LOCUS       NM_001411769            4937 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus syntrophin, basic 1 (Sntb1), transcript variant 2,
            mRNA.
ACCESSION   NM_001411769 XM_006520671
VERSION     NM_001411769.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4937)
  AUTHORS   Rao,S.B., Skauli,N., Jovanovic,N., Katoozi,S., Frigeri,A.,
            Froehner,S.C., Adams,M.E., Ottersen,O.P. and Amiry-Moghaddam,M.
  TITLE     Orchestrating aquaporin-4 and connexin-43 expression in brain:
            Differential roles of alpha1- and beta1-syntrophin
  JOURNAL   Biochim Biophys Acta Biomembr 1863 (8), 183616 (2021)
   PUBMED   33872576
  REMARK    GeneRIF: Orchestrating aquaporin-4 and connexin-43 expression in
            brain: Differential roles of alpha1- and beta1-syntrophin.
REFERENCE   2  (bases 1 to 4937)
  AUTHORS   Katoozi,S., Rao,S.B., Skauli,N., Froehner,S.C., Ottersen,O.P.,
            Adams,M.E. and Amiry-Moghaddam,M.
  TITLE     Functional specialization of retinal Muller cell endfeet depends on
            an interplay between two syntrophin isoforms
  JOURNAL   Mol Brain 13 (1), 40 (2020)
   PUBMED   32178707
  REMARK    GeneRIF: Functional specialization of retinal Muller cell endfeet
            depends on an interplay between two syntrophin isoforms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4937)
  AUTHORS   Rao,S.B., Katoozi,S., Skauli,N., Froehner,S.C., Ottersen,O.P.,
            Adams,M.E. and Amiry-Moghaddam,M.
  TITLE     Targeted deletion of beta1-syntrophin causes a loss of Kir 4.1 from
            Muller cell endfeet in mouse retina
  JOURNAL   Glia 67 (6), 1138-1149 (2019)
   PUBMED   30803043
  REMARK    GeneRIF: Targeted disruption of Beta1-syntrophin causes a loss of
            Kir4.1 from Muller cell endfeet in the retina.
REFERENCE   4  (bases 1 to 4937)
  AUTHORS   Ye,R., Onodera,T., Blanchard,P.G., Kusminski,C.M., Esser,V.,
            Brekken,R.A. and Scherer,P.E.
  TITLE     beta1 Syntrophin Supports Autophagy Initiation and Protects against
            Cerulein-Induced Acute Pancreatitis
  JOURNAL   Am J Pathol 189 (4), 813-825 (2019)
   PUBMED   30653956
REFERENCE   5  (bases 1 to 4937)
  AUTHORS   Kim,M.J., Whitehead,N.P., Bible,K.L., Adams,M.E. and Froehner,S.C.
  TITLE     Mice lacking alpha-, beta1- and beta2-syntrophins exhibit
            diminished function and reduced dystrophin expression in both
            cardiac and skeletal muscle
  JOURNAL   Hum Mol Genet 28 (3), 386-395 (2019)
   PUBMED   30256963
REFERENCE   6  (bases 1 to 4937)
  AUTHORS   Gee,S.H., Madhavan,R., Levinson,S.R., Caldwell,J.H., Sealock,R. and
            Froehner,S.C.
  TITLE     Interaction of muscle and brain sodium channels with multiple
            members of the syntrophin family of dystrophin-associated proteins
  JOURNAL   J Neurosci 18 (1), 128-137 (1998)
   PUBMED   9412493
REFERENCE   7  (bases 1 to 4937)
  AUTHORS   Peters,M.F., Adams,M.E. and Froehner,S.C.
  TITLE     Differential association of syntrophin pairs with the dystrophin
            complex
  JOURNAL   J Cell Biol 138 (1), 81-93 (1997)
   PUBMED   9214383
REFERENCE   8  (bases 1 to 4937)
  AUTHORS   Gorecki,D.C., Abdulrazzak,H., Lukasiuk,K. and Barnard,E.A.
  TITLE     Differential expression of syntrophins and analysis of
            alternatively spliced dystrophin transcripts in the mouse brain
  JOURNAL   Eur J Neurosci 9 (5), 965-976 (1997)
   PUBMED   9182949
REFERENCE   9  (bases 1 to 4937)
  AUTHORS   Ahn,A.H., Yoshida,M., Anderson,M.S., Feener,C.A., Selig,S.,
            Hagiwara,Y., Ozawa,E. and Kunkel,L.M.
