LOCUS       NP_766539                539 aa            linear   ROD 27-APR-2025
DEFINITION  gamma-2-syntrophin isoform 1 [Mus musculus].
ACCESSION   NP_766539 NP_598503
VERSION     NP_766539.2
DBSOURCE    REFSEQ: accession NM_172951.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 539)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   3  (residues 1 to 539)
  AUTHORS   Alessi,A., Bragg,A.D., Percival,J.M., Yoo,J., Albrecht,D.E.,
            Froehner,S.C. and Adams,M.E.
  TITLE     gamma-Syntrophin scaffolding is spatially and functionally distinct
            from that of the alpha/beta syntrophins
  JOURNAL   Exp Cell Res 312 (16), 3084-3095 (2006)
   PUBMED   16857187
  REMARK    GeneRIF: Gamma1-Syntrophin is highly expressed in brain and is
            specifically localized in hippocampal pyramidal neurons, Purkinje
            neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is
            expressed in many tissues including skeletal muscle.
REFERENCE   4  (residues 1 to 539)
  AUTHORS   Chen,Z., Hague,C., Hall,R.A. and Minneman,K.P.
  TITLE     Syntrophins regulate alpha1D-adrenergic receptors through a PDZ
            domain-mediated interaction
  JOURNAL   J Biol Chem 281 (18), 12414-12420 (2006)
   PUBMED   16533813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098098.1, AK035310.1, BC138956.1 and AK087560.1.
            
            On Nov 28, 2009 this sequence version replaced NP_766539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137345.1, AK035310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     Protein         1..539
                     /product="gamma-2-syntrophin isoform 1"
                     /note="gamma-2-syntrophin; syntrophin-5"
                     /calculated_mol_wt=59467
     Region          72..154
                     /region_name="PDZ_syntrophin-like"
                     /note="PDZ domain of syntrophins, and related domains;
                     cd06801"
                     /db_xref="CDD:467262"
     Site            order(83..89,101,104,134,138,141..142)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467262"
     CDS             1..539
                     /gene="Sntg2"
                     /gene_synonym="2210008K22Rik; 9530013L23; G2syn; Syn5"
                     /coded_by="NM_172951.3:147..1766"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25858.1"
                     /db_xref="GeneID:268534"
                     /db_xref="MGI:MGI:1919541"
ORIGIN      
        1 msaegsqsla aprgrpshll vpartktala llydeglena ydvrlkltke vltiqkqdvv
       61 ciggappgan hrtvtlrrqp vgglglsikg gaehgvpvvi skifkdqaad qtemlfigda
      121 vlqvnginve natheevvhl lrnagddvti tveylreaps flklplgspg pssdhssras
      181 splfdsglhl nghcshtaps spsspianep kyekrwldtl svplsmaris rykagteklr
      241 ssalevlald gastgvlqfs taqdcadwlr sistnisdlt lqhmkmankc cspcdqvvhm
      301 gwvnerlqga dnsqnfrpkf lalrgssfyi fgappvstld wgraeraynl cevlfkvhkf
      361 wlsdnywlqa nlylglqdfd cedprsycfs vlanhgkshi fsvelgsela vwekafqrat
      421 fmevqrtgsk tylcswqget lcftvdfalg ftcfdgktkn vlwrfkfsql kgssddgktr
      481 vkllfqnldt kqietkelef qdltavlhci hsfiaakvas ldpvfmdsqs marrylcss
//
