LOCUS       NM_001127348            2464 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sorting nexin 10 (Snx10), transcript variant 2, mRNA.
ACCESSION   NM_001127348
VERSION     NM_001127348.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Barnea-Zohar,M., Stein,M., Reuven,N., Winograd-Katz,S., Lee,S.,
            Addadi,Y., Arman,E., Tuckermann,J., Geiger,B. and Elson,A.
  TITLE     SNX10 regulates osteoclastogenic cell fusion and osteoclast size in
            mice
  JOURNAL   J Bone Miner Res 39 (10), 1503-1517 (2024)
   PUBMED   39095084
  REMARK    GeneRIF: SNX10 regulates osteoclastogenic cell fusion and
            osteoclast size in mice.
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Wu,D., Wang,Y., Xu,J., Wang,D., Zhang,J., Meng,L., Hu,Y., Wang,P.,
            Lin,J. and Zhou,S.
  TITLE     SNX10 promoted liver IR injury by facilitating macrophage M1
            polarization via NLRP3 inflammasome activation
  JOURNAL   Mol Immunol 166, 79-86 (2024)
   PUBMED   38271879
  REMARK    GeneRIF: SNX10 promoted liver IR injury by facilitating macrophage
            M1 polarization via NLRP3 inflammasome activation.
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Bao,W., You,Y., Ni,J., Hou,H., Lyu,J., Feng,G., Wang,Y., You,K.,
            Zhang,S., Zhang,L., Cao,X., Wang,X., Li,H., Li,H., Xu,J., Liu,C.,
            Luo,X., Du,P., Chen,D. and Shen,X.
  TITLE     Inhibiting sorting nexin 10 promotes mucosal healing through
            SREBP2-mediated stemness restoration of intestinal stem cells
  JOURNAL   Sci Adv 9 (35), eadh5016 (2023)
   PUBMED   37647408
  REMARK    GeneRIF: Inhibiting sorting nexin 10 promotes mucosal healing
            through SREBP2-mediated stemness restoration of intestinal stem
            cells.
            Erratum:[Sci Adv. 2024 Apr 12;10(15):eadp3968. doi:
            10.1126/sciadv.adp3968.. PMID: 38608031]
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   Hansen,G.T., Sobreira,D.R., Weber,Z.T., Thornburg,A.G., Aneas,I.,
            Zhang,L., Sakabe,N.J., Joslin,A.C., Haddad,G.A., Strobel,S.M.,
            Laber,S., Sultana,F., Sahebdel,F., Khan,K., Li,Y.I.,
            Claussnitzer,M., Ye,L., Battaglino,R.A. and Nobrega,M.A.
  TITLE     Genetics of sexually dimorphic adipose distribution in humans
  JOURNAL   Nat Genet 55 (3), 461-470 (2023)
   PUBMED   36797366
REFERENCE   6  (bases 1 to 2464)
  AUTHORS   Zhou,C., You,Y., Shen,W., Zhu,Y.Z., Peng,J., Feng,H.T., Wang,Y.,
            Li,D., Shao,W.W., Li,C.X., Li,W.Z., Xu,J. and Shen,X.
  TITLE     Deficiency of sorting nexin 10 prevents bone erosion in
            collagen-induced mouse arthritis through promoting NFATc1
            degradation
  JOURNAL   Ann Rheum Dis 75 (6), 1211-1218 (2016)
   PUBMED   26141367
  REMARK    GeneRIF: SNX10 plays an important role in the bone destruction of
            collagen-induced arthritis mice.
REFERENCE   7  (bases 1 to 2464)
  AUTHORS   Ye,L., Morse,L.R., Zhang,L., Sasaki,H., Mills,J.C., Odgren,P.R.,
            Sibbel,G., Stanley,J.R., Wong,G., Zamarioli,A. and Battaglino,R.A.
  TITLE     Osteopetrorickets due to Snx10 deficiency in mice results from both
            failed osteoclast activity and loss of gastric acid-dependent
            calcium absorption
  JOURNAL   PLoS Genet 11 (3), e1005057 (2015)
   PUBMED   25811986
  REMARK    GeneRIF: supplementation with calcium gluconate rescued mice from
            the rachitic phenotype and extended life span in global
            Snx10-deficient mice, suggesting that this may be a life-saving
            component of the clinical approach to Snx10-dependent human
            osteopetrosis
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2464)
  AUTHORS   Zhu,C.H., Morse,L.R. and Battaglino,R.A.
  TITLE     SNX10 is required for osteoclast formation and resorption activity
  JOURNAL   J Cell Biochem 113 (5), 1608-1615 (2012)
   PUBMED   22174188
  REMARK    GeneRIF: Immunohistochemical analysis of embryo sections showed
            expression in long bone, calvariae, and developing teeth. The
            expression was limited to cells that also expressed TRAP,
            demonstrating osteoclastic localization.
