LOCUS       NM_009229               4473 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus syntrophin, basic 2 (Sntb2), transcript variant 2,
            mRNA.
ACCESSION   NM_009229 XM_916246 XM_924171 XM_924175
VERSION     NM_009229.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4473)
  AUTHORS   Rein-Fischboeck,L., Pohl,R., Haberl,E.M., Mages,W., Girke,P.,
            Liebisch,G., Krautbauer,S. and Buechler,C.
  TITLE     Lower adiposity does not protect beta-2 syntrophin null mice from
            hepatic steatosis and inflammation in experimental non-alcoholic
            steatohepatitis
  JOURNAL   Gene 859, 147209 (2023)
   PUBMED   36681100
REFERENCE   2  (bases 1 to 4473)
  AUTHORS   Kim,M.J., Whitehead,N.P., Bible,K.L., Adams,M.E. and Froehner,S.C.
  TITLE     Mice lacking alpha-, beta1- and beta2-syntrophins exhibit
            diminished function and reduced dystrophin expression in both
            cardiac and skeletal muscle
  JOURNAL   Hum Mol Genet 28 (3), 386-395 (2019)
   PUBMED   30256963
REFERENCE   3  (bases 1 to 4473)
  AUTHORS   Krautbauer,S., Neumeier,M., Rein-Fischboeck,L., Haberl,E.M.,
            Tilg,H., Eisinger,K. and Buechler,C.
  TITLE     Adipocyte Hypertrophy and Improved Postprandial Lipid Response in
            Beta 2 Syntrophin Deficient Mice
  JOURNAL   Cell Physiol Biochem 52 (5), 1151-1165 (2019)
   PUBMED   30990585
  REMARK    GeneRIF: Current study shows that high SNTB2 in obese adipose
            tissues restricts adipocyte growth and thereby may contribute to
            metabolic diseases.
REFERENCE   4  (bases 1 to 4473)
  AUTHORS   Hebel,T., Eisinger,K., Neumeier,M., Rein-Fischboeck,L., Pohl,R.,
            Meier,E.M., Boettcher,A., Froehner,S.C., Adams,M.E., Liebisch,G.,
            Krautbauer,S. and Buechler,C.
  TITLE     Lipid abnormalities in alpha/beta2-syntrophin null mice are
            independent from ABCA1
  JOURNAL   Biochim Biophys Acta 1851 (5), 527-536 (2015)
   PUBMED   25625330
  REMARK    GeneRIF: Suggest alpha/beta2-syntrophins do not regulate ABCA1
            activity and insulin release but may have a role in regulating
            glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism
            in obesity.
REFERENCE   5  (bases 1 to 4473)
  AUTHORS   Kim,M.J., Froehner,S.C., Adams,M.E. and Kim,H.S.
  TITLE     alpha-Syntrophin is required for the hepatocyte growth
            factor-induced migration of cultured myoblasts
  JOURNAL   Exp Cell Res 317 (20), 2914-2924 (2011)
   PUBMED   22001117
REFERENCE   6  (bases 1 to 4473)
  AUTHORS   Ahn,A.H., Freener,C.A., Gussoni,E., Yoshida,M., Ozawa,E. and
            Kunkel,L.M.
  TITLE     The three human syntrophin genes are expressed in diverse tissues,
            have distinct chromosomal locations, and each bind to dystrophin
            and its relatives
  JOURNAL   J Biol Chem 271 (5), 2724-2730 (1996)
   PUBMED   8576247
REFERENCE   7  (bases 1 to 4473)
  AUTHORS   Adams,M.E., Dwyer,T.M., Dowler,L.L., White,R.A. and Froehner,S.C.
  TITLE     Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome
            localization, and homology with a discs large domain
  JOURNAL   J Biol Chem 270 (43), 25859-25865 (1995)
   PUBMED   7592771
REFERENCE   8  (bases 1 to 4473)
  AUTHORS   Mills,K.A., Sunada,Y., Campbell,K.P. and Mathews,K.D.
