LOCUS       NM_001290393            7213 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus syntrophin, gamma 1 (Sntg1), transcript variant 4,
            mRNA.
ACCESSION   NM_001290393 XM_006495568
VERSION     NM_001290393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7213)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   2  (bases 1 to 7213)
  AUTHORS   Alessi,A., Bragg,A.D., Percival,J.M., Yoo,J., Albrecht,D.E.,
            Froehner,S.C. and Adams,M.E.
  TITLE     gamma-Syntrophin scaffolding is spatially and functionally distinct
            from that of the alpha/beta syntrophins
  JOURNAL   Exp Cell Res 312 (16), 3084-3095 (2006)
   PUBMED   16857187
  REMARK    GeneRIF: Gamma1-Syntrophin is highly expressed in brain and is
            specifically localized in hippocampal pyramidal neurons, Purkinje
            neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is
            expressed in many tissues including skeletal muscle.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038698.1, AF367759.1, AK080034.1, AK083241.1, AC102786.7 and
            CJ254355.1.
            
            On Mar 13, 2014 this sequence version replaced XM_006495568.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 4 encode the same protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.144761.1, AF367759.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1626              AK038698.1         2-1627
            1627-2109           AF367759.1         333-815
            2110-4195           AK080034.1         1526-3611
            4196-4324           AK083241.1         3235-3363
            4325-6713           AC102786.7         114633-117021
            6714-7213           CJ254355.1         1-500
FEATURES             Location/Qualifiers
     source          1..7213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     gene            1..7213
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="syntrophin, gamma 1"
                     /db_xref="GeneID:71096"
                     /db_xref="MGI:MGI:1918346"
     exon            1..1745
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1827
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1891
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1945
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1919..3472
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="isoform 1 is encoded by transcript variant 4;
                     gamma-1-syntrophin; syntrophin-4"
                     /codon_start=1
                     /product="gamma-1-syntrophin isoform 1"
                     /protein_id="NP_001277322.1"
                     /db_xref="CCDS:CCDS35509.1"
                     /db_xref="GeneID:71096"
                     /db_xref="MGI:MGI:1918346"
                     /translation="MDFRTTCEETKTGVCLLQDGNQEPFKVRLHLARDLLMLQEQDVL
                     CVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVISKISKEQRAELSGLLFIG
                     DAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPVNEDCACAPSD
                     QSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHARFSQ
                     YVPGTDLSRQNAFQVVAVDGVCSGILQCLSAEDCMDWLQAIASNISNLTKHNIKKINR
                     NFPVNQQIVYMGWCEAREQESLQDRVYTPVFLALRGSCLYRFLSPPVTTWDWTRAEKT
                     FSVCEIMCKVLKDSDLLDRRKHCFTMQSECGEDLYFSVELESDLAQWERAFQTATFLE
                     VERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKI
                     KFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQAATTAAVSSA
                     STSKAKHLA"