REFERENCE   9  (bases 1 to 2464)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   10 (bases 1 to 2464)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028163.1, AK166121.1, AK151320.1 and AK150878.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 4. Variants 1-9 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166121.1, SRR1660817.113166.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK028163.1         2-29
            29-1045             AK166121.1         2-1018
            1046-1790           AK151320.1         1054-1798
            1791-2464           AK150878.1         1713-2386
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.95 cM"
     gene            1..2464
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="sorting nexin 10"
                     /db_xref="GeneID:71982"
                     /db_xref="MGI:MGI:1919232"
     exon            1..127
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            128..174
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..756
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-10 isoform a"
                     /protein_id="NP_001120820.1"
                     /db_xref="CCDS:CCDS20136.1"
                     /db_xref="GeneID:71982"
                     /db_xref="MGI:MGI:1919232"
                     /translation="MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFT
                     MKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFL
                     RKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEEE
                     EEGKKDADVEYDSESSSSGLGHSSDDSSSHGCKTSPALQES"
     exon            175..261
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            262..362
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            363..461
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            462..674
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..2464
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2041..2046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2062
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="major polyA site"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="hexamer: AATATA"
     polyA_site      2398
                     /gene="Snx10"
                     /gene_synonym="2410004M09Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttcttcctc ttctccaggc tcaggctcag gcggcttagc tgtgtaagaa caaaataccc
       61 tgggatgtcc agtctgtcat cagactgatg agcaaacaaa gccacagccc ctaagaactc
      121 ctgagaggtt gatcgtgtcc tgagctgaag atgttcccag aacagcagaa agaggagttc
      181 gtgagtgtct gggtccggga ccccaggatt cagaaggagg acttttggca ctcttatatc
      241 gactatgaga tctgcattca cacaaatagc atgtgtttta caatgaaaac atcttgtgta
      301 cgaagaaggt atagagagtt cgtgtggctg aggcaaagac tccaaagcaa cgcgttgctg
      361 gtacaattac cagaacttcc gtctaaaaac ctgtttttca acatgaacaa tcgccagcat
      421 gtcgaccaac gccgccaggg cttggaagat ttcctcagaa aagtcctgca gaatgcactc
      481 ttgctttccg atagcagcct ccacctcttc ctgcagagcc atctgaactc cgaggacatt
      541 gaagcatgtg tttctgggca gaccaagtac tcggtggaag aagccattca caagtttgct
      601 ttaatgaata gacggtttcc cgaagaagaa gaagaaggga agaaagacgc cgacgtagag
      661 tatgattcag aaagttcatc ctctgggctt ggacacagta gtgatgacag cagttctcat
      721 ggatgtaaaa cgagcccagc tctgcaggag tcctgagaag gaattctggg gctaccacct
      781 taggaacgaa attgtgccca gccagaaaga atgctggctc ataatagatt cttacccaat
      841 gccactgtca gtatcccagg tagtgaaatt cttaaagtgg tggggtatta gtactagtag
      901 ttttatgttg tctaattcta gccaagcttc tgtgtgaagc tataaggtct gtgaatgcca
      961 tacggccctt tattgccatc ctatacttgt aaatacgatc ctgctctcaa gtgaaatgag
     1021 ttatatgaga tatatatata tatatttggt cttaactgga ttttaaagag tttggcgtat
     1081 tagtagcatt taaagccaga tagggcaccc ttgctgtgtc aatgaggaag ttactgtaaa
     1141 cacagtgttc gactgaagct agagtgcaga gtcgcagcac tgctgactgc ctgcctctct
     1201 gacatgtggc tcttgtttcg tggggacttt tcctctggaa aatactttgc cttcaggtat
     1261 ttgattgaaa tatttaagag tatttaagct ttccagtatc ctgtatcatg tgtaaatgga
     1321 aaatatgtct tacaaataga gatgcactaa aacaacaaaa acaacaacaa aacaaacgtt
     1381 tacatcctag gagggaaaaa aaacaaaagt ctttgtaatt ttgcttaaat ttgccagaca
     1441 cagatttaga aatacattct cactgtccaa aatcagctta aacactggct ctggcgatga
     1501 gtcattgtgc aattagaatc atatcttatg atttattttc tgtcattaaa aaaatgtaca
     1561 ttaaaaaaaa aagtcaccag gtagcttcca tgaggaatag ctcctcacgg ttcatttttt
     1621 cagttagaag aaggttttta tgagttaatt ttacccataa atatttcagt aattttggag
     1681 tggaagttgg gttgctaaca tcagagctca tgttcatgtt ttagaagccc tttctttcta
     1741 ggtgtctctc aaaagactgg cttaattgga ataaaatagc tttttttttt taagtgtccc
     1801 aaagataaga tatcttgggg tccaccatga gcttccagtt tcagccgagg cagcagtttt
     1861 cctgggataa ttagccaagg gttccccaga gtcttcctag gtatctctgg gaaccagcag
     1921 aaggaatttt cacctaagag ggataacttg ttgcttccaa tgaatggctc ccactctcgt
     1981 gggtgcaaaa gcggcagcaa aaagcagcca tttacttggg tacttaagag ttattgtatt
     2041 aataaaaagt tattgacttg tcctttgaga gccttcttac agagaattgg ttaaaaaaac
     2101 caaacattca atttggaata agaatgattt tttaaagttc tgtctgaaac attatcaaac
     2161 ttgtgtaaat attttgattt atgtcttaga tcctgttaac cgtgtcctct aattgtcttt
     2221 attttaatgc caaaaggaag tgattatgca gctgtgtgta gagtttcaga gcaagttcct
     2281 cagcagtgta gatgaattca catcatttat gttttaacgg cgtttttttg gaaagcataa
     2341 attgtgacat cagttatcat gctacttctt ggtgacataa tataaccttt gaagttaata
     2401 tgaagtgatg tttgctccat aaactccaca gtcactgttt tcacattaaa catgaaagca
     2461 aagc
//
