LOCUS       NM_001413574             962 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus U1 small nuclear ribonucleoprotein C (Snrpc),
            transcript variant 2, mRNA.
ACCESSION   NM_001413574
VERSION     NM_001413574.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Sun,S., Ling,S.C., Qiu,J., Albuquerque,C.P., Zhou,Y., Tokunaga,S.,
            Li,H., Qiu,H., Bui,A., Yeo,G.W., Huang,E.J., Eggan,K., Zhou,H.,
            Fu,X.D., Lagier-Tourenne,C. and Cleveland,D.W.
  TITLE     ALS-causative mutations in FUS/TLS confer gain and loss of function
            by altered association with SMN and U1-snRNP
  JOURNAL   Nat Commun 6, 6171 (2015)
   PUBMED   25625564
  REMARK    GeneRIF: these studies establish potentially converging disease
            mechanisms in amyotrophic lateral sclerosis (ALS) and spinal
            muscular atrophy, with ALS-causative mutants acquiring properties
            representing both gain and loss of function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Huang,S.C., Ou,A.C., Park,J., Yu,F., Yu,B., Lee,A., Yang,G.,
            Zhou,A. and Benz,E.J. Jr.
  TITLE     RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP
            recruitment
  JOURNAL   Mol Cell Biol 32 (2), 513-526 (2012)
   PUBMED   22083953
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
REFERENCE   4  (bases 1 to 962)
  AUTHORS   Morales,C.R., Leyne,M., el-Alfy,M. and Oko,R.
  TITLE     Molecular cloning and developmental expression of a small
            ribonuclear protein in the mouse testis
  JOURNAL   Mol Reprod Dev 46 (4), 459-470 (1997)
   PUBMED   9094092
REFERENCE   5  (bases 1 to 962)
  AUTHORS   Nelissen,R.L., Gunnewiek,J.M., Lambermon,M.H. and Van Venrooij,W.J.
  TITLE     Cloning and characterization of two processed pseudogenes and the
            cDNA for the murine U1 snRNP-specific protein C
  JOURNAL   Gene 184 (2), 273-278 (1997)
   PUBMED   9031639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126040.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV652855.1, SRR7345562.1370790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC126040.3         102314-102597       c
            285-327             AC126040.3         102171-102213       c
            328-436             AC126040.3         100299-100407       c
            437-526             AC126040.3         97405-97494         c
            527-631             AC126040.3         94620-94724         c
            632-962             AC126040.3         90709-91039         c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.59 cM"
     gene            1..962
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="U1 small nuclear ribonucleoprotein C"
                     /db_xref="GeneID:20630"
                     /db_xref="MGI:MGI:109489"
     exon            1..284
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..756
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="isoform 2 is encoded by transcript variant 2; U1
                     snRNP protein C; U1 snRNP C; U1 small nuclear
                     ribonucleoprotein 1C"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein C isoform 2"
                     /protein_id="NP_001400503.1"
                     /db_xref="GeneID:20630"
                     /db_xref="MGI:MGI:109489"
                     /translation="MAGGDPGSPAILAEWARTLAQKPRILFYCDYCDTYLTHDSPSVR
                     KTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPAPFSAPPPAGAMIPP
                     PPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPP
                     MMRPPARPMMVPTRPGMTRPDR"
     exon            285..327
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            328..436
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            437..526
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            527..631
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     exon            632..962
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      935..940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="hexamer: AATAAA"
     polyA_site      962
                     /gene="Snrpc"
                     /gene_synonym="Snrp1c; U1-C; U1C"
                     /note="major polyA site"
ORIGIN      
        1 atcctttgct cgcgtcggcg cagcctgtgt gcgtcagttc ctggcggcgg ggatcggggt
       61 agccaacggc ttgtggagca tcatgcccaa gtgagtgtgg ccctgggagc aagcggactt
      121 gcggtggtca gttgggtcct ggtgaaggtg cagggcggcg gcctcgggtt ctggacgttc
      181 cgaggggaag gcgagcccct ccgagggatg gcgggtggag acccaggctc tccggccatc
      241 ctggcagagt gggcgcggac cctcgctcag aagcctcgca ttctgtttta ttgtgactac
      301 tgtgatacgt atcttaccca cgattctcca tctgtgagga agacacactg cagtggtcgg
      361 aaacacaaag agaatgtgaa agactattat cagaaatgga tggaagagca ggcccagagc
      421 ctgattgaca agacaacggc tgcatttcaa caagggaaga tccctcctgc tccgttctct
      481 gctcctccgc ctgcaggggc catgatccca cctcccccca gtctcccggg ccctcctcgg
      541 cctggcatga tgcctgcccc ccacatggga ggccctccca tgatgccaat gatgggcccc
      601 cctccgcccg gaatgatgcc cgtgggacca gctcctggga tgagaccacc catgggaggc
      661 cacatgccca tgatgcccgg acctcccatg atgagacctc ctgcccgccc tatgatggtg
      721 cccacccggc ctggcatgac ccggccagac agataagagc agaagcgctc ttgatggttt
      781 tgtatttctt gttctgttcc accaggagct cttggtgctg agcccgagtg tttactagat
      841 gcatggaaag gaaacttccc ttcctaactg aatatttttg gagggagaaa taatacaaaa
      901 aagtgcagtt ttcacttata ttgtgaaatg tgaaaataaa gtcatcagct cttttagtta
      961 aa
//