     exon            1946..2080
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2137
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2195
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2239
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2281
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2384
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2467
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2598
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2728
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2767
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2884
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2956
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3109
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3202
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3313
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..7208
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="hexamer: AATAAA"
     polyA_site      3766
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="major polyA site"
     regulatory      4270..4275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="hexamer: AATAAA"
     polyA_site      4291
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
     regulatory      7030..7035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
                     /note="hexamer: AATAAA"
     polyA_site      7055
                     /gene="Sntg1"
                     /gene_synonym="4933426D16Rik; G1SYN; SYN4"
ORIGIN      
        1 agtgcagccg gaggtggata ggagcgagca cccagcagca ctgcgtgccc acgcgttgtc
       61 cctgcgctaa gcctgcacgc ccccctcggt cggaacaaac tccgggtgca caagtctgcg
      121 ctgcacaagt tcttcagctg gagctgggcg cttacccagg ttggcgtttg tggggcgctc
      181 ttcagcctta ccacagtcac tcagagctcc gcaaagacgc cgtgttaagc agattgcccc
      241 attctcactc tgtgtatttc agttccccca tctcactcca ttcgtgcctg caccagttgc
      301 cttgtgtggg cggcggaacc tcggcggcct cctacagggc caccttctcg aacccgcgtc
      361 caattccacc gcaagcttct ctactggaag ccaccagaag cctgaccgcg gagctaagta
      421 acccggggga cgtctcggtc cggtgcctag gccttgctgg agccttttag ggataacagc
      481 cctgcctacc tgatccacta ccctcatcca gtcttttgtg cggcgacacg cccccgcccc
      541 tgcgggaacc cgggctgtag gcggtgggag ggcgggagct ggaacccaac ctccctgtcc
      601 ctgctgtccc tgtctggggc tcccggccac ggctaagctc ttcgcggcga tacagcctct
      661 cggaaacaaa ggtatcccta gccttttcct ggccctttca cggtttctgc attttctgac
      721 aagagtctgt ctgtgtatct gggaactgag catccttact ctgtcatctc ggaattccat
      781 ctagagctcc gaaaatgtga acgtgtccgc gccctggtta ggaagcaaga tcgcaggggg
      841 acctccaaaa tagcccttct catcttatgt aattaaggac ccacgagctt cccaaaagca
      901 cctctacagt ctccacagtg ctcagcttct ctcctcctcc cccttctctc ccctgtctct
      961 ttctctctgt cccccgtccc tgtgcgcgct tgtgcgcgcg cccgtgttcg tgcgttcttt
     1021 tttcatttct accattagga aacctactca gagccgctgt gaacttagaa gaggctcagc
     1081 atttgtttcc cacggatttc tgcctctccg gaaacgttgc cagcgtatac acataagggt
     1141 atcaagatgg agagaccatt aatccccaag aaatgaaaca cggcggagaa acggcaaagc
     1201 tagaagtctg gaagaggcct tagcaggagt atagggtctg gagtagacta aggggtcctg
     1261 gttcccctcg cttcagcacc ggaagggatg gacagcgtct cccagctgcg tggctgcctg
     1321 ggagacccaa ctgtgttgct gctgctgcct ctgctgctgt cctcctggcc acagtcatct
     1381 acaagagctc ttagcagcta aaaggcggtg cctctggtcc ccttccttga tggacgaaaa
     1441 ccagccctcc tcatcctcta ccactcatat caacctagtt aaactctagg cagcaacttc
     1501 aagaaaaatt tctatacagg actccgggga atgcaggcag aagagtggag ttgaagttct
     1561 tagaagcacc aaagaaccat gggcgttgca gtaggaattg aaattctcaa aggcccagag