  TITLE     Cloning of human basic A1, a distinct 59-kDa dystrophin-associated
            protein encoded on chromosome 8q23-24
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4446-4450 (1994)
   PUBMED   8183929
REFERENCE   10 (bases 1 to 4937)
  AUTHORS   Yang,B., Ibraghimov-Beskrovnaya,O., Moomaw,C.R., Slaughter,C.A. and
            Campbell,K.P.
  TITLE     Heterogeneity of the 59-kDa dystrophin-associated protein revealed
            by cDNA cloning and expression
  JOURNAL   J Biol Chem 269 (8), 6040-6044 (1994)
   PUBMED   8119949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122769.11, AC123704.21 and AC123682.13.
            
            On Sep 1, 2022 this sequence version replaced XM_006520671.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.1351944.1,
                                           SRR9219381.162806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC122769.11        76796-76948         c
            154-944             AC122769.11        75661-76451         c
            945-1161            AC123704.21        136038-136254       c
            1162-1369           AC123704.21        93192-93399         c
            1370-1509           AC123682.13        2426-2565
            1510-1706           AC123682.13        30816-31012
            1707-1897           AC123682.13        36024-36214
            1898-4937           AC123682.13        39442-42481
FEATURES             Location/Qualifiers
     source          1..4937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 22.14 cM"
     gene            1..4937
                     /gene="Sntb1"
                     /note="syntrophin, basic 1"
                     /db_xref="GeneID:20649"
                     /db_xref="MGI:MGI:101781"
     exon            1..153
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..944
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1990
                     /gene="Sntb1"
                     /note="DAPA1B; syntrophin-2; 59 kDa dystrophin-associated
                     protein A1 basic component 1; 59-1 DAP; beta1-Syntrophin"
                     /codon_start=1
                     /product="beta-1-syntrophin"
                     /protein_id="NP_001398698.1"
                     /db_xref="GeneID:20649"
                     /db_xref="MGI:MGI:101781"
                     /translation="MAVAAAAVAAPAGGGGARAQRSGLLEVLVRDRWHKVLVNLSEDA
                     LVLSCEEGAAAYNGIGAATNGSFCRGSGTGHPVPGVAQAPDSPAGVRTAFTDLPEQVP
                     ESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAIL
                     SVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPES
                     PRLGGGSAEPLSSQSFSFHRDRKSIPLKMCYVTRNMTLADPENRQLEIHSPDAKHTVI
                     LRSKDSATAQAWFSAIHSNAGDLLTRVVADIREQLGKTGIAGSREIRHLGWLAEKVPG
                     ESEKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHSYPLLATRLVHSGPGKGSPQAG
                     MDLSFATRTGTKQGIETHLFRAEISRDLSHWTRSIVQGCHNSAELTAEITTACTYRNQ
                     ECRLTIHYDNGFSISTEPQDGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKEGEIQ
                     LDLHSCPKPIVFIIHSFLSAKITRLGLVA"
     exon            945..1161
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1369
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1509
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1706
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1897
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..4937
