xu,J., Liu,C.,
            Luo,X., Du,P., Chen,D. and Shen,X.
  TITLE     Inhibiting sorting nexin 10 promotes mucosal healing through
            SREBP2-mediated stemness restoration of intestinal stem cells
  JOURNAL   Sci Adv 9 (35), eadh5016 (2023)
   PUBMED   37647408
  REMARK    GeneRIF: Inhibiting sorting nexin 10 promotes mucosal healing
            through SREBP2-mediated stemness restoration of intestinal stem
            cells.
            Erratum:[Sci Adv. 2024 Apr 12;10(15):eadp3968. doi:
            10.1126/sciadv.adp3968. PMID: 38608031]
REFERENCE   5  (bases 1 to 2469)
  AUTHORS   Hansen,G.T., Sobreira,D.R., Weber,Z.T., Thornburg,A.G., Aneas,I.,
            Zhang,L., Sakabe,N.J., Joslin,A.C., Haddad,G.A., Strobel,S.M.,
            Laber,S., Sultana,F., Sahebdel,F., Khan,K., Li,Y.I.,
            Claussnitzer,M., Ye,L., Battaglino,R.A. and Nobrega,M.A.
  TITLE     Genetics of sexually dimorphic adipose distribution in humans
  JOURNAL   Nat Genet 55 (3), 461-470 (2023)
   PUBMED   36797366
REFERENCE   6  (bases 1 to 2469)
  AUTHORS   Zhou,C., You,Y., Shen,W., Zhu,Y.Z., Peng,J., Feng,H.T., Wang,Y.,
            Li,D., Shao,W.W., Li,C.X., Li,W.Z., Xu,J. and Shen,X.
  TITLE     Deficiency of sorting nexin 10 prevents bone erosion in
            collagen-induced mouse arthritis through promoting NFATc1
            degradation
  JOURNAL   Ann Rheum Dis 75 (6), 1211-1218 (2016)
   PUBMED   26141367
  REMARK    GeneRIF: SNX10 plays an important role in the bone destruction of
            collagen-induced arthritis mice.
REFERENCE   7  (bases 1 to 2469)
  AUTHORS   Ye,L., Morse,L.R., Zhang,L., Sasaki,H., Mills,J.C., Odgren,P.R.,
            Sibbel,G., Stanley,J.R., Wong,G., Zamarioli,A. and Battaglino,R.A.
  TITLE     Osteopetrorickets due to Snx10 deficiency in mice results from both
            failed osteoclast activity and loss of gastric acid-dependent
            calcium absorption
  JOURNAL   PLoS Genet 11 (3), e1005057 (2015)
   PUBMED   25811986
  REMARK    GeneRIF: supplementation with calcium gluconate rescued mice from
            the rachitic phenotype and extended life span in global
            Snx10-deficient mice, suggesting that this may be a life-saving
            component of the clinical approach to Snx10-dependent human
            osteopetrosis
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2469)
  AUTHORS   Zhu,C.H., Morse,L.R. and Battaglino,R.A.
  TITLE     SNX10 is required for osteoclast formation and resorption activity
  JOURNAL   J Cell Biochem 113 (5), 1608-1615 (2012)
   PUBMED   22174188
  REMARK    GeneRIF: Immunohistochemical analysis of embryo sections showed
            expression in long bone, calvariae, and developing teeth. The
            expression was limited to cells that also expressed TRAP,
            demonstrating osteoclastic localization.
