LOCUS       NM_019727               2079 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus sorting nexin 1 (Snx1), mRNA.
ACCESSION   NM_019727
VERSION     NM_019727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Liu,J., Qi,Y., Chao,J., Sathuvalli,P., Y Lee,L. and Li,S.
  TITLE     CREG1 promotes lysosomal biogenesis and function
  JOURNAL   Autophagy 17 (12), 4249-4265 (2021)
   PUBMED   33966596
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Sun-Wada,G.H., Tabata,H. and Wada,Y.
  TITLE     Vacuolar-type proton ATPase is required for maintenance of
            apicobasal polarity of embryonic visceral endoderm
  JOURNAL   Sci Rep 11 (1), 19355 (2021)
   PUBMED   34588579
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Zhang,Y., Pang,X., Li,J., Xu,J., Hsu,V.W. and Sun,F.
  TITLE     Structural insights into membrane remodeling by SNX1
  JOURNAL   Proc Natl Acad Sci U S A 118 (10) (2021)
   PUBMED   33658379
  REMARK    GeneRIF: Structural insights into membrane remodeling by SNX1.
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Kawamura,N., Takaoka,K., Hamada,H., Hadjantonakis,A.K.,
            Sun-Wada,G.H. and Wada,Y.
  TITLE     Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity
            through Inactivation of Dkk Antagonism
  JOURNAL   Cell Rep 31 (10), 107733 (2020)
   PUBMED   32521258
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   Schwarz,D.G., Griffin,C.T., Schneider,E.A., Yee,D. and Magnuson,T.
  TITLE     Genetic analysis of sorting nexins 1 and 2 reveals a redundant and
            essential function in mice
  JOURNAL   Mol Biol Cell 13 (10), 3588-3600 (2002)
   PUBMED   12388759
  REMARK    GeneRIF: show that mice lacking sorting nexin 1 or sorting nexin 2
            are viable and fertile, whereas embryos deficient in both proteins
            arrest at midgestation.
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Nakamura,N., Sun-Wada,G.H., Yamamoto,A., Wada,Y. and Futai,M.
  TITLE     Association of mouse sorting nexin 1 with early endosomes
  JOURNAL   J Biochem 130 (6), 765-771 (2001)
   PUBMED   11726276
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF154120.1, AB019214.1, BC066189.1 and BB198783.1.
            
            On Jul 21, 2005 this sequence version replaced NM_019727.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154120.1, AK168742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AF154120.1         2-68
            68-491              AB019214.1         8-431
            492-2069            BC066189.1         383-1960
            2070-2079           BB198783.1         214-223
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.71 cM"
     gene            1..2079
                     /gene="Snx1"
                     /note="sorting nexin 1"
                     /db_xref="GeneID:56440"
                     /db_xref="MGI:MGI:1928395"
     exon            1..280
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1687
                     /gene="Snx1"
                     /codon_start=1
                     /product="sorting nexin-1"
                     /protein_id="NP_062701.2"
                     /db_xref="CCDS:CCDS52839.1"
                     /db_xref="GeneID:56440"
                     /db_xref="MGI:MGI:1928395"
                     /translation="MASGGGGCSASERLPPPFPGMDPESEGAAGGSEPEAGDSDTEGE
                     DIFTGAAAATKPQSPKKTTSLFPIKNGSKENGIHEDQDQEPQDLFADATVELSLDSTQ
                     NNQKTMPGKTLTSHPPQEATNSPKPQPSYEELEEEQEDQFDLTVGITDPEKIGDGMNA
                     YVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGM
                     TKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQ
                     ALSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVN
                     HRKELALNTALFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLA
