LOCUS       NM_001412650            1104 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus small nuclear ribonucleoprotein B (Snrpb), transcript
            variant 2, mRNA.
ACCESSION   NM_001412650
VERSION     NM_001412650.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Turner,B.R.H., Mellor,C., McElroy,C., Bowen,N., Gu,W., Knill,C. and
            Itasaki,N.
  TITLE     Non-ubiquitous expression of core spliceosomal protein SmB/B' in
            chick and mouse embryos
  JOURNAL   Dev Dyn 252 (2), 276-293 (2023)
   PUBMED   36058892
  REMARK    GeneRIF: Non-ubiquitous expression of core spliceosomal protein
            SmB/B' in chick and mouse embryos.
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Alam,S.S., Kumar,S., Beauchamp,M.C., Bareke,E., Boucher,A.,
            Nzirorera,N., Dong,Y., Padilla,R., Zhang,S.J., Majewski,J. and
            Jerome-Majewska,L.A.
  TITLE     Snrpb is required in murine neural crest cells for proper splicing
            and craniofacial morphogenesis
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35593225
  REMARK    GeneRIF: Snrpb is required in murine neural crest cells for proper
            splicing and craniofacial morphogenesis.
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Liu,N., Chen,A., Feng,N., Liu,X. and Zhang,L.
  TITLE     SNRPB is a mediator for cellular response to cisplatin in
            non-small-cell lung cancer
  JOURNAL   Med Oncol 38 (5), 57 (2021)
   PUBMED   33835288
  REMARK    GeneRIF: SNRPB is a mediator for cellular response to cisplatin in
            non-small-cell lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1104)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   5  (bases 1 to 1104)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1104)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
REFERENCE   7  (bases 1 to 1104)
  AUTHORS   Larsson,S.H., Charlieu,J.P., Miyagawa,K., Engelkamp,D.,
            Rassoulzadegan,M., Ross,A., Cuzin,F., van Heyningen,V. and
            Hastie,N.D.
  TITLE     Subnuclear localization of WT1 in splicing or transcription factor
            domains is regulated by alternative splicing
  JOURNAL   Cell 81 (3), 391-401 (1995)
   PUBMED   7736591
REFERENCE   8  (bases 1 to 1104)
  AUTHORS   Seraphin,B.
  TITLE     Sm and Sm-like proteins belong to a large family: identification of
            proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs
  JOURNAL   EMBO J 14 (9), 2089-2098 (1995)
   PUBMED   7744014
REFERENCE   9  (bases 1 to 1104)
  AUTHORS   Brunet,C., Quan,T. and Craft,J.
  TITLE     Comparison of the Drosophila melanogaster, human and murine Sm B
            cDNAs: evolutionary conservation
  JOURNAL   Gene 124 (2), 269-273 (1993)
   PUBMED   7680326
REFERENCE   10 (bases 1 to 1104)
  AUTHORS   Griffith,A.J., Schmauss,C. and Craft,J.
  TITLE     The murine gene encoding the highly conserved Sm B protein contains
            a nonfunctional alternative 3' splice site
  JOURNAL   Gene 114 (2), 195-201 (1992)
   PUBMED   1376292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833804.16.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.3774808.1,
                                           SRR17784644.1357848.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL833804.16        89433-89565         c
            134-285             AL833804.16        87214-87365         c
            286-397             AL833804.16        85529-85640         c
            398-555             AL833804.16        83801-83958         c
            556-678             AL833804.16        83235-83357         c
            679-804             AL833804.16        82802-82927         c
            805-1104            AL833804.16        81843-82142         c
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.19 cM"
     gene            1..1104
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /note="small nuclear ribonucleoprotein B"
                     /db_xref="GeneID:20638"
                     /db_xref="MGI:MGI:98342"
     exon            1..133
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1069
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /note="isoform 2 is encoded by transcript variant 2; small
                     nuclear ribonucleoprotein-associated protein B; sm protein
                     B"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein-associated
                     protein B isoform 2"
                     /protein_id="NP_001399579.1"
                     /db_xref="GeneID:20638"
                     /db_xref="MGI:MGI:98342"
                     /translation="MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCD
                     CDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAG
                     GPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVRKRHCCSCCRCSHSQYCRS
                     PNSVPTWSWGSSSTYGPRSPSSRYDGPTSWHAASHGSPNGAPSWPRNSNGHAPSWHAA
                     SSSRHARSALIFTQHYVSSSEAMWTLFPRVRLPQTCLFVMQFMESPWIVWFPFQGSLP
                     GKCALQGPRLILVLLSSLPVSFPKGCMYIVLFLCGL"
     exon            134..285
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..397
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            398..555
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            556..678
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            679..804
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1104
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /note="hexamer: AATAAA"
     polyA_site      1104
                     /gene="Snrpb"
                     /gene_synonym="SM-B; SM11; SMB; SNRNP-B"
                     /note="major polyA site"
ORIGIN      
        1 actagcggcg gcattttgca ggcagcattt ccgttagcgg cggcggcggg aatccagcgg
       61 ctggctggct ggcgactagg cctctgtggc agagaatccg gcgggaatct gagccatccg
      121 agccgccacc atgacggtgg gcaagagcag caagatgctg cagcacattg actacaggat
      181 gaggtgcatc ctgcaggacg gccgcatctt catcgggacc ttcaaagcct ttgacaagca
      241 catgaacttg atcctgtgtg actgtgatga gttcaggaag atcaagccaa agaactccaa
      301 acaagcagaa agggaagaga agcgagtcct tggtctggtg ttgcttcgag gggagaacct
      361 ggtctccatg acagtagaag gacctcctcc caaagatact ggcattgccc gagtgccact
      421 tgctggagct gctggggggc caggcatcgg cagggctgct ggcagaggaa tcccggctgg
      481 tgttcctatg ccccaggctc ctgcaggact tgctgggcca gtccgaggtg ttggagggcc
      541 atcccaacag gtgaggaaga ggcactgttg cagctgctgc cgctgcagcc acagccagta
      601 ttgcaggagc cccaactcag tacccacctg gtcgtggggg tcctcctcca cctatgggcc
      661 gaggagcccc tcctccaggt atgatgggcc cacctcctgg catgcggcct cccatgggtc
      721 ccccaatggg gctccctcct ggccgaggaa ctccaatggg catgccccct cctggcatgc
      781 ggcctcctcc tccaggcatg cgaggtctgc tttgatcttc acacagcatt atgtcagtag
      841 ctcagaggcg atgtggaccc tgttccccag ggtcaggtta ccacagacct gtttgtttgt
      901 tatgcagttc atggagtctc cctggattgt ctggtttccc tttcagggct ccctccctgg
      961 gaaatgtgcc ctccaaggcc ctagactcat cttggttctc ctcagctcct tgcctgtttc
     1021 cttcccaaaa ggctgtatgt acatagtcct ttttctctgt ggcctatgaa gctggtttat
     1081 aataaactaa gagactgtta taca
//