REFERENCE   9  (bases 1 to 2469)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   10 (bases 1 to 2469)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151320.1 and AK150878.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 4. Variants 1-9 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150999.1, SRR1660813.172696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1795              AK151320.1         4-1798
            1796-2469           AK150878.1         1713-2386
FEATURES             Location/Qualifiers
     source          1..2469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.95 cM"
     gene            1..2469
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="sorting nexin 10"
                     /db_xref="GeneID:71982"
                     /db_xref="MGI:MGI:1919232"
     exon            1..132
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            133..179
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            180..266
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..367
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            368..466
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            467..679
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            680..2469
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2046..2051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2067
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="major polyA site"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="hexamer: AATATA"
     polyA_site      2403
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agggcggggc ggggcgctgc gtgcgctgga cgcggggctg cgctcctcgg gttcgctctt
       61 aggcgctcgt cgccgccgcg ccttgagtca gcaaactccg ccgtgctccg ggccgggcgt
      121 tcagaaccgc gtgttgatcg tgtcctgagc tgaagatgtt cccagaacag cagaaagagg
      181 agttcgtgag tgtctgggtc cgggacccca ggattcagaa ggaggacttt tggcactctt
      241 atatcgacta tgagatctgc attcacacaa atagcatgtg ttttacaatg aaaacatctt
      301 gtgtacgaag aaggtataga gagttcgtgt ggctgaggca aagactccaa agcaacgcgt
      361 tgctggtaca attaccagaa cttccgtcta aaaacctgtt tttcaacatg aacaatcgcc
      421 agcatgtcga ccaacgccgc cagggcttgg aagatttcct cagaaaagtc ctgcagaatg
      481 cactcttgct ttccgatagc agcctccacc tcttcctgca gagccatctg aactccgagg
      541 acattgaagc atgtgtttct gggcagacca agtactcggt ggaagaagcc attcacaagt
      601 ttgctttaat gaatagacgg tttcccgaag aagaagaaga agggaagaaa gacgccgacg
      661 tagagtatga ttcagaaagt tcatcctctg ggcttggaca cagtagtgat gacagcagtt
      721 ctcatggatg taaaacgagc ccagctctgc aggagtcctg agaaggaatt ctggggctac
      781 caccttagga acgaaattgt gcccagccag aaagaatgct ggctcataat agattcttac
      841 ccaatgccac tgtcagtatc ccaggtagtg aaattcttaa agtggtgggg tattagtact
      901 agtagtttta tgttgtctaa ttctagccaa gcttctgtgt gaagctataa ggtctgtgaa
      961 tgccatacgg ccctttattg ccatcctata cttgtaaata cgatcctgct ctcaagtgaa
     1021 atgagttata tgagatatat atatatatat ttggtcttaa ctggatttta aagagtttgg
     1081 cgtattagta gcatttaaag ccagataggg cacccttgct gtgtcaatga ggaagttact
     1141 gtaaacacag tgttcgactg aagctagagt gcagagtcgc agcactgctg actgcctgcc
     1201 tctctgacat gtggctcttg tttcgtgggg acttttcctc tggaaaatac tttgccttca
     1261 ggtatttgat tgaaatattt aagagtattt aagctttcca gtatcctgta tcatgtgtaa
     1321 atggaaaata tgtcttacaa atagagatgc actaaaacaa caaaaacaac aacaaaacaa
     1381 acgtttacat cctaggaggg aaaaaaaaca aaagtctttg taattttgct taaatttgcc
     1441 agacacagat ttagaaatac attctcactg tccaaaatca gcttaaacac tggctctggc
     1501 gatgagtcat tgtgcaatta gaatcatatc ttatgattta ttttctgtca ttaaaaaaat
     1561 gtacattaaa aaaaaaagtc accaggtagc ttccatgagg aatagctcct cacggttcat
     1621 tttttcagtt agaagaaggt ttttatgagt taattttacc cataaatatt tcagtaattt
     1681 tggagtggaa gttgggttgc taacatcaga gctcatgttc atgttttaga agccctttct
     1741 ttctaggtgt ctctcaaaag actggcttaa ttggaataaa atagcttttt ttttttaagt
     1801 gtcccaaaga taagatatct tggggtccac catgagcttc cagtttcagc cgaggcagca
     1861 gttttcctgg gataattagc caagggttcc ccagagtctt cctaggtatc tctgggaacc
     1921 agcagaagga attttcacct aagagggata acttgttgct tccaatgaat ggctcccact
     1981 ctcgtgggtg caaaagcggc agcaaaaagc agccatttac ttgggtactt aagagttatt
     2041 gtattaataa aaagttattg acttgtcctt tgagagcctt cttacagaga attggttaaa
     2101 aaaaccaaac attcaatttg gaataagaat gattttttaa agttctgtct gaaacattat
     2161 caaacttgtg taaatatttt gatttatgtc ttagatcctg ttaaccgtgt cctctaattg
     2221 tctttatttt aatgccaaaa ggaagtgatt atgcagctgt gtgtagagtt tcagagcaag
     2281 ttcctcagca gtgtagatga attcacatca tttatgtttt aacggcgttt ttttggaaag
     2341 cataaattgt gacatcagtt atcatgctac ttcttggtga cataatataa cctttgaagt
     2401 taatatgaag tgatgtttgc tccataaact ccacagtcac tgttttcaca ttaaacatga
     2461 aagcaaagc
//
