LOCUS       NM_177624               1240 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sentan, cilia apical structure protein (Sntn), mRNA.
ACCESSION   NM_177624
VERSION     NM_177624.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1240)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1240)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1240)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   4  (bases 1 to 1240)
  AUTHORS   Kubo,A., Yuba-Kubo,A., Tsukita,S., Tsukita,S. and Amagai,M.
  TITLE     Sentan: a novel specific component of the apical structure of
            vertebrate motile cilia
  JOURNAL   Mol Biol Cell 19 (12), 5338-5346 (2008)
   PUBMED   18829862
  REMARK    GeneRIF: Data suggest that sentan is the first molecular component
            of the ciliary tip to bridge the cell membrane and peripheral
            singlet microtubules, making the distal portion of the cilia narrow
            and stiff to allow for better airway clearance or ovum transport.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK040281.1.
            
            On Apr 6, 2007 this sequence version replaced NM_177624.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040281.1, BU146274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1240              AK040281.1         2-1241
FEATURES             Location/Qualifiers
     source          1..1240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.93 cM"
     gene            1..1240
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /note="sentan, cilia apical structure protein"
                     /db_xref="GeneID:218739"
                     /db_xref="MGI:MGI:3045373"
     exon            1..130
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..464
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /codon_start=1
                     /product="sentan"
                     /protein_id="NP_808292.1"
                     /db_xref="CCDS:CCDS26822.1"
                     /db_xref="GeneID:218739"
                     /db_xref="MGI:MGI:3045373"
                     /translation="MGGCMHSTWDHALHSRGEPRPSEAPASISAPSKMPKSVSISKQL
                     ASIKALKKGSDLEKAIATIALVFRNASDPDGKLGKATAKKLLQTQFKKFTEREETKPK
                     YQDILSELDEHTENKLDFEDFVILLLSLAIMSDLLRNMWNENTMK"
     exon            131..165
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            166..305
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            306..1240
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      460..465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      479
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
     regulatory      505..510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      532
                     /gene="Sntn"
                     /gene_synonym="A430083B19Rik"
                     /note="major polyA site"
ORIGIN      
        1 acaacaggca aagcaagagt atgggaggct gtatgcacag cacctgggac cacgcactcc
       61 actcaagagg agagcccagg ccttctgaag ccccagcatc catttcagca cctagcaaaa
      121 tgcctaaaag tgtttcaata tctaagcaac tggcttcaat aaaagctttg aagaaggggt
      181 cagatctgga aaaagccatt gctactattg ctctggtttt cagaaatgct tctgaccctg
      241 atggtaaact tgggaaagcc actgccaaga aactgctaca aacccaattt aaaaaattca
      301 cagagagaga agaaaccaag ccaaaatacc aagacatcct ttctgagctt gatgagcaca
      361 cagaaaataa gctggacttt gaggacttcg tgatcttgct cctgagcctt gccatcatgt
      421 cagatctgct acgaaatatg tggaatgaaa atactatgaa ataaacaaat ttaaacatgt
      481 gatggacaaa tgatgtgcca cagcattaaa tgtgtctcta tctggtttgt aataagtgtg
      541 ggactgcaac tctcttcaga aatgtttgaa tgatatggtt tgtgacacga taaactggat
      601 accacttctg atgagtaatg agcaacttaa aggcatctcc tactgagtgt ggaatcacat
      661 ttattcattg atcatgaaat caaatttgtg agcatcttcc cagtaacgtt attttaaaac
      721 tgcagtgacg aatggccagg tgactccttc cctttctcat gtttacacaa ttccagaaga
      781 aaaatacggc atacaacaat aatttctgtg tccatgttta tgcaacattg tgcatgtatt
      841 tgtgtgatgg taactacaca tgtacatatg gcaaccagag gtcaatctcc agtgttcttt
      901 tttcatgtga tctctacctt aattttttag ttctcattgc cctgaggctc actgagaggc
      961 taagctggcg gatcagtgat ccccagattc acctatctct acctccccag tgctgggact
     1021 ttccccatgc ccagctttgg taagtgagtt ctagggatcg aactcagatg ctcatgcttg
     1081 cattagtgag taatttaaaa tatgacccat ctccctagct ctgaacaact atttaataag
     1141 tttaaaacac actgcaatta taaataaaat gagggttaca gaatgataag catagtttat
     1201 tacaagaaca tttgttcaaa tatcagaccc ttactaacct
//