  TITLE     A syntrophin gene maps to mouse chromosome 8 and is not the
            myodystrophy gene
  JOURNAL   Mamm Genome 6 (9), 664-665 (1995)
   PUBMED   8535078
REFERENCE   9  (bases 1 to 4473)
  AUTHORS   Ahn,A.H., Yoshida,M., Anderson,M.S., Feener,C.A., Selig,S.,
            Hagiwara,Y., Ozawa,E. and Kunkel,L.M.
  TITLE     Cloning of human basic A1, a distinct 59-kDa dystrophin-associated
            protein encoded on chromosome 8q23-24
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4446-4450 (1994)
   PUBMED   8183929
REFERENCE   10 (bases 1 to 4473)
  AUTHORS   Adams,M.E., Butler,M.H., Dwyer,T.M., Peters,M.F., Murnane,A.A. and
            Froehner,S.C.
  TITLE     Two forms of mouse syntrophin, a 58 kd dystrophin-associated
            protein, differ in primary structure and tissue distribution
  JOURNAL   Neuron 11 (3), 531-540 (1993)
   PUBMED   7691103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123864.4 and AC123868.4.
            
            On Feb 6, 2019 this sequence version replaced NM_009229.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080059.1, AK040423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               AC123864.4         72358-72939         c
            583-796             AC123864.4         27340-27553         c
            797-1007            AC123864.4         17073-17283         c
            1008-1150           AC123864.4         11471-11613         c
            1151-1347           AC123864.4         6973-7169           c
            1348-1532           AC123868.4         33943-34127
            1533-4473           AC123868.4         35454-38394
FEATURES             Location/Qualifiers
     source          1..4473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.38 cM"
     gene            1..4473
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="syntrophin, basic 2"
                     /db_xref="GeneID:20650"
                     /db_xref="MGI:MGI:101771"
     exon            1..582
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1625
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="isoform 2 is encoded by transcript variant 2;
                     beta-2-syntrophin; syntrophin-3; 59 kDa
                     dystrophin-associated protein A1 basic component 2"
                     /codon_start=1
                     /product="beta-2-syntrophin isoform 2"
                     /protein_id="NP_033255.1"
                     /db_xref="CCDS:CCDS22642.1"
                     /db_xref="GeneID:20650"
                     /db_xref="MGI:MGI:101771"
                     /translation="MAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAVEP
                     EPPAAAFNGLPNGGGGESLPGSPNRGLGPPSPPAPPRGPAGEASASPPVRRVRVVKQE
                     AGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV
                     QALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGASPQSPSFSGSEDSGSPKHQN
                     TTKDRKVIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIH
                     TNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTE
                     KDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGI
                     EMHLFRVETHRDLSTWTRILVQGCHAAAELIKEVSLGCTLSGQEVRFTVHYEHGFTIT
                     RDNGGASSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTF
                     LSAKVTRMGLLV"
     exon            583..796
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1007