                     /gene="Sntb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4294..4299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb1"
                     /note="hexamer: ATTAAA"
     polyA_site      4319
                     /gene="Sntb1"
                     /note="major polyA site"
     regulatory      4912..4917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sntb1"
                     /note="hexamer: AATAAA"
     polyA_site      4937
                     /gene="Sntb1"
                     /note="major polyA site"
ORIGIN      
        1 gtagtttcct tcccagagtc ctgggatggg ggtggaggga gactgagttg aggcagcgaa
       61 ggtctggttt gaggaagact tggatcttca aacacctgcg ggaggagaga ggggagttga
      121 ctcaagagga tagagtgagc gcacctacta aaggttgctc caccccgccc aggatcaggc
      181 gagggggaac aagctccgcc gctgcaactg gcgcccggcg cagccgcgaa cacggggagt
      241 ggagtccggg gtctgagcgc gcgctgccag gcatctgctt cttccgtgcc tcggttaccc
      301 tgagtcctcc catcctcacc ccttctctac ttttcccccg tttgcaatca catggcattt
      361 taagaatgct ggaaagatgg cggtagcggc agcggctgtg gctgcgccgg ctggcggtgg
      421 aggcgcccgg gcgcagcgga gcggactgct ggaagttttg gtgcgggatc gctggcataa
      481 agttctggtg aacttgagcg aggacgccct ggtgttgagc tgcgaggagg gcgctgcggc
      541 gtacaacggc ataggggctg ccaccaatgg ttcgttctgc aggggctccg ggaccgggca
      601 cccggtcccc ggtgtcgctc aagccccgga ctctcccgcc ggggtccgca ccgccttcac
      661 cgacctcccg gagcaggtac ctgagtccat ctcaaaccag aagaggggcg tgaaggtgct
      721 gaagcaggag ctgggcgggc tgggcattag catcaaaggg ggcaaggaaa acaagatgcc
      781 catactcatc agcaagatct tcaaggggct ggcagcggat cagacccaag ccctgtatgt
      841 gggcgatgcc atcctgtcgg tgaacggagc agacctgcgg gacgccaccc acgacgaggc
      901 agtgcaggca ttgaagcgcg caggcaagga agtgctgctg gaagtgaagt atatgagaga
      961 agccacacct tacgtgaaga aagggtcccc ggtgtctgag attggatggg aaacacctcc
     1021 acctgagtct ccaagattag ggggtggctc tgcagagcct ctgtcatccc agtccttctc
     1081 cttccataga gaccggaaaa gcatccccct caagatgtgt tatgtcaccc ggaacatgac
     1141 cttggctgac cctgaaaaca ggcagctaga aattcactcg ccagatgcta agcacacagt
     1201 gattctgaga agtaaggact ctgccactgc ccaagcctgg ttcagcgcca ttcattccaa
     1261 cgctggtgac ttgctgaccc gtgtggttgc tgacatcagg gagcagctgg ggaaaacagg
     1321 cattgctggc agtcgtgaga tcaggcatct tggctggctt gcagaaaagg tgcccggaga
     1381 gagtgagaaa cagtggaaac cagccctggt tgttctgact gagaaagatc ttttaatcta
     1441 cgacagcatg ccacggagga aagaggcctg gttcagcccg gtgcattcgt atccacttct
     1501 tgctaccagg ctggtccatt caggtccagg gaaaggatca ccccaggctg ggatggatct
     1561 gtcctttgca acacgaactg gcaccaagca aggaattgaa acacatctct tcagggcaga
     1621 gatcagcagg gacctctccc actggacaag aagcatagta caggggtgcc acaattcagc
     1681 ggagctcact gccgaaatca ccacagcctg cacctacaga aaccaggaat gccgcttgac
     1741 catacattat gacaatggat tttctatttc cactgagcct caggatggtg ccttccccaa
     1801 gacaatcata cagtcccctt atgagaagct caaaatgtct tcggatgatg gaatcaggat
     1861 gctctattta gactttggag gcaaagaagg agagattcaa ctggaccttc actcctgccc
     1921 caagccgatc gttttcatca tccactcctt tctgtctgct aagataacac gactgggctt
     1981 ggtggcctga acagagaggc gacttgcctt tggaaaggaa gccggccgtg cctcaggact
     2041 gtgacatcag gcagtgcacc agacgtaaca tgcacagcca ggttcaggtt taaggagtca
     2101 catgtaacat cccagcctcc tctattggtt tcagaaactt caaggggcac cctaaagaaa
     2161 acaccacagg gaatatcaga atagaatttc atagatcaga acaaagaggt gagggcaggt
