LOCUS       NM_172951               2337 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus syntrophin, gamma 2 (Sntg2), transcript variant 1,
            mRNA.
ACCESSION   NM_172951 NM_133742
VERSION     NM_172951.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Alessi,A., Bragg,A.D., Percival,J.M., Yoo,J., Albrecht,D.E.,
            Froehner,S.C. and Adams,M.E.
  TITLE     gamma-Syntrophin scaffolding is spatially and functionally distinct
            from that of the alpha/beta syntrophins
  JOURNAL   Exp Cell Res 312 (16), 3084-3095 (2006)
   PUBMED   16857187
  REMARK    GeneRIF: Gamma1-Syntrophin is highly expressed in brain and is
            specifically localized in hippocampal pyramidal neurons, Purkinje
            neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is
            expressed in many tissues including skeletal muscle.
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Chen,Z., Hague,C., Hall,R.A. and Minneman,K.P.
  TITLE     Syntrophins regulate alpha1D-adrenergic receptors through a PDZ
            domain-mediated interaction
  JOURNAL   J Biol Chem 281 (18), 12414-12420 (2006)
   PUBMED   16533813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098098.1, AK035310.1, BC138956.1 and AK087560.1.
            
            On Nov 28, 2009 this sequence version replaced NM_172951.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137345.1, AK035310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY098098.1         2-48
            48-1331             AK035310.1         2-1285
            1332-1573           BC138956.1         1246-1487
            1574-2337           AK087560.1         1513-2276
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     gene            1..2337
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /note="syntrophin, gamma 2"
                     /db_xref="GeneID:268534"
                     /db_xref="MGI:MGI:1919541"
     exon            1..218
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            219..356
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            357..413
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..471
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..515
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..557
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            558..645
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            646..737
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            738..865
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            866..995
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1034
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1151
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1223
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1430
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1523
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1634
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2337
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /note="major polyA site"
ORIGIN      
        1 ggggttccgt gcctgccctg cttgctagcg cagtggctgc tggctctgtc cgccccagcc
       61 cgtccacaga ggggcgcggg cgccgtgctg gcgctggact taggagctcc ggagcccgaa
      121 gcgcacgcct agccgcgtgg gcggcgatga gcgccgaggg atcgcagtcc ctggccgccc
      181 cccgcgggcg tcctagtcac ctactggtgc ccgcgcggac caaaacagct ctggccttgt
      241 tgtatgacga ggggttggaa aatgcctatg acgtccgcct gaagctgaca aaagaggtgc
      301 tgactattca aaagcaagat gtcgtctgca tcgggggagc tcctcctggt gctaatcaca
      361 gaactgttac acttcgcaga caacctgtgg gtggcctggg cctaagtatc aagggaggag
      421 cagagcatgg ggtccccgtc gtcatatcta aaatattcaa agaccaagca gctgaccaga
      481 cagagatgtt gttcatagga gatgctgtac tacaggttaa tggcattaat gtagaaaacg
      541 caacccatga agaagtggtg catcttctga gaaacgctgg cgatgacgtc accatcactg
      601 ttgagtatct cagggaagca ccctcatttc tgaagctgcc attagggtcc ccagggccat
      661 ccagtgacca tagcagcagg gcctcatcgc ctctctttga cagtggcctg cacctgaatg
      721 gacactgcag ccacacagct ccatcatcac cttcctcacc catagctaat gaaccaaagt
      781 atgagaagcg ttggctagac accttgtcag tccctctgtc tatggctcgg atctccagat
      841 acaaagctgg aacagaaaag ctcaggtcca gtgcattgga ggtgctggcc ctggatggag
      901 ccagcacagg agtccttcaa ttctccactg cccaggactg tgctgactgg ttgcgttcaa
      961 tctcaaccaa catcagtgac ctgacgcttc aacatatgaa aatggcaaat aaatgctgtt
     1021 ctccctgtga ccaggtggtg cacatgggat gggtaaatga gaggctccaa ggagctgaca
     1081 actctcagaa cttcagaccc aagttcttgg ccctgagggg ttcatcattc tacatttttg
     1141 gcgctcctcc ggtaagcaca ctggactggg gacgagcaga acgtgcctat aacctctgtg
     1201 aggtgctgtt taaagttcac aagttctggc tttcagataa ctattggctg caggcaaacc
     1261 tgtatcttgg tctccaagat tttgactgtg aagaccccag gtcatactgc ttcagcgtcc
     1321 tggccaacca tgggaagagc cacatcttca gtgtagagct gggcagtgag ctggccgtgt
     1381 gggagaaggc attccaaaga gcaactttca tggaagttca gagaaccggg tccaaaacat
     1441 atctgtgcag ctggcaaggg gagacgctgt gcttcacggt ggattttgct ctgggattca
     1501 cctgctttga cggtaagaca aagaacgtac tctggagatt caagttctct cagcttaagg
     1561 gatcctcaga tgatgggaag actcgagtaa agctgctgtt tcagaatctg gacaccaagc
     1621 agattgaaac gaaggagctg gagttccagg atttgacggc ggtcctccac tgcatccact
     1681 ccttcattgc cgccaaggtg gcctccctgg accccgtgtt catggatagc cagagtatgg
     1741 caagaagata cctgtgcagc agctaaaaca agtttgaaga gtgctgcaag caattaaatt
     1801 attttcttaa gaaactaatc tttcctgcac aatgttgcac ctttgtgtgg ttttataatg
     1861 agcctatagt tgtgatacca ataaagacat cactagtttc acagatgggt cagactgttg
     1921 aatgtgacaa tagggtatca atctgaccag gcacagtggt ggtaggaact cagggtcctc
     1981 tgaaactatc ccatcccagc ctgtctcaaa cagctggtga tgtaacgccg cagtctactg
     2041 cttgcatcaa tgaaacccaa attttatttt tgcaaagtgc caggtaggag agtgagaagt
     2101 caccatttac cctttcttaa gagaaatggg cttcccacag gcaagttggt aactctccct
     2161 ttgccatggg tgggaccagc atttgggctg taaagtgaac agggtgataa atgaatagag
     2221 tgaagaggga atttgaatta tttagtttta tattaaatgc ttacatgttt attatatatc
     2281 atttaaatgt gaattctatt ttttcctaat taatcaaata cagtacatgc tttggtt
//