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1150
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1347
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1532
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..4473
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1963..1968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="hexamer: CATAAA"
     polyA_site      1981
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="major polyA site"
     regulatory      4385..4390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="hexamer: AATAAA"
     polyA_site      4411
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
     regulatory      4438..4443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="hexamer: AATAAA"
     regulatory      4449..4454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="hexamer: AATAAA"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
                     /note="hexamer: AACAAA"
     polyA_site      4458
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
     polyA_site      4466
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
     polyA_site      4473
                     /gene="Sntb2"
                     /gene_synonym="Snt2; SNT3; SNTL"
ORIGIN      
        1 gaggctgcct gactggaatc gggggagctg cagcaacggc ggctgcggga gcagggccgg
       61 ccatggcggt gtggacgcgg gccaccaaag cggggctggt ggagctgctt ctaagggagc
      121 gctgggtgcg ggtggtggcc gagctcagtg gcgagagcct gagcctgacg ggcgacgccg
      181 ccgcagtcga gcctgagccg ccggcggccg ccttcaacgg tcttccgaac ggcggcggcg
      241 gcgagtctct gcccgggagc ccgaaccgtg gcctggggcc gcccagccct cccgcgccgc
      301 cccgcggtcc cgcgggggaa gcgagcgcct cgccgcccgt gcgccgagtg cgagtggtga
      361 agcaagaggc gggcggcctg ggcatcagca tcaagggcgg ccgcgagaac cggatgccga
      421 tcctcatctc caagatcttc ccggggctgg cggccgacca gagccgggcg ctgcggctgg
      481 gcgacgccat cctgtcggtg aacggcaccg acctgcgcca ggccacccac gaccaggccg
      541 tgcaggcgct gaagcgcgcg ggcaaggagg tgctgctgga ggtcaaattc atccgagaag
      601 taacaccata tatcaagaaa ccatctttag tatcagatct gccatgggaa ggtgcctctc
      661 cccagtctcc aagctttagt ggcagtgaag actctggctc tccaaagcat cagaacacca
      721 ccaaggacag gaaggtcatc cctctcaaaa tgtgctttgc tgctcgaaac ctgagcatgc
      781 cagatctgga gaacagattg atagagctac attctcctga tagcaggaac accttgatct
      841 tacgctgcaa ggatacggcc acagcacact cctggttcgt agctatccac accaacataa
      901 tggctctcct cccacaggta ctggctgagc tcaatgccat gcttggtgca accagtacag
      961 cgggaggcag caaggaagtc aagcatattg cctggctggc agagcaggca aagctggatg
     1021 gtggacgaca gcagtggagg cctgttctca tggctgtgac tgagaaggac ttgctacttt
     1081 atgactgcat gccttggaca agagatgcct gggcatcacc gtgtcatagc taccctcttg
     1141 ttgccacaag gttggttcat tcaggttctg gatgtcggtc accctccctt ggatctgacc
     1201 tgacctttgc taccaggaca ggctctcggc agggcattga gatgcatctc ttcagggttg
     1261 aaactcatcg ggatttgtcg acctggacca gaatacttgt tcagggctgc catgctgctg
     1321 ctgagctgat caaggaagtc tccctaggct gcaccttaag tggccaagag gtaaggttca
     1381 ctgtccacta tgaacacggg ttcactatca ccagagacaa tggaggcgcc agcagcatat
     1441 tgtaccgcta tccctttgaa cggctgaaga tgtctgctga tgatggaatc agaaatctct
     1501 atttggattt tggtggccct gagggagaac tgactatgga cctgcattct tgtccaaagc
     1561 cgattgtatt tgtattgcac acgttcttat ccgccaaagt cactcgcatg ggactgcttg
     1621 tgtgagcagc aagagtgaag aaagagcttt gactgtcaca agaagtattt ccacctcaaa
     1681 agatgaaaag aaagaaaaag caacaacaaa gaagcacaaa cagaagccct tgctcctgcc