     1621 tttttaaaat aagaacgtcc ctgagtggat tgcagctgtt gtggagacag ctttgtgaga
     1681 ggtcagagat actaaaaccc caacattaaa gaagctgaga agacgtcaat tcctctgctc
     1741 agcagggata actctctgcc tggccgagga cagcttccat ctccttccaa ctgtgacctg
     1801 ccatctcact ctgaatccat gcatgtgatc tggcagtgag tgttcctgct gctgtaagaa
     1861 caagaagcca ccctgggttc ctgtagccaa gaccacatcc ttcacagtgc cacagcacat
     1921 ggatttcaga actacctgtg aggagacgaa gacaggtgtt tgcttgctac aagatggtaa
     1981 tcaagaacct tttaaagtcc ggttacacct tgccagagac ctgttgatgc tacaggagca
     2041 ggatgtgctg tgtgtgtctg gtgagccttt ctattctggt gaaagaacgg tgaccatcag
     2101 aagacagaca gtaggaggat tcggattaag cataaaggga ggtgcagaac ataacatccc
     2161 ggttgtcatt tccaaaatat ctaaggagca aagagcagag ctgtcggggc tgctttttat
     2221 tggagatgca attctacaga taaatggaat taatgtgagg aaatgcagac atgaggaggt
     2281 ggttcaggtt cttcggaatg ctggggagga agtgaccctg acagtgtcat tcttaaaacg
     2341 agcacctgct ttcctcaaac tcccagttaa tgaagactgt gcatgtgctc caagtgacca
     2401 aagcagtggt acctcctctc ctctttgtga cagtggctta cacctcaact accatccaaa
     2461 taacacagac acgctttcct gctcttcgtg gcccacatct ccaggcctga ggtgggagaa
     2521 gcggtggtgt gacctcaggc tcattcccct acttcatgcc cgcttctctc agtatgtgcc
     2581 cgggactgac ctgagtcggc agaacgcttt ccaagttgtt gctgtggatg gagtctgcag
     2641 tggaattctt cagtgcctct ctgctgaaga ctgcatggat tggctccaag caatagcatc
     2701 taacatttca aacctcacaa agcacaatat caaaaaaatc aacagaaatt tccctgtaaa
     2761 ccagcagata gtctacatgg gctggtgtga agcccgggag caggaatccc tccaagaccg
     2821 tgtgtataca cctgtgtttc ttgccctgag gggctcctgt ctttacaggt tcctgtcacc
     2881 tccagtgacc acctgggact ggactcgagc agagaaaacc ttctccgtgt gtgagatcat
     2941 gtgcaaggtt ctcaaggaca gtgacctgct ggatcggcgg aaacattgct tcactatgca
     3001 gtctgagtgt ggggaggacc tctacttctc tgtggagcta gagagtgacc ttgcccaatg
     3061 ggaacgagcc ttccaaacag ccacctttct tgaagtggag cgcatacagt gcaagaccta
     3121 tgcatgtgtg ttggagagtc acttaatggg cctcactatt gacttcagca caggcttcat
     3181 ctgctttgac gcagcaacaa aggctgtact ttggaggtat aaattttctc agcttaaagg
     3241 ctcatcagat gacggcaaaa gcaaaatcaa atttctgttt cagaatccag atacgaaaca
     3301 gattgaagca aaggagttgg aattttcaaa tttatttgct gttcttcact gtattcattc
     3361 attttttgct gccaaagtag cttgtttgga ccctctgttt ttaggtaatc aggctgccac
     3421 tactgctgct gtcagctctg cttctacaag caaggcaaag cacctggctt gacatgctga
     3481 gctctgcctg acagccttca gggtcactca ctccctactt ccaccctgaa gagaccatgc
     3541 tgtcaccaag tcaaccatgg agtcagactg caattccagc agcagaaagg tcaggaggca
     3601 tctgtaaatg accctgggat ggcagagcaa cctatttttt ctccactgat ctctaccagg
     3661 atacagctgc catcatgttt ggtgacaagg attgattggt gtaaagtatg taaataatat
     3721 aaaaattgta agctacctat aaataaaaat accaattaaa tggccatttc tctattttag
     3781 atgattttgt atgacaaata gatattgggc cagatcatga atcaatgccc tatcattgta
     3841 ttatgagtgt aagaagttaa aaaataaaat caaggcaagt agcatgcaaa tcaaacaaac
     3901 aacaaaacaa aatgaaagca aatgacctca aagacagaag caccttaact tactcatgtg
     3961 agttacttcc tataatctca tcagatggtt caatatgagc acgccagctg tgtttaatct
     4021 tactgtaaaa tattctgcag aattaataaa gacaattaca ttggcctgtg acaacaccct
     4081 agtaaattaa ctatttcttc tttggtgaat gttactaaca tgttttatat tagaaaatgg
     4141 tattaatcat gaatgtcaaa aacactcttc atttaaatac atttcttctt tttttgccta
     4201 atgagattaa tgaacaaact aaactttaat aaatttaaat gtcccaaaac tcttgcagaa
     4261 aaatatatca ataaattctg tgtaagaaac atgtctttgt tatacttttc tatttagtca
     4321 tgaactaaag agttcctgaa agttagccac agacattatg agagctggtg atattttcat
     4381 ttgagtttat ttttgtgtaa attgagcgag atttgaaaac cagcatcaaa attcatgtta
