LOCUS       NM_009228               2115 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus syntrophin, acidic 1 (Snta1), mRNA.
ACCESSION   NM_009228
VERSION     NM_009228.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Sequeira,C., Wackerbarth,L.M., Pena,A., Sa-Pereira,M., Franco,C.A.
            and Gomes,E.R.
  TITLE     Myonuclear position and blood vessel organization during skeletal
            muscle postnatal development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39289869
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Tan,R.L., Sciandra,F., Hubner,W., Bozzi,M., Reimann,J., Schoch,S.,
            Brancaccio,A. and Blaess,S.
  TITLE     The missense mutation C667F in murine beta-dystroglycan causes
            embryonic lethality, myopathy and blood-brain barrier
            destabilization
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38616731
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Pedersen,T.J., Keil,S.A., Han,W., Wang,M.X. and Iliff,J.J.
  TITLE     The effect of aquaporin-4 mis-localization on Abeta deposition in
            mice
  JOURNAL   Neurobiol Dis 181, 106100 (2023)
   PUBMED   36990365
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Rao,S.B., Skauli,N., Jovanovic,N., Katoozi,S., Frigeri,A.,
            Froehner,S.C., Adams,M.E., Ottersen,O.P. and Amiry-Moghaddam,M.
  TITLE     Orchestrating aquaporin-4 and connexin-43 expression in brain:
            Differential roles of alpha1- and beta1-syntrophin
  JOURNAL   Biochim Biophys Acta Biomembr 1863 (8), 183616 (2021)
   PUBMED   33872576
  REMARK    GeneRIF: Orchestrating aquaporin-4 and connexin-43 expression in
            brain: Differential roles of alpha1- and beta1-syntrophin.
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Adams,M.E., Dwyer,T.M., Dowler,L.L., White,R.A. and Froehner,S.C.
  TITLE     Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome
            localization, and homology with a discs large domain
  JOURNAL   J Biol Chem 270 (43), 25859-25865 (1995)
   PUBMED   7592771
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Madhavan,R. and Jarrett,H.W.
  TITLE     Interactions between dystrophin glycoprotein complex proteins
  JOURNAL   Biochemistry 34 (38), 12204-12209 (1995)
   PUBMED   7547961
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Ahn,A.H., Yoshida,M., Anderson,M.S., Feener,C.A., Selig,S.,
            Hagiwara,Y., Ozawa,E. and Kunkel,L.M.
  TITLE     Cloning of human basic A1, a distinct 59-kDa dystrophin-associated
            protein encoded on chromosome 8q23-24
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4446-4450 (1994)
   PUBMED   8183929
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Adams,M.E., Butler,M.H., Dwyer,T.M., Peters,M.F., Murnane,A.A. and
            Froehner,S.C.
  TITLE     Two forms of mouse syntrophin, a 58 kd dystrophin-associated
            protein, differ in primary structure and tissue distribution
  JOURNAL   Neuron 11 (3), 531-540 (1993)
   PUBMED   7691103
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Matsumura,K., Ervasti,J.M., Ohlendieck,K., Kahl,S.D. and
            Campbell,K.P.
  TITLE     Association of dystrophin-related protein with
            dystrophin-associated proteins in mdx mouse muscle
  JOURNAL   Nature 360 (6404), 588-591 (1992)
   PUBMED   1461282
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137379.1, BB625367.1 and AV328512.1.