     1741 tccatcacag tgccttcctg aggacctgca gaccactgct ggaccacaac agggttttag
     1801 gaagggccga cctttcccac acagccttgg tcagaaattc tagaactgtt ataagctcca
     1861 aatgaaagct attgatttac cgtcttattt cataatgtga tctcaagtaa tcaggtttct
     1921 tttccctgtt atgaagtctg gcactttggg tttctctttg gacataaaca gatagccaaa
     1981 aggggctctt cttttctttg tgtaggaatc atttgggtat agccttgagc tcttcctggg
     2041 atgactgtcg ctctccggtg ctagtgtgca gctgccgtcc ctcaggcaca tcccacacag
     2101 gtccttgcac cacagtgacc ccgccctgtc ccaccctccc cacctctatc tggcaccagc
     2161 tctgccaccc ataagtgctg cctttaggac tcagaacttg cacagtctgg ttgcctttgc
     2221 cttcactccc cttttttgtg gtgtccaagt tgaaaagcaa gttggaaatg ctgcccggaa
     2281 agaggagtgt tgctttcttt agtttatatt gagtttatat ttggtaggag ccaggggatg
     2341 gtctacagtt tattttgaaa gatcctcatc ttacgctaag ccatttctta ttgcttacca
     2401 aatgtgcctt tgggtagggt cagtggagct ttattagtga ctgtgggatg accgggtctc
     2461 actgctgttc ctgggatccc agctggcttt caggagttgt ccttgaggtc agttccttag
     2521 tggcatcttt tggtggtggt tttgtgggtc acgttagctt tgtagcacag atgccgtttt
     2581 gagtgacaca gagcacgggg gctaggagag gtcctggcac tggtcttttg tggccccaaa
     2641 gtagtaagga caagtcgcct ccagctcaag gttaacgttg gtttcctagc gccccctggg
     2701 tggctgggac gatgagagcg agaccatggt agtcacctgc attttgttca gcacggccac
     2761 atgttgtcat gactcagggt aagtgtgacc tggaagacca tcctgtttgt ttctcctgaa
     2821 acactctaca taaaacctca agattagcac agctcccgaa tctgaacaaa aaggaaatat
     2881 taatatctga tatcttctag aggttttcta acctctctga aaacatgtct agaaacagct
     2941 ctcatgttct agatttctct ggagtgctac acagggatat ggctcttcaa atggggtaga
     3001 gggtgaaagg gaagaaaaca taagtatttg tgcagagcct gagctgcctt gattggcagg
     3061 gtagccagag gaaagagcag acgccaagca gaggtgtcac cctgctgtcc tccgctgtca
     3121 gtgagtcagg cctcctgctc tgcagtcaga ctaacagtac ccagaggctg gggagaaagt
     3181 cttaaccctg agataggttc catccctgat acatcttcaa ctcaaaagaa aaagaagaaa
     3241 tgtcccagct ctgagtgcag aaagcagagc tatagcagta agagagctct ggctcctgcc
     3301 ccactgagct gcgggtgtga aaggcggaga caccagggag actgacagga gcctctgccc
     3361 cctgttcctt agaagagctg taagtgggta agctgtgctc ttcttctggc tgaggcctgt
     3421 ggcccacagg gtttttaata ctgtcatttg aggcttataa aatgaaggct tatgggtgat
     3481 tttgttgtca ttaggagcac caagagcaag gtcctaagct gcttgttcca gaagctgtag
     3541 cagccccaac ccccgcaggt ggtcagttag gaattttaaa ccacaagtgg aatgcttttt
     3601 gtgagtgtgg gacaccttga tacaaaccta tattatcaat tttgtactca aaagccaaaa
     3661 tatagcaaac tattttcaaa tgataactaa aaatgggcat ctttgataat tcacctcttt
     3721 ttatagaatc agctatattg tctttaattt ttcatcttga acattattgg ggatgttgtg
     3781 ggctcctggg tgtgagtggg caggaaactg tggagcgcct cctgttggat gggccacttc
     3841 ctaggcatct gtgcattcca cacagtccca ggtcatcctg cagatgagag ctctcctccc
     3901 cataagaaag aggactaaag gaagctcatg ttaccaacaa gccttgccta gaaattggta
     3961 tcaaatattt tatataaaga aatgcttgtg tgtatatgcc atatttatta ataattgtaa
     4021 ctaaagtcac tgacctatag acagtaccag gttaaatatt gggatatgta tgggcaatca
     4081 gaaatgttac tttaaatgcc atctgcctat tttgaggcca tgtttggcac tttttagact
     4141 agggtaagtc tgataatacc tggtggggtt ttgtcttttt tttttttttt tgtctgaact
     4201 ctcaaagttt gttactggaa attatttgca tggtaggaga gattgaatta tttatttttt
     4261 atatgtagaa aaatctctct aaccaacaaa tagctcattg ttactgattt gtttgttttc
     4321 ctaacttatt ctcctggaca gaacggtagc aaagttttgt tcagctgaat aaatgcactc
     4381 agctaataaa ccaaaattta ttctttcaaa ataagaaatt atctgttatc accaaaaaat
     4441 aaaattaaaa taaacaaatt aagctatgtg gaa
//