     4441 taaaatgcaa tggaaagtaa ttgactatgt caaatgatgt aggctgctgc aggtagcttg
     4501 tttcagaatt aggaaggtaa aaagtcagaa atgtgcattg tgaggtgggc actcaaggcc
     4561 aggaactaga gactgttcat catacaaaac aagaagcatt cttcattctt tactaaggct
     4621 ctgttggtgt ctgcttttaa acaactagct acttcttgaa aagtgaacaa ataaagtcca
     4681 cttttattgg tatgcatttc aattgaacat tgtttgattc cccttaaaat gaccaaattt
     4741 ctaataagta gttcagtatc ccttctttaa atagaagaca gtcgcacatt agactcaaga
     4801 ggaaagctaa attatttttt aaagaaacac ttatccataa gtataaagtc atcaagtagt
     4861 aaactatttt cataataatt aaaatattaa ttcattttgc agtggattaa gtgaaatctc
     4921 acaatgagat ctgaaaatgt tattttggat gtaagatgcc ttgtcaacat aacatgaaaa
     4981 tttgataata aaggtttata tattctactt ttacaagaaa tttcaatgta tacccacaat
     5041 aatcatcttg ggattactgc ttactagagc aaccaaacac atgagctatg ataattttga
     5101 atttcactga attctgagtt ctgcctttct aacatagagg agaaagatta aagaaagacg
     5161 cctctatcat ctcttctgaa agctctgcca ctacacttgt tgctgccaca tagtaggcaa
     5221 caactggaat ttaaaactat acagaggtct tctgtaatca ttcaaaataa ctgtatggag
     5281 caggagagat ggattagtgg ataaaaattt ttacatctct ttcaaggacc tggatttgat
     5341 tgtagcactc acaaagtgac tcacaatcat ctgaaactac aatttttaga gaattaaatg
     5401 cttgcttcag aactcagtag caccagatac acacgtggtg catatacata cacgcaggtg
     5461 aaatgtcacc tgaaaaaaat aaacaaaaaa caaaacctaa aagtagattt tacaaagctc
     5521 catttaaaat tcaaacctga gttaagtcct tttgctgttg ttgttatatc aacaactcta
     5581 tcagtgcaca tgttgggaaa acagctgaag tgtgatatta gatcttgagt atggagctta
     5641 tatcctatgt gtgcttacag acacataaat atatgtacag atacaagtat aaaatgttaa
     5701 gcttaattat actgaaagaa aatgtttcac atatgtgaca catagctatg tatgtattca
     5761 gctataaaga gttggttgaa ttaaaaccta ctagaacaac cttggttttg ttacattata
     5821 taatcttggt taaaatatca ccatactgaa ttgctattta acatgattag tggaataggc
     5881 accaattagg aaaggactgt tctggttctc atccatttaa cagttagtgt ttaaagcttt
     5941 ctttatagtg tggttaacca ctgtcagttg ctatgacttt agctacttaa atgaaaaata
     6001 aatgtaaaaa ttcatgaaaa cacagatttc aacttctcag taagttaggt tcagatatag
     6061 atttttttta acaatcccaa gtttgagcat taagcataca tgagaatgct taatgatgtg
     6121 ttaacccttc cagtgccttt ttagatgtgc atgcacatac atgtgtatgt gtgtgcatgt
     6181 gtagatcatt aaagggcttc ttacagtgta cacactgcta gcttacagga aatgtagtta
     6241 catgagttag acagagatct tttaaacaac taagataaga atgtcttttc tgtgattaaa
     6301 aataaaaaaa aattcaactg aaatgtagtg tatctaagta ggaggacttg aatttgttat
     6361 agattaactt caaattacct tagtaattta aatataacaa atacccaagg ctttcctatc
     6421 taatttaatt ttatagagct gaatgtgcta ggaatctcac attttagtca tgggctgact
     6481 tgtcatttta aagcctttgc tcataaaact ttcattcagc aagaagaaaa gaaaatgatg
     6541 tcaagtcaat attggcaagc agagaaggca cttccatata ggcagtgtgg ttgtgctccg
     6601 gacatattag ctaatgaatc cacatgtccc tcattttcag tgacaaagat tgtttatagt
     6661 atagtctatg ctgaatgctg gtcttaagtg aagcttaact tcttcctgat gaaacctaaa
     6721 tcagaacaat cacttcattt tattgtttca aaccagcagt gtgaagaagc tttatcagtg
     6781 caagcacaca cttgtgctta actttgtaag gtaagtgtct gttccaactt aaaattttgt
     6841 ttctgttggt actgatgtgc ttataagcta aaggaacatc ttcatccata tctttaaact
     6901 cgctgtttgt gttttgttct gactccttaa tattttaaat catgtcactt tacattatag
     6961 cttaccttta aagataaata aattattata aatattatat attttataca tattacaatg
     7021 caatgagaaa ataaaatgta aatatattta tttcctattt aaatgttttg gtggatgttt
     7081 gtaaaatgta aattcagatc tgtgataact ggccacttgt ctttgagttc attaatgtac
     7141 tattactaaa aagaaaatat cttttttaat gaaccatatt agaaaataaa aatggaagct
     7201 tttctatgaa aaa
//