     2221 gaatgtacac gtcgtatctt ttaaacaatg acaaccaagg acacagccat tacaacagca
     2281 tagggagatc ttaatcacac cagtttctag gcaactggat cacccaggta agccagagcc
     2341 gagcagatga gaaatggata gttatacctg ttcctctgcc cctagtaacc agccccttgc
     2401 ttccttgtga tttcctgact caagttgagc taactttcat tggtaggaac aacagcaaca
     2461 atacacacct tttaaaaaaa gaatgaagca gctgctactt aatttcttta atgagttatt
     2521 ttgttgttgt tgttgttatt ggtccagact gattccaaag tgttctcctt agcatatgtt
     2581 gaacaggaat gaaatagagc actggatacc gacctgagtt ctaagctgcc agaatctgaa
     2641 gcaaagtgga ctgtttcaat tgcaagacta tcctgaagac tcttacacac aaatgatggg
     2701 taattctgca actccattcc acacccctgg atgctgtctc ccagccaaaa ctggtacctg
     2761 tacttacaga aatcaaattg caggcaattt taagaaagat tgtcattaca cacacagaaa
     2821 cacagacaca taacacacac acacacacac acacacacac acacacacac acacacacac
     2881 acacaccggt tgggagttaa ttatctgcat tttacagttt tcagtggaag tacctttcag
     2941 tggtccctgt ttctgcctgt tcccatgcac atgcatttta agtaatggaa agcatctctc
     3001 agttctcaat gatgcttatt ttgcacattc aggaagagat aggatcaaat ctaccgatag
     3061 catctttatt aattttgaaa ttccagggga atgatacttt ttttgatact gatatttttc
     3121 tacaagagta ttttgaggca gtatctagcc tataaatact taatgctttc catttttgcc
     3181 tttcaagatc cagtcactaa aaactacacc cattatttga tttttggagc tacttttcac
     3241 aagccctgaa aattaagcct agaattttga attctcagta cgtgttttcc atggagtttt
     3301 acgctagccc atgccctgtg ttctgccagc actggaagag gcatcgttta gcagatgccc
     3361 atgcaaagcg aaactgccta aaggcccagg atttggcttc ctcagctctg tgtgtttata
     3421 gggttacagt tgtagtttaa agcatcatct ccccaaagag ttcccacaca accccatttc
     3481 caagggacac tgaacagtgt tttcagatgg gggggggcgt tggtaattta ggagcttgtt
     3541 gataaaaata ttcccaagat agcaacttaa gatattttat agacccttgt tggatttact
     3601 aggctcctca agaattctgg tcttcaggaa tcttagtctt gaatgtgggg gtgagggctc
     3661 tatgccttgc acttctttgt aatgggggca tctgtgaagc tagtggcttt tgtagatggt
     3721 ggtcgaggat atctcaccac aggacattga cttttggttg gtttcctgtt ttaaaatgtt
     3781 gaagagtgga ggccagcttc aaacctgtag gaaagtgttg atgcatttgt aaattgtatt
     3841 gtaccctttc acactatata ttttcagaga tcactggaat gttgttatac aagagaatta
     3901 tacttatgta ttgtaaataa catgatacat atattaattc caatagtttt attcaacaat
     3961 gtgtaatcta aggtgctcgg tactacatga agtttgagtt aattactcaa gttgcaaaga
     4021 ttctattata tatttataga caaattaaat tgaccatagt cacagatact gtttctttat
     4081 cgcttacgtt ttagcctgat cgatatctgg ataagagtca acataaactg tcttttccat
     4141 ttttaaaatt ttaatttaaa tatttatatt ttaggaaaag tatatttgaa taaaatcgat
     4201 gcattttctg aagtaaattg aaaggtgtta ttagcaagaa atagaaagat tttactaagg
     4261 gagttatgta tatgaatgat ttttttcctc ctaattaaag tatatcatat cagagtggct
     4321 atgatgagtc aatttcactg ttgtttctca gcttgaattt taaacatcat tttaaataat
     4381 gactttagag tgtatttttt tttattttgt cttaggcgtt agtggatgat acaaagtaag
     4441 tcaggttcat gtcctggtca gtgcatcaac ctagtcattt gggagagatt gtttgtttgg
     4501 gttttttttt ttttttctga tttgctttgt tcttatttct gtgacgtatg gaacccataa
     4561 tacttgttcc taaatgaaaa ccaggacaga tgaactatct ttacttggta gattcttcct
     4621 cagttgcccg agcctggatt cattagtctg gtaatttgcc catgcttctc atcttatggc
     4681 catttcaaga aggcaagagg gatagagatt atgtcatctc tttctaacat aagctaaata
     4741 atacaaaatc aaactatata attattatga actacccaga ccaaggtatt taatgaatgg
     4801 catcaatgaa gtatggaaat aatttttggg tgtatcttga gtgttttttt tttctaaatc
     4861 tgcctgtgtt atagccccta tgaatgtcat gtacaattga tatataaact gaataaatat
     4921 ttgtctcaga tctccaa
//
