LOCUS       NM_033174               2020 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SNRPN upstream reading frame (Snurf), mRNA.
ACCESSION   NM_033174 XM_359327
VERSION     NM_033174.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Stefan,M., Simmons,R.A., Bertera,S., Trucco,M., Esni,F., Drain,P.
            and Nicholls,R.D.
  TITLE     Global deficits in development, function, and gene expression in
            the endocrine pancreas in a deletion mouse model of Prader-Willi
            syndrome
  JOURNAL   Am J Physiol Endocrinol Metab 300 (5), E909-E922 (2011)
   PUBMED   21343540
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Miyazaki,K., Mapendano,C.K., Fuchigami,T., Kondo,S., Ohta,T.,
            Kinoshita,A., Tsukamoto,K., Yoshiura,K., Niikawa,N. and Kishino,T.
  TITLE     Developmentally dynamic changes of DNA methylation in the mouse
            Snurf/Snrpn gene
  JOURNAL   Gene 432 (1-2), 97-101 (2009)
   PUBMED   19095049
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Liang,X.W., Zhu,J.Q., Miao,Y.L., Liu,J.H., Wei,L., Lu,S.S., Hou,Y.,
            Schatten,H., Lu,K.H. and Sun,Q.Y.
  TITLE     Loss of methylation imprint of Snrpn in postovulatory aging mouse
            oocyte
  JOURNAL   Biochem Biophys Res Commun 371 (1), 16-21 (2008)
   PUBMED   18381202
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Ogawa,H., Wu,Q., Komiyama,J., Obata,Y. and Kono,T.
  TITLE     Disruption of parental-specific expression of imprinted genes in
            uniparental fetuses
  JOURNAL   FEBS Lett 580 (22), 5377-5384 (2006)
   PUBMED   16987518
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Mapendano,C.K., Kishino,T., Miyazaki,K., Kondo,S., Yoshiura,K.I.,
            Hishikawa,Y., Koji,T., Niikawa,N. and Ohta,T.
  TITLE     Expression of the Snurf-Snrpn IC transcript in the oocyte and its
            putative role in the imprinting establishment of the mouse 7C
            imprinting domain
  JOURNAL   J Hum Genet 51 (3), 236-243 (2006)
   PUBMED   16429232
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Tsai,T.F., Chen,K.S., Weber,J.S., Justice,M.J. and Beaudet,A.L.
  TITLE     Evidence for translational regulation of the imprinted Snurf-Snrpn
            locus in mice
  JOURNAL   Hum Mol Genet 11 (14), 1659-1668 (2002)
   PUBMED   12075010
  REMARK    GeneRIF: the ATG-to-AAG mutation causes a 15-fold or more increase
            in translation of the downstream ORF in two fusion constructs, and
            it is likely that similar translational control affects the normal
            Snurf-Snrpn transcript as well
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Choi,J.D., Underkoffler,L.A., Collins,J.N., Marchegiani,S.M.,
            Terry,N.A., Beechey,C.V. and Oakey,R.J.
  TITLE     Microarray expression profiling of tissues from mice with
            uniparental duplications of chromosomes 7 and 11 to identify
            imprinted genes
  JOURNAL   Mamm Genome 12 (10), 758-764 (2001)
   PUBMED   11668390
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Bressler,J., Tsai,T.F., Wu,M.Y., Tsai,S.F., Ramirez,M.A.,
            Armstrong,D. and Beaudet,A.L.
  TITLE     The SNRPN promoter is not required for genomic imprinting of the
            Prader-Willi/Angelman domain in mice
  JOURNAL   Nat Genet 28 (3), 232-240 (2001)
   PUBMED   11431693
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Gray,T.A., Saitoh,S. and Nicholls,R.D.
  TITLE     An imprinted, mammalian bicistronic transcript encodes two
            independent proteins
  JOURNAL   Proc Natl Acad Sci U S A 96 (10), 5616-5621 (1999)
   PUBMED   10318933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167813.4, BC132082.1, CF751578.1, BY648312.1 and AC172750.1.
            
            On Mar 23, 2017 this sequence version replaced NM_033174.3.