                     ELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKRESEARLLWANKPDKLQQAKD
                     EITEWESRVTQYERDFERISTVVRKEVTRFEKEKSKDFKNHVMKYLETLLHSQQQLAK
                     YWEAFLPEAKAIS"
     exon            281..392
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..520
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..584
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..628
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..770
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..849
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..925
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1039
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1133
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1339
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1483
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1564
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1636
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..2079
                     /gene="Snx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2049..2054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snx1"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="Snx1"
                     /note="major polyA site"
ORIGIN      
        1 tccgccccga tggtccctct gggtccataa cggccctcgc gcacctcaca cggctggagc
       61 gctttgctcg cggcactgtc tataaagttg ttgttgctgc ttccgccacg ggtggaggaa
      121 gatggcgtca ggaggtggtg gctgtagcgc ttcggagcga ctccctccgc ccttccctgg
      181 catggatccg gagtcggaag gggctgccgg ggggtcagaa cccgaggctg gggacagcga
      241 caccgagggg gaggatattt tcactggcgc cgcggcagcc actaagcccc agtctccaaa
      301 gaaaaccaca tccctttttc ctatcaaaaa tggttccaaa gagaatggga tccatgagga
      361 ccaagaccaa gagccacagg atctctttgc agatgccaca gtggaactat ccctggacag
      421 cacacagaat aaccagaaga caatgccagg caaaaccctt acttctcatc ctccgcaaga
      481 agccacaaat tctccgaagc cacagccaag ctatgaggag ctggaggaag aacaggagga
      541 tcagtttgat ttgacagttg gtatcaccga tcctgagaag atcggggatg gtatgaatgc
      601 ctatgtagcc tacaaagtca ccacacagac aagcttaccg atgttcagaa gtaggcagtt
      661 tgcagtgaaa agaagattca gtgacttcct gggtctttat gagaagcttt cagagaagca
      721 ctcccagaat ggtttcattg tgcctcctcc acccgagaag agcctaatag gaatgacaaa
      781 ggtgaaggtt gggaaggaag attcttcttc cgcagagttt cttgagaaac ggagggctgc
      841 tttggaaagg taccttcaaa gaattgtgaa tcatcccacc atgttacagg acccagatgt
      901 cagggagttt ctggaaaaag aagagctgcc tcgagctgtg ggcacgcagg ctttgagtgg
      961 cgctggtctc cttaagatgt tcaacaaagc tacagatgca gtcagcaaaa tgaccatcaa
     1021 gatgaatgaa tcagacattt ggttcgagga gaaactccag gaggtagagt gtgaggagca
     1081 gcgcctacgg aagctgcatg ctgtggtgga gactctagtc aaccatagga aagaactagc
     1141 gctgaacaca gccctgtttg ccaagagtct agccatgctt gggagctccg aggacaacac
     1201 agcactttct cgagcgctct cccaactggc tgaggtggaa gaaaagattg agcagctcca
     1261 ccaggaacag gccaacaatg acttcttcct ccttgctgaa ctcctgagtg actatattcg
     1321 cctcctggcc attgtccgag ctgccttcga ccagcgcatg aagacatggc agcgctggca
     1381 ggatgctcaa gccacgctgc agaagaagcg ggagtctgag gcacggctgc tgtgggccaa
     1441 caagcctgac aaactgcagc aggctaagga tgagatcaca gagtgggaat ctcgggtgac
     1501 tcagtatgaa agggactttg aaaggatttc cacagttgtc cgaaaggaag tgacacgatt
     1561 tgagaaagag aagtccaagg atttcaaaaa ccacgtgatg aagtacctgg agacactcct
     1621 acattcccag cagcagctgg caaaatactg ggaagccttc cttcctgagg caaaggccat
     1681 ctcctgaggg accaaggaca ccagagccta ccttcgtgac gctgcctttt tatacactgt
     1741 ccttcttcct cgatggaccc taactgatgc ccctgccttg gctggactta gcccttccac
     1801 tctgccccac agacaaactg ttcccagtta ctctaaccaa catttcattt agcttccacg
     1861 tatattttct tacctaagag aatagtttcc tgctttaagc aaaagaccta caataggtgg
     1921 tggaattata ggttggggtg gagtgttgat ataaatatat aaatacaaat gtatattttt
     1981 caggatgtgg tttaggaact gggaataacg ttttctgtta ctcctgatgg tgccatgaaa
     2041 gattatgtaa taaaatattt gaaaatcatg tcacaggac
//