            
            On Nov 15, 2007 this sequence version replaced NM_009228.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137379.1, BC018546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AK137379.1         2-246
            246-571             BB625367.1         239-564
            572-2099            AK137379.1         573-2100
            2100-2115           AV328512.1         190-205
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.52 cM"
     gene            1..2115
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /note="syntrophin, acidic 1"
                     /db_xref="GeneID:20648"
                     /db_xref="MGI:MGI:101772"
     exon            1..405
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1613
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /note="syntrophin-1; 59 kDa dystrophin-associated protein
                     A1 acidic component 1; alpha1-syntrophin"
                     /codon_start=1
                     /product="alpha-1-syntrophin"
                     /protein_id="NP_033254.2"
                     /db_xref="CCDS:CCDS50763.1"
                     /db_xref="GeneID:20648"
                     /db_xref="MGI:MGI:101772"
                     /translation="MASGRRAPRTGLLELRCGAGSGAGGERWQRVLLSLAEDALTVSP
                     ADGEPGPEPEPAQLNGAAEPGAAPPQLPEALLLQRRRVTVRKADAGGLGISIKGGREN
                     KMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEV
                     KYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLSEAKHVSLKMAYVSR
                     RCTPTDPEPRYLEICAADGQDAVFLRAKDEASARSWAGAIQAQIGTFIPWVKDELQAL
                     LTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLFYCSLPQSREALSRPTRT
                     APLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVD
                     GCHRAAEGIQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAMLLRQPFEKLQMS
                     SDDGTSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA"
     exon            406..591
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..796
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1004
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1135
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1332
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1520
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2115
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /note="hexamer: AATAAA"
     polyA_site      2108
                     /gene="Snta1"
                     /gene_synonym="Snt1"
                     /note="major polyA site"
ORIGIN      
        1 agggtggcga ctggctctgc tgccccgccg ccctctgccc tgggcgctgg gtcggagcgg
       61 gccgggtacg gcgggaccgg gcgagcgcag tgtactggga cttcgaggcg aagatggcgt
      121 caggcaggcg cgctccgcgc accgggttgc tggaactgcg ctgcggggcg ggctccgggg
      181 cgggtggcga gcggtggcag cgggtgttgc tctctctggc ggaggacgcg ctgaccgtga
      241 gtcccgccga cggcgagccc ggcccggagc cggagcccgc gcagctcaac ggcgccgctg
      301 agcccggcgc ggcgccccca cagctgccag aagcgctgct gctccagcgg cgccgcgtga
      361 cggtgcgcaa ggccgacgcc ggcgggctgg gcatcagcat caaggggggc cgggaaaaca
      421 agatgcctat tctcatttcc aagatcttca agggactggc agcagaccag acggaggccc
      481 tttttgttgg ggatgccatc ctgtctgtga atggtgaaga tttgtcctct gccacccacg
      541 atgaagcggt acaggccctc aagaagacag gcaaggaggt tgtgttggag gttaagtaca
      601 tgaaggaggt ctcaccctat ttcaagaatt ctgctggagg gacctccgtt ggctgggact
      661 cacctcctgc ctcgcctctt cagcggcagc cttcttcccc tggcccccaa ccccggaacc
      721 tcagtgaggc caaacacgta tctttgaaga tggcgtatgt ctcaaggagg tgcaccccca
      781 ctgacccaga gcccaggtac ctggagatct gtgcagcgga cggccaggac gctgtcttct
      841 tgagggccaa ggatgaggcc agcgcaaggt catgggcggg cgccatccaa gcgcagatcg
      901 gcacattcat accttgggtc aaagatgagc tccaggctct gctgacagcc acaggtacag
      961 ctgggagcca ggacatcaag cagattggct ggctgacaga acagttgccc agcgggggaa
     1021 cggcaccaac cctggccctg ctgactgaga aggagctgct cttctactgc tctctccctc
     1081 agagccgaga ggccctgagc aggccgaccc gcactgcccc gctcattgcc accaggctgg
     1141 tgcactcagg cccctccaag ggctcagtgc cctatgatgc agaactctcc tttgccctgc
     1201 gcacgggtac acggcacggt gtggacactc acctgttcag tgtggagtcg ccgcaagagc
     1261 tggcagcctg gacccgacag ttggtggatg gctgtcatcg ggctgctgaa ggcatacaag
     1321 aagtgtctac agcctgcacg tggaacggcc gtccctgcag cctgtctgtg cacatcgaca
     1381 agggcttcac cctgtgggca gctgagcctg gagcagcccg agccatgctg ctccgacagc
     1441 ccttcgagaa acttcagatg tcatcagatg atggcacgag tctccttttc ctggactttg
     1501 ggggtgctga aggagagatc cagctggacc tgcactcgtg tcccaaaacg atggtcttta
     1561 tcatccactc tttcctgtcc gccaaggtca cccgcttggg gctcttggcc tagaagctgt
     1621 cagatgcacc agccctgaag aggatcgttc atcttgtggc ctgacctgtc cttctgctga
     1681 ctgcctgctc gtctgggggc tgagggaagg gagaggaggg gaactagggc ctcagagacc
     1741 agcctgagga agcagaactc agacctggga cagcgagtct ggcttgtgtt gggcagcctt
     1801 cctactgctc acctccacca gtgcctttct aagagagata ttttgtgtac acagaagcca
     1861 ttccgagcct gggacctgac cctgtgtgga tcccgtcccc agccaacagc agagctgcca
     1921 ggcctcctgg aggcctctaa gccaccctga gatctctgca gctggagtct tctgggtcag
     1981 tggcaagagg aagaagagga gcctttctgt tcacttcccc ttgagccccg tggggcatct
     2041 gggttttctc ctcgtcctct ctcccctcct tcatcttgaa taataaacag cctgtgagca
     2101 caatggcagc ctggc
//
