LOCUS       NM_009226                837 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus small nuclear ribonucleoprotein D1 (Snrpd1), mRNA.
ACCESSION   NM_009226
VERSION     NM_009226.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 837)
  AUTHORS   Riemekasten,G., Langnickel,D., Enghard,P., Undeutsch,R.,
            Humrich,J., Ebling,F.M., Hocher,B., Humaljoki,T., Neumayer,H.,
            Burmester,G.R., Hahn,B.H., Radbruch,A. and Hiepe,F.
  TITLE     Intravenous injection of a D1 protein of the Smith proteins
            postpones murine lupus and induces type 1 regulatory T cells
  JOURNAL   J Immunol 173 (9), 5835-5842 (2004)
   PUBMED   15494537
  REMARK    GeneRIF: SmD1 83-119 peptide may play a dominant role in the
            activation of helper and regulatory T cells that influence
            autoantibody generation and murine lupus.
REFERENCE   2  (bases 1 to 837)
  AUTHORS   Miranda,T.B., Khusial,P., Cook,J.R., Lee,J.H., Gunderson,S.I.,
            Pestka,S., Zieve,G.W. and Clarke,S.
  TITLE     Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically
            dimethylated at arginine residues in the nucleus
  JOURNAL   Biochem Biophys Res Commun 323 (2), 382-387 (2004)
   PUBMED   15369763
REFERENCE   3  (bases 1 to 837)
  AUTHORS   Sundar,K., Jacques,S., Gottlieb,P., Villars,R., Benito,M.E.,
            Taylor,D.K. and Spatz,L.A.
  TITLE     Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in
            the mouse can elicit the production of anti-dsDNA and anti-Sm
            antibodies
  JOURNAL   J Autoimmun 23 (2), 127-140 (2004)
   PUBMED   15324931
  REMARK    GeneRIF: data suggest that the anti-Sm D response arises as a
            consequence of antigenic cross-reactivity by anti-EBNA-1
            antibodies, supporting a possible association between EBV infection
            and SLE
REFERENCE   4  (bases 1 to 837)
  AUTHORS   Charroux,B., Pellizzoni,L., Perkinson,R.A., Yong,J., Shevchenko,A.,
            Mann,M. and Dreyfuss,G.
  TITLE     Gemin4. A novel component of the SMN complex that is found in both
            gems and nucleoli
  JOURNAL   J Cell Biol 148 (6), 1177-1186 (2000)
   PUBMED   10725331
REFERENCE   5  (bases 1 to 837)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   6  (bases 1 to 837)
  AUTHORS   Mitsuda,T., Eisenberg,R.A. and Cohen,P.L.
  TITLE     The murine Sm-D autoantigen: multiple genes, genetic polymorphism,
            evolutionary conservation and lack of intervening sequences in the
            coding region
  JOURNAL   J Autoimmun 5 (3), 277-287 (1992)
   PUBMED   1388635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC105947.11.
            
            On Apr 27, 2007 this sequence version replaced NM_009226.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007674.1, BG518789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC105947.11        22192-22322
            132-208             AC105947.11        28027-28103
            209-400             AC105947.11        31222-31413
            401-837             AC105947.11        32190-32626
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 5.25 cM"
     gene            1..837
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="small nuclear ribonucleoprotein D1"
                     /db_xref="GeneID:20641"
                     /db_xref="MGI:MGI:98344"
     exon            1..131
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..477
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="sm-D1; sm-D autoantigen; snRNP core protein D1"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein Sm D1"
                     /protein_id="NP_033252.1"
                     /db_xref="CCDS:CCDS29056.1"
                     /db_xref="GeneID:20641"
                     /db_xref="MGI:MGI:98344"
                     /translation="MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVK
                     MTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGR
                     GRGRGRGRGRGRGGPRR"
     exon            132..208
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..400
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..837
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      602..607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="hexamer: ATTAAA"
     polyA_site      629
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="major polyA site"
     regulatory      669..674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="hexamer: AATACA"
     polyA_site      690
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
                     /note="hexamer: AATAAA"
     polyA_site      783
                     /gene="Snrpd1"
                     /gene_synonym="SMD1"
ORIGIN      
        1 gtcgcgcgtc cgcaggcctc cgcgcgcttt tccggccatt cataacccca gtccgtggat
       61 ctctggagcc tgaattctgt gaacagtcgg gccagaaggg agaactgcgt cgctaggatg
      121 aagctcgtga gatttttgat gaaattgagt catgaaactg taaccattga attgaagaat
      181 gggacacaag tccatggaac aatcacaggt gtagatgtca gcatgaacac acaccttaaa
      241 gctgtgaaaa tgaccctgaa gaacagagaa cctgtacagt tggaaacatt gagtattcga
      301 ggcaataaca ttcggtattt tattctacca gacagcttac ctctagatac actacttgtg
      361 gatgttgaac ctaaggtgaa gtctaagaaa agagaagctg ttgcaggaag aggccgaggc
      421 cggggtagag gaagaggacg tggtcgtggc agaggaagag ggggtcctag gcgataatgt
      481 ctctcaagat tactgtttca aattgataag gaatttgggg atatcttttg tacaggtttt
      541 gtttgtttgt cagtttttaa taaacataag tgtagggaca gagttgtctg ttgattgtca
      601 aattaaagtt gtagtgagta tctactatat tcacatagtg tgttcagttc ggggagttgg
      661 acgcatgaaa tacatatgta ctgaacatgg gtttgatttc tttgagtcca ttatttgggc
      721 ctcttttgag atgaaataaa ttcttggcat ttcaataaag ttcttttggg atgagatcta
      781 aaactcactc catggagctt tagtggtaaa agcgaaaaat aaatgatttt gcctggc
//