            
            Summary: This gene is located within the mouse orthologous
            Prader-Willi Syndrome critical region and is imprinted and
            expressed from the paternal allele. This transcipt is thought to be
            bicistronic and can encode the small nuclear ribonucleoprotein
            polypeptide N (Snrpn) from a downstream open reading frame. The
            small protein represented by this gene is encoded by an
            evolutionarily-conserved upstream open reading frame and is
            localized to the nucleus. [provided by RefSeq, Mar 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019589.1, SRR1660811.134375.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 10318933
            imprinted gene         :: PMID: 11431693
            NMD candidate          :: PMID: 10318933
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC167813.4         86987-87079         c
            94-550              BC132082.1         1-457
            551-1237            CF751578.1         7-693
            1238-1406           BY648312.1         248-416
            1407-2020           AC172750.1         125176-125789       c
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.04 cM"
     gene            1..2020
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /note="SNRPN upstream reading frame"
                     /db_xref="GeneID:84704"
                     /db_xref="MGI:MGI:1891236"
     exon            1..164
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..366
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /note="small nuclear ribonucleoprotein N"
                     /codon_start=1
                     /product="SNRPN upstream reading frame protein"
                     /protein_id="NP_149409.1"
                     /db_xref="CCDS:CCDS57553.1"
                     /db_xref="GeneID:84704"
                     /db_xref="MGI:MGI:1891236"
                     /translation="MERGRDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECHLYPRR
                     SQQQQVPVVDFQAELRQAFLAETPRGG"
     exon            165..260
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            261..409
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..555
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..707
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..819
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..972
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1111
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1237
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..2020
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /note="hexamer: AATACA"
     polyA_site      1401
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /note="major polyA site"
     polyA_site      1452
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2015
                     /gene="Snurf"
                     /gene_synonym="2410045I01Rik"
ORIGIN      
        1 ggcaaaaatg tgcgcatgtg cagccattgc ctgggacgca tgcgtaggga gccgcgcgac
       61 aaacctgagc cattgcggca agactagcgc agagaggaga gggagccgga gatgccagac
      121 gcttggttct gaggagtgat ttgcaacgca atggagcgag gaagggatcg cttacacttg
      181 agaagaacta ctgaacagca cgtgcccgag gtcgaggtcc aggtcaaacg tcgaaggaca
      241 gcctcactga gcaaccaaga gtgtcacttg tacccacgac gttctcagca acagcaagtt
      301 cctgtggtgg atttccaggc agaactaaga caggcattct tagctgagac accaagaggt
      361 ggttaaagca gtattgcaac ttcaaggtgg tggaattcaa ggaaaacagg acccatcctc
      421 tgtctgtgaa actttggtca agcttacatt gtttgttaat agcctgcatc gaacctttat
      481 ttatatccct tccccgagta ttaaggatct tgaaatttta gtgttgacaa cggctattgt
      541 ggaacagcaa tcatgactgt gggtaagagt agcaagatgc tgcagcacat tgactatagg
      601 atgagatgta tcctgcaaga tgggagaatc ttcattggca ccttcaaggc ttttgacaag
      661 catatgaatt tgatcctctg tgattgtgat gagttcagga agatcaagcc aaagaatgca
      721 aaacagccag aacgtgaaga aaaacgggtt ttgggtctgg tcttgctacg tggggagaac
      781 ttggtttcaa tgactgtgga gggcccacct cctaaagata ctggcattgc tcgtgtgcct
      841 cttgctggcg ctgcaggtgg ccctggggtt ggaagagcag ctggcagagg agtgccagca
      901 ggtgtaccta ttccccaggc tcctgctgga ttagcaggcc ctgtcagagg agttggaggc
      961 ccatcccagc aggtcatgac cccacaggga agaggcactg ttgcagctgc tgctgttgct
     1021 gctactgcta gcattgcagg agccccaacc cagtacccgc caggacgggg aactccacct
     1081 ccacctgtag gcagagcaac cccacctcca ggcattatgg ctcctccacc tggtatgaga
     1141 ccacccatgg gcccacccat tgggcttccc cctgctcgtg ggacacctat aggcatgcct
     1201 cctccaggaa tgagaccccc tccaccagga attagaggcc cacctccccc aggaatgcgc
     1261 ccaccaagac cctaagatac agttgataaa tctcagccct tctcttcccc tacaatgctt
     1321 cttgtgaaat tgtgtacctg caagcttttt gacccctctt actgcattaa ctatagataa
     1381 taaatacata gagcaattca attggggttt ttctttgtct gctgattttg ttaaagttag
     1441 agtgaaacca aatgtgtttc agtggtgaaa ttattgttaa agattactat attaagttta
     1501 tattaactaa acacagatat gacatttgct caagctaggt tcttaggatc agatagttga
     1561 aatattttcc tgatttctga cattcacttc aagcattggt tcaaaatctt acagataagg
     1621 aaaatcaaga tccatttgct aagatttaca agccattccg gttcaattaa atatgtttca
     1681 cttaaaggtg tgtgaagata tttaagcaga tatttaaatt cacatcattt atggcactgg
     1741 tatgtcatta ttgcttatga attaaaacat ggaatgcaag gtattttcca atcttccaaa
     1801 catgctctat tacttagcag tctataatta tgtttacaac tatacataca tccatataca
     1861 cacatacaca tgcattccat gcatgcatgc gcacacacac acacacacac acacacagac
     1921 atctatcatg tactgggtct attttggttt tagtttgtac atttgtttag gtgcattaat
     1981 tggtattaaa taaattataa aatgattttc ctgaagaaga
//
